Enhanced renal clearance of vancomycin in rats with carcinogen-induced osteosarcoma.

Abstract:

:Recently, it has been reported that total clearance (CLtot) of vancomycin is significantly higher in patients with malignancies compared to those without malignancies. In the present study, to clarify the mechanism of this enhancement in malignancy, we adopted rat animal models, using chemical carcinogen-induced osteosarcoma, selected lung metastatic lesions (C-SLM), transplanted into thigh muscles. The CLtot and renal clearance (CLr) of vancomycin in the tumor-bearing rats were increased compared to the ones of the control rats without tumor. However, there was no difference in the glomerular filtration rate. The plasma concentrations of interleukin (IL)-1β and IL-6, were elevated in the tumor-bearing rats. When renal proximal tubular epithelial cells (RPTEC) were exposed to IL-1β, IL-6, and tumor necrosis factor (TNF)-α simultaneously, the excretory ratio increased significantly. These findings suggest that tubular excretion or re-absorption by cytokines might be associated with changes in the vancomycin CLtot enhancement in the tumor-bearing rats.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Shimada I,Iwata C,Taga S,Teramachi H,Nomura M,Miyamoto K,Tsuciya H,Wada T,Kimura K,Matsushita R

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

823-9

issue

3

eissn

0250-7005

issn

1791-7530

pii

32/3/823

journal_volume

32

pub_type

杂志文章
  • Overexpression of hnRNPA2/B1 in bronchoscopic specimens: a potential early detection marker in lung cancer.

    abstract:BACKGROUND:Overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has recently been suggested to be a promising marker for early detection of lung cancer. The aim of this study was to determine the utility of its detection in bronchoscopic specimens. PATIENTS AND METHODS:Brushing and biopsy specimens ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Katsimpoula S,Patrinou-Georgoula M,Makrilia N,Dimakou K,Guialis A,Orfanidou D,Syrigos KN

    更新日期:2009-04-01 00:00:00

  • Detection and clinical relevance of tumor cells in blood and bone marrow of patients with colorectal cancer.

    abstract::In colorectal cancer, the predictive value of the currently used staging method is limited. Therefore, many parameters have been studied to improve the prediction of final clinical outcome, including several aspects of the primary tumor that are associated with its aggressiveness and the capacity of the host response....

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Vlems FA,Wobbes T,Punt CJ,Van Muijen GN

    更新日期:2003-01-01 00:00:00

  • Global MicroRNA Expression Profiling Identifies Unique MicroRNA Pattern of Radioresistant Glioblastoma Cells.

    abstract::Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques and chemotherapy, the median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure is considered the...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11422

    authors: Ondracek J,Fadrus P,Sana J,Besse A,Loja T,Vecera M,Radova L,Smrcka M,Slampa P,Slaby O

    更新日期:2017-03-01 00:00:00

  • Clarification of the functional significance of human folate-binding protein-alpha, peptide 191-199, based on a correct GenBank sequence and on other FBP (191-199) sequences.

    abstract::It has been brought to our attention that one of the folate binding protein (FBP) peptides, which we reported first as antigenic and immunogenic in cancer patients, the FBP 191-199, is "off by one amino acid from the amino acid sequence that is listed in GenBank". We searched the published information on FBP and found...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ioannides CG

    更新日期:2007-07-01 00:00:00

  • The effects of cantharidin analogues on xanthine oxidase.

    abstract::Norcantharidin[3], the demethylated product of cantharidin[1] has been used for the treatment of hepatoma, carcinomas of esophagus and gastric cardia, leukopenia and hepatitis. Since the enzyme xanthine oxidase is involved in the diseases mentioned above, and the reactive oxygen species produced by the enzyme induces ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tsauer W,Lin JG,Lin PY,Hsu FL,Chiang HC

    更新日期:1997-05-01 00:00:00

  • Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents.

    abstract:BACKGROUND:Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation of Cdc2, are required for the G2 arrest induced by DNA damage. METHODS:We treated 184B5 cell line and its E6 transformed ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Luo Y,Rockow-Magnone SK,Joseph MK,Bradner J,Butler CC,Tahir SK,Han EK,Ng SC,Severin JM,Gubbins EJ,Reilly RM,Rueter A,Simmer RL,Holzman TF,Giranda VL

    更新日期:2001-01-01 00:00:00

  • PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer.

