Immunological and Clinical Impact of Cancer Stem Cells in Vulvar Cancer: Role of CD133/CD24/ABCG2-Expressing Cells.

abstract：:In order to define genes which mediate liver tropism of colon cancer metastasis we have compared the transcriptional profile of 5600 full-length genes using the Affymetrix HuGene FL array technology of the non-metastatic colon cancer cell lines KM12C and the two metastatic cell lines, KM12SM and KM12L4A, which are der...

journal_title：Anticancer research

authors： De Lange R,Burtscher H,Jarsch M,Weidle UH

更新日期：2001-07-01 00:00:00

abstract：:Tenascin is a multifunctional extracellular matrix glycoprotein generally expressed in epithelial tumors at sites of epithelial tumor-mesenchymal tissue interface. Studies so far have indicated that mesenchymal cells are a major source of tenascin in tumor tissues. The present study evaluated biopsies and surgically r...

journal_title：Anticancer research

authors： Mori M,Muramatsu Y,Yamada K,Shrestha P,Takai Y

更新日期：1996-09-01 00:00:00

abstract：:In this study, a protein kinase C inhibitor, H-7, was found to potentiate the antiproliferative effects of difluoromethyl ornithine (DFMO), inhibitor of the polyamine biosynthesis, on NIH 3T3 and 3T3/SV40 cells in culture. Incubation of the cells with DFMO inhibited the cell growth, whereas the addition of polyamine s...

journal_title：Anticancer research

authors： Khan NA,Havouis R,Quemener V,Moulinoux JP

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND/AIM:Patients with metastatic head-and-neck cancer require individual therapies facilitated by prognostic tools. A tool to estimate the risk of recurrent or new cerebral metastases following whole-brain irradiation (WBI) is presented. PATIENTS AND METHODS:Age, gender, performance status, cancer site, number ...

journal_title：Anticancer research

authors： Staackmann C,Janssen S,Schild SE,Rades D

更新日期：2018-07-01 00:00:00

abstract：:The antitumor effect of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on human osteosarcoma cell lines such as KHOS-240S, MG-63 and G-292 cells, and its effect in combination with anticancer drugs such as methotrexate (MTX), adriamycin (ADM) and 4-hydroperoxyfosfamid...

journal_title：Anticancer research

authors： Sonoda J,Hibasami H,Yamada H,Fujinami S,Nakashima K,Ogihara Y

更新日期：1995-05-01 00:00:00

abstract：:P53 mutation, through defects in repairing DNA damages, is associated with genomic instability. In 24 adult patients with relapsed acute lymphoblastic leukemia (ALL), the status of the p53 gene at different stages was serially followed by cytogenetic and polymerase-chain reaction/single strand conformation polymorphis...

journal_title：Anticancer research

authors： Tang JL,Tien HF,Lin MT,Chen PJ,Chen YC

更新日期：1998-03-01 00:00:00

abstract：:A report that effects of butyrate on some cells may be mediated by activation of AMP-activated protein kinase (AMPK) prompted this study which examines if other AMPK activators can induce differentiation and inhibit proliferation of colon cancer cells in a manner similar to butyrate. Using induction of alkaline phosph...

journal_title：Anticancer research

authors： Lea MA,Chacko J,Bolikal S,Hong JY,Chung R,Ortega A,desbordes C

更新日期：2011-02-01 00:00:00

abstract：:Total sialic acid (TSA) and "lipid-bound" sialic acid (LSA) were evaluated in comparison to carcinoembryonic antigen (CEA) and ferritin and neuron specific enolase (NSE) in 152 untreated patients with primary lung cancer, 107 benign pulmonary disease patients and 207 notmal controls. The mean concentrations of TSA, LS...

journal_title：Anticancer research

authors： Kakari S,Stringou E,Toumbis M,Ferderigos AS,Poulaki E,Chondros K,Dema A,Kotsovoulou V,Pavlidis N

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Although oncological results for resection of colon cancer with inferior mesenteric artery (IMA) ligation at its origin (high tie) or immediately below the left colic artery (low tie) are similar, injury of the superior hypogastric plexus may be caused when the IMA is tied at its origin, thus impairing defec...

journal_title：Anticancer research

authors： Fiori E,Crocetti D,Lamazza A,DE Felice F,Scotti GB,Sterpetti AV,Mingoli A,Sapienza P,DE Toma G

