Interphase FISH for follow-up of Philadelphia chromosome-positive chronic myeloid leukemia treatment.

abstract：:In tumor cells, doxorubicin (DOX) is excreted by P-glycoprotein (P-gp) and the multidrug resistance-associated protein (mrp). Both transporters might also be involved in cellular regulatory volume decrease (RVD). To study the hepatobiliary excretion of DOX during RVD, isolated livers of Wistar and multidrug resistance...

journal_title：Anticancer research

authors： Gaugg M,Haslmayer P,Jäger W,Thalhammer T

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Platinum-based chemotherapy represents the standard of care for advanced non-small cell lung cancer (NSCLC) while non-platinum-based regimens are frequently administered in patients with relapse. A retrospective analysis of the sequence administration of these regimens in the first- and second-line setting w...

journal_title：Anticancer research

authors： Kotsakis A,Hatzidaki D,Vamvakas L,Vardakis N,Kalykaki A,Bozionelou V,Androulakis N,Kalbakis K,Saridaki Z,Georgoulias V,Agelaki S

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether surgical margin (SM) status would affect the biochemical recurrence (BCR) after robot-associated RP (RARP). PATIENTS AND METHODS:We evaluated BCR after RARP and the association between pre- and postoperative predictive factors and BCR. RESULTS:Positive SM (PSM) was observed in 97...

journal_title：Anticancer research

authors： Kano H,Kadono Y,Kadomoto S,Iwamoto H,Yaegashi H,Iijima M,Kawaguchi S,Nohara T,Shigehara K,Izumi K,Ikeda H,Mizokami A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Prediction of biological behavior is crucial for selection of new therapeutic modalities in GIST. Here, we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS:Fifty-five Brazilian patients with completely resected GIST were ex...

journal_title：Anticancer research

authors： Braggio E,Braggio Dde A,Small IA,Lopes LF,Valadão M,Gouveia ME,Moreira Ados S,Linhares E,Romano S,Bacchi CE,Renault IZ,Guimarães DP,Ferreira CG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral b...

journal_title：Anticancer research

authors： Ishizuka Y,Horimoto Y,Nakamura M,Arakawa A,Fujita T,Iijima K,Saito M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The rearrangement of actin cytoskeleton is being increasingly considered a marker of cancer cell activity, but the fine structure and remodeling of microfilaments within tumor tissue still remains unclear. MATERIALS AND METHODS:We used the recently introduced silicon-rhodamine (SiR)-actin dye to visualize e...

journal_title：Anticancer research

authors： Klementieva NV,Snopova LB,Prodanets NN,Furman OE,Dudenkova VV,Zagaynova EV,Lukyanov KA,Mishin AS

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:In non-small cell lung cancer (NSCLC), pleural effusion is a frequently observed complication, and often provides a treatment difficulties. The aim of this study is to evaluate prognostic significance of pleural effusion in patients with NSCLC. MATERIALS AND METHODS:Seven hundred and eight untreated patient...

journal_title：Anticancer research

authors： Naito T,Satoh H,Ishikawa H,Yamashita YT,Kamma H,Takahashi H,Ohtsuka M,Hasegawa S

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:One of the major changes in the new TNM classification (5th edition, 1997) for gastric cancer was made in the classification of N category: the 5th edition employs the number of involved nodes and a minimum of 15 examined nodes is required for N0 classification. The validity of the new TNM classification was...

journal_title：Anticancer research

authors： Nio Y,Yamasawa K,Yamaguchi K,Itakura M,Omori H,Koike M,Kitamura Y,Tsuji M,Endo S,Ogo Y,Yano S,Sumi S

更新日期：2003-01-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) ranks as a leading cause of cancer-related death globally. Brain metastases are a frequent complication of NSCLC, with 25-40% of patients developing brain metastases during the course of the disease, often within the first 2 years after diagnosis of the primary tumor. Improvements in...

journal_title：Anticancer research

authors： Dempke WC,Edvardsen K,Lu S,Reinmuth N,Reck M,Inoue A

更新日期：2015-11-01 00:00:00

abstract：:The effects of two gallium (Ga) compounds, Ga chloride (GaCl3) and tris(8-quinolinolato)Ga (III) on the viability of A549 human malignant lung adenocarcinoma cells were investigated. The results demonstrated that both drugs reduced the viability of A549 cells but to different extents. The inhibitory effects of tris(8-...

