Current Status and Problems of T790M Detection, a Molecular Biomarker of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors, with Liquid Biopsy and Re-biopsy.

abstract：BACKGROUND/AIM:This study aimed to identify the survival benefit of intrahepatic tumour control by hepatic arterial infusion chemotherapy (HAIC) in hepatocellular carcinoma (HCC) patients with portal vein tumour thrombus (PVTT) or extrahepatic metastasis. PATIENTS AND METHODS:Between 2010 and 2017, a total of 187 cons...

journal_title：Anticancer research

authors： Sung PS,Yang K,Bae SH,Oh JS,Chun HJ,Nam HC,Jang JW,Choi JY,Yoon SK

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIM:Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermin...

journal_title：Anticancer research

authors： Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

更新日期：2018-08-01 00:00:00

abstract：:The vascular endothelium participates in angiogenesis, inflammation and the immune response, which are modulated by vasoactive cytokines such as tumour necrosis factor-alpha (TNF alpha) and transforming growth factor-beta 1 (TGF beta 1). CD105 is a component of the TGF beta receptor complex and is abundantly expressed...

journal_title：Anticancer research

authors： Li C,Guo B,Ding S,Rius C,Langa C,Kumar P,Bernabeu C,Kumar S

更新日期：2003-03-01 00:00:00

abstract：AIM:To investigate frequent quantitative alterations of intestinal-type gastric adenocarcinoma. MATERIALS AND METHODS:We analyzed genome-wide DNA copy numbers of 22 samples and using CytoScan® HD Array. RESULTS:We identified 22 gene alterations that to the best of our knowledge have not been described for gastric can...

journal_title：Anticancer research

authors： Seabra AD,Araújo TM,Mello Junior FA,Di Felipe Ávila Alcântara D,De Barros AP,De Assumpção PP,Montenegro RC,Guimarães AC,Demachki S,Burbano RM,Khayat AS

更新日期：2014-11-01 00:00:00

abstract：:Peptides extracted from tumor cells after mild acid treatment can function as antigenic epitopes when presented by cultured dendritic cells. Peptides were extracted from four tumors syngeneic to C3H mice, three weakly immunogenic tumors (FSA, MCAK, HCA) and one non-immunogenic tumor (NFSA). Dendritic cells pulsed with...

journal_title：Anticancer research

authors： Ribas A,Bui LA,Butterfield LH,Vollmer CM,Jilani SM,Dissette VB,Glaspy JA,McBride WH,Economou JS

更新日期：1999-03-01 00:00:00

abstract：:Taking into account the possible regulatory influences of the beta-adrenergic system on lymphocyte proliferation as well as the proposed role of cyclic 3'-5'-adenosine monophosphate (cAMP) in the modulation of multidrug resistance (MDR) in tumour cells, we have tried to assess the status of the interactions between th...

journal_title：Anticancer research

authors： D'Amico C,Crescimanno M,Armata MG,Leonardi V,Palazzoadriano M,D'Alessandro N

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Most cancer cells exhibit increased anaerobic glycolysis and use this metabolic pathway for the generation of ATP as a main source of energy. This impaired metabolism of glucose, leading to the secretion of lactic acid even in the presence of oxygen, is named the Warburg effect. Because cancer cells are part...

journal_title：Anticancer research

authors： Zhang X,Varin E,Briand M,Allouche S,Heutte N,Schwartz L,Poulain L,Icard P

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND/AIM:We previously identified that promoter DNA methylation of cysteine dioxygenase type 1 (CDO1) and homeobox only protein homeobox (HOPX) were both cancer specific, and have a clinical potential as prognostic biomarkers in breast cancer (BC). The present study compared the differential prognostic relevance ...

journal_title：Anticancer research

authors： Tanaka Y,Kosaka Y,Waraya M,Yokota K,Harada H,Kaida T,Kikuchi M,Minatani N,Nishimiya H,Katoh H,Sengoku N,Watanabe M,Yamashita K

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The results of chemotherapy in patients with advanced, hormone-refractory prostate cancer (HRPC) have been disappointing. Mitoxantrone has been used in the past for palliation, but it does not prolong survival. It was recently demonstrated that docetaxel is able to improve median survival as compared to mito...

journal_title：Anticancer research

authors： Boehmer A,Anastasiadis AG,Feyerabend S,Nagele U,Kuczyk M,Schilling D,Corvin S,Merseburger AS,Stenzl A

更新日期：2005-11-01 00:00:00

abstract：:Malignant gliomas are often treated with cisplatin (cis-diamminedichloroplatinum(II), CDDP) and radiation but results remain unsatisfactory. To investigate whether CDDP induces radioresistance in glioma, T98G human glioblastoma cells were pretreated 5 times with 10(-6)M CDDP for 24 hours and then the sensitivity of wi...

