Abstract:
:Gastric involvement is unusual in primary mediastinal large B-cell lymphoma (PMLBCL), which has not yet been adequately studied. The aim of this retrospective study was to investigate the frequency of gastric involvement in 204 consecutive patients with PMLBCL that presented at 23 hospitals in Greece. Two out of 204 patients (1.0%) had gastric involvement at presentation. The first patient had symptomatic gastric disease manifested as upper gastrointestinal (GI) hemorrhage, which was the presenting symptom (first case reported in the literature). The second patient underwent positron emission tomography/computed tomography (PET/CT) at baseline staging which revealed abnormal gastric uptake. Histological examination revealed discordant lymphomatous involvement (MALT lymphoma, in a 33-year old female). The estimated frequency of gastric involvement by conventional staging was 1/204 (0.49%), but no cases were identified among asymptomatic patients. Among asymptomatic patients who underwent PET/CT at baseline staging, the PET/CT-based frequency of gastric involvement was 7.1%, but lymphomatous gastric involvement was discordant. Finally, the frequency of gastric involvement in primary progressive or relapsed disease was 2.2%. Our study shows that gastric involvement is uncommon but can be seen in different clinical settings at presentation or at progression/relapse of PMLBCL. PET/CT-based staging may provide more accurate information regarding the true incidence of sub-clinical gastric involvement in this entity, but histological confirmation is essential in order to confirm the diagnosis.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Papageorgiou SG,Sachanas S,Pangalis GA,Tsopra O,Levidou G,Foukas P,Rondogianni P,Sotiropoulos V,Ioannidou HD,Gassiamis A,Iliakis T,Korkolopoulou P,Angelopoulou MK,Pappa V,Konstantopoulos K,Vassilakopoulos TPsubject
Has Abstractpub_date
2014-11-01 00:00:00pages
6717-23issue
11eissn
0250-7005issn
1791-7530pii
34/11/6717journal_volume
34pub_type
杂志文章abstract::F16 is a plant-derived pharmacologically active fraction extracted from Eurycoma longifolia Jack. Previously, we have reported that F16 inhibited the proliferation of MCF-7 human breast cancer cells by inducing apoptotic cell death while having some degree of cytoselectivity on a normal human breast cell line, MCF-10A...
journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章,评审
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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doi:
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pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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doi:
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pub_type: 临床试验,杂志文章
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journal_title:Anticancer research
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doi:
更新日期:2000-01-01 00:00:00
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journal_title:Anticancer research
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更新日期:1997-07-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:1998-03-01 00:00:00
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journal_title:Anticancer research
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