journal_title：Anticancer research

authors： Collery P,Lechenault F,Cazabat A,Juvin E,Khassanova L,Evangelou A,Keppler B

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND/AIM:Silencing mediator of retinoid and thyroid receptors (SMRT) is a nuclear corepressor in thyroid and estrogen hormones pathways. The aim was to evaluate SMRT expression in relation to thyroid hormone levels and prognostic markers in breast cancer (BC). PATIENTS AND METHODS:Serum and tumor tissues were ob...

journal_title：Anticancer research

authors： Nisman B,Allweis TM,Carmon E,Kadouri L,Maly B,Maimon O,Meierovich A,Peretz T

更新日期：2020-11-01 00:00:00

abstract：:L-Histidinol, a structural analogue of the essential amino acid L-histidine, enhances the toxicity of a variety of anticancer drugs for many tumor cells of animal origin. In this study, the effects of L-histidinol on the proliferation and anticancer drug susceptibility of two human tumor cell lines of lymphoid origin,...

journal_title：Anticancer research

authors： Warrington RC,Cheng I,Zhang L,Fang WD

更新日期：1993-11-01 00:00:00

abstract：:We have previously shown that transfection of NIH 3T3 cells with the T24 H-ras oncogene converts the cells to a tumorigenic and metastatic phenotype, in proportion to levels of ras expression. We hypothesize that ras-induced increases in malignancy occur via altered expression of various genes. We have identified OPN ...

journal_title：Anticancer research

authors： Chambers AF,Behrend EI,Wilson SM,Denhardt DT

更新日期：1992-01-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (CDDP) is the most active anticancer agent. It has been reported that intracellular accumulation of CDDP is an important step as a determinant for resistance to CDDP, which may be modulated by Na+, K(+)-ATPase activity. In this study, the significance of membrane Na+, K(+)-ATPase activ...

journal_title：Anticancer research

authors： Bando T,Fujimura M,Kasahara K,Matsuda T

更新日期：1998-03-01 00:00:00

abstract：:The incidence of female breast cancer was studied as a function of age in 71 different populations throughout the world. Incidence data was normalized for differences in frequency of occurrence. Median normalized incidence increased exponentially from age 20 to 45. After age 45 the rate of incidence decreased, and we ...

journal_title：Anticancer research

authors： Dix D,Cohen P

更新日期：1982-01-01 00:00:00

abstract：:Considerable progress has recently been achieved in understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1), and in improving the efficacy of antiretroviral therapies for the treatment of patients with the acquired immunodeficiency syndrome (AIDS). The pharmacological properties of new drugs are ...

journal_title：Anticancer research

authors： Romano G,Massi D,Giordano A

更新日期：1998-07-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7), MMP-9, MMP-13, and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are considered to have important roles in the invasiveness and outcomes of colorectal cancer (CRC). This study examined the clinicopathological significance of the relative expression of these genes in patien...

journal_title：Anticancer research

authors： Yamada T,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Inagaki D,Yamamoto N,Sato T,Fujii S,Numata K,Kunisaki C,Shiozawa M,Morinaga S,Akaike M,Rino Y,Tanaka K,Masuda M,Imada T

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Bacillus Calmette-Guérin (BCG) vaccine is a non-specific immunostimulant which has been used clinically in the treatment of melanoma. In this communication, the antimelanoma activity of BCG was related to its fibronectin-binding properties and mimicked using gelatin nanoparticles. MATERIALS AND METHODS:The ...

journal_title：Anticancer research

authors： Farrugia CA,Groves MJ

更新日期：1999-03-01 00:00:00

abstract：:We report a 64-year-old woman with a 9-cm liver tumor in the left lateral section. The patient had neither hepatitis B or C virus infection, nor cirrhosis. Carbohydrate antigen 19-9 (CA 19-9) level was 1,889 U/ml. We also suspected bulky hilar lymph node metastasis, and a left lateral sectionectomy without lymph node ...

