CA 125 measurement in the follow-up of breast cancer patients.

abstract：BACKGROUND/AIM:The European MRI and Rectal Cancer Surgery (EuMaRCS) score was proposed to identify preoperatively difficult laparoscopic total mesorectal excision (L-TME) for locally advanced rectal cancer (LARC). This study aimed to test EuMaRCS's validity. PATIENTS AND METHODS:Data were retrieved from a European mul...

journal_title：Anticancer research

authors： de'ANGELIS N,Martínez-Pérez A,Vitali GC,Pigneur F,Luciani A,Brunetti F,Kraft M,Martí-Martínez E,Moroni P,Espin E,Ris F,Pucciarelli S,EuMaRCS Study Group.

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND/AIM:Peripheral neurotoxicity is a dose-limiting factor of many chemotherapeutic agents, including cisplatin. Mesenchymal stem cells are promising for the treatment of several neurological disorders, and our aim was to verify the neuroprotective potential of human mesenchymal stem cells (hMSCs) on dorsal root...

journal_title：Anticancer research

authors： Scuteri A,Ravasi M,Monfrini M,Milano A,D'Amico G,Miloso M,Tredici G

更新日期：2015-10-01 00:00:00

abstract：:Ten cell sublines the MDA-MB 231 human breast cell line were analyzed for their phenotypic diversity: morphology, karyotype, growth rate, clonogenicity in semisolid medium, tumorigenicity in nude mice, number and affinity of nuclear receptors for oestradiol, progesterone and glucocorticoids. Karyotypic analysis showed...

journal_title：Anticancer research

authors： Crépin M,Salle V,Raux H,Berger R,Hamelin R,Brouty-Boyé D,Israel L

更新日期：1990-11-01 00:00:00

abstract：:We report application of a novel immunohistochemical procedure for the staining of apoptotic (AP) cells in paraffin sections using monoclonal antibody (MAb) to single-stranded DNA. MAb differentiated between apoptosis and necrosis and in contrast to in situ end labelling specifically stained only AP cells. AP carcinom...

journal_title：Anticancer research

authors： Frankfurt OS,Robb JA,Sugarbaker EV,Villa L

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND/AIM:To predict pCR during neoadjuvant chemotherapy is still difficult. The aim of this study was to evaluate the optimal tumor reduction rate and modalities for predicting pCR after two cycles of docetaxel. PATIENTS AND METHODS:We analyzed 52 patients with HER2-positive or triple-negative breast cancer. The...

journal_title：Anticancer research

authors： Kuba S,Maeda S,Matsumoto M,Yamanouchi K,Iwata T,Morita M,Sakimura C,Otsubo R,Yano H,Sato S,Kanetaka K,Nagayasu T,Eguchi S

更新日期：2020-04-01 00:00:00

abstract：:Malignant mesothelioma of the tunica vaginalis testis is a rare and aggressive asbestos-related malignancy that may pose difficult diagnostic problems. After 16 years of asbestos exposure, a 38-year-old petrochemical worker came to our notice with acute right testicular pain and swelling, simulating torsion of the spe...

journal_title：Anticancer research

authors： Candura SM,Canto A,Amatu A,Gerardini M,Stella G,Mensi M,Poggi G

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND AIMS:We examined the prognostic value of pre-treatment C-reactive protein (CRP) after surgical resection (SR) for hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 298 patients with HCC who underwent SR were analyzed. They were categorized into a CRP-positive group (group A: CRP >0.2 mg/dl...

journal_title：Anticancer research

authors： Nishikawa H,Arimoto A,Wakasa T,Kita R,Kimura T,Osaki Y

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND/AIM:Cisplatin nephrotoxicity includes early activation of the pro-apoptotic p66Shc and disorganization of the actin cytoskeleton, integrity which is regulated by heat-shock protein-27 (Hsp27). Here we determined the potential role of p66Shc in abrogating the Hsp27 function. MATERIALS AND METHODS:Effects of ...

journal_title：Anticancer research

authors： Arany I,Clark JS,Reed DK,Ember I,Juncos LA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND/AIM:Surgical resection for esophageal cancer has remained the gold-standard therapy provided worldwide. Subcarinal lymph-nodes are classified as peri-esophageal nodes and their dissection may be performed during a 2- or 3-stage esophagectomy. The necessity and prognostic value of subcarinal lymphadenectomy i...

journal_title：Anticancer research

authors： Sdralis EK,Davakis S,Syllaios A,Lorenzi B,Kordzadeh A,Athanasiou A,Petousis S,Liakakos T,Charalabopoulos A

