Effect of head and neck cancer supernatant and CpG-oligonucleotides on migration and IFN-alpha production of plasmacytoid dendritic cells.

abstract：:Radiation therapy plays a critical role in women with advanced-stage cervical cancer worldwide, particularly in developing countries, and most of the time it may be the only available treatment. The efficacy of radiation largely depends on the radiosensitivity of the tumor. The high radiation dose associated with ther...

journal_title：Anticancer research

authors： Qin C,Chen X,Bai Q,Davis MR,Fang Y

更新日期：2014-09-01 00:00:00

abstract：:In this study, we set out to determine if the differential sensitivities to CPT between a radioresistant (Sk-Mel-3) and a radiosensitive (HT-144) human melanoma cell line, and also between cultures with a different growth phase in each cell line, were related to endogenous differences in cellular transport of CPT or t...

journal_title：Anticancer research

authors： Ng CE,Cybulski SE,Bussey AM,Aubin RA,Raaphorst GP

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIM:Although insulin-like growth factor-1 (IGF-1) is well-implicated in cancer biology, the potential roles of IGF-1 variants in different types of cancer are largely unknown. The aim of the present study was to in vitro characterize several human cancers for their IGF-1 variant expression patterns. MATERIA...

journal_title：Anticancer research

authors： Christopoulos PF,Philippou A,Koutsilieris M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the progression-free survival (PFS) and toxicity associated with adjuvant administration of carboplatin and pemetrexed for completely resected patients with stage IB, II and IIIA non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-five eligible NSCLC patient...

journal_title：Anticancer research

authors： Karapanagiotou EM,Boura PG,Papamichalis G,Konstantinou M,Sepsas E,Chamalakis G,Simsiris P,Gkiozos I,Syrigos KN

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIM:Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients. MATERIALS AND METHODS:Using the Surveillance, Epidemiology...

journal_title：Anticancer research

authors： Li MU,Gu S,Mao R,Ning Y,Trivedi N,Siddiqui A,Li P,Huo L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorecta...

journal_title：Anticancer research

authors： Takahashi Y,Sawada G,Kurashige J,Matsumura T,Uchi R,Ueo H,Ishibashi M,Takano Y,Akiyoshi S,Iwaya T,Eguchi H,Sudo T,Sugimachi K,Yamamoto H,Doki Y,Mori M,Mimori K

更新日期：2013-05-01 00:00:00

abstract：:We have recently identified ICBP90 as being a protein able to bind in vitro a CCAAT box of the topoisomerase II alpha gene promoter. The aim of the present work was to check whether ICBP90 is able to regulate in vivo topoisomerase II alpha expression in human lung fibroblasts under various proliferating conditions. Tr...

journal_title：Anticancer research

authors： Hopfner R,Mousli M,Oudet P,Bronner C

更新日期：2002-11-01 00:00:00

abstract：:B-1 F is a cell line established from estrogen-responsive murine Leydig cell tumor and maintained in vitro. We investigated the effects of steroid hormones on the growth of tumors produced by the inoculation of B-1 F cells into mice. When tumor tissues were transplanted into castrated male mice, injections of estradio...

journal_title：Anticancer research

authors： Yamamoto T,Li I,Uchida N,Nishizawa Y,Yamamoto R,Terada N,Taniguchi H,Matsumoto K,Sato B

更新日期：1992-09-01 00:00:00

abstract：:Ascorbate has dose-dependent inverse effects on cancer cells growth and expression of matrixmetalloproteinases (MMP) and transforming growth factor-beta (TGF-beta), which regulate extracellular matrix (ECM) remodeling. We examined melanoma cell viability and ECM remodeling mechanisms of ascorbate and its modulation by...

journal_title：Anticancer research

authors： Philips N,Dulaj L,Upadhya T

更新日期：2009-08-01 00:00:00

abstract：:The multifaceted involvement of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 (henceforth referred to by the synonyms 1,25(OH)2D3, calcitriol or vitamin D) in blunting the growth of cancer cells is amply recognized. In this review we focused our attention on the cross-talk between 1,25 (OH)2D3 and the tumor...

journal_title：Anticancer research

authors： Shany S,Sigal-Batikoff I,Lamprecht S

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In previous reports, changes in oxytocinase activity in human breast cancer tissue and in the serum of N-methyl-nitrosourea (NMU)-induced rat mammary tumors were described. Insulin-regulated aminopeptidase (IRAP) has been identified with oxytocinase and has also been referred to as placental leucine aminopep...

