Abstract：
:The purpose of this study was to investigate the nature of the action of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) as the modulator of gene expression. Practically, both the acceleration of daily liquid consumption following salt-hydrocortisone conditioning (sea water adaptation phenomenon) and the suppressive effect of MNNG on that gene expression were comparatively investigated among Wistar rats of both sexes, Buffalo rats of both sexes and Swiss/ICR mice of both sexes. Results obtained are as follows: 1) the responsiveness to the salt-hydrocortisone conditioning, as assessed in terms of weight-adjusted liquid consumption, decreased in the order of female Swiss mice greater than male Swiss mice greater than Buffalo rats of both sexes greater than female Wistar rats greater than male Wistar rats, a finding which indicates that an inverse relationship exists between the expression of the sea water adaptation gene and that of putative stomach proto-oncogene. 2) Additional MNNG conditioning (provision of MNNG drink) eradicated the accelerating effect of the salt-hydrocortisone conditioning on the water turnover of a rodent. 3) Evidence was presented to indicate that MNNG acted as an antiandrogen in expressing the above effect. In conclusion, our findings are taken as evidence to support the proposition that the sea water adaptation gene and the stomach proto-oncogene compete with each other in the possession of one common MNNG-sensitive (and/or steroid-sensitive) enhancer gene in their gene expressions.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kodama M,Inoue F,Kodama T,Kodama Msubject
Has Abstractpub_date
1992-03-01 00:00:00pages
433-9issue
2eissn
0250-7005issn
1791-7530journal_volume
12pub_type
杂志文章abstract：:Chloroethyl-nitrosourea is a potent chemotherapeutic agent for brain tumors. However, acquired resistance to this drug has become a serious problem for the treatment of patients. Previously, we established an animal model resistant to nitrosourea (Anticancer Res 19: 5313-5318, 1999). In this study, we evaluate the eff...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Several attempts have been made to determine whether interphase fluorescence in situ hybridization (I-FISH) on bone marrow or peripheral blood specimens is a good alternative to conventional cytogenetics (CC) in calculating the residual proportion of Philadelphia (Ph) chromosome-positive cells during treatme...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:We examined 11 patients (9 male and 2 female, age 41 +/- 13) presenting astrocytomas of different malignancy grade (WHO) with single voxel (PRESS) and double voxel (STABLE) spectroscopy techniques. The content of choline in the tumors was determined as a function of their grade of malignity and a significant correlati...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:In the colon of F344 rats treated with 2 x 15 mg/kg body weight of azoxymethane (AOM), the density (number of lesions/cm2/rat) of flat aberrant crypt foci (ACF) was 13-fold higher (p < 0.05) in the surface area of mucosa immediately adjacent to lymphoid follicles compared with the density of these lesions in the rest ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:The emergence of molecular and cytogenetic correlates has opened exciting avenues to a better understanding of acute lymphocytic leukemia (ALL) and in turn has sharpened the clinician's ability for classification and treatment. While the pathophysiology and etiology of ALL remains vague, the clinical significance of t...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1990-03-01 00:00:00
abstract：:The MIB1 monoclonal antibody which is used as a marker of cell proliferation was studied by immunohistochemistry on formalin-fixed and paraffin embedded biopsy specimens of lymph nodes in 40 high- and 46 lowgrade cases of non-Hodgkin's lymphomas (NHL) classified according to the Kiel classification. All cases were fou...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:One hundred and eighty-seven patients with a transitional cell bladder cancer were followed by retrospectively for a mean of 9.5 years. Clinical stage (p less than 0.0001), histological grade (p less than 0.0001), papillary (p less than 0.0001), SPF (p less than 0.0001), M/V index (p less than 0.0001), MAI (p less tha...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:We have recently demonstrated that Thymax, a gross thymic extract, induces an apoptotic effect against human breast cancer cells. In this study, the ability of Thymax to activate human dendritic cells (DCs) and the DC-directed T-cell response was examined in an in vitro culture model of peripheral blood mono...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:The effects of dehydroepiandrosterone (DHEA) and 5-en-androstene-3 beta, 17 beta-diol (ADIOL) on the proliferation of MCF-7 cells were studied both in steroid - free and estradiol (E2) supplemented media. Growth was evaluated by counting the cells after six days of culture. The results show that DHEA 500 nM and ADIOL ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND/AIM:Pelvic exenteration is a radical procedure for certain advanced or recurrent gynaecological cancers, performed with curative or palliative intent. Its validity has evolved as operative mortality and morbidity have improved. This surgery was evaluated to determine the validity of these claims. PATIENTS A...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13759
更新日期：2019-10-01 00:00:00
abstract：:Tumor growth delay (TGD) is a widely accepted method for in situ assessment of tumor treatment modalities. However, it has some drawbacks: (1) dependency on arbitrary endpoints and, even more serious, (2) lack of alterations of the tumor-growth pattern after treatment. In the present study a generalization of TGD is p...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:The polysaccharide produced by the red microalga Porphyridium sp. was highly inhibitory for cell transformation of mouse fibroblast cells by an MSV-124 virus stock. This inhibition was most effective if the polysaccharide was added 2 h before or at the time of infection. The finding that the inhibition of cell transfo...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Matrix metalloproteinase-7 (MMP-7), MMP-9, MMP-13, and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are considered to have important roles in the invasiveness and outcomes of colorectal cancer (CRC). This study examined the clinicopathological significance of the relative expression of these genes in patien...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND/AIM:There is no definite consensus regarding management of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). This study aimed to compare clinical outcomes according to initial treatment modality for treatment of naïve HCC combined with subsegmental (Vp1)/ segmental (Vp2) PVTT with live...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12808
