Pre-treatment C-reactive protein as a prognostic factor for recurrence after surgical resection of hepatocellular carcinoma.

Abstract:

BACKGROUND AND AIMS:We examined the prognostic value of pre-treatment C-reactive protein (CRP) after surgical resection (SR) for hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 298 patients with HCC who underwent SR were analyzed. They were categorized into a CRP-positive group (group A: CRP >0.2 mg/dl, n=130) and a CRP-negative group (group B: CRP <0.2 mg/dl, n=168). Overall survival (OS) and recurrence-free survival (RFS) were compared. RESULTS:The 1- and 3-year cumulative OS rates were 87.0% and 68.3% in group A and 95.9% and 81.1% in group B (p=0.194). The corresponding RFS rates were 61.6% and 30.3% in group A and 77.2% and 44.9% in group B (p=0.004). In multivariate analysis, the pre-treatment CRP level was a significant prognostic factor linked to RFS (p=0.046). CONCLUSION:Pre-treatment CRP levels may be a useful predictor of recurrence after SR for HCC.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Nishikawa H,Arimoto A,Wakasa T,Kita R,Kimura T,Osaki Y

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

1181-8

issue

3

eissn

0250-7005

issn

1791-7530

pii

33/3/1181

journal_volume

33

pub_type

杂志文章
  • Two-step Intensity-modulated Radiation Therapy for Oropharyngeal Cancer: Initial Clinical Experience and Validation of Clinical Staging.

    abstract:AIM:To evaluate the clinical results of two-step intensity-modulated radiation therapy (IMRT) for oropharyngeal cancer. PATIENTS AND METHODS:Eighty patients were treated with two-step IMRT between 2002 and 2014. Whole-neck radiotherapy (44.0-50.0 Gy/22-25 fractions) was delivered by IMRT, followed by boost IMRT to the...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12312

    authors: Tatebe H,Doi H,Ishikawa K,Kawakami H,Yokokawa M,Nakamatsu K,Kanamori S,Shibata T,Kitano M,Nishimura Y

    更新日期:2018-02-01 00:00:00

  • Estrogen-dependent release of serum proteins from MCF-7 breast carcinoma cells in vitro.

    abstract::The human breast carcinoma cell line MCF-7, propagated in a chemically defined medium, released alfa-1-antitrypsin and alfa-1-antichymotrypsin to the medium under the influence of estradiol. Furthermore, an estrogen-independent release of antigenic material crossreacting with alfa-1-lipoprotein was demonstrated. In th...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Krøll J,Briand P

    更新日期:1988-01-01 00:00:00

  • Image-guided Stereotactic Body Radiotherapy in Metastatic Prostate Cancer.

    abstract:BACKGROUND/AIM:In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. MATERIALS AND METHODS:Primary ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12572

    authors: Pasqualetti F,Panichi M,Sainato A,Baldaccini D,Cocuzza P,Gonnelli A,Montrone S,Molinari A,Barbiero S,Bruschi A,Notini E,Ursino S,Mazzotti V,Morganti R,Coraggio G,Cantarella M,Erba PA,Paiar F

    更新日期:2018-05-01 00:00:00

  • Touch imprint cytology and frozen-section analysis for intraoperative evaluation of sentinel nodes in early breast cancer.

    abstract::Sentinel lymph node biopsy (SLNB) is currently the suggested axillary staging procedure in patients with early-stage breast cancer (BC) and usually requires intraoperative frozen-section (FS) examination of the removed nodes. However, other techniques, such as touch imprint cytology (IC), real-time reverse transcripta...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Lumachi F,Marino F,Zanella S,Chiara GB,Basso SM

    更新日期:2012-08-01 00:00:00

  • Activating Gs a mutation rarely occurs in musculoskeletal tumors other than fibrous dysplasia.

    abstract:BACKGROUND:Activating Gs a mutations have been identified in most instances of fibrous dysplasia (FD). This mutation leads to consistently elevated intracellular cyclic adenosine monophosphate (cAMP) levels, with various biological consequences. The development of secondary sarcoma in FD is a rare but well-established ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Gu W,Ogose A,Matsuba A,Kawashima H,Hotta T,Kudo N,Hoshino M,Kondo N,Mera H,Endo N

    更新日期:2006-03-01 00:00:00

  • Photochemical enhancement of gene delivery to glioblastoma cells is dependent on the vector applied.

    abstract:BACKGROUND:Photodynamic therapy (PDT) and gene therapy protocols are separately under clinical evaluation for treatment of brain malignancies. Here, the potential of a novel combination technique, photo-induced delivery of macromolecules and genes to glioblastoma cells, is evaluated. MATERIALS AND METHODS:The photoche...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Bonsted A,Høgset A,Hoover F,Berg K