更新日期：2019-08-01 00:00:00

abstract：:This review focuses on the functional role and structural features of the genes involved in common hereditary cancers. Most of these tumors are sporadic and the genetic alterations responsible for their genesis take place over several cell generations; nevertheless, 5 to 10% of the human tumors are hereditary, with a ...

journal_title：Anticancer research

authors： Russo A,Zanna I,Tubiolo C,Migliavacca M,Bazan V,Latteri MA,Tomasino RM,Gebbia N

更新日期：2000-11-01 00:00:00

abstract：:We have previously reported that lignin carbohydrate complex and E. coli lipopolysaccharide (LPS), but not their precursors or (-)-epigallocatechin-3-gallate (EGCG), enhanced the nitric oxide (NO), citrulline and asparagines production by the mouse-macrophage-like cell line Raw264.7. Here the EGCG inhibition of NO pro...

journal_title：Anticancer research

authors： Hashimoto K,Sakagami H

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:UNC5C, one of the Netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, two reports indicated that UNC5C methylation was closely associated with loss of gene expression in colorectal cancer. ...

journal_title：Anticancer research

authors： Hibi K,Mizukami H,Shirahata A,Goto T,Sakata M,Saito M,Ishibashi K,Kigawa G,Nemoto H,Sanada Y

更新日期：2009-01-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a major endogenous regulator of matrix metalloproteinases. This study examined the relation between TIMP-1 gene expression and postoperative mortality in patients with colorectal cancer (CRC). Specimens of CRC were obtained from 202 patients. The relative expression ...

journal_title：Anticancer research

authors： Inagaki D,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Yamada T,Yamamoto N,Sato T,Shiozawa M,Morinaga S,Akaike M,Fujii S,Numata K,Kunisaki C,Rino Y,Tanaka K,Masuda M,Imada T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The standard treatment of epithelial ovarian cancer is tumor debulking by surgery, followed by six cycles of chemotherapy consisting of cisplatinum and paclitaxel. However, this therapy protocol is not satisfactory, since about 50% of the treated patients eventually experience recurrence within a few years o...

journal_title：Anticancer research

authors： Law KS,Chen HC,Liao SK

更新日期：2007-03-01 00:00:00

abstract：:Carcinoma cell metastasis is mediated by increased mobility and invasiveness via epithelial-mesenchymal transition (EMT). Snail, a zinc-finger transcription factor, triggers EMT by directly repressing E-cadherin expression. In this study, the correlation between E-cadherin and Snail expression was investigated. In add...

journal_title：Anticancer research

authors： Zhang A,Chen G,Meng L,Wang Q,Hu W,Xi L,Gao Q,Wang S,Zhou J,Xu G,Meng L,Ma D

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND/AIM:Dynamics of circulating tumor cells (CTCs) after molecular targeting therapy remain unclear. MATERIALS AND METHODS:We examined changes in CTC numbers and morphology early after targeting therapy in EGFR-mutated PC-9 human lung cancer and HER2-gene amplified GLM-1 gastric cancer mouse CTC models using a ...

journal_title：Anticancer research

authors： Ito A,Nakanishi H,Yoshimura M,Ito S,Sakao Y,Kodera Y,Yatabe Y,Kaneda N

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:Stage-specific embryonic antigen-4 (SSEA-4) expression is associated with malignant aggressiveness and is useful as a marker for identifying cancer stem cells. Our aim was to assess the relationship between hormonal therapy and SSEA-4 expression in prostate cancer (PC). MATERIALS AND METHODS:SSEA-4 expr...

journal_title：Anticancer research

authors： Yuno T,Miyata Y,Matsuo T,Mukae Y,Otsubo A,Mistunari K,Ohba K,Suda T,Saito S,Sakai H

更新日期：2020-10-01 00:00:00

abstract：:Whether serum testosterone (T) can become an adjunct test able to validate the PSA-weighted risk of prostate cancer (PR.CA) in the "grey" diagnostic area (PSA =3.0 to <10.0 ng/ml) was investigated. Seven hundred and eighteen men participated in a prostate screening program using the cutoff PSA value of > or =3.0 ng/ml...

journal_title：Anticancer research

authors： Karamanolakis D,Lambou T,Bogdanos J,Milathianakis C,Sourla A,Lembessis P,Halapas A,Pissimissis N,Dessypris N,Petridou ET,Koutsilieris M

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND/AIM:Patients with metastatic head-and-neck cancer require individual therapies facilitated by prognostic tools. A tool to estimate the risk of recurrent or new cerebral metastases following whole-brain irradiation (WBI) is presented. PATIENTS AND METHODS:Age, gender, performance status, cancer site, number ...