更新日期：2020-05-01 00:00:00

abstract：:The therapeutic opportunities for an improved management of malignant bone disease are currently extensively studied. The conventional management of symptomatic bone lesions in patients with advanced cancer involves various combinations of local and systemic standard anticancer therapies and the symptomatic treatment ...

journal_title：Anticancer research

authors： Lüftner D,Henschke P,Possinger K

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND/AIM:3,4',7-O-trimethylquercetin (34'7TMQ), a derivative of quercetin, inhibited ovarian cancer cell migration and invasion without affecting proliferation. In this study, the apoptotic effect of 34'7TMQ on three cancer cell lines (CRL-1978, CRL-11731, SK-OV-3) was evaluated. MATERIALS AND METHODS:Expression...

journal_title：Anticancer research

authors： Ashraf AHMZ,Afroze SH,Yamauchi K,Zawieja DC,Keuhl TJ,Erlandson LW,Uddin MN

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:Nodal staging is used in colorectal cancer (CRC) to determine which patients should receive adjuvant chemotherapy. The aim of this study was to evaluate the role of indocyanine green fluorescence imaging (ICG-FI) in sentinel lymph node (SLN) detection compared to the standard technique. MATERIALS AND ME...

journal_title：Anticancer research

authors： Liberale G,Vankerckhove S,Galdon MG,Larsimont D,Ahmed B,Bouazza F,Moreau M,El Nakadi I,Donckier V,Bourgeois P,R&D Group for the Clinical Application of Fluorescence Imaging at the Jules Bordet Institute.

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The prognostic impact of neutrophil to lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) was examined using patients with a follow-up period more than 5 years. PATIENTS AND METHODS:Two hundred and eighty four consecutive resected NSCLC patients were reviewed retrospectively. In this study, patien...

journal_title：Anticancer research

authors： Tomita M,Shimizu T,Ayabe T,Yonei A,Onitsuka T

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIM:The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. PATIENTS AND METHODS:Twenty patients with small intestinal lymphoma who underw...

journal_title：Anticancer research

authors： Iida T,Nozawa H,Sonoda H,Toyama K,Kawai K,Hata K,Tanaka T,Nishikawa T,Sasaki K,Shuno Y,Kaneko M,Murono K,Emoto S,Ishii H,Kurokawa M,Ishihara S

更新日期：2020-04-01 00:00:00

abstract：:The in vitro antioxidative activity of benzylideneascorbate (SBA) and the in vivo effect on adriamycin (ADR)-induced cardiotoxicity in a mouse model were investigated. The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase an...

journal_title：Anticancer research

authors： Kojima S,Iizuka H,Yamaguchi H,Tanuma S,Kochi M,Ueno Y

更新日期：1994-09-01 00:00:00

abstract：:Gallic acid induced apoptotic cell death in human promyelocytic leukemia HL-60 cells. The effect of gallic acid was significantly reduced by blocking the free hydroxyl or carboxyl group with acetyl, methyl, ethyl, n-propyl or isoamyl group. This was paralleled with the decrease in the intensity of both gallate radical...

journal_title：Anticancer research

authors： Sakagami H,Satoh K,Hatano T,Yoshida T,Okuda T

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Signaling between androgen receptor (AR) and mTOR may be crucial for prostate cancer cells to endure the low androgen and suboptimal nutrient conditions produced by androgen deprivation therapy. MATERIALS AND METHODS:AR and mTOR cross-talk was examined in LNCaP cells exposed to either high or low testostero...

journal_title：Anticancer research

authors： Wu Y,Chhipa RR,Cheng J,Zhang H,Mohler JL,Ip C

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:In 1979, Montgomery and Asberg introduced an inventory for screening of depression. To our knowledge, the associations between the MADRS and the risk of breast cancer (BC) are rarely considered together in a prospective study. PATIENTS AND METHODS:In an extension of the Kuopio Breast Cancer Study, 115 women...

journal_title：Anticancer research

authors： Eskelinen M,Ollonen P

更新日期：2011-03-01 00:00:00

abstract：:Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in o...

journal_title：Anticancer research

authors： Alterio D,Jereczek-Fossa BA,Fiore MR,Piperno G,Ansarin M,Orecchia R

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND/AIM:Many studies have shown an antiproliferative, anti-inflammatory, anti-angiogenetic, and apoptosis-inducing effect of Vitamin D. A vitamin D deficiency has been associated with an increased risk for different types of cancer. This study examined vitamin D 25(OH)D levels in gynaecological cancers in compar...

