Pelvic Exenteration as Potential Cure and Symptom Relief in Advanced and Recurrent Gynaecological Cancer.

abstract：BACKGROUND/AIM:To clarify whether renal dysfunction affects the incidence of adverse events associated with oxaliplatin, the present study was designed to investigate the relationship between creatinine clearance (Ccr) and the incidence of oxaliplatin-related adverse events. PATIENTS AND METHODS:A total of 287 CRC pat...

journal_title：Anticancer research

authors： Watanabe D,Fujii H,Yamada Y,Iihara H,Ishihara T,Matsuhashi N,Takahashi T,Yoshida K,Suzuki A

更新日期：2020-01-01 00:00:00

abstract：AIM:To assess outcomes in patients treated with first-line bevacizumab-containing therapy for human epidermal growth factor receptor (HER)2-negative metastatic breast cancer (mBC) at a single centre with a homogenous standard-of-care. PATIENTS AND METHODS:Information on patient and disease characteristics, efficacy, a...

journal_title：Anticancer research

authors： Dieras V,Pop S,Berger F,Dujaric ME,Beuzeboc P,Escalup L,Bidard FC,Cottu PH,LE Tourneau C,Piperno-Neumann S,Laurence V,Robain M,Asselain B,Pierga JY

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:HER2-positive breast cancers eventually relapse in about one third of patients. Is anti-HER2-directed therapy with Herceptin® (trastuzumab) effective in re-treatment? Between 2008 and 2018, 216 patients with recurrent HER2-positive breast cancer (BC) were re-treated with Herceptin (HER) during first-line...

journal_title：Anticancer research

authors： Hanker LC,FÖrster F,SchrÖder J,Grafe A,Hitschold T,Hesse T,Lattrich CR,Rody A

更新日期：2020-07-01 00:00:00

abstract：AIM:The aim of this study was to investigate if Linomide affects growth and spread of a rat liver tumour when given alone and in combination with interstitial laser thermotherapy (ILT). MATERIALS AND METHODS:Experiments were performed in Wistar rats using a dimethyl-hydrazine-induced adenocarcinoma implanted into the ...

journal_title：Anticancer research

authors： Ivarsson K,Sturesson C,Stenram U,Tranberg KG

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND/AIM:Secretory phospholipase-A2 (sPLA2) mediates growth and proliferation of human esophageal adenocarcinoma cells (HEAC). Two major molecular pathways of cancer growth regulation include extracellular signal-regulated kinase 1/2 (ERK 1/2) and protein kinase-B (AKT). Phospholipase enzymes have been demonstrat...

journal_title：Anticancer research

authors： Sadaria MR,Yu JA,Meng X,Fullerton DA,Reece TB,Weyant MJ

更新日期：2013-04-01 00:00:00

abstract：:During follow-up examinations for breast cancer the serum tumor marker CA 125 was measured routinely in the Universitätsfrauenklinik Erlangen. We found elevated CA 125 levels in 18 of 510 clinical asymptomatic patients. These patients were followed closely. A second malignant neoplasm was found in six of these patient...

journal_title：Anticancer research

authors： Böhmer C,Jäger W,Lang N

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Cyclooxygenases (COXs) and prostanoids play pivotal roles in colon carcinogenesis. This study was designed to determine the chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in male F344...

journal_title：Anticancer research

authors： Kawamori T,Uchiya N,Kitamura T,Ohuchida S,Yamamoto H,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2001-11-01 00:00:00

abstract：:Studies on taurine transport in MDR (multidrug resistant) and non-MDR KB cancer cells show that both cell types contain Na(+)- and Cl(-)-dependent high-affinity and low-affinity transport systems selective for beta-amino acids and a taurine diffusion component. Good buffers, such as HEPES or MOPS, interfered with taur...

journal_title：Anticancer research

authors： Wersinger C,Rebel G,Lelong-Rebel IH

更新日期：2001-09-01 00:00:00

abstract：:Ten patients with neuroblastoma were treated with a standard pulsed administration schedule of cis-platinum and etoposide (VP16-213). Two patients are experiencing good partial responses lasting over 8 months. One other patient had a partial response. Toxicity was mild and limited to high frequency hearing loss, tempo...

