Decreased migration of myeloid dendritic cells through increased levels of C-reactive protein.

abstract：:Calcitriol is a potent antiproliferative agent against various tumour cells in vitro. Here, the results of a study on vitamin D compounds (calcitriol's analogues PRI-1906 and PRI-2191) as potential agents in combined antitumour therapy in vitro are presented. Applying antiproliferative SRB and MTT assays, the growth i...

journal_title：Anticancer research

authors： Pelczynska M,Switalska M,Maciejewska M,Jaroszewicz I,Kutner A,Opolski A

更新日期：2006-07-01 00:00:00

abstract：:A pharmacokinetic study on cis-(glycolato-O,O)/ (4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane-2-spiro-1'- cyclohexane]platinum(II) (SKI 2032R) was performed in dogs. A single dose of 2.0 mg/kg of SKI 2032R was administered i.v. bolus to three beagle dogs. Plasma samples were analyzed for platinum by flameless atomic abso...

journal_title：Anticancer research

authors： Kim DK,Cho YB,Kim HT,Kim TS,Kim KH,Hong WS

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND/AIM:The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has been shown to predict the clinical outcomes of a variety of cancer types. The aim of this study was to determine whether the GPS predicts clinical outcomes of patients with pancreatic cancer treated with adjuvant chemotherapy...

journal_title：Anticancer research

authors： Morinaga S,Murakawa M,Katayama Y,Yamaoku K,Aoyama T,Kanazawa A,Higuchi A,Shiozawa M,Kobayashi S,Ueno M,Morimoto M

更新日期：2015-09-01 00:00:00

abstract：:In order to estimate the environmental risk of the use of Alachlor, experiments on laboratory animals were conducted. Alachlor and 2,6 diethylaniline content in blood serum was quantified. Three groups of male ACI/T rats and C3H/FEJ mice were treated with three different doses of Alachlor. Six hours after the intraper...

journal_title：Anticancer research

authors： Galati R,Federico A,Cortese G,Zito R

更新日期：1998-03-01 00:00:00

abstract：:Chemotherapy for patients with multiple myeloma was individually selected on the basis of antiproliferative drug sensitivity determined in vitro by a clonogenic assay. Myeloma stem cells were preincubated with various cytostatic drugs and allowed to form colonies in a plasma clot culture system. In 21 out of 24 prospe...

journal_title：Anticancer research

authors： Ludwig H,Fritz E

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral b...

journal_title：Anticancer research

authors： Ishizuka Y,Horimoto Y,Nakamura M,Arakawa A,Fujita T,Iijima K,Saito M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Zoledronate (Zol), an anti-osteoclastic and anticancer drug, is used to control bone metastasis in several cancer types, including non-small cell lung cancer (NSCLC). However, the mechanisms behind Zol resistance in NSCLC are unclear. MATERIALS AND METHODS:Zol-resistant cell lines were developed by repeated...

journal_title：Anticancer research

authors： Aoyagi T,Morii T,Ohtsuka K,Ohnishi H,Tajima T,Yoshiyama A,Mochizuki K,Satomi K,Ichimura S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Epstein-Barr virus-associated gastric carcinoma (EBV-GC) has been characterized as a special gastric cancer subset. Lifestyle and other major factors that may contribute to EBV-GC and non-EBV-GC were investigated here. MATERIALS AND METHODS:A total of 247 patients with gastric cancer were interviewed, clini...

journal_title：Anticancer research

authors： Kim RH,Chang MS,Kim HJ,Song KS,Kim YS,Choi BY,Kim WH

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Bisphosphonates (BPs) are considered the standard of care in metastatic breast cancer (MBC) patients with bone metastases. Because the survival for these patients may be prolonged compared with those patients with visceral metastases, they may be prescribed BPs for several years. The effects of this long-ter...

journal_title：Anticancer research

authors： Simmons C,Amir E,Dranitsaris G,Clemons M,Wong B,Veith R,Cole DE

更新日期：2009-07-01 00:00:00

abstract：:D-penicillamine (PSH) is a copper chelator that generates hydrogen peroxide and inhibits neovascularization. As hydrogen peroxide is toxic to some tumor cells and to blood vessels, we reasoned that PSH plus copper would inhibit tumors in vivo and in vitro. To test this hypothesis, we first incubated murine J558L plasm...

journal_title：Anticancer research

authors： Samoszuk M,Nguyen V

更新日期：1996-05-01 00:00:00

abstract：:A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-...

