Decitabine, a DNA methyltransferase inhibitor, reduces P-glycoprotein mRNA and protein expressions and increases drug sensitivity in drug-resistant MOLT4 and Jurkat cell lines.

abstract：BACKGROUND:Zoledronate (Zol), an anti-osteoclastic and anticancer drug, is used to control bone metastasis in several cancer types, including non-small cell lung cancer (NSCLC). However, the mechanisms behind Zol resistance in NSCLC are unclear. MATERIALS AND METHODS:Zol-resistant cell lines were developed by repeated...

journal_title：Anticancer research

authors： Aoyagi T,Morii T,Ohtsuka K,Ohnishi H,Tajima T,Yoshiyama A,Mochizuki K,Satomi K,Ichimura S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The tumour suppressor gene 'mutated in colorectal cancer' (MCC) is silenced through promoter methylation in colorectal cancer and has been implicated as a regulator of the nuclear factor kappa B (NFκB) pathway. Therefore, we aimed to determine whether MCC modulates NFκB activation in colorectal cancer. MATE...

journal_title：Anticancer research

authors： Sigglekow ND,Pangon L,Brummer T,Molloy M,Hawkins NJ,Ward RL,Musgrove EA,Kohonen-Corish MR

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to evaluate the impact of laparoscopic gastrectomy (LG) for gastric cancer on long-term survival in patients with postoperative infectious complications (PIC). PATIENTS AND METHODS:A total of 608 patients who underwent gastrectomy were classified into two groups based on the su...

journal_title：Anticancer research

authors： Nagata H,Tsujimoto H,Kouzu K,Itazaki Y,Ishibashi Y,Tsuchiya S,Sugihara T,Ito N,Harada M,Nomura S,Kishi Y,Ueno H

更新日期：2020-12-01 00:00:00

abstract：:The expression of epidermal growth factor (EGF) and its receptor (EGF-R) was examined immunohistochemically in 60 primary and 26 metastatic lesions of pancreatic carcinoma. EGF was stained mainly in the cytoplasm of tumor cells, and EGF-R was stained mainly on the surface of cells. The expression rates of EGF and EGF-...

journal_title：Anticancer research

authors： Uegaki K,Nio Y,Inoue Y,Minari Y,Sato Y,Song MM,Dong M,Tamura K

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Delayed elimination of methotrexate associated with serious side-effects has been attributed to the co-administration of benzimidazole proton pump inhibitors. PATIENTS AND METHODS:We have retrospectively analyzed the causes of delayed methotrexate elimination in patients who had received the rescue agent gl...

journal_title：Anticancer research

authors： Santucci R,Levêque D,Kemmel V,Lutz P,Gérout AC,N'guyen A,Lescoute A,Schneider F,Bergerat JP,Herbrecht R

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:We have previously shown that human metallopanstimulin (MPS-1) is a 9.4-kDa multifunctional ribosomal S27/nuclear "zinc finger" protein which is expressed in a wide variety of actively proliferating cells and tumor tissues. Furthermore, we have shown that detection of MPS-N immunoreactive material in sera co...

journal_title：Anticancer research

authors： Fernandez-Pol JA,Fletcher JW,Hamilton PD,Klos DJ

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The efficacy and toxicity of adjuvant chemo-immunotherapy using dendritic cells and activated killer cells are not clear in post-surgical primary lung cancer patients. PATIENTS AND METHODS:Pathologically diagnosed N2 lung cancer patients were selected for postsurgical adjuvant chemo-immunotherapy. The activ...

journal_title：Anticancer research

authors： Kimura H,Iizasa T,Ishikawa A,Shingyouji M,Yoshino M,Kimura M,Inada Y,Matsubayashi K

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Anastomotic leakage is a major critical complication in colorectal resection. Although its relevance to oncological outcome has been widely investigated, the correlation between the severity of anastomotic leakage and oncological outcome is not well understood. PATIENTS AND METHODS:The clinical characterist...

journal_title：Anticancer research

authors： Takahashi H,Haraguchi N,Nishimura J,Hata T,Yamamoto H,Matsuda C,Mizushima T,Doki Y,Mori M

更新日期：2018-01-01 00:00:00

abstract：:Prophylactic cranial irradiation (PCI) is still an open question despite the fact that ten randomized trials have been published in the past, addressing its impact on overall survival, disease-free survival and incidence of brain recurrences. The majority of these trials allow us to conclude that PCI is only useful in...

