Abstract:
:Recently, it has been reported that total clearance (CLtot) of vancomycin is significantly higher in patients with malignancies compared to those without malignancies. In the present study, to clarify the mechanism of this enhancement in malignancy, we adopted rat animal models, using chemical carcinogen-induced osteosarcoma, selected lung metastatic lesions (C-SLM), transplanted into thigh muscles. The CLtot and renal clearance (CLr) of vancomycin in the tumor-bearing rats were increased compared to the ones of the control rats without tumor. However, there was no difference in the glomerular filtration rate. The plasma concentrations of interleukin (IL)-1β and IL-6, were elevated in the tumor-bearing rats. When renal proximal tubular epithelial cells (RPTEC) were exposed to IL-1β, IL-6, and tumor necrosis factor (TNF)-α simultaneously, the excretory ratio increased significantly. These findings suggest that tubular excretion or re-absorption by cytokines might be associated with changes in the vancomycin CLtot enhancement in the tumor-bearing rats.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Shimada I,Iwata C,Taga S,Teramachi H,Nomura M,Miyamoto K,Tsuciya H,Wada T,Kimura K,Matsushita Rsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
823-9issue
3eissn
0250-7005issn
1791-7530pii
32/3/823journal_volume
32pub_type
杂志文章abstract:BACKGROUND:Overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has recently been suggested to be a promising marker for early detection of lung cancer. The aim of this study was to determine the utility of its detection in bronchoscopic specimens. PATIENTS AND METHODS:Brushing and biopsy specimens ...
journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
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doi:
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pub_type: 历史文章,杂志文章
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
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doi:
更新日期:2011-01-01 00:00:00
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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