journal_title：Anticancer research

authors： Staackmann C,Janssen S,Schild SE,Rades D

更新日期：2018-07-01 00:00:00

abstract：:Malignant gliomas are often treated with cisplatin (cis-diamminedichloroplatinum(II), CDDP) and radiation but results remain unsatisfactory. To investigate whether CDDP induces radioresistance in glioma, T98G human glioblastoma cells were pretreated 5 times with 10(-6)M CDDP for 24 hours and then the sensitivity of wi...

journal_title：Anticancer research

authors： Poppenborg H,Münstermann G,Knüpfer MM,Hotfilder M,Hacker-Klom U,Wolff JE

更新日期：1997-03-01 00:00:00

abstract：:We report the synthesis of a series of merocyanines and the structure-effect relationship as cytotoxic agents for human adenocarcinoma cells in vitro. The cytotoxicity of these compounds in vitro makes them potential anticancer agents. One of these compounds was found active on human and mouse tumor models. ...

journal_title：Anticancer research

authors： Gruda I,Pagé M,Bolduc F,Laliberté S,Noel C

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Incidence of brain metastases (BM) from breast cancer (BC) is increasing. However, prognostic evaluation and treatment strategies are still a matter of debate. AIM:To describe the clinical outcome of BM from BC treated by neurosurgical resection and to identify the actual prognostic factors in this specific...

journal_title：Anticancer research

authors： Tabouret E,Metellus P,Tallet-Richard A,Figarella-Branger D,Charaffe-Jauffret E,Viens P,Gonçalves A

更新日期：2013-05-01 00:00:00

abstract：:In node-negative breast cancer, 70% of patients are cured by surgery alone and thus should be spared the necessity of systemic adjuvant treatment. Histomorphological and tumor biological prognostic factors may be employed to assess the patient's risk profile with regard to disease recurrence and death. To evaluate the...

journal_title：Anticancer research

authors： Thomssen C,Oppelt P,Jänicke F,Ulm K,Harbeck N,Höfler H,Kuhn W,Graeff H,Schmitt M

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Bone lesions in multiple myeloma (MM) are screened with radiological skeletal survey (RSS) due to its widespread availability. Although bone lesions can be missed by RSS, more sensitive radiological surveys are not as yet recommended for routine use due to the low availability of the methodology and economic...

journal_title：Anticancer research

authors： Engelhardt M,Kleber M,Frydrychowicz A,Pache G,Schmitt-Gräff A,Wäsch R,Durie BG

更新日期：2009-11-01 00:00:00

abstract：:Megakaryocyte polyploidization is an advantageous and regulated mechanism which leads to an increase in platelet production. In megakaryocyte cell lines, polyploidization can be obtained by using cytochalasin B, an inhibitor of the actin polymerization. The Nucleolar Organizer Regions (AgNORs) are parts of nucleolar D...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical implications of pre- and post-treatment hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). PATIENTS AND METHODS:We retrospectively analyzed 125 patients with LACC (...

journal_title：Anticancer research

authors： Lee HJ,Kim JM,Chin YJ,Chong GO,Park SH,Lee YH,Hong DG,Lee YS

更新日期：2020-01-01 00:00:00

abstract：:Regulation of apoptosis by extracellular molecules binding to cell death receptors has received much attention in recent years. Fas, a member of the tumor necrosis factor receptor superfamily, is a transmembrane protein whose extracellular domain binds its cognate ligand (FasL), which can induce apoptosis in sensitive...

journal_title：Anticancer research

authors： Crowe DL,Yoon E

更新日期：2003-05-01 00:00:00

abstract：:TNF alpha is known to exert multi-regulatory effects on normal and malignant cell functions by binding to the corresponding cell surface receptor. However, the existence of cross interaction between TNF alpha and EGF receptor has been proposed. In this study, we investigated the modulatory effect of TNF alpha on EGF r...

journal_title：Anticancer research

authors： Wang D,Yang EB,Cheng LY

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

journal_title：Anticancer research

authors： Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

更新日期：2017-12-01 00:00:00

abstract：:The therapeutic opportunities for an improved management of malignant bone disease are currently extensively studied. The conventional management of symptomatic bone lesions in patients with advanced cancer involves various combinations of local and systemic standard anticancer therapies and the symptomatic treatment ...

journal_title：Anticancer research

authors： Lüftner D,Henschke P,Possinger K

更新日期：2007-07-01 00:00:00