journal_title：Anticancer research

authors： Helson L

更新日期：1986-11-01 00:00:00

abstract：:We herein report a case of locally advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer that achieved a pathological complete response (pCR) with pertuzumab, trastuzumab and docetaxel therapy. A 70-year-old female presented with an elastic hard mass, 5.0 cm in diameter with broad redness and...

journal_title：Anticancer research

authors： Inoue Y,Yamashita N,Tokunaga E,Tanaka K,Ueo H,Saeki H,Oki E,Yamamoto H,Maehara Y

更新日期：2017-04-01 00:00:00

abstract：:Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...

journal_title：Anticancer research

authors： Khan MZ,Spandidos DA,Kerr DJ,McNicol AM,Lang JC,De Ridder L,Freshney RI

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial. PATIENTS AND METHODS:We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with ...

journal_title：Anticancer research

authors： Yang WC,Chen CH,Tang JY,Wu CF,Liu YC,Sun Y,Lin SF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND/AIM:Multidrug resistance (MDR) is often associated with overexpression of P-glycoprotein (ABCB1) in cancer cells. Apatinib is a novel Vascular endothelial growth factor receptor-TKI (VEGFR-TKI) which inhibits the function of ABCB1 in certain cancers. This study aimed to investigate the effect of apatinib on ...

journal_title：Anticancer research

authors： Zhang Q,Song Y,Cheng X,Xu Z,Matthew OA,Wang J,Sun Z,Zhang X

更新日期：2019-10-01 00:00:00

abstract：UNLABELLED:The present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of São Paulo. Interleukin-6 polymorphism was...

journal_title：Anticancer research

authors： Porto CR,De Oliveira Kleine JP,Longatto Filho A,Da Silva ID

更新日期：2014-07-01 00:00:00

abstract：:The antitumor effects of "half-mustard type" phenothiazines were studied on 57 different tumor cell lines, including leukemias, non-small lung cancer, colon, central nervous system, ovarian, renal, breast, and prostate cancer, as well as melanoma cell cultures. Alkyl-urea derivatives of phenothiazines displayed in vit...

journal_title：Anticancer research

authors： Wuonola MA,Palfreyman MG,Motohashi N,Kawase M,Gabay S,Nacsa J,Molnár J

更新日期：1997-09-01 00:00:00

abstract：:Several lines of evidence have postulated that reduction in the activity of lipoprotein lipase (LPL) is involved in cachexia induction in cancer patients. Recently we have demonstrated that murine melanoma B16 has the ability to reduce the LPL activity and thereby induce cachexia symptoms in mice following intraperito...

journal_title：Anticancer research

authors： Tsujimoto S,Kawamura I,Inami M,Lacey E,Nishigaki F,Naoe Y,Manda T,Goto T

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the study was to evaluate the necessity of gastrectomy including endoscopic submucosal dissection (ESD) scar with margin-negative early gastric cancer (EGC). PATIENTS AND METHODS:We analyzed 83 patients with EGC who received additional gastrectomy after non-curative ESD and evaluated the risk...

journal_title：Anticancer research

authors： Ishida R,Kanaji S,Maehara R,Hasegawa H,Yamamoto M,Matsuda Y,Yamashita K,Matsuda T,Oshikiri T,Sumi Y,Nakamura T,Suzuki S,Kakeji Y

更新日期：2018-09-01 00:00:00

abstract：AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

journal_title：Anticancer research

authors： Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

更新日期：2011-07-01 00:00:00

abstract：:The need for dependable prognostic markers in colorectal cancer, both in the advanced as well the as adjuvant setting, is greater than ever. The introduction of new chemotherapeutic agents in the clinic, with different mechanisms of action as well as different side-effect profiles, has made this even more important. A...

journal_title：Anticancer research

authors： Papamichael D

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Farnesyltransferase inhibitor R115777 (Tipifamib, Zarnestra) is active in breast cancer, but its efficacy in drug combinations has not been extensively investigated. MATERIALS AND METHODS:The activity of R115777 and paclitaxel, alone and in combination, was studied in the human breast cancer cell lines, BT-...