journal_title：Anticancer research

authors： Pilar Carrera M,Ramírez-Expósito MJ,Dueñas B,Dolores Mayas M,Jesús García M,De la Chica S,Cortés P,Ruíz-Sanjuan M,Martínez-Martos JM

更新日期：2006-03-01 00:00:00

abstract：:The vascular endothelium participates in angiogenesis, inflammation and the immune response, which are modulated by vasoactive cytokines such as tumour necrosis factor-alpha (TNF alpha) and transforming growth factor-beta 1 (TGF beta 1). CD105 is a component of the TGF beta receptor complex and is abundantly expressed...

journal_title：Anticancer research

authors： Li C,Guo B,Ding S,Rius C,Langa C,Kumar P,Bernabeu C,Kumar S

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:A limited number of permanent ovarian carcinoma cell lines have been described so far and the majority of them have been derived from ovarian ascitic fluid cells taken from patients with serous ovarian carcinoma usually after chemotherapy treatment. MATERIALS AND METHODS:The cells for culture were obtained ...

journal_title：Anticancer research

authors： Bar JK,Harlozińska A

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Cytolysins are pore-forming toxins that show anticancer activity by a mechanism hitherto poorly investigated. MATERIALS AND METHODS:To investigate how cytolysins are cytotoxic to resistant cancer cells, proliferation and cell death were evaluated on U87 glioblastoma cells treated with toxin Bc2 or equinatox...

journal_title：Anticancer research

authors： Soletti RC,Alves T,Vernal J,Terenzi H,Anderluh G,Borges HL,Gabilan NH,Moura-Neto V

更新日期：2010-04-01 00:00:00

abstract：:The local growth and metastatic potential of colorectal cancer is the outcome of a dynamic balance between cancer cells and the immune system, at both a local and systemic level, summarized as the "seed and soil" hypothesis. Until recently, the staging and treatment approaches for colorectal cancer appeared to be orie...

journal_title：Anticancer research

authors： Seretis F,Seretis C,Youssef H,Chapman M

更新日期：2014-05-01 00:00:00

abstract：:Mast cells are frequently found in close proximity to blood vessels and have been implicated in tumour angiogenesis. The aim of the present ultrastructural study was to characterize, in detail, the mutual association between mast cells and microvasculature in 9 cases of advanced gastric carcinoma. Perivascular mast ce...

journal_title：Anticancer research

authors： Caruso RA,Ieni A,Fabiano V,Basile G,Inferrera C

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Different oncogenes (Fas and bcl-2) and diverse cytokines (IL-10 and alfa-TNF) may have an effect on the regulation of apoptosis. The majority of studies to date have evaluated only one or two of these elements independently and it is difficult to obtain a global view of apoptosis disregulation in the pathog...

journal_title：Anticancer research

authors： Miret C,Font J,Molina R,Garcia-Carrasco M,Filella X,Ramos M,Cervera R,Ballesta A,Ingelmo M

更新日期：2001-07-01 00:00:00

abstract：:Angiogenesis is essential for tumour growth. Mostly hypervasculariced renal cell carcinoma (RCC) usually express angiogenic factors, e.g. basic fibroblast factor (bFGF), vascular endothelial growth factor, and angiogenin (ag). This study was designed to evaluate the improvement of serological angiogenesis-factors, the...

journal_title：Anticancer research

authors： Wechsel HW,Bichler KH,Feil G,Loeser W,Lahme S,Petri E

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical impact of FOLFOXIRI regimen aiming for conversion surgery in patients with unresectable multiple colorectal liver metastasis (CRLM). PATIENTS AND METHODS:A total of 42 patients with unresectable multiple CRLM who received chemotherapy with molecular agents were included in the ...

journal_title：Anticancer research

authors： Morine Y,Ikemoto T,Iwahashi S,Saito YU,Yamada S,Takasu C,Higashijima J,Imura S,Shimada M

更新日期：2019-09-01 00:00:00

abstract：:Due to their estrogen-mimicking ability, pesticides are considered as prime etiological suspects of increasing tumor incidence, although a direct link is still undefined. The present study aimed to identify the effect of xenoestrogens (lindane, propoxur and endosulfan) at 20 mg/l each on tumorigenesis, by evaluating e...