journal_title：Anticancer research

authors： Lin WH,Song JS,Lien TW,Chang CY,Wu SH,Huang YW,Chang TY,Fang MY,Yen KJ,Chen CH,Chu CY,Hsieh HP,Chen YR,Chao YS,Hsu JT

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIM:SLC9A9 plays an oncogenic role in esophageal squamous carcinoma and glioblastoma. Herein, we showed an oncogenic function of SLC9A9 in colorectal cancer (CRC). MATERIALS AND METHODS:We examined SLC9A9 expression in CRC specimens by immunohistochemistry. In CRC tissues, the relationship between SLC9A9 ex...

journal_title：Anticancer research

authors： Ueda M,Iguchi T,Masuda T,Komatsu H,Nambara S,Sakimura S,Hirata H,Uchi R,Eguchi H,Ito S,Sugimachi K,Mizushima T,Doki Y,Mori M,Mimori K

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation of Cdc2, are required for the G2 arrest induced by DNA damage. METHODS:We treated 184B5 cell line and its E6 transformed ...

journal_title：Anticancer research

authors： Luo Y,Rockow-Magnone SK,Joseph MK,Bradner J,Butler CC,Tahir SK,Han EK,Ng SC,Severin JM,Gubbins EJ,Reilly RM,Rueter A,Simmer RL,Holzman TF,Giranda VL

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. PATIENTS AND METHODS:This was a retrospective study comparing patients with advanced ovarian cancer treate...

journal_title：Anticancer research

authors： Nicoletto MO,Casarin A,Baldoni A,Rulli E,Tasca G,Baretta Z,Artioli G,Lombardi G,Cappetta A,Floriani I,Randon G,Valpione S,Litta P,Conte P,Mocellin S,Aliberti C

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Plasmacytoid dendritic cells (PDCs) infiltrating solid tumor tissues and draining lymph nodes of head and neck squamous cell carcinoma (HNSCC) show an impaired immune response. Immunosuppressive cytokines secreted by HNSCC have been recognized to account for reduced interferon-alpha (IFN-alpha) production, w...

journal_title：Anticancer research

authors： Thiel A,Pries R,Jeske S,Trenkle T,Wollenberg B

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND/AIM:Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. PATIENTS AND METHODS:The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of...

journal_title：Anticancer research

authors： Sumida T,Otawa N,Kamata YU,Yamada T,Uchida K,Nakano H,Hamakawa H,Yamamoto T,Ueyama Y,Mori Y

更新日期：2015-08-01 00:00:00

abstract：AIM:To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. PATIENTS AND METHODS:We conduct...

journal_title：Anticancer research

authors： Fujikawa H,Toiyama Y,Inoue Y,Imaoka H,Shimura T,Okigami M,Yasuda H,Hiro J,Yoshiyama S,Saigusa S,Kobayashi M,Ohi M,Araki T,Mohri Y,Kusunoki M

更新日期：2017-03-01 00:00:00

abstract：:The time course and characteristics of the tumor marker CASA (Cancer Associated Serum Antigen) during the menstrual cycle were analysed. We investigated whether hormonal influences in women and the score of this tumor marker ought to be considered in diagnosis. It could be demonstrated that CASA is not influenced by p...

journal_title：Anticancer research

authors： Meisel M,Römer T,Straube W

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:The sonodynamically-induced in vitro and in vivo antitumor effects of mono-l-aspartyl chlorin e6 (NPe6) was investigated. MATERIALS AND METHODS:Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. RESULTS:The rate of ultrasonically-induced damage on isolated sarc...

journal_title：Anticancer research

authors： Yumita N,Iwase Y,Nishi K,Ikeda T,Komatsu H,Fukai T,Onodera K,Nishi H,Takeda K,Umemura S,Okudaira K,Momose Y

更新日期：2011-02-01 00:00:00

abstract：:Polyamines are ubiquitous cellular compounds which are required for estradiol induced proliferation in breast cancer. Complete polyamine deprivation, using 2 alpha-difluoromethyl-ornithine (DFMO, Eflornithine), a specific inactivator of ornithine decarboxylase (key-enzyme of the polyamine biosynthesis) combined with i...

journal_title：Anticancer research

authors： Leveque J,Foucher F,Havouis R,Desury D,Grall JY,Moulinoux JP

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:To investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities and p53 status in sensitivity to high-LET heavy-ion beam and in sensitizing effect of etoposide or cisplatin in combination with heavy-ion beam. MATERIALS AND METHODS:NMT-1 (wild-type p53 cell) is a pa...

journal_title：Anticancer research

authors： Takahashi T,Fukawa T,Hirayama R,Yoshida Y,Musha A,Furusawa Y,Ando K,Nakano T