journal_title：Anticancer research

authors： Vitale V,Scolaro T,Orsatti M

更新日期：1994-01-01 00:00:00

abstract：:Bax, bcl-2 and their homologues regulate a distal step in an evolutionary very well conserved pathway of apoptotic cell death. It plays a crucial role in the balance between proliferation rate and cell viability. Thus in the last years the attention of the scientific community towards these proteins has remarkably inc...

journal_title：Anticancer research

authors： Caputi M,Groeger AM,Esposito V,De Luca A,Murabito M,Tahir T,Giordano GG,Baldi F,Giordano A,Wolner E

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The presence of cytokeratin (CK)-positive cells in the bone marrow (BM) of breast cancer patients is an independent prognostic marker for long-term survival. While the exact nature of these cells remains under investigation, their persistence after chemotherapy is linked to decreased survival, making them a ...

journal_title：Anticancer research

authors： Becker S,Becker-Pergola G,Fehm T,Wallwiener D,Solomayer EF

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Vinflunine is a novel Vinca alkaloid currently undergoing Phase II clinical trials, which have previously demonstrated anti-vascular effects in a transplantable murine colon adenocarcinoma model. Previous studies with compounds showing similar effects in combination with standard anti-cancer agents have demo...

journal_title：Anticancer research

authors： Shnyder SD,Cooper PA,Gyselinck N,Hill BT,Double JA,Bibby MC

更新日期：2003-11-01 00:00:00

abstract：:Tumor angiogenesis seems to be an important factor in determining therapeutic effectiveness and patient prognosis. An abundance of data on tumor angiogenesis is available and it clearly shows that most human solid tumors are heterogeneously vascularized and oxygenated and contain hypoxic regions. Such regions and area...

journal_title：Anticancer research

authors： Mattern J

更新日期：2001-11-01 00:00:00

abstract：:One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin resistance in vitro. However, the expression of ATP7B has not p...

journal_title：Anticancer research

authors： Sugeno H,Takebayashi Y,Higashimoto M,Ogura Y,Shibukawa G,Kanzaki A,Terada K,Sugiyama T,Watanabe K,Katoh R,Nitta Y,Fukushima T,Koyama Y,Inoue N,Sekikawa K,Ogawa K,Sato Y,Takenoshita S

更新日期：2004-03-01 00:00:00

abstract：:A human ovarian mesodermal mixed heterologous carcinoma, with a high content of cellular retinol-binding protein (CRBP), was used to study the effects of retinoid and hormonal treatment on tumour CRBP content, tumour growth rate, differentiation and turnover of CRBP. Tumour growth in general was accompanied by an incr...

journal_title：Anticancer research

authors： Wahlberg P,Fex G,Wennerberg J,Willén R

更新日期：1989-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC), a rare calcitonin-producing tumor, is derived from parafollicular C-cells of the thyroid and is characterized by constitutive Bcl-2 overexpression. The tumor is relatively insensitive to radiation therapy as well as conventional chemotherapy. To date, the only curative treatment is t...

journal_title：Anticancer research

authors： Rinner B,Li ZX,Haas H,Siegl V,Sturm S,Stuppner H,Pfragner R

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Tumor cells expressing excessive anionic-charged sialic acid can be potentially targeted by cationic polymers which may inhibit tumor growth. In the present study, three new families of cationic polymers were synthesized to assess their effects on prostate cancer cells. MATERIALS AND METHODS:Cationic polyme...

journal_title：Anticancer research

authors： Gakhar G,Liu H,Shen R,Scherr D,Wu D,Nanus D,Chu CC

更新日期：2014-08-01 00:00:00

abstract：:The usefulness of prostate specific antigen (PSA) in screening for prostatic carcinoma was studied in 262 inpatients of the department of internal medicine. All patients underwent a rectal digital examination and determination of PSA by the Tandem-E method (Hybritech). The plan was to perform biopsies if there were su...

journal_title：Anticancer research

authors： Waidelich R,Jansen HM,Stieber P,Schmeller N,Lamerz R,Werdan K,Fateh-Moghadam A

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIM:Only 30-50% of patients with sentinel lymph node (SLN) metastases present with further axillary lymph node metastases. Therefore, up to 70% of patients with positive SLN are overtreated by axillary dissection (AD) and may suffer from complications such as sensory disturbances or lymphedema. According to ...

journal_title：Anticancer research

authors： Gruber I,Henzel M,Schönfisch B,Stäbler A,Taran FA,Hahn M,Röhm C,Helms G,Oberlechner E,Wiesinger B,Nikolaou K,LA Fougère C,Wallwiener D,Hartkopf A,Krawczyk N,Fehm T,Brucker S

