Gefitinib in combination with gemcitabine and vinorelbine in patients with metastatic breast cancer pre-treated with taxane and anthracycline chemotherapy: a phase I/II trial.

abstract：BACKGROUND/AIM:This study aimed to identify the survival benefit of intrahepatic tumour control by hepatic arterial infusion chemotherapy (HAIC) in hepatocellular carcinoma (HCC) patients with portal vein tumour thrombus (PVTT) or extrahepatic metastasis. PATIENTS AND METHODS:Between 2010 and 2017, a total of 187 cons...

journal_title：Anticancer research

authors： Sung PS,Yang K,Bae SH,Oh JS,Chun HJ,Nam HC,Jang JW,Choi JY,Yoon SK

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Certain viruses, notably human papillomavirus (HPV), cytomegalovirus (CMV), herpes simplex virus (HSV) and Epstein-Barr virus (EBV), are known to produce tumors in animals and cell transformation in vitro and they have been implicated in the pathogenesis of human cancers. All these viruses are also known to ...

journal_title：Anticancer research

authors： Chang F,Syrjänen S,Shen Q,Cintorino M,Santopietro R,Tosi P,Syrjänen K

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:To develop a scoring system to predict bone metastasis after radical resection within 5 years. PATIENTS AND METHODS:We evaluated the patient records of 1,749 patients, of whom 50 patients developed bone metastasis. Treatment-related factors (age, gender, localization, histology, preoperative carbohydrat...

journal_title：Anticancer research

authors： Li A,Käsmann L,Rades D,Fu C

更新日期：2017-09-01 00:00:00

abstract：:Binding of 20-[3H]-phorbol 2, 13-dibutyrate [( 3H] PDB) to intact human K 562 cells was characterized. Specific binding of [3H] PDB to K 562 cells at 20 degrees C or 37 degrees C reached a maximum within 15-20 min. Maximal specific [3H] PDB binding to K 562 cells was followed by a decline (down regulation) of radioact...

journal_title：Anticancer research

authors： Louache F,Villeval JL,Pelicci PG,Rouis M,Titeux M,Henri A,Rochant H,Thomopoulos P,Testa U

更新日期：1984-01-01 00:00:00

abstract：:The overexpression of p53, c-erbB-2 and p21ras gene products was evaluated immunohistochemically in ovarian carcinomas, borderline, and benign neoplasms. All studies were performed on cytospin preparations of cyst and/or ascitic fluid cells and mutual relations between oncoproteins were analysed. p53 and c-erbB-2 immu...

journal_title：Anticancer research

authors： Harłozińska A,Bar JK,Sobańska E,Goluda M

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND/AIM:Neuroendocrine neoplasms (NEN) of the female genital tract account for 2% of gynecological cancers. The aim of this study was to share our experience of 11 primary neuroendocrine neoplasms of the ovary. PATIENTS AND METHODS:All patients who presented and/or were treated at our Institution with histologi...

journal_title：Anticancer research

authors： Sehouli J,Woopen H,Pavel M,Richter R,Lauterbach LK,Taube E,Darb-Esfahani S,Fotopoulou C,Pietzner K

更新日期：2016-03-01 00:00:00

abstract：:In human colorectal tissue samples, the gene expressions of 4 coactivators, p300, pCAF, TIF-2 and TRAP 220, and 7 corepressors, N-CoR, REA, MTA1, MTA1L1, HDAC1, HDAC2 and HDAC3, linked to estrogen receptors (ER), were revealed by traditional RT-PCR. Cofactors ERalpha, ERbeta and ERRalpha mRNA levels were then measured...

journal_title：Anticancer research

authors： Giannini R,Cavallini A

更新日期：2005-11-01 00:00:00

abstract：:Beta-casein-like protein (BCLP) is a putative protein on cervical cancer and exhibits immunological characteristics similar to those of bovine beta-casein. We evaluated if BCLP mRNA detection in the blood is useful in gynecologic malignancies. We examined 30 patients with uterine cancer, nine cultured cancer cell line...

journal_title：Anticancer research

authors： Baba T,Koizumi M,Suzuki T,Yamanaka I,Yamashita S,Kudo R

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND/AIM:High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein that exerts a range of proinflammatory actions when it is secreted extracellularly. We hypothesized that HMGB1 released from damaged cells in pituitary apoplexy would exacerbate the neurological symptoms due to acute inflammation. PATIEN...

journal_title：Anticancer research

authors： Okuda T,Fujita M,Kato A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Abnormal hypermethylation of the CDKN2A (p14ARF and p16INK4a) gene can lead to repression of gene expression and contribute to carcinogenesis and tumor progression. MATERIALS AND METHODS:In esophageal squamous cell carcinoma (ESCC), the promoter methylation of the p14ARF and p16INK4a gene was investigated i...