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:HIC-1 (hypermethylated in cancer-1) is a candidate tumor suppressor gene, identified in a region of frequent loss of heterozygosity on chromosome 17p13.3, which is telomeric from TP53 and often deleted in surgically resected lung cancers. To determine the significance of HIC-1 in lung cancer, we assessed its...

journal_title：Anticancer research

authors： Hayashi M,Tokuchi Y,Hashimoto T,Hayashi S,Nishida K,Ishikawa Y,Nakagawa K,Tsuchiya S,Okumura S,Tsuchiya E

更新日期：2001-01-01 00:00:00

abstract：:Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor. The sternum is a rare location. To date, only four cases have been reported with detailed information. Here, we present a case with sternal GCT and discuss the clinical manifestation and treatment, in addition to reviewing the lite...

journal_title：Anticancer research

authors： Futani H,Okumura Y,Fukuda Y,Fukunaga S,Hasegawa S,Yoshiya S

更新日期：2008-11-01 00:00:00

abstract：:Total sialic acid (TSA) and "lipid-bound" sialic acid (LSA) were evaluated in comparison to carcinoembryonic antigen (CEA) and ferritin and neuron specific enolase (NSE) in 152 untreated patients with primary lung cancer, 107 benign pulmonary disease patients and 207 notmal controls. The mean concentrations of TSA, LS...

journal_title：Anticancer research

authors： Kakari S,Stringou E,Toumbis M,Ferderigos AS,Poulaki E,Chondros K,Dema A,Kotsovoulou V,Pavlidis N

更新日期：1991-11-01 00:00:00

abstract：:The adenomatous polyposis coli (APC) gene was investigated in Swedish patients with familial adenomatous polyposis (FAP). A combination of analyses including single stranded conformation polymorphism (SSCP), heteroduplex (HD), protein truncation test (PTT) and direct sequencing was used to enable optimal mutation dete...

journal_title：Anticancer research

authors： Nordling M,Engwall Y,Wahlström J,Wiklund L,Eriksson MA,Gustavsson B,Fasth S,Larsson PA,Martinsson T

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Wilms' tumor 1 (WT1) gene has different functional properties depending on the isoform type. This gene correlates with cell proliferation in various types of cancer. Here, we investigated the expression of WT1 isoforms in breast cancer tissues, and focused on the oncogenic role through estrogen receptor-alph...

journal_title：Anticancer research

authors： Nasomyon T,Samphao S,Sangkhathat S,Mahattanobon S,Graidist P

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND/AIM:Activation of the c-JUN N-terminal kinase (JNK) signaling pathway has been associated with poor survival of ovarian cancer patients, but the role(s) and significance of JNK signaling in ovarian cancer cells remain poorly understood. In the present study, we aimed to investigate the role of JNK specifical...

journal_title：Anticancer research

authors： Seino M,Okada M,Shibuya K,Seino S,Suzuki S,Ohta T,Kurachi H,Kitanaka C

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Primary small cell carcinoma of the ovary (SCCO) is rare, making prognosis and outcomes largely undefined. PATIENTS AND METHODS:Using case listing session of SEER 18 (1973-2010), we examined outcomes for patients with SCCO. Analyses were conducted with SEER(*)Stat 8.1.2, Microsoft Excel 2007 and GraphPad Pr...

journal_title：Anticancer research

authors： Jamy O,Yaghmour G,Hare F,Martin MG

更新日期：2015-05-01 00:00:00

abstract：:Alteration of T-cell-associated signal transduction molecules has recently been implicated in immune suppression in tumour-bearing hosts. Here we report the immunoregulatory effects of human lactoferrin (LF) on zeta-chain expression in peripheral blood T lymphocytes from cervical cancer patients and healthy donors. By...

journal_title：Anticancer research

authors： Frydecka I,Zimecki M,Bocko D,Kosmaczewska A,Teodorowska R,Ciszak L,Kruzel M,Wlodarska-Polinsk J,Kuliczkowski K,Kornafel J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the role of radiation therapy alone, employing standard fractionation, in stage III-IV hypopharyngeal carcinoma. MATERIALS AND METHODS:Fourteen (38.9%) stage III and 22 (61.1%) stage IV patients with hypopharyngeal carcinoma were submitted, with curative intent, to excl...

journal_title：Anticancer research

authors： Tombolini V,Santarelli M,Raffetto N,Donato V,Valeriani M,Ferretti A,Enrici RM

更新日期：2004-01-01 00:00:00