journal_title：Anticancer research

authors： Bharathi SP,Raj HM,Jain S,Banerjee BD,Ahmed T,Arora VK

更新日期：2013-01-01 00:00:00

abstract：AIM:To elucidate the behavior of 1 phosphatidylinositol 4,5 bisphosphate (PIP2) 5 phosphatase (PIP2 5-Pase, EC 3.1.3.36) and 1 phosphatidylinositol 4 phosphate (PIP) 4-phosphatase (PIP 4-Pase) in cancer cells, the steady state activities of PIP2 5-Pase and PIP 4-Pase were determined in the particulate fractions of rat ...

journal_title：Anticancer research

authors： Yang H,Shen F,Weber G

更新日期：1999-11-01 00:00:00

abstract：:To investigate the specific transduction of a suicide gene into human small cell lung carcinoma (SCLC) cells, we explored the promoter region of the neuron specific enolase (NSE) gene as a tumor-specific promoter. In Northern blot analysis, NSE mRNA was expressed more abundantly in the SBC3 human SCLC cell line than i...

journal_title：Anticancer research

authors： Tanaka M,Inase N,Miyake S,Yoshizawa Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIM:An active metabolite of the anti-leukemia agent clofarabine (Cl-F-ara-A) is an intracellular triphosphate form, Cl-F-ara-ATP. Monitoring this active form could provide crucial information for optimizing treatment regimens based on Cl-F-ara-A. A simple, isocratic HPLC method was developed. MATERIALS AND ...

journal_title：Anticancer research

authors： Yamauchi T,Nishi R,Ueda T

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Live animal studies using an inoculation model of breast cancer indicate that anaesthetic drugs and techniques differentially affect cancer metastasis, inversely related to Natural Killer (NK) cell and T lymphocyte levels. Clinical histological studies demonstrate that the distribution of these immune cells ...

journal_title：Anticancer research

authors： Desmond F,McCormack J,Mulligan N,Stokes M,Buggy DJ

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Aggrecan, the large aggregating proteoglycan, is a major component of the cartilage extracellular matrix. The C-terminal globular domain (G3) of the aggrecan molecule exhibits a pattern of alternative splicing that involves three exons. Each corresponds to a subdomain, epidermal growth factor 1(EGF1), EGF2, ...

journal_title：Anticancer research

authors： Matsui Y,Araki N,Tsuboi H,Tsumaki N,Nakata K,Kawabata H,Eyre DR,Yoshikawa H

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay. PATIEN...

journal_title：Anticancer research

authors： Kalfert D,Ludvik J,Kucera R,Topolcan O,Celakovsky P,Pesta M,Kholova I,Plzak J,Ludvikova M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Immune cells (lymphocytes and macrophages) provide the microenvironment for immune surveillance of metastatic prostate cancer (PCa) cells in pelvic lymph nodes. We have hypothesized that degeneration and/or apoptosis of metastatic PCa cells in pelvic lymph nodes can distinguish between aggressive and non-agg...

journal_title：Anticancer research

authors： Sinha AA,Fernandes ET,Ewing SL,Wilson MJ

更新日期：2013-09-01 00:00:00

abstract：AIM:The purpose of this study was to identify patient-, facility-, disease-, and treatment-specific characteristics that increase mortality in patients with upper limb osteosarcoma. PATIENTS AND METHODS:The National Cancer Data Base (NCDB) was queried for bone cancer. With Cox regression, the demographic, facility, tu...

journal_title：Anticancer research

authors： Restrepo DJ,Huayllani MT,Boczar D,Sisti A,Spaulding AC,Carter RE,Moran SL,Parker AS,Perdikis G,Forte AJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The process of tumour invasion and subsequent metastasis represents the most lethal aspect of cancer and is responsible for the majority of deaths among cancer patients. Our objective was to identify invasion-specific genes in a series of isogenic breast cancer cell lines of differing invasive potential usin...

journal_title：Anticancer research

authors： Hughes L,O'Brien SL,Gallagher WM,Mcdonnell S

更新日期：2007-05-01 00:00:00

abstract：:CEA is discussed as a potential tumour marker for carcinomas of the urothelium. However, investigations by means of polyclonal antibodies have shown various cross reactions which are not to be expected with monoclonal antibodies (MAb). Immunohistochemistry was done with the MAb anti-CEA BW 431/26 (Behring), N 1522 (Da...

journal_title：Anticancer research

authors： Feil G,Wechsel HW,Nelde HJ,Bichler KH

更新日期：1999-07-01 00:00:00