journal_title：Anticancer research

authors： Poppenborg H,Münstermann G,Knüpfer MM,Hotfilder M,Hacker-Klom U,Wolff JE

更新日期：1997-03-01 00:00:00

abstract：AIM:Metastasis of unknown primary (MUP) is commonly treated with radiation therapy (RT) to the entire mucosal surfaces and bilateral neck nodes (LN). We report outcomes of oropharynx-targeted RT, retropharyngeal nodes (RPN) and bilateral LN in this context. PATIENTS AND METHODS:Single-Institution retrospective study o...

journal_title：Anticancer research

authors： Mourad WF,Hu KS,Shasha D,Concert C,Ishihara D,Lin W,Shourbaji RA,Ryniak M,Gamez ME,Lukens JN,Li Z,Culliney BE,Khorsandi AS,Tran T,Jacobson A,Manolidis S,Schantz S,Urken M,Persky MS,Harrison LB

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The leptin receptor is involved in modulating leptin activity, acting as a carrier protein. A link between leptin or leptin receptor and cancer development has been proposed and here, the hypothesis that leptin and its receptor might be implicated in colorectal cancer (CRC) progression and invasion was inves...

journal_title：Anticancer research

authors： Tutino V,Notarnicola M,Guerra V,Lorusso D,Caruso MG

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND/AIM:The impact of testosterone or obesity on the pathological grade of prostate cancer remains controversial. Therefore, in this study, we investigated the relationship of serum testosterone and body mass index (BMI) to Gleason score at biopsy. PATIENTS AND METHODS:This study included 128 Japanese patients ...

journal_title：Anticancer research

authors： Shiota M,Takeuchi A,Sugimoto M,Dejima T,Kashiwagi E,Kiyoshima K,Inokuchi J,Tatsugami K,Yokomizo A

更新日期：2015-11-01 00:00:00

abstract：AIM:We aimed to investigate whether 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) can estimate thymidine kinase 1 (TK1) activity after thymidylate synthase (TS) inhibition by 5-fluorouracil (5-FU) in a mouse tumor model. MATERIALS AND METHODS:Nude mice with HT29 tumors were injecte...

journal_title：Anticancer research

authors： Hong IK,Kim SY,Chung JH,Lee SJ,Oh SJ,Lee SJ,Oh J,Ryu JS,Kim TW,Kim DY,Moon DH

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Endometrial carcinoma is the most common malignancy of the female genital tract and its incidence is increasing. However, treatment results have not improved during the last decades. PATIENTS AND METHODS:Our regional quality register was used to evaluate treatment results for the period between January 1995...

journal_title：Anticancer research

authors： Paulsson G,Genell A,Jakobsen AM,Horvath G

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND/AIM:Perioperative intra-abdominal infection has been reported as a risk factor for metastasis. The aim of this study was to investigate the mechanism by which peritonitis induces immunosuppression in the lung, which in turn promotes lung metastasis. MATERIALS AND METHODS:C57BL/6 mice were intravenously admi...

journal_title：Anticancer research

authors： Arimoto A,Yamashita K,Hasegawa H,Sugita Y,Fukuoka E,Tanaka T,Suzuki S,Kakeji Y

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial. PATIENTS AND METHODS:We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with ...

journal_title：Anticancer research

authors： Yang WC,Chen CH,Tang JY,Wu CF,Liu YC,Sun Y,Lin SF

更新日期：2014-07-01 00:00:00

abstract：:The immunomodulatory and antimetastatic/antitumor activity of thymic humoral factor-gamma 2 (THF-gamma 2) was evaluated in BALB/c-mice. Daily subcutaneous applications (7 consecutive days, 20, 200 ng of THF-gamma 2 per injection/mouse) upregulated counts of thymocytes and peripheral blood cells in tumor bearing mice. ...

journal_title：Anticancer research

authors： Beuth J,Schierholz JM,Mayer G,Keisari Y

更新日期：2000-11-01 00:00:00

abstract：:Human papillomavirus (HPV)-positive tonsillar- and base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negative cancer and most other head and neck cancers with around 80% 3-year disease free survival with conventional radiotherapy and surgery. Consequently, most HPV-pos...

journal_title：Anticancer research

authors： Näsman A,Bersani C,Lindquist D,Du J,Ramqvist T,Dalianis T

更新日期：2017-10-01 00:00:00

abstract：:Interleukin-10 (IL-10) is an immunosuppressive cytokine involved in carcinogenesis via immune escape. The present study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of lung cancer in Taiwan. Associations of three IL...

journal_title：Anticancer research

authors： Hsia TC,Chang WS,Liang SJ,Chen WC,Tu CY,Chen HJ,Yang MD,Tsai CW,Hsu CM,Tsai CH,Bau DT