journal_title：Anticancer research

authors： Miyata T,Beppu T,Imamura YU,Hayashi H,Imai K,Chikamoto A,Yamashita YI,Fukubayashi K,Ishiko T,Baba H

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND/AIM:Glioblastoma multiforme (GBM) is a malignant primary brain tumor with high rates of recurrence. This study aimed to investigate the effect of repurposed drug combinations on GBM. MATERIALS AND METHODS:Viability of U87 MG and 11ST patient-derived GMB cell lines, after valproic acid, tranylcypromine or ri...

journal_title：Anticancer research

authors： Sachkova A,Sperling S,Mielke D,Schatlo B,Rohde V,Ninkovic M

更新日期：2019-01-01 00:00:00

abstract：:Using a cultured human colon cancer cell line (Col 2), a structurally diverse group of chemopreventive agents was evaluated for their potential to induce apoptosis. As a result, 1,4-phenylenebis(methylene)selenocyanate (p-xylylselenocyanate; p-XSC) was found to be active in this process. p-XSC, a synthetic organoselen...

journal_title：Anticancer research

authors： Lee SK,Heo YH,Steele VE,Pezzuto JM

更新日期：2002-01-01 00:00:00

abstract：AIMS AND BACKGROUND:Radiation therapy holds a fundamental role in oncological emergencies such as superior vena cava syndrome, spinal cord compression and endocranial hypertension. The purpose of our study was, by comparing schedules of treatment, to confirm the efficacy of hypofractionated radiation therapy. METHODS:...

journal_title：Anticancer research

authors： Donato V,Bonfili P,Bulzonetti N,Santarelli M,Osti MF,Tombolini V,Banelli E,Enrici RM

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that doxorubicin (DXR) showed much higher cytotoxicity against human oral squamous cell carcinoma cell lines compared to normal human mesenchymal normal oral cells (gingival fibroblast, periodontal ligament fibroblast, pulp cell), yielding high tumor-specificity. However, we u...

journal_title：Anticancer research

authors： Sakagami H,Okudaira N,Masuda Y,Amano O,Yokose S,Kanda Y,Suguro M,Natori T,Oizumi H,Oizumi T

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:Amentoflavone has been shown to be effective against a variety of cancer cells, but its role in bladder cancer remains unclear. Thus, the aim of this study is to evaluate whether amentoflavone may induce toxicity effect of bladder cancer. MATERIALS AND METHODS:Herein, we evaluated amentoflavone effects ...

journal_title：Anticancer research

authors： Chiang CH,Yeh CY,Chung JG,Chiang IT,Hsu FT

更新日期：2019-07-01 00:00:00

abstract：:VP-16 and ICRF-193 are different types of antitumor topoisomerase II inhibitors, being cleavable and non-cleavable complex-stabilizing types, respectively. To examine the possibility of enhancing the efficacy of combination chemotherapy, we carried out simultaneous and sequencial treatment of cells with the two drugs....

journal_title：Anticancer research

authors： Ishida R,Iwai M,Hara A,Andoh T

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The differential diagnosis of well-differentiated tumors of follicular cell origin remains a most problematic task in thyroid pathology. Therefore, various diagnostic/prognostic thyroid markers are currently being studied. The aim of our study was to evaluate the proliferative MIB-1 and topoisomerase II-alph...

journal_title：Anticancer research

authors： Ludvíková M,Holubec L Jr,Ryska A,Topolcan O

更新日期：2005-05-01 00:00:00

abstract：AIM:To assess progression-free survival (PFS) and overall survival (OS) in patients with advanced epithelial ovarian cancer receiving the combination of cisplatin (75 mg/m(2) i.v.) and cyclophosphamide (700 mg/m(2) i.v.) (CP), or the combination of paclitaxel (175 mg/m2) followed by cisplatin (75 mg/m2) (TP). PATIENTS...

journal_title：Anticancer research

authors： Mouratidou D,Gennatas C,Michalaki V,Papadimitriou A,Andreadis CH,Sykiotis C,Tsavaris N

更新日期：2007-01-01 00:00:00

abstract：:Ten patients with advanced renal cell carcinoma were given combined chemoendocrine treatment with tegafur and tamoxifen. Patients were orally administered 800 mg/body tegafur and 20 mg/body tamoxifen daily. One