更新日期：2018-07-01 00:00:00

abstract：UNLABELLED:Reduced serum-zinc concentrations are well known as typical laboratory characteristics in advanced head and neck cancer. Our aim was to follow the development of this phenomenon during the disease. PATIENTS AND METHODS:A total of 21 patients were included in this pilot-study (1 female, 20 male). The median ...

journal_title：Anticancer research

authors： Büntzel J,Bruns F,Glatzel M,Garayev A,Mücke R,Kisters K,Schäfer U,Schönekaes K,Micke O

更新日期：2007-07-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the detection rate of bone metastases and the added value of 11C-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC). MATERIALS AND METHODS:A total of 66 untreated patients with high-risk ...

journal_title：Anticancer research

authors： Strandberg S,Karlsson CT,Ogren M,Axelsson J,Riklund K

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND/AIM:The definition of vault (ribonucleoprotein particles) function remains highly complex. Vaults may cooperate with multidrug resistance (MDR) proteins, supporting their role in drug resistance. This topic is the main theme of this publication. MATERIALS AND METHODS:The cell viability was determined by an ...

journal_title：Anticancer research

authors： Wojtowicz K,Januchowski R,Nowicki M,Zabel M

更新日期：2017-06-01 00:00:00

abstract：:P53 mutation, through defects in repairing DNA damages, is associated with genomic instability. In 24 adult patients with relapsed acute lymphoblastic leukemia (ALL), the status of the p53 gene at different stages was serially followed by cytogenetic and polymerase-chain reaction/single strand conformation polymorphis...

journal_title：Anticancer research

authors： Tang JL,Tien HF,Lin MT,Chen PJ,Chen YC

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Investigation of transcription regulators in carcinoma can contribute greatly to clarifying the biological character of the carcinoma. In this study, we examined the expression of ets-1 and ets-2, prominent transcription regulators belonging to the ets family, in various colonic tissues. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Ito Y,Takeda T,Okada M,Matsuura N

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND/AIM:To validate the melanoma nomogram and improve its function in prediction of nodal dissemination by incorporating a molecular marker in the model. Microphthalmia transcription factor (MITF) is an important regulator of melanocyte homeostasis and differentiation. We have shown that the grade of MITF expres...

journal_title：Anticancer research

authors： Naffouje SA,Naffouje R,Chen J,Salti GI

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:A gastrostomy feeding tube is one method for long-term feeding support in patients undergoing radio(chemo)therapy for head and neck cancer (HNC). The aim of this study was to analyze the safety of prophylactic gastrostomy tube placement and usage in HNSCC patients. PATIENTS AND METHODS:HNC patients undergoi...

journal_title：Anticancer research

authors： Sieron HL,Eberle F,Gress TM,Mahnken AH,Wiegand S

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Immune cells (lymphocytes and macrophages) provide the microenvironment for immune surveillance of metastatic prostate cancer (PCa) cells in pelvic lymph nodes. We have hypothesized that degeneration and/or apoptosis of metastatic PCa cells in pelvic lymph nodes can distinguish between aggressive and non-agg...

journal_title：Anticancer research

authors： Sinha AA,Fernandes ET,Ewing SL,Wilson MJ

更新日期：2013-09-01 00:00:00

abstract：:Alterations in histone acetylation status appear to play a central role in the regulation of neoplasia, tumor suppression, cell cycle control, hormone responsiveness and senescence. These alterations of chromatin control gene transcription. The histone acetylation status is regulated by the equilibrium of histone acet...

journal_title：Anticancer research

authors： Dressel U,Renkawitz R,Baniahmad A

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a key role in extracellular matrix (ECM) turnover and remodeling. Changes in their expression levels have been observed in various tumor types. However, their clinical significance and prognostic importance in the progr...

journal_title：Anticancer research

authors： Honkavuori M,Talvensaari-Mattila A,Puistola U,Turpeenniemi-Hujanen T,Santala M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Pure or metaplastic squamous cell carcinoma (SCC) of the breast is a rare entity with an unclear pathogeny and aggressive clinical behaviour. An attempt was made to characterize its differential immunohistochemical and biological profile. PATIENTS AND METHODS:Twenty-seven cases of SCC (pure or not) of the b...

journal_title：Anticancer research

authors： Grenier J,Soria JC,Mathieu MC,Andre F,Abdelmoula S,Velasco V,Morat L,Besse B,Dunant A,Spielmann M,Delaloge S

更新日期：2007-01-01 00:00:00