Histone Deacetylase Inhibitors and Anaplastic Thyroid Carcinoma.

abstract：:The androgen-signaling pathway plays a critical role in prostate cancer development and progression. We have recently demonstrated that the Wilms' tumor suppressor gene product, WT1, binds to multiple sites in the androgen receptor (AR) promoter and transcriptionally represses the AR gene promoter in vitro. We asked w...

journal_title：Anticancer research

authors： Zaia A,Fraizer GC,Piantanelli L,Saunders GF

更新日期：2001-01-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor (CDK1) p27(kip1) is a negative regulator of cell cycling and has antitumor effects. In our previous study, the recombinant adenovirus expressing wild-type p27(kip1) (Adp27-wt) induced cell cycle arrest and apoptosis, and proved that p27 is a tumor suppressor gene like p53. Another...

journal_title：Anticancer research

authors： Shiraso S,Katayose Y,Yamamoto K,Mizuma M,Yabuuchi S,Oda A,Rikiyama T,Onogawa T,Yoshida H,Hayashi H,Ohtsuka H,Motoi F,Egawa S,Kato J,Unno M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Expression of novel stem cell-associated marker human embryonic stem cell 77 (HES77) was studied in rectal neuroendocrine tumors (NETs), which comprise 10 to 15% of gastroenteropancreatic NETs, some with metastatic potential. MATERIALS AND METHODS:WHO 2010 classification was applied, and immunohistochemical...

journal_title：Anticancer research

authors： Jernman J,Hagström J,Mäenpää H,Välimäki MJ,Haapasalo H,Nilsson O,Fermér C,Haglund C,Arola J

更新日期：2015-07-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a major endogenous regulator of matrix metalloproteinases. This study examined the relation between TIMP-1 gene expression and postoperative mortality in patients with colorectal cancer (CRC). Specimens of CRC were obtained from 202 patients. The relative expression ...

journal_title：Anticancer research

authors： Inagaki D,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Yamada T,Yamamoto N,Sato T,Shiozawa M,Morinaga S,Akaike M,Fujii S,Numata K,Kunisaki C,Rino Y,Tanaka K,Masuda M,Imada T

更新日期：2010-10-01 00:00:00

abstract：:Triple-negative breast cancer phenotype (estrogen receptor-, progesterone receptor- and human epidermal growth receptor 2-negative) is one of the most aggressive molecular subtypes, accounting for 15-20% of all breast tumors. There is no standard treatment for this setting of patients except anthracyclines and taxanes...

journal_title：Anticancer research

authors： De Iuliis F,Salerno G,Taglieri L,Vicinanza R,Lanza R,Scarpa S

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Human mesenchymal stem cells (MSCs) are thought to be multipotent cells which primarily reside in the bone marrow. Besides their well-known ability to replicate as undifferentiated cells and to differentiate into diverse lineages of mesenchymal tissues, they were recently suggested to also give rise to haema...

journal_title：Anticancer research

authors： Wöhrer S,Rabitsch W,Shehata M,Kondo R,Esterbauer H,Streubel B,Sillaber C,Raderer M,Jaeger U,Zielinski C,Valent P

更新日期：2007-11-01 00:00:00

abstract：:Mutations in the p53 gene stimulate cell division. In our study we assessed the prognostic value of mutant p53 overexpression in cervical cancer stage FIGO III detected by immunohistochemistry. In 43 tissue specimens were detected p53 overexpression in 20 cases. Mean survival time was 36.4 (SE +/- 7.66) months in the ...

journal_title：Anticancer research

authors： Gitsch G,Kainz C,Joura E,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND/AIM:Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermin...

journal_title：Anticancer research

authors： Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

更新日期：2018-08-01 00:00:00

abstract：:Ovarian clear cell carcinoma represents a distinct histopathological subtype of epithelial ovarian cancer, with poor outcomes, especially in cases diagnosed in advanced stages of disease. However, even in these cases, it seems that the most effective treatment remains debulking surgery to no residual disease. We prese...

journal_title：Anticancer research

authors： Bacalbasa N,Balescu I,Filipescu A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:To improve long-term survival by reducing toxicity in intermediate stage Hodgkin's disease patients, we compared the effects of involved field (IF) versus extended field (EF) irradiation administered after four cycles of ABVD regimen. MATERIALS AND METHODS:Two hundred and ten Hodgkin's disease patients, at ...