更新日期：2014-12-01 00:00:00

abstract：:Colchicine is an alkaloid widely used for the treatment of inflammatory diseases, such as gout. It suppresses cell division by inhibiting mitosis. We investigated the anticancer effects of colchicine on human hypopharyngeal cancer cells and the mechanisms underlying its anticancer effects. XTT cell proliferation assay...

journal_title：Anticancer research

authors： Cho JH,Joo YH,Shin EY,Park EJ,Kim MS

更新日期：2017-11-01 00:00:00

abstract：:The objective of this study was to discover whether the peptides LRMK and LRMK-Ava linked to the N-terminus of peptides HER-2 (774-788) and HER-2 (776-788), respectively, help differentiation of E75-TCR(+)CD8(+) cells. Activation was quantified in terms of proliferation of E75-TCR(+)CD8(+) cells expressing high, mediu...

journal_title：Anticancer research

authors： Matsueda S,Gao H,Efferson CL,Tsuda N,Ishiyama S,Li Y,Ioannides MG,Fisk B,Peoples GE,Ioannides CG

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

journal_title：Anticancer research

authors： Woo HY,DO SI,Kim SH,Song SY,Kim HS

更新日期：2019-10-01 00:00:00

abstract：AIM:To investigate the expression and significance of glypican-3 (GPC3) in human hepatocellular carcinoma (HCC). MATERIALS AND METHODS:DNA chips were used to measure the expression of mRNAs for members of the glypican and syndecan families of heparan sulfate proteoglycans (HSPGs) in normal liver tissue, non-tumor tiss...

journal_title：Anticancer research

authors： Suzuki M,Sugimoto K,Tanaka J,Tameda M,Inagaki Y,Kusagawa S,Nojiri K,Beppu T,Yoneda K,Yamamoto N,Ito M,Yoneda M,Uchida K,Takase K,Shiraki K

更新日期：2010-12-01 00:00:00

abstract：:The proteasome inhibitor, bortezomib, is known to be effective in the therapy of various neoplasms. The objective of this study was the analysis of the ex vivo activity of bortezomib in paediatric acute lymphoblastic leukaemia (ALL), in comparison to paediatric acute myeloid leukaemia (AML). A total of 159 patients en...

journal_title：Anticancer research

authors： Szczepanek J,Pogorzala M,Konatkowska B,Juraszewska E,Badowska W,Olejnik I,Kuzmicz M,Stanczak E,Malinowska I,Stefaniak J,Sobol G,Szczepanski T,Czyzewski K,Wysocki M,Styczynski J

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Cyclooxygenases (COXs) and prostanoids play pivotal roles in colon carcinogenesis. This study was designed to determine the chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in male F344...

journal_title：Anticancer research

authors： Kawamori T,Uchiya N,Kitamura T,Ohuchida S,Yamamoto H,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2001-11-01 00:00:00

abstract：:We report a case of renal cell carcinoma with solitary metachronous metastasis to contralateral adrenal gland occurring 9 months after radical nephrectomy. The patient was treated with a contralateral adrenalectomy and is alive for 87 months. The literature was reviewed and 5-year survival of solitary metachronous met...

journal_title：Anticancer research

authors： Yamasaki Y,Koga S,Nishikido M,Noguchi M,Kanetake H,Saito Y

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of oxaliplatin (L-OHP) fractionated over two days with bimonthly 5-fluorouracil (5-FU) and leucovorin (LV), as first-line treatment of metastatic colorectal cancer (MCC) patients. PATIENTS AND METHODS:Fifty-four patients with inoperable MCC (median age, 60 years) were entere...

journal_title：Anticancer research

authors： Recchia F,Rea S,Nuzzo A,Lalli A,Di Lullo L,De Filippis S,Saggio G,Biondi E,Massa E,Mantovani G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs), which are endogenously expressed regulatory noncoding RNAs, have an altered expression in tumor tissues. MiRNAs regulate cancer-related processes such as cell growth and tissue differentiation, and therefore, might function as oncogenes or tumor-suppressor genes. The aim of our study was ...

journal_title：Anticancer research

authors： Pesta M,Klecka J,Kulda V,Topolcan O,Hora M,Eret V,Ludvikova M,Babjuk M,Novak K,Stolz J,Holubec L

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Intratumoural hypoxia is associated with chemoresistance in glioblastoma multiforme (GBM), a highly malignant brain tumour. Adaptive response to endoplasmic reticulum stress induced by temozolomide is a major obstacle in recurrent GBM. We investigated whether hyperoxia resensitizes temozolomide-resistant GBM...

journal_title：Anticancer research

authors： Lee D,Sun S,Ho AS,Kiang KM,Zhang XQ,Xu FF,Leung GK

更新日期：2014-06-01 00:00:00