Abstract：
:One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin resistance in vitro. However, the expression of ATP7B has not previously been addressed in human liver and HCC. Our purpose was to investigate ATP7B expression in human liver and hepatocellular carcinoma and its clinical significance. We retrospectively examined the expression of ATP7B in primary hepatocellular carcinoma. Immunohistochemical analysis of ATP7B was performed using a monoclonal antibody against ATP7B in 19 surgically removed hepatocellular carcinomas. A variable degree of cytoplasmic staining of tumor cells was observed in 21.1% (4/19) of the analyzed carcinomas. ATP7B expression was not observed in normal hepatic cells. Strong expression of ATP7B was observed in all the analyzed bile ducts. These findings suggest that overexpression of ATP7B in hepatocellular carcinoma might be associated with unfavorable clinical outcome in patients treated with cisplatin-based chemotherapy. Further, ATP7B is expressed in bile duct epithelial cells, where it may mediate copper secretion into bile fluid.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Sugeno H,Takebayashi Y,Higashimoto M,Ogura Y,Shibukawa G,Kanzaki A,Terada K,Sugiyama T,Watanabe K,Katoh R,Nitta Y,Fukushima T,Koyama Y,Inoue N,Sekikawa K,Ogawa K,Sato Y,Takenoshita Ssubject
Has Abstractpub_date
2004-03-01 00:00:00pages
1045-8issue
2Ceissn
0250-7005issn
1791-7530journal_volume
24pub_type
杂志文章abstract：UNLABELLED:The aim of this study was to examine the interobserver variance in delineating the contour of unresectable pancreatic cancer for chemoradiotherapy. PATIENTS AND METHODS:CT images of two cases of unresectable pancreatic tumors (head and body cancer) were sent to eight radiation therapy facilities in a CD-ROM...
journal_title：Anticancer research
pub_type： 杂志文章,多中心研究
doi：
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Prostate cancer metastases to bone are associated with significant morbidity and mortality. Presently, there is little known about the biological interaction between prostate cancer cells and bone. Development of an animal model using adult human bone will enhance our ability to study the biology of prostate...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:Urachal cancer is a rare malignancy and the standard treatment is surgical resection. The prognosis of recurrent and metastatic urachal cancer is extremely poor because there is no established chemotherapy regimen. Here, the response of one patient with recurrent urachal cancer to combination chemotherapy of gemcitabi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematolog...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
abstract：:Mutations in the p53 gene occur frequently in bladder cancers. Better prognostic factors are needed to help select appropriate treatment for patients with TCC stage T1. Paraffin-embedded tumors from 73 patients with TCC stage T1 were processed for two-parameter flow cytometry, measuring both p53 protein and DNA. There...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:The purpose of our study was to evaluate the presence of anatomical and functional damage to the afferent and sensorial fibres using the Neurometer CPT test. A questionnaire regarding pain was sent to 300 women who had undergone surgery six months earlier. Out of 300 patients 67 did not respond; 105 experienced no pai...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:This epidemiological study was performed to evaluate the influence of postoperative complementary treatment with lectin-standardized mistletoe extract (sME) on breast cancer patients. The design (retrolective cohort analysis with parallel groups) and conduct of the study were in agreement with current standards for pr...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND/AIM:γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHO...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13297
更新日期：2019-04-01 00:00:00
abstract：:The multistep nature of cancer suggested from chemical carcinogenesis studies, epidemiological data and cell culture experiments could be explained by the occurrence of somatic mutations resulting in inappropriate expression of normal cellular sequences which have an intrinsic potential of becoming cancer genes. The d...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:The CSEIL/CAS protein (CAS) is a Ran-binding protein with a function as a nuclear transport (export) factor. CSEIL/CAS, similar to Ran and other ran-binding proteins, plays at the same time an important role in the mitotic spindle checkpoint, which assures genomic stability during cell division. This checkpoint is fre...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:The production of DNA interstrand crosslinks (ISC) by BCNU and other bifunctional alkylators and the effects of these drugs on the repair of radiation-induced DNA-single strand breaks (SSB) were studied in two human glioblastoma used to assess both DNA-ISCs and DNA-SSBs. BCNU-treated UWR2 and UWR3 cells showed a signi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:Along with advancements in treatment, early detection of primary tumor, and relapse seems to remain a key factor for improving the survival rate of patients with head and neck squamous cell carcinoma (HNSCC), in which a high proportion of patients are diagnosed at an advanced stage. Recent advancements in basic resear...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Tetrandrine, a bisbenzylisoquinoline alkaloid, has cancer cell cytotoxicity. The effects of combined tetrandrine and radiation, alone or combined, on human SH-SY5Y neuroblastoma cells were examined. MATERIALS AND METHODS:A combination treatment, using either concomitant irradiation at the beginning or end o...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis. Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Twenty-seven children with abdominal Burkitt's lymphoma (stage III), who had achieved complete remission, were entered into a prospective controlled trial of adjunct treatment with Epstein-Barr virus (EBV)-specific transfer factor (TF). Two patients treated with TF and 2 controls relapsed early (less than or equal to ...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Transforming growth factor beta (TGF-beta) plays a complex role in breast carcinogenesis. Initially functioning as a tumor suppressor, this cytokine later contributes to the progression of malignant cells by enhancing their invasive and metastatic potential as well as suppressing antitumor immunity. The purp...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：:Interferon-alpha (IFN-alpha) has been found to exert multiple enhancing effects in the immune response in vitro, IFN-alpha has been also used in clinical trials with variable response rates. The aim of the present study was to assess the effectiveness of IFN-alpha in the treatment of 25 patients with malignant pleural...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：:Between 70 and 75% of ovarian carcinomas are not discovered until they have reached an advanced stage III or later. Efforts should therefore be concentrated on earlier diagnosis. Ovarian cancer is not an entirely silent disease. Today, it is known that there are key symptoms which, depending on their frequency and int...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2008-09-01 00:00:00
abstract：:The incidence of female breast cancer was studied as a function of age in 71 different populations throughout the world. Incidence data was normalized for differences in frequency of occurrence. Median normalized incidence increased exponentially from age 20 to 45. After age 45 the rate of incidence decreased, and we ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The influence of cytostatically active alkyllysophospholipid analogs with different chemical structure on IP3 (inositol-1,4,5-trisphosphate) formation and intracellular Ca++ concentration was studied in human mammary epithelial cells before and after transfection with v-erb B oncogene DNA. Transformed cells showed an ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:In head and neck squamous cell carcinoma (HNSCC), a variety of immunomodulatory mediators contribute to strongly impaired immune functions. The secretion of C-reactive protein (CRP) by HNSCC cells and its influence on human myeloid dendritic cells (MDC) was investigated. MATERIALS AND METHODS:The CRP levels...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：:We examined the influence of a regularly moderate endurance training program on qualitative and quantitative alterations of monocytes from 24 breast cancer patients. At the beginning, after 5 weeks and 7 months of bicycle training we analyzed the composition of leucocytes and phagocytotic activity of monocytes using t...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The active vitamin D3, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), is now well recognized as a potent regulator of cell proliferation and differentiation in addition to possessing a regulatory effect on calcium and phosphorus metabolism. From research on the synthesis of 1,25(OH)2D3 analogs with the goal of separatin...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:PAR-1 has been involved in inflammation of the gastrointestinal tract, tumour cell growth and invasion of gastric carcinoma cells. Thus, we aimed at determining, for the first time, the association between PAR-1 - 506 ins/del and -IVSn-14 A/T and risk of Helicobacter pylori-related gastric cancer (GC) in an ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:MicroRNAs (miRNA) are a class of small noncoding RNAs that regulate the expression of their target genes. The aim of the present study was to explore the effects of miR-206 on laryngeal suamous cell carcinoma (LSCC) cells. The expression level of miR-206 was quantified by qRT-PCR in primary LSCC tissues and correspond...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND/AIM:Nitric oxide (NO) functions have been studied in many cancer types, but rarely in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the behavior of HNSCC cells following exposure to high NO (HNO). MATERIALS AND METHODS:Two pairs of isogenic HNSCC cell lines (HN18/HN17, HN30/...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14236
更新日期：2020-05-01 00:00:00
abstract：:Sentinel lymph node biopsy (SLNB) is currently the suggested axillary staging procedure in patients with early-stage breast cancer (BC) and usually requires intraoperative frozen-section (FS) examination of the removed nodes. However, other techniques, such as touch imprint cytology (IC), real-time reverse transcripta...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND/AIM:To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS:Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13779
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND/AIM:The single nucleotide polymorphism -31C/G identified in the survivin gene promoter seems to be associated with over-expression of survivin, an anti-apoptotic protein. In gliomas, increased survivin expression correlated with decreased survival. The aim of the study was to investigate whether survivin gen...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12947
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Transformed cells have abnormalities in the survival pathways contributing to drug resistance. These abnormalities include p53 mutations and increased focal adhesion kinase (FAK) expression. Because FAK regulates cell survival via p53-dependent and -independent pathways, it was hypothesized that combined the...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