journal_title：Anticancer research

authors： Anselmo AP,Cavalieri E,Osti FM,Cantonetti M,De Sanctis V,Alfo M,Amadori S,Enrici RM

更新日期：2004-11-01 00:00:00

abstract：:The use of lysozyme preparations in the treatment of tumor diseases is based on more than 30 years' experience, using different methodologies and showing various results from which suggestions on the mechanism of action were derived. Lysozymes have no established place in the treatment of human tumors in spite of some...

journal_title：Anticancer research

authors： Sava G,Benetti A,Ceschia V,Pacor S

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors are uncommon intra-abdominal tumors. In fewer than 5% of cases, they originate primarily from the mesentery, omentum or peritoneum and these extra-gastrointestinal stromal tumors tend to have characteristics similar to gastrointestinal stromal. CASE REPORT:We report a case of...

journal_title：Anticancer research

authors： Rediti M,Pellegrini E,Molinara E,Cerullo C,Fonte C,Lunghi A,Iori A,Neri B

更新日期：2014-02-01 00:00:00

abstract：:Mutations in the p53 gene occur frequently in bladder cancers. Better prognostic factors are needed to help select appropriate treatment for patients with TCC stage T1. Paraffin-embedded tumors from 73 patients with TCC stage T1 were processed for two-parameter flow cytometry, measuring both p53 protein and DNA. There...

journal_title：Anticancer research

authors： Vatne V,Maartmann-Moe H,Hoestmark J

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND/AIM:Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients. PATIENTS AND METHODS:A total of 544 elderly patients (aged ≥65 years) receiving whole-brain radiotherapy alone were divided into a test (n=272) and a v...

journal_title：Anticancer research

authors： Evers JN,Schild SE,Segedin B,Nagy V,Khoa MT,Trang NT,Rades D

更新日期：2014-05-01 00:00:00

abstract：:The content, composition and physicochemical characteristics of glycosaminoglycans in human rectum and rectum carcinoma were investigated by chemical analyses, enzymic treatments, chromatographic and electrophoretic techniques. The overall glycosaminoglycan content was increased about 2 fold in neoplastic tissues comp...

journal_title：Anticancer research

authors： Tsara ME,Papageorgacopoulou N,Karavias DD,Theocharis DA

更新日期：1995-09-01 00:00:00

abstract：:A series of simple alpha, beta-unsaturated carbonyl compounds (1-26) was characterized for their cytotoxic profiles against oral human normal and tumor cells. Several cycloalkenones showed potent cytotoxic activities against human oral squamous cell carcinoma HSC-2 cell line. Among them, 4,4-dimethyl-2-cyclopenten-1-o...

journal_title：Anticancer research

authors： Nakayachi T,Yasumoto E,Nakano K,Morshed SR,Hashimoto K,Kikuchi H,Nishikawa H,Kawase M,Sakagami H

更新日期：2004-03-01 00:00:00

abstract：METHODS:Induction chemotherapy, consisting of 3 courses of cisplatin (30 mg/m2/i.v. 1st and 2nd day), epirubicin (30 mg/m2/i.v. 1st and 2nd day), etoposide (75 mg/m2/i.v. 1st and 2nd day) and bleomycin (15 mg/i.v. 1st and 2nd day), prior to radical hysterectomy and lymph nodes resection, was used in the primary treatme...

journal_title：Anticancer research

authors： Panetta A,Angelelli B,Martoni A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized, facilita...

journal_title：Anticancer research

authors： Kölbl AC,Wellens R,Koch J,Rack B,Hutter S,Friese K,Jeschke U,Andergassen U

更新日期：2016-06-01 00:00:00

abstract：:Hormone-dependent (HD) mammary tumors can be induced in mice and rats either by endocrine manipulations or by treatment with carcinogens. The tumors metastasize at a low frequency which may be due to immunogenic properties and does not exclude that the tumors are malignant. Hormone deprival may lead to tumor regressio...

journal_title：Anticancer research

authors： Briand P

更新日期：1983-07-01 00:00:00

abstract：:In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin...

journal_title：Anticancer research

authors： Vernole P,Tedeschi B,Melino G,Pianca C,Nicoletti B

更新日期：1992-09-01 00:00:00

abstract：:Ascorbyl stearate is a lipophilic, vitamin C derivative with antitumorigenic properties. The molecular mechanism(s) underlying the anticarcinogenic effect of this compound have not been well documented. The effect of ascorbyl stearate was studied in a panel of human ovarian epithelial cancer cells. Treatment with asco...