    更新日期:2005-01-01 00:00:00

  • Is pancreatic resection justified for metastasis of papillary thyroid cancer?

    abstract:BACKGROUND:This case report describes a patient with symptomatic anaemia due to a bleeding duodenal metastasis from metastasising differentiated thyroid cancer (DTC), which was treated by partial duodenopancreatectomy (DP). CASE REPORT:A 71-year old male was sent to hospital with severe anaemia. This patient had suffe...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Meyer A,Behrend M

    更新日期:2006-05-01 00:00:00

  • High-throughput molecular genotyping for small biopsy samples in advanced non-small cell lung cancer patients.

    abstract:BACKGROUND:Despite the key role of mutational analysis in targeted therapy, the difficulty in acquisition of adequate tumor tissues for molecular genotyping in advanced non-small cell lung cancer (NSCLC) has led to the need for a fast and efficient method for detecting genetic alterations for targeted therapy. PATIENT...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Maeng CH,Lee HY,Kim YW,Choi MK,Hong JY,Jung HA,Lee KS,Kim H,Kwon OJ,Sun JM,Ahn JS,Park K,Um SW,Ahn MJ

    更新日期:2013-11-01 00:00:00

  • Thymidine kinase levels correlate with prognosis in aggressive lymphoma and can discriminate patients with a clinical suspicion of indolent to aggressive transformation.

    abstract::Serum levels of thymidine kinase 1 (TK1), an enzyme involved in the G1-S phase of the cell cycle, have been previously shown to correlate with the prognosis of lymphoid malignancies. We hypothesized that TK1 levels will be higher in aggressive, compared to indolent lymphoproliferative, malignancies and this may serve ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Gatt ME,Goldschmidt N,Kalichman I,Friedman M,Arronson AC,Barak V

    更新日期:2015-05-01 00:00:00

  • Relationship Between Stage-specific Embryonic Antigen-4 and Anti-cancer Effects of Neoadjuvant Hormonal Therapy in Prostate Cancer.

    abstract:BACKGROUND/AIM:Stage-specific embryonic antigen-4 (SSEA-4) expression is associated with malignant aggressiveness and is useful as a marker for identifying cancer stem cells. Our aim was to assess the relationship between hormonal therapy and SSEA-4 expression in prostate cancer (PC). MATERIALS AND METHODS:SSEA-4 expr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14569

    authors: Yuno T,Miyata Y,Matsuo T,Mukae Y,Otsubo A,Mistunari K,Ohba K,Suda T,Saito S,Sakai H

    更新日期:2020-10-01 00:00:00

  • Prophylactic Radiotherapy to Intervention Sites in Malignant Pleural Mesothelioma--Single-institution Experience and Literature Review.

    abstract:AIM:To evaluate the efficacy of prophylactic radiotherapy at intervention sites in patients with malignant pleural mesothelioma (MPM). PATIENTS AND METHODS:From 05/2010 to 12/2014, 53 patients with histologically confirmed MPM were treated in order to prevent interventional site metastases. Irradiation was carried out...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Janssen S,Schönhofer B,Rades D

    更新日期:2015-07-01 00:00:00

  • Comparison of common terminology criteria for adverse events v3.0 and radiation therapy oncology group toxicity score system after high-dose-rate interstitial brachytherapy as monotherapy for prostate cancer.

    abstract:AIM:The evaluation of toxicity after high-dose-rate interstitial brachytherapy (HDR-ISBT) as monotherapy for localized prostate cancer. MATERIALS AND METHODS:We analyzed early and late toxicities in 100 patients treated by HDR-ISBT as monotherapy at the National Hospital Organization Osaka National Hospital using both...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yoshida K,Yamazaki H,Nakamara S,Masui K,Kotsuma T,Akiyama H,Tanaka E,Yoshioka Y

    更新日期:2014-04-01 00:00:00

  • Enhanced renal clearance of vancomycin in rats with carcinogen-induced osteosarcoma.

    abstract::Recently, it has been reported that total clearance (CLtot) of vancomycin is significantly higher in patients with malignancies compared to those without malignancies. In the present study, to clarify the mechanism of this enhancement in malignancy, we adopted rat animal models, using chemical carcinogen-induced osteo...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Shimada I,Iwata C,Taga S,Teramachi H,Nomura M,Miyamoto K,Tsuciya H,Wada T,Kimura K,Matsushita R

    更新日期:2012-03-01 00:00:00

  • Creation of ultra-rare restriction sites in intact eucaryotic chromosomes mediated by bacterial methylases: an approach to sequencing and analyzing tumor and normal genomes.