    abstract:BACKGROUND:It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer. However, its correlation with gastric cancer is unclear. MATERIALS AND METHODS:Our study analyzed the effect of PROX1 knockdown on the migration, invas...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12966

    authors: Ueta K,Otowa Y,Kakeji Y,Hirashima M

    更新日期:2018-11-01 00:00:00

  • Modification of the blood-brain barrier permeability following intracarotid infusion of vinorelbine.

    abstract::The effects of the antineoplastic compound, vinorelbine, on the permeability of the blood-brain barrier (BBB) to the complex Evans blue/albumin were studied. Vinorelbine, at a dose range from 5 to 10 mg/kg, was infused (4 ml/kg over 2 min) into the left carotid artery of anesthetised male Sprague-Dawley rats. BBB disr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Mouchard-Delmas C,Gourdier B,Vistelle R,Wiczewski M

    更新日期:1995-11-01 00:00:00

  • Local control by breast-conserving surgery with nipple resection.

    abstract::Local control was compared between patients who had undergone breast-conserving therapy with and without nipple resection. We explored whether there was any difference in local control between the two treatment methods for patients with early breast cancer. A total of 333 women with breast cancer, who had undergone br...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Horiguchi J,Koibuchi Y,Iijima K,Yoshida T,Takata D,Rokutanda N,Nagaoka R,Oyama T,Iino Y,Sakurai H,Morishita Y

    更新日期:2005-07-01 00:00:00

  • Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol.

    abstract:BACKGROUND:Experimental data at the molecular, cellular and organismal levels have implicated dietary components in cancer. Exposure to numerous growth factors, hormones and environmental agents, that can regulate signaling events, is involved in carcinogenesis. Research targets on gene-nutrient interactions may give u...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Updike MS,Sawdy JC,Wang LS,Liu S,Huang YW,Ye W,Farrar WB,Lin YC,Wick M

    更新日期:2007-01-01 00:00:00

  • In vitro studies of human bladder cancer.

    abstract::Explantation and cultivation in vitro of 55 human biopsies of histologically normal urothelial tissue, and 63 biopsies from transitional cell carcinomas (TCC) revealed a primary success rate of about 75% and a secondary success rate of about 50% with no significant differences, between normal and TCC derived cultures....

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kieler J,Christensen B,Ottesen S,Tromholt V,Ostrowski K

    更新日期:1987-09-01 00:00:00

  • Yeast-derived beta-(1-3),(1-6)-D-glucan induces up-regulation of CD86 on dectin-1-positive human B-lymphoma cell lines.

    abstract:BACKGROUND:The knowledge of direct effects of β-glucans on tumor cells is limited. This study evaluated the impact of a soluble yeast-derived beta-(1-3),(1-6)-d-glucan, containing a fraction of aggregated sugar polymers, on viability, proliferation and expression of CD86 of the human B-cell lymphoma cell lines Daudi an...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Harnack U,Kellermann U,Pecher G

    更新日期:2011-12-01 00:00:00

  • Effectiveness of Photodynamic Screening Using 5-Aminolevulinic Acid for the Diagnosis of Pancreatic Cancer.

    abstract:BACKGROUND/AIM:We evaluated urinary levels of porphyrin metabolites, such as uroporphyrin (UP) and coproporphyrin (CP), after 5-Aminolevulinic acid (ALA) administration in patients with or without pancreatic cancer (PaC). PATIENTS AND METHODS:Sixty-seven subjects with PaC, 11 with pancreatitis, and 9 with normal pancr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14347

    authors: Ikeura T,Hori Y,Mitsuyama T,Miyoshi H,Shimatani M,Uchida K,Takaoka M,Ota U,Kamiya A,Takahashi K,Ishizuka M,Kaibori M,Okazaki K

    更新日期:2020-06-01 00:00:00

  • The isolation of colon cancer organ specific neoantigen by the use of the leukocyte adherence inhibition assay and monoclonal antibodies.

    abstract::The LAI reactivity of a colon organ specific neoantigen (OSN) was recovered from the urine of advanced colon cancer patients. In this study three physico-chemical steps were employed; precipitation by 80% ammonium sulfate, ion exchange, and molecular sieve chromatography. Each isolate was tested for activity and speci...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Fink A,Harpaz N,Weisman Z,Shani A,Bentwich Z

    更新日期:1986-07-01 00:00:00

  • Adenocarcinoma production in rats administered 1,2-dimethylhydrazine and fed iron salt and guar gum diets.