journal_title：Anticancer research

authors： Ito S,Ohga T,Saeki H,Watanabe M,Kakeji Y,Morita M,Yamada T,Maehara Y

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Intronic microRNAs (miRNAs) are considered to be transcribed using their host gene promoter. However, about one third of intronic miRNAs are predicted to have independent promoter elements. MATERIALS AND METHODS:Human breast cancer cells were cultured under normoxia or hypoxia, and expression levels of intr...

journal_title：Anticancer research

authors： Kondo H,Shimono Y,Mukohyama J,Tanaka Y,Shibuya N,Minami H,Kakeji Y,Suzuki A

更新日期：2017-07-01 00:00:00

abstract：:The antitumoral and immunostimulating properties of rViscumin (recombinant mistletoe lectin) were investigated in two mouse tumor models. After intravenous inoculation with RAW-117-P or L-1 sarcoma cells in Balb/c mice, rViscumin was given s.c. at non-toxic doses ranging from 0.3 to 150 ng rViscumin/kg. One set of exp...

journal_title：Anticancer research

authors： Schaffrath B,Mengs U,Schwarz T,Hilgers RD,Beuth J,Möckel B,Lentzen H,Gerstmayer B

更新日期：2001-11-01 00:00:00

abstract：:K-ras-NIH3T3 cells were more invasive than NIH3T3 cells in a chemotactic invasion assay. Conophylline, a new vinca alkaloid isolated as a ras function inhibitor, inhibited the invasion of K-ras-NIH3T3 cells, while it showed no effect on NIH3T3 cells. Conophylline did not increase expression of fibronectin but induced ...

journal_title：Anticancer research

authors： Amino N,Ohse T,Koyano T,Umezawa K

更新日期：1996-01-01 00:00:00

abstract：AIM:The expression level of DNA repair-related genes and their association with breast cancer status among participants of the New York site of the Breast Cancer Family Registry was investigated. MATERIALS AND METHODS:RNA from mononuclear cells in 194 sister sets (n=475 women) were assayed for ATM, BRCA1, MSH2, MUTYH ...

journal_title：Anticancer research

authors： Kappil MA,Liao Y,Terry MB,Santella RM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:While procarbazine with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (PC) added to vincristine (PCV) was proven beneficial in the treatment of co-deleted anaplastic oligodendroglioma (AO), the question of whether PC alone is sufficient is important, as vincristine adds toxicity with uncertain benefit. This r...

journal_title：Anticancer research

authors： Webre C,Shonka N,Smith L,Liu D,De Groot J

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND/AIM:Forodesine inhibits purine nucleoside phosphorylase, resulting in an accumulation of intracellular dGTP and consequently cell death. 9-β-D-Arabinofuranosylguanine (ara-G) is an active compound of nelarabine that is intracellularly phosphorylated to a triphosphate form, which inhibits DNA synthesis. Both ...

journal_title：Anticancer research

authors： Yamauchi T,Uzui K,Nishi R,Tasaki T,Ueda T

更新日期：2014-09-01 00:00:00

abstract：:A human ovarian mesodermal mixed heterologous carcinoma, with a high content of cellular retinol-binding protein (CRBP), was used to study the effects of retinoid and hormonal treatment on tumour CRBP content, tumour growth rate, differentiation and turnover of CRBP. Tumour growth in general was accompanied by an incr...

journal_title：Anticancer research

authors： Wahlberg P,Fex G,Wennerberg J,Willén R

更新日期：1989-01-01 00:00:00

abstract：:The compound 317615 x 2HCl, a selective protein kinase Cbeta inhibitor, was not very cytotoxic toward human CaKi1 renal cell carcinoma cells or human HT-29 colon carcinoma cells in monolayer culture. Isobologram analysis was used to determine additivity or synergy of the combination regimens. Exposure of CaKi1 cells t...

journal_title：Anticancer research

authors： Teicher BA,Menon K,Alvarez E,Galbreath E,Shih C,Faul MM

更新日期：2001-09-01 00:00:00

abstract：:2-4 Dinitrochlorobenzene (D.N.C.B.) is a synthetic primary allergenic molecule which has proved to have at least two useful clinical applications as regards neoplastic conditions. As a diagnostic measure, it serves in the detection of global alterations of cellular immunity. As a therapeutical measure, its epicutaneou...

journal_title：Anticancer research

authors： Truchetet F,Heid E,Friedel J,Chartier C,Grosshans E

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND/AIM:This study aimed to assess whether low-molecular-weight heparin (LMWH) is effective and safe in preventing postoperative venous thromboembolism (VTE) in patients undergoing esophageal cancer surgery. PATIENTS AND METHODS:In this single-institution, prospective, randomized trial, 73 patients with esophag...

journal_title：Anticancer research

authors： Tanaka Y,Yamada A,Hirata S,Tanaka H,Sakuratani T,Matsuhashi N,Yamaguchi K,Shimokawa T,Yoshida K

