Abstract：
BACKGROUND/AIM:Although insulin-like growth factor-1 (IGF-1) is well-implicated in cancer biology, the potential roles of IGF-1 variants in different types of cancer are largely unknown. The aim of the present study was to in vitro characterize several human cancers for their IGF-1 variant expression patterns. MATERIALS AND METHODS:Using a novel quantitative real-time polymerase chain reaction (qRT-PCR) assay, twelve human cancer cell lines were investigated for their endogenous expression levels of IGF-1 variants, including classes. Additionally, the hormonal regulation of IGF-1 transcripts was investigated in PC3 cells. RESULTS:IGF-1Ea and Eb were found at higher levels in KLE and MEL28 cells, respectively. MCF7 had the lowest expression of Ec peptide and, along with MB231, lacked IGF-1Eb. In most cases, class 1 proved as the predominant origin. Estradiol (E2) or dexamethasone (Dexa) significantly modulated IGF-1Ea and IGF-1Eb and down-regulated the Ec peptide in PC3. CONCLUSION:Our results contribute to the notion of distinct roles of IGF-1 isoforms in human cancer depending on the type of malignancy.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Christopoulos PF,Philippou A,Koutsilieris Msubject
Has Abstractpub_date
2015-01-01 00:00:00pages
107-15issue
1eissn
0250-7005issn
1791-7530pii
35/1/107journal_volume
35pub_type
杂志文章abstract：BACKGROUND/AIM:It is generally believed that the plasma concentration of 5-fluorouracil (5-FU) is constant when 5-FU is continually administered for chemotherapy. The aim of the present study was to verify whether this is true. PATIENTS AND METHODS:Nine patients with colorectal cancer were enrolled in this study. All ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Endometrial carcinoma is a well known complex gynecological disorder. Our team suggests that this tumor is related to immortalization-up-regulated protein 1 and 2 (imup-1, imup-2), which are known to be involved in SV40-mediated immortalization. PATIENTS AND METHODS:RT-PCR and immunohistochemical staining w...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:To overcome 5-Fluorouracil (5FU) infusion-related problems, oral 5FU precursors and inhibitors of 5FU degradation have been developed. Capecitabine is one of these new oral fluoropyrimidines. Capecitabine treatment of advanced colorectal carcinoma, when compared to 5FU, results in superior response rates (26.6% versus...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2006-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12312
更新日期：2018-02-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2012-10-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11482
更新日期：2017-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Dimethylsilane tetramines are structural analogues of spermine with a (CH3)2 Si-group incorporated into the central carbon chain. They have potential as anticancer drugs. Their cytotoxic effect was considered to rely mainly on their polyamine antagonist property. In order to obtain new ideas about cellular mechanisms,...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：1998-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12359
更新日期：2018-03-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：
更新日期：2016-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11841
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