    abstract::Iron salts supplemented in a basal ratio, were fed to young Sprague-Dawley male rats for prolonged periods and the frequency of colonic adenocarcinomas induced by repeated s.c. injection of 1,2-dimethylhydrazine (DMH) at unit base doses of 9.0 mg/kg, ascertained and compared with the respective controls. In a series e...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Gershbein LL,Rezai VK,Amir-Mokri E,Rao KC

    更新日期:1993-11-01 00:00:00

  • Transcriptional regulation of the androgen signaling pathway by the Wilms' tumor suppressor gene WT1.

    abstract::The androgen-signaling pathway plays a critical role in prostate cancer development and progression. We have recently demonstrated that the Wilms' tumor suppressor gene product, WT1, binds to multiple sites in the androgen receptor (AR) promoter and transcriptionally represses the AR gene promoter in vitro. We asked w...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Zaia A,Fraizer GC,Piantanelli L,Saunders GF

    更新日期:2001-01-01 00:00:00

  • Pelvic Exenteration as Potential Cure and Symptom Relief in Advanced and Recurrent Gynaecological Cancer.

    abstract:BACKGROUND/AIM:Pelvic exenteration is a radical procedure for certain advanced or recurrent gynaecological cancers, performed with curative or palliative intent. Its validity has evolved as operative mortality and morbidity have improved. This surgery was evaluated to determine the validity of these claims. PATIENTS A...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13759

    authors: Soeda S,Furukawa S,Sato T,Ueda M,Kamo N,Endo Y,Kojima M,Nomura S,Kataoka M,Fujita S,Endo H,Takahashi T,Watanabe T,Yamada H,Fujimori K

    更新日期:2019-10-01 00:00:00

  • Characterisation of taurine uptake in human KB MDR and non-MDR tumour cell lines in culture.

    abstract::Studies on taurine transport in MDR (multidrug resistant) and non-MDR KB cancer cells show that both cell types contain Na(+)- and Cl(-)-dependent high-affinity and low-affinity transport systems selective for beta-amino acids and a taurine diffusion component. Good buffers, such as HEPES or MOPS, interfered with taur...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Wersinger C,Rebel G,Lelong-Rebel IH

    更新日期:2001-09-01 00:00:00

  • Experimental induction of apoptosis by a combination of etoposide and radiation treatment.

    abstract::The present study was undertaken to investigate cell death (particularly apoptosis) induced by etoposide, radiation, and both, and to examine p53 protein expression in relation to cell death. Nude mice transplanted with a human tumor (ependymoblastoma) were treated with etoposide (5-40 mg/kg) or 1-2 Gy X-ray irradiati...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Toda H,Hasegawa M,Hayakawa K,Kawashima M,Nakamura Y,Yamakawa M,Mitsuhashi N,Niibe H

    更新日期:2000-01-01 00:00:00

  • Intraperitoneal Chemotherapy in Patients Pretreated for Ovarian Cancer Matched with Patients Treated with Parenteral Chemotherapy.

    abstract:BACKGROUND:Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. PATIENTS AND METHODS:This was a retrospective study comparing patients with advanced ovarian cancer treate...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11256

    authors: Nicoletto MO,Casarin A,Baldoni A,Rulli E,Tasca G,Baretta Z,Artioli G,Lombardi G,Cappetta A,Floriani I,Randon G,Valpione S,Litta P,Conte P,Mocellin S,Aliberti C

    更新日期:2016-12-01 00:00:00

  • Macrophage apolipoprotein E and proliferation of MCF-7 breast cancer cells: role of LXR.

    abstract:BACKGROUND:Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabolism, is expressed by macrophages under the control of the transcription factor Liver X Receptor (LXR), an oxysterol-activated transcriptional factor involved in cholesterol metabolism. Recent work has shown that ...

    journal_title:Anticancer research

    pub_type: 历史文章,杂志文章

    doi:

    authors: El Roz A,Bard JM,Valin S,Huvelin JM,Nazih H

    更新日期:2013-09-01 00:00:00

  • A Prognostic Nomogram for Overall Survival of Patients After Hepatectomy for Intrahepatic Cholangiocarcinoma.

    abstract:AIM:We hypothesized that a nomogram can accurately predict overall survival (OS) for patients with intrahepatic cholangiocarcinoma (ICC) after hepatectomy. MATERIALS AND METHODS:A nomogram to predict OS based was developed using data from 185 ICC patients who had undergone hepatectomy. The nomogram was evaluated by co...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yeh CN,Wang SY,Chen YY,Chen MH,Chiang KC,Cheng CT,Tsai CY,Wang CC,Yeh TS,Chen TC

