Effects of antioxidants and pro-oxidants on cytotoxicity of dihydroartemisinin to Molt-4 human leukemia cells.

Abstract:

BACKGROUND:The objective of the present study was to investigate how oxidative status influences the effectiveness of cytotoxicity of artemisinin towards cancer cells. It is hypothesized that antioxidants would reduce, whereas pro-oxidants would enhance, cytotoxicity. MATERIALS AND METHODS:Molt-4 human leukemia cells were incubated with vitamins C, E, D3, dexamethasone, or hydrogen peroxide alone or in combination with dihydroartemisinin (DHA). Concentrations of these compounds studied were similar to those achievable by oral administration. Viable cell counts were performed before (0 h) and at, 24 and 48 h after treatment. RESULTS:Vitamin C, vitamin D3, dexamethasone, and H2O2 caused significant Molt-4 cell death. Vitamin E caused an increase in Molt-4 cell growth. Vitamin C and vitamin D3 significantly interacted with DHA at the 48-h time point and with H2O2 at both 24-h and 48-h time points. CONCLUSION:Cellular oxidative status could alter the potency of artemisinin in killing cancer cells.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Gerhardt T,Jones R,Park J,Lu R,Chan HW,Fang Q,Singh N,Lai H

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1867-71

issue

4

eissn

0250-7005

issn

1791-7530

pii

35/4/1867

journal_volume

35

pub_type

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