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Intermedilysin (ILY) is a human specific cytolysin secreted by Streptococcus intermedius. In the present study, we performed molecular modeling of ILY and cholesterol-dependent cytolysins (CDCs) (pneumolysin, PLY; listeriolysin O, LLO; streptolysin O, SLO; alveolysin, ALV; suilysin, SLY; pyolysin, PLO) to co...

journal_title：Anticancer research

authors： Ohkura K,Nagamune H,Kourai H

更新日期：2004-09-01 00:00:00

abstract：:A pilot study to evaluate the predictive value of Indium-111-labelled somatostatin analogue [DTPA-D-Phe1]-octreotide scintigraphy (OctreoScan111) in the Octreotide treatment of hormone-refractory prostatic adenocarcinoma was initiated. Ten patients were investigated with OctreoScan111 with regard to disease extension ...

journal_title：Anticancer research

authors： Kälkner KM,Nilsson S,Westlin JE

更新日期：1998-01-01 00:00:00

abstract：:Various lignified materials, including pine cone extract and a commercial lignin, stimulated the morphological change (spreading) of mouse peritoneal macrophages, and their functional maturation as judged by increase in NBT-reducing activity. When these materials were treated with NaClO2 to decompose the phenolic stru...

journal_title：Anticancer research

authors： Kikuchi K,Sakagami H,Fujinaga S,Kawazoe Y,Oh-Hara T,Ichikawa S,Kurakata Y,Takeda M,Sato T

更新日期：1991-03-01 00:00:00

abstract：AIM:To analyze female gender as a possible age-dependent prognostic factor for overall (OS) and cancer-specific survival (CSS) in patients with upper urinary tract urothelial carcinoma (UUTUC) after radical nephroureterectomy (RNU). PATIENTS AND METHODS:A total of 167 men and 101 women with UUTUC treated with RNU with...

journal_title：Anticancer research

authors： Sikic D,Wach S,Taubert H,Richterstetter M,Kunath F,Goebell PJ,Schick S,Olbert P,Huber J,Wullich B,Keck B

更新日期：2015-07-01 00:00:00

abstract：AIM:Despite recent improvements in treatment strategies, the results of chemotherapy in patients with advanced squamous cell carcinoma of the larynx are not satisfactory. Thus, the development of new approaches which influence specific metabolic pathways are needed. In the last decade, evidence has emerged implicating ...

journal_title：Anticancer research

authors： Stepulak A,Luksch H,Uckermann O,Sifringer M,Rzeski W,Polberg K,Kupisz K,Klatka J,Kielbus M,Grabarska A,Marzahn J,Turski L,Ikonomidou C

更新日期：2011-02-01 00:00:00

abstract：AIM:Metabolic syndrome has been identified as a risk factor for colorectal cancer and adenoma. The aim of our study was to assess the risk of colorectal cancer and adenoma in an adult Italian population with metabolic syndrome. PATIENTS AND METHODS:Ninety patients with metabolic syndrome were prospectively compared ag...

journal_title：Anticancer research

authors： Fiori E,Lamazza A,De Masi E,Schillaci A,Crocetti D,Antoniozzi A,Sterpetti AV,De Toma G

更新日期：2015-04-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen presenting cells. Two x 10(7) peripheral blood mononuclear cells (PBMCs) from each of 6 melanoma patients and 4 normal donors were incubated in 6-well plates. The adherent cells were cultured in GM-CSF (800 U/ml) and IL-4 (1000 U/ml) for 10 days. Anti-CD80, anti-CD86, ant...

journal_title：Anticancer research

authors： Chang JW,Vaquerano JE,Zhou YM,Peng M,Leong SP

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to investigate how oxidative status influences the effectiveness of cytotoxicity of artemisinin towards cancer cells. It is hypothesized that antioxidants would reduce, whereas pro-oxidants would enhance, cytotoxicity. MATERIALS AND METHODS:Molt-4 human leukemia cells ...

journal_title：Anticancer research

authors： Gerhardt T,Jones R,Park J,Lu R,Chan HW,Fang Q,Singh N,Lai H

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Antioxidants have the potential to protect normal tissues against radiation-induced damage, but must not protect tumor cells during radiotherapy. The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tumor response to radiation and identify possible mechanisms of inte...

journal_title：Anticancer research

authors： Gridley DS,Makinde AY,Luo X,Rizvi A,Crapo JD,Dewhirst MW,Moeller BJ,Pearlstein RD,Slater JM

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND/AIM:Vimentin3 (Vim3) was recently described as a tumour marker for the direct discrimination between benign and malignant kidney tumours. Here, we examined its expression in prostate cancer (PCa) cell lines and the regulation of its expression by endothelin receptors. MATERIALS AND METHODS:Prostate cancer c...

journal_title：Anticancer research

authors： KÖditz B,Stog A,GÖbel H,Heidegger I,Fries J,Heidenreich A,VON Brandenstein M

更新日期：2021-01-01 00:00:00