    abstract::The limited restriction of eucaryotic chromosomes would facilitate our understanding of the aberrant genomes of genetic diseases and cancer. We have described methods for methylating eucaryotic chromosomes embedded in agarose plugs. We now describe how Cla I methylase can be utilized in a methylation-dependent restric...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Wilson WW,Mebane EW,Hoffman RM

    更新日期:1993-01-01 00:00:00

  • Merkel cell carcinoma of the skin. Treatment of primary, recurrent, and metastatic disease: review of clinical cases.

    abstract::The clinical features of 10 cases with the adjunct of a literature review of primary neuroendocrine carcinoma of the skin (Merkel cell tumor) are reported. This cancer arises in the dermis and subcutaneous tissue of elderly individuals. Natural history is characterized by local recurrences (40%), regional lymph-nodes ...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Queirolo P,Gipponi M,Peressini A,Disomma CF,Vecchio S,Raposio E,Guenzi M,Sertoli MR,Cafiero E

    更新日期:1997-01-01 00:00:00

  • A possible clinical adaptation of CRM197 in combination with conventional chemotherapeutic agents for ovarian cancer.

    abstract:AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

    更新日期:2011-07-01 00:00:00

  • Female Gender Is an Age-dependent Negative Prognostic Factor for Patients with Upper Tract Urothelial Carcinoma.

    abstract:AIM:To analyze female gender as a possible age-dependent prognostic factor for overall (OS) and cancer-specific survival (CSS) in patients with upper urinary tract urothelial carcinoma (UUTUC) after radical nephroureterectomy (RNU). PATIENTS AND METHODS:A total of 167 men and 101 women with UUTUC treated with RNU with...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Sikic D,Wach S,Taubert H,Richterstetter M,Kunath F,Goebell PJ,Schick S,Olbert P,Huber J,Wullich B,Keck B

    更新日期:2015-07-01 00:00:00

  • Pre-transplant Quantitative Determination of NPM1 Mutation Significantly Predicts Outcome of AIlogeneic Hematopoietic Stem Cell Transplantation in Patients with Normal Karyotype AML in Complete Remission.

    abstract:BACKGROUND/AIM:Minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (alloHSCT) can influence the results of therapy. With the aim of evaluating the potential role of pre-transplant MRD, we studied the impact of pre-transplant MRD level on...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11130

    authors: Karas M,Steinerova K,Lysak D,Hrabetova M,Jungova A,Sramek J,Jindra P,Polivka J,Holubec L

    更新日期:2016-10-01 00:00:00

  • The RING finger protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling.

    abstract:BACKGROUND:In breast carcinomas, prolonged signalling through the TGF-beta receptor promotes latent tumour progression, metastasis and the epithelial-to-mesenchymal transition of tumour cells. Previously, it has been found that the 154 amino acid RING finger protein, RNF11, was overexpressed in high-grade breast tumour...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Azmi PB,Seth AK

    更新日期:2009-06-01 00:00:00

  • High concentration of beta-defensin-2 in oral squamous cell carcinoma.

    abstract::We have previously reported the presence of human beta-defensin-2 (HBD-2), a peptide with antimicrobial and cytotoxic properties, in oral squamous cell carcinomas. The aim of the present study was to measure the concentration of HBD-2 in abnormal tissues such as oral squamous cell carcinomas. HBD-2 was extracted from ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Sawaki K,Mizukawa N,Yamaai T,Yoshimoto T,Nakano M,Sugahara T

    更新日期:2002-07-01 00:00:00

  • Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart.

    abstract::P-glycoprotein (P-gp) and multidrug resistance related protein (MRP) overexpression is often responsible of the development of multidrug resistance in cancer therapy. These proteins are also expressed in normal tissues, where their physiological role is related to the extrusion of endogenous toxins or to secretory fun...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rosati A,Decorti G,Klugmann FB,Candussio L,Granzotto M,Melato M,Giraldi T

    更新日期:2000-09-01 00:00:00

  • Yeast-derived beta-(1-3),(1-6)-D-glucan induces up-regulation of CD86 on dectin-1-positive human B-lymphoma cell lines.

    abstract:BACKGROUND:The knowledge of direct effects of β-glucans on tumor cells is limited. This study evaluated the impact of a soluble yeast-derived beta-(1-3),(1-6)-d-glucan, containing a fraction of aggregated sugar polymers, on viability, proliferation and expression of CD86 of the human B-cell lymphoma cell lines Daudi an...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Harnack U,Kellermann U,Pecher G

    更新日期:2011-12-01 00:00:00

  • LEA.135 expression: identifies low-risk patients with breast ductal carcinoma in situ.

