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Vinflunine in the Treatment of Upper Tract Urothelial Carcinoma - Subgroup Analysis of an Observational Study.

Abstract：

BACKGROUND/AIM:Despite an expected prognostic disadvantage for upper tract versus lower tract metastatic urothelial carcinomas (UTUC/LTUC), only few studies have been conducted to elucidate potential differences in chemotherapy treatment. PATIENTS AND METHODS:A post-hoc subgroup analysis of a non-interventional study investigating vinflunine after failure of a platinum-based chemotherapy in metastatic/locally advanced UC patients was performed. RESULTS:A total of 18 and 59 out of 77 patients had UTUC and LTUC, respectively. The effectiveness of vinflunine treatment was comparable with an overall response rate of 22.2% and 23.7% respectively and a median progression-free survival of 2.76 months in both groups. Median overall survival was 5.0 months in UTUC compared to 8.2 months in the LTUC group (p=0.478). The safety profile was in accordance with previous vinflunine experiences, with a comparable frequency of adverse events in both groups. CONCLUSION:Vinflunine can be applied in the 2nd line for UC regardless of the primary tumor localization.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Heers H,DE Geeter P,Goebell PJ,Matz U,DE Schultz W,Edlich B,Retz M,Hegele A

doi

10.21873/anticanres.12098

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

6437-6442

issue

11

eissn

0250-7005

issn

1791-7530

pii

37/11/6437

journal_volume

37

pub_type

杂志文章

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