journal_title：Anticancer research

authors： Izbicka E,Campos D,Carrizales G,Patnaik A

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND/AIM:Recent studies implied a significant role of hypoxia-inducible factor-1α (HIF1α) in cell transformation. This study aimed to assess the effects of HIF1α on the epithelial-to-mesenchymal transition (EMT) and tumorigenesis of lung adenocarcinoma cells. MATERIALS AND METHODS:Invasion, migration and colony ...

journal_title：Anticancer research

authors： Liu KH,Tsai YT,Chin SY,Lee WR,Chen YC,Shen SC

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS:Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180....

journal_title：Anticancer research

authors： Glei M,Fischer S,Lamberty J,Ludwig D,Lorkowski S,Schlörmann W

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：:The expression of a cell surface-associated sialoglycoprotein (LEA.135), which has been shown to be significantly associated with decreased incidence of recurrence and increased overall survival of patients with primary invasive breast carcinoma, was evaluated in a retrospective study to identify subsets of patients w...

journal_title：Anticancer research

authors： Baltayan A,Naritoku WY,Chaiwun B,Tsao-Wei DD,Groshen S,Hern RA,Gusterson BA,Taylor CR,Imam SA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND/AIM:Activation of the c-JUN N-terminal kinase (JNK) signaling pathway has been associated with poor survival of ovarian cancer patients, but the role(s) and significance of JNK signaling in ovarian cancer cells remain poorly understood. In the present study, we aimed to investigate the role of JNK specifical...

journal_title：Anticancer research

authors： Seino M,Okada M,Shibuya K,Seino S,Suzuki S,Ohta T,Kurachi H,Kitanaka C

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIM:Signaling regulation of myeloid zinc finger 1 (MZF1) has been implicated in the progression of many human malignancies; however, the mechanistic action of MZF1 in triple-negative breast cancer (TNBC) progression remains elusive. In this study, the aim was to investigate the molecular mechanisms of MZF1 a...

journal_title：Anticancer research

authors： Yue CH,Liu JY,Chi CS,Hu CW,Tan KT,Huang FM,Pan YR,Lin KI,Lee CJ

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:It has recently been reported that sulindac has an apoptotic effect on KYN-2 cells, an undifferentiated hepatoma cell line. The present work investigates whether sulindac also has an apoptotic effect on well-differentiated hepatoma cells and what its potential mechanism might be. MATERIALS AND METHODS:Hep G...

journal_title：Anticancer research

authors： Liu JJ,Wang JY,Hertervig E,Nilsson A,Duan RD

更新日期：2002-01-01 00:00:00

abstract：AIM:To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). PATIENTS AND METHODS:We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as first-line chemotherapy whenever ...

journal_title：Anticancer research

authors： Fukuchi M,Ishibashi K,Tajima Y,Okada N,Yokoyama M,Chika N,Hatano S,Matsuzawa T,Kumamoto K,Kumagai Y,Baba H,Mochiki E,Ishida H

更新日期：2013-10-01 00:00:00

abstract：:The local growth and metastatic potential of colorectal cancer is the outcome of a dynamic balance between cancer cells and the immune system, at both a local and systemic level, summarized as the "seed and soil" hypothesis. Until recently, the staging and treatment approaches for colorectal cancer appeared to be orie...

journal_title：Anticancer research

authors： Seretis F,Seretis C,Youssef H,Chapman M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Previously, the antitumour activity of some flavone-8-acetic acid (FAA) derivatives substituted with an acid function in position 2 of the benzene ring was evaluated. The most active compound resulted the one bearing a fluorine atom in position 7 of the flavone nucleus. In this paper, we evaluated new mono- ...

journal_title：Anticancer research

authors： Carrara M,Zampiron A,Barbera M,Caputo A,Bisi A,Gobbi S,Belluti F,Piazzi L,Rampa A,Valenti P

更新日期：2005-03-01 00:00:00