    abstract::The expression of a cell surface-associated sialoglycoprotein (LEA.135), which has been shown to be significantly associated with decreased incidence of recurrence and increased overall survival of patients with primary invasive breast carcinoma, was evaluated in a retrospective study to identify subsets of patients w...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Baltayan A,Naritoku WY,Chaiwun B,Tsao-Wei DD,Groshen S,Hern RA,Gusterson BA,Taylor CR,Imam SA

    更新日期:2002-09-01 00:00:00

  • Detection of oncogenic HPV and identification of 72Arg polymorphic p53 by in situ PCR for clinical routine purposes.

    abstract:BACKGROUND:Ano-genital carcinoma is a polyfactorial and polygenic disease. Certain strains of human papillomavirus (HPV) have been detected in a high percentage of patients. It has been suggested that p53 polymorphisms may be relevant for the interaction with viral proteins that inactivates p53. MATERIALS AND METHODS:...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Realacci M,Perrone GA,Sale P,Tafani M,Di Vito M,Perrone-Donnorso R,Zotti G,Russo MA

    更新日期:2006-07-01 00:00:00

  • Efficacy and Safety of Enoxaparin for Prophylaxis of Postoperative Venous Thromboembolism After Esophagectomy: A Single-center Prospective Randomized Controlled Phase II Study.

    abstract:BACKGROUND/AIM:This study aimed to assess whether low-molecular-weight heparin (LMWH) is effective and safe in preventing postoperative venous thromboembolism (VTE) in patients undergoing esophageal cancer surgery. PATIENTS AND METHODS:In this single-institution, prospective, randomized trial, 73 patients with esophag...

    journal_title:Anticancer research

    pub_type: 杂志文章,随机对照试验

    doi:10.21873/anticanres.13385

    authors: Tanaka Y,Yamada A,Hirata S,Tanaka H,Sakuratani T,Matsuhashi N,Yamaguchi K,Shimokawa T,Yoshida K

    更新日期:2019-05-01 00:00:00

  • Release of daunorubicin from polymethylmethacrylate for the improvement of the local growth control of bone metastasis animal experiments.

    abstract::Bone metastases are a sign of advanced tumor disease. Surgical therapy is only occasionally curative. Therefore, the therapeutic goals are a limited surgical excision, immediate mobilization, effective stabilization and the avoidance of local recurrence. We investigated the effect of the anthracycline daunorubicin (DN...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Fröschle GW,Mählitz J,Langendorff HU,Achilles E,Pollock J,Jungbluth KH

    更新日期:1997-03-01 00:00:00

  • Preliminary phase I clinical study and pharmacokinetics of (1,2-diaminocyclohexane) (isocitrato) platinum (II) or PHIC.

    abstract::PHIC [NSC-350602; (1,2-diaminocyclohexane) (isocitrato) platinum (II)] is a new highly water-soluble platinum derivative. Preclinical studies showed antitumor activity on a wide range of tumors, no cross-resistance with cisplatin and little or no nephrotoxicity in mice and baboons. A phase I clinical trial was then in...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Gouyette A,Ducret JP,Caillé P,Amiel JL,Rouëssé J,Foka M,Carde P,Hayat M,Sancho-Garnier H

    更新日期:1986-09-01 00:00:00

  • Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis.

    abstract:BACKGROUND:F-Box protein 45 (FBXO45) is reported to be associated with cancer aggressiveness. We investigated the relationship between FBXO45 and clinicopathological factors in gastric cancer (GC). MATERIALS AND METHODS:We used immunohistochemistry to investigate FBXO45 expression in 104 GC samples; the prognostic val...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11305

    authors: Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

    更新日期:2017-01-01 00:00:00

  • Genetic alternations of p73 are infrequent but may occur in early stage hepatocellular carcinoma.

    abstract::p73, a structural homologue of the tumor suppressor gene, p53, has recently been identified and mapped to chromosome 1p36, where genomic loss of heterozygosity (LOH) often occurs in human hepatocellular carcinoma (HCC). To determine whether p73 is involved in the development of HCC and whether there is an inverse corr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Peng CY,Tsai SL,Yeh CT,Hung SP,Chen MF,Chen TC,Chu CM,Liaw YF

    更新日期:2000-05-01 00:00:00

  • The inhibitory effect of docetaxel and p38 MAPK inhibitor on TZT-1027 (Soblidotin)-induced antivascular activity.

    abstract:BACKGROUND:TZT-1027 (Soblidotin), a microtubule (MT)-depolymerizing agent, has antivascular activity through the disruption of microtubules in vascular endothelial cells. Our aim was to elucidate the mechanism of TZT-1027-induced antivascular activity by investigating the impact of various inhibitors. MATERIALS AND ME...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Watanabe J,Natsume T,Kobayashi M

    更新日期:2007-11-01 00:00:00