journal_title：Anticancer research

authors： Fang Q,Naidu KA,Naidu KA,Zhao H,Sun M,Dan HC,Nasir A,Kaiser HE,Cheng JQ,Nicosia SV,Coppola D

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:Exposure of organs at risk with prostate radiotherapy (RT) is lower in the prone position. This study is a prospective evaluation of setup accuracy, side-effects, and quality of life (QOL) during and after prone positioned RT. PATIENTS AND METHODS:Image-guided (IG) intensity-modulated (IM) RT was admini...

journal_title：Anticancer research

authors： Varga L,Kószó RL,Fodor E,Cserháti A,Varga Z,Darázs B,Kahán Z,Hideghéty K,Borzási E,Szabó D,Müllner K,Maráz A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:DNA topoisomerase II alpha (topo II alpha) is associated with active cell proliferation of mammalian cells. Topo II alpha overexpression has been reported in a number of human malignancies and is considered to be related to their biological behaviors. MATERIALS AND METHODS:We examined the expression of topo...

journal_title：Anticancer research

authors： Ohashi Y,Sasano H,Yamaki H,Shizawa S,Kikuchi A,Shineha R,Akaishi T,Satomi S,Nagura H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest and stimulate apoptosis of cancer cells. MATERIALS AND METHODS:The effects of a novel HDACI, MS-275, on 4 endometrial cancer cell lines and normal human endometrial epithelial cells was investigated. Endometrial...

journal_title：Anticancer research

authors： Takai N,Ueda T,Nishida M,Nasu K,Narahara H

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated patients undergoing salvage hysterectomy after brachytherapy (BT) following concomitant chemoradiation (CRT) for locally advanced cervical cancers (LACC), when residual disease was suspected. PATIENTS AND METHODS:From 2004 to 2013, 29 patients had a radical hysterectomy at the Gustave Rouss...

journal_title：Anticancer research

authors： Gosset M,Chargari C,Bentivegna E,Leary A,Genestie C,Maulard A,Morice P,Gouy S

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Oxidised ferrocenium compounds often possess antineoplastic activity. In contrast, reduced ferrocene derivatives frequently only show activity if cell components can oxidise them inside cells to the ferrocenium species. Ferrocene compounds having the lowest formal reduction potential are normally expected to...

journal_title：Anticancer research

authors： Swarts JC,Vosloo TG,Cronje SJ,Du Plessis WC,Van Rensburg CE,Kreft E,Van Lier JE

更新日期：2008-09-01 00:00:00

abstract：:Cytochrome P450 CYP2D6 polymorphism is an autosomal recessive trait leading to impaired sparteine/ debrisoquine metabolism in 5-10% of the Caucasian population. Previous studies have associated affected individuals (poor metabolizers = PM) with susceptibility to bladder cancer and various forms of leukemia. In many ot...

journal_title：Anticancer research

authors： Wundrack I,Sasiadek M,Blin N

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Since superparamagnetic iron oxide nanoparticles (SPION) possess unique features, they provide a huge platform for medical applications, especially for cancer diagnosis and therapy (e.g. imaging, and drug targeting). However, heterogeneous effects on mammalian cells with regard to reproductive tissue are des...

journal_title：Anticancer research

authors： Pöttler M,Hofmann S,Dürr S,Unterweger H,Wiest I,Zaloga J,Alexiou C,Jeschke U,Janko C

更新日期：2016-06-01 00:00:00

abstract：:During intercellular induction of apoptosis, TGF-beta-treated nontransformed fibroblasts induce apoptosis specifically in transformed fibroblasts. To test whether sensitivity to intercellular induction of apoptosis is causally related to the expression of the transformed phenotype, NRK 536 cells were reversibly transf...

journal_title：Anticancer research

authors： Häufel T,Bauer G

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) remains the most aggressive and frequently occurring brain neoplasm. Members of the Rho family of small GTP-binding proteins, including Rho, Rac, and Cdc42, have been shown to participate in cell growth differentiation and motility. The mitogen-activated protein kinase (MAPK) pa...

journal_title：Anticancer research

authors： Zohrabian VM,Forzani B,Chau Z,Murali R,Jhanwar-Uniyal M

更新日期：2009-01-01 00:00:00