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:The aim of the study was to document the delay in diagnosis of Hodgkin's disease (HD) and clarify the impact on clinical stage and survival in our region. MATERIAL AND METHODS:A retrospective study of the records of 50 patients treated for primary HD in northern-Norway in the time period 1985 - 1993 was per...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Clonal subpopulations of neoplastic cells were derived, in soft agar, from the spontaneously metastazing variant (MV522) of a human lung carcinoma cell line. The ability of these clones to spontaneously metastasize from subcutaneous sites in athymic mice was then tested. A variation in metastatic ability was expected ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:The effects of two gallium (Ga) compounds, Ga chloride (GaCl3) and tris(8-quinolinolato)Ga (III) on the viability of A549 human malignant lung adenocarcinoma cells were investigated. The results demonstrated that both drugs reduced the viability of A549 cells but to different extents. The inhibitory effects of tris(8-...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:A gastrostomy feeding tube is one method for long-term feeding support in patients undergoing radio(chemo)therapy for head and neck cancer (HNC). The aim of this study was to analyze the safety of prophylactic gastrostomy tube placement and usage in HNSCC patients. PATIENTS AND METHODS:HNC patients undergoi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14059
更新日期：2020-02-01 00:00:00
abstract：:Chloroethylnitrosourea (CENU) chemotherapy is used for the treatment of melanoma tumors. The main mechanism of action of this anticancer agent is via DNA damage. We recently showed in murine experiments using a parental double B16 melanoma tumor model that, after treatment of primary tumors with cystemustine (CENU age...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to assess the relationship between p53 status and the clinical outcome of patients with advanced ovarian cancer treated with a paclitaxel-based regimen. PATIENTS AND METHODS:The investigation was conducted on 38 patients with FIGO stage III-IV ovarian cancer from whom tumor tissue ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:For the selection of patients responding well to lentinan, we performed two immunological analysis of patients. Flow cytometric analysis was obtained from peripheral blood lymphocytes; the patients who had greater than 2.5 ratio of [CD11(-) CD8(+)/CD11(+) CD8(+) after treatment]/[CD11(-) CD8(+)/CD11(+) CD8(+) before t...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Docetaxel is a very active drug against breast cancer, but at the standard dose causes severe myelosuppression. In order to reduce the toxicity while maintaining the activity, weekly docetaxel administration was tested. PATIENTS AND METHODS:We enrolled 30 patients with metastatic breast cancer, who had been...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Lipomas are the most common benign tumors of the mesenchyme; they are composed of mature lipocytes. Benign fatty tumours can arise in any location in which fat is present. Most patients affected by such tumours are in their fifth or sixth decade of life. Only rarely are children affected. Lipomas may be single or mult...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND/AIM:Despite an expected prognostic disadvantage for upper tract versus lower tract metastatic urothelial carcinomas (UTUC/LTUC), only few studies have been conducted to elucidate potential differences in chemotherapy treatment. PATIENTS AND METHODS:A post-hoc subgroup analysis of a non-interventional study ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12098
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND/AIM:This study aimed to investigate the effect of a new 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) ciprofloxacin-derivative on the proliferation and migration abilities of HeLa cells. MATERIALS AND METHODS:Cell viability and morphological alterations were examined. Changes in migration were detect...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14505
更新日期：2020-09-01 00:00:00
abstract：:We studied a combined utilization of serum tumour markers and proton nuclear magnetic resonance 1H NMR spectroscopy of plasma in the detection of pancreatic cancer. Serum concentrations of carcinoembryonic antigen (CEA), carboanhydrate antigens CA 50 and CA 242, and 1H NMR spectra of plasma were determined in a series...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:We have recently found that sodium fluoride (NaF) induced apoptotic cell death in tumor cell lines. We investigated here whether 6 popular antitumor compounds modify the cytotoxic activity of NaF against human squamous cell carcinoma (HSC-2) and human promyelocytic leukemia (HL-60) cell lines. Cytotoxic concentrations...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Mifepristone has been demonstrated to improve longevity and quality of life in mice with spontaneous murine cancer without progesterone receptors and in human colon cancer. The present study evaluated the palliative effect of mifepristone in a variety of different types of human cancer. PATIENTS AND METHODS...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-02-01 00:00:00
abstract：:As with SV40-transformed BHK cells (1), pretreatment of BHK cells with 1-beta-D-arabinofuranosylcytosine (araC) very markedly enhanced the resistance frequency to N-phosphonoacetyl-L-aspartate (PALA) but only modestly increased the resistance frequency to vincristine (VCR). AraC pretreatment of cells that already had ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Metastatic cancer is the most common malignant disease of the skeletal system. Traditionally, conventional fractionated external beam radiotherapy has been the treatment of choice. Recently, minimally invasive surgical techniques (MISS) have been added to the therapeutic armamentarium. The purpose of our stu...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