    更新日期:2016-08-01 00:00:00

  • Mast cells in invasive ductal breast cancer: different behavior in high and minimum hormone-receptive cancers.

    abstract:BACKGROUND:Studies on the role of mast cells (MC) in cancer have given contrasting results. In order to contribute to the clarification of their role, research on breast cancer was carried out, because some aspects of its carcinogenesis, such as the diversity of the hormonal component, differ greatly. MATERIALS AND ME...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: della Rovere F,Granata A,Familiari D,D'Arrigo G,Mondello B,Basile G

    更新日期:2007-07-01 00:00:00

  • Oncogene transfection of mink lung cells: effect on growth characteristics in vitro and in vivo.

    abstract::Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Khan MZ,Spandidos DA,Kerr DJ,McNicol AM,Lang JC,De Ridder L,Freshney RI

    更新日期:1991-05-01 00:00:00

  • Effect of genistein on p90RSK phosphorylation and cell proliferation in T47D breast cancer cells.

    abstract:BACKGROUND:The molecular mechanisms of genistein's proliferative effects on breast cancer cells are largely unknown. This study aimed to examine estrogen-receptor (ER)-related signaling molecules involved in genistein-associated cell proliferation and survival (ERK1/2, p90RSK, JNK, Akt and NFκB) and to correlate these ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Gwin J,Drews N,Ali S,Stamschror J,Sorenson M,Rajah TT

    更新日期:2011-01-01 00:00:00

  • Preoperative neutrophil to lymphocyte ratio as a prognostic predictor after curative resection for non-small cell lung cancer.

    abstract:BACKGROUND:The prognostic impact of neutrophil to lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) was examined using patients with a follow-up period more than 5 years. PATIENTS AND METHODS:Two hundred and eighty four consecutive resected NSCLC patients were reviewed retrospectively. In this study, patien...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tomita M,Shimizu T,Ayabe T,Yonei A,Onitsuka T

    更新日期:2011-09-01 00:00:00

  • Interaction of radiation and etoposide on two cell lines with different radiosensitivities in vitro.

    abstract:PURPOSE:To investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities in etoposide sensitivity and in the sensitizing effect of etoposide in combination with irradiation. MATERIALS AND METHODS:NMT-1 is a parent radiosensitive cell line and NMT-1R is a variant radioresistant...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Takahashi T,Mitsuhashi N,Akimoto T,Matsumoto H,Ishikawa H,Saito Y,Niibe H

    更新日期:2003-07-01 00:00:00

  • Amentoflavone Enhances the Therapeutic Efficacy of Sorafenib by Inhibiting Anti-apoptotic Potential and Potentiating Apoptosis in Hepatocellular Carcinoma In Vivo.

    abstract:BACKGROUND/AIM:In a previous study, we showed that amentoflavone promotes sorafenib-induced apoptosis in hepatocellular carcinoma (HCC) cells in vitro. However, whether amentoflavone augments anticancer efficacy of sorafenib in HCC in vivo is unknown. The aim of the present study was to verify the anticancer effect of ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12452

    authors: Tsai JJ,Hsu FT,Pan PJ,Chen CW,Kuo YC

    更新日期:2018-04-01 00:00:00

  • Effect of hexafluoro-1,25-dihydroxyvitamin D3 and sodium butyrate combination on differentiation and proliferation of HL-60 leukemia cells.

    abstract::We have investigated the combined effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and its fluoroanalog 26,26,26,27,27,27-hexafluoro-1,25-(OH)2D3 [F6-1,25-(OH)2D3] with sodium butyrate (NaB) on growth and differentiation of HL-60 human promyelocytic leukemia cells. F6-1,25-(OH)2D3 was 10-fold more active than 1,25-(...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yoshida M,Tanaka Y,Eguchi T,Ikekawa N,Saijo N

    更新日期:1992-11-01 00:00:00

  • Changes in cell proliferation and apoptosis during local progression of prostate cancer.

    abstract::To determine the changes in biological features of the prostate during the course of local recurrence of prostate cancer after endocrine therapy, histologic grade, proliferating activity and apoptotic indices were examined in prostate specimens obtained before treatment and at recurrence. A total of 16 patients, who h...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kaibuchi T,Furuya Y,Akakura K,Masai M,Ito H

    更新日期:2000-03-01 00:00:00