journal_title：Anticancer research

authors： Kolnsberg L,Riffelmann M,Friedrich M

更新日期：2020-01-01 00:00:00

abstract：:Iron salts supplemented in a basal ratio, were fed to young Sprague-Dawley male rats for prolonged periods and the frequency of colonic adenocarcinomas induced by repeated s.c. injection of 1,2-dimethylhydrazine (DMH) at unit base doses of 9.0 mg/kg, ascertained and compared with the respective controls. In a series e...

journal_title：Anticancer research

authors： Gershbein LL,Rezai VK,Amir-Mokri E,Rao KC

更新日期：1993-11-01 00:00:00

abstract：:Mechanisms of tumor growth are concerned with the possibility that neoplasms are disturbed in their response to growth factors. Interleukin 2 (IL 2) is secreted by activated T-cells and is required for autocrine T-cell growth. Controversy exists as to the functional capacity of T-lymphocytes in patients with B-cell ch...

journal_title：Anticancer research

authors： Jehn U,Gross HJ,Wachholz K,Pauls R

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND/AIM:The oxazaphosphorines, ifosfamide and cyclophosphamide, represent a class of alkylating agents. The aim of the present in vitro study was to compare antileukemic activity of 4-hydroperoxyifosfamide (4-OOH-IF) and 4-hydroperoxycyclophosphamide (4-OOH-CP). MATERIALS AND METHODS:The experiments were perfor...

journal_title：Anticancer research

authors： Opydo-Chanek M,Śladowska K,Blicharski K,Mikeš J,Fedoročko P,Niemeyer U,Mazur L

更新日期：2017-11-01 00:00:00

abstract：:The purpose of this study was to investigate the nature of the action of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) as the modulator of gene expression. Practically, both the acceleration of daily liquid consumption following salt-hydrocortisone conditioning (sea water adaptation phenomenon) and the suppressive effec...

journal_title：Anticancer research

authors： Kodama M,Inoue F,Kodama T,Kodama M

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:The mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) has been identified as a biomarker of breast cancer. The present study aimed to investigate the biological role of TIMM17A in human breast cancer cells. MATERIALS AND METHODS:Anti-TIMM17A transgenes were stably tran...

journal_title：Anticancer research

authors： Yang X,Si Y,Tao T,Martin TA,Cheng S,Yu H,Li J,He J,Jiang WG

更新日期：2016-03-01 00:00:00

abstract：:The emergence of molecular and cytogenetic correlates has opened exciting avenues to a better understanding of acute lymphocytic leukemia (ALL) and in turn has sharpened the clinician's ability for classification and treatment. While the pathophysiology and etiology of ALL remains vague, the clinical significance of t...

journal_title：Anticancer research

authors： Botti AC,Verma RS

更新日期：1990-03-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide, with approximately 1.2 million deaths annually. The standard-of-care in patients with advanced disease is platinum-based doublet chemotherapy. Recent advances in the understanding of biological mechanisms of tumor growth have allowed for identificatio...

journal_title：Anticancer research

authors： Lauro S,Onesti CE,Righini R,Marchetti P

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The BCL2 proto-oncogene in non-Hodgkin's lymphoma is a dominant inhibitor of apoptosis. The goal of this work was to develop a (177)Lu-labeled anti-BCL2-peptide nucleic acid (PNA) conjugate designed for dual modality NHL therapy, i.e., simultaneous down-regulation of BCL2-mediated resistance to apoptosis and...

journal_title：Anticancer research

authors： Balkin ER,Jia F,Miller WH,Lewis MR

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND/AIM:The associations between emotional personality, proximity and authenticity in patient-physician communication during breast cancer (BC) consultations are rarely considered together in a prospective study. We, therefore, investigated emotional personality/proximity versus authenticity in patient-physician...

journal_title：Anticancer research

authors： Eskelinen M,Korhonen R,Selander T,Ollonen P

更新日期：2015-03-01 00:00:00

abstract：:Intrinsic or acquired resistance of pancreatic cancer to gemcitabine (2'-deoxy-2'-difluorodeoxycytidine) is an important factor in the failure of gemcitabine treatment. Proteomic analysis of gemcitabine-sensitive KLM1 pancreatic cancer cells and -resistant KLM1-R cells identified heat-shock protein-27(HSP27) as a biom...

journal_title：Anticancer research

authors： Kuramitsu Y,Suenaga S,Wang Y,Tokuda K,Kitagawa T,Tanaka T,Akada J,Maehara S,Maehara Y,Nakamura K

更新日期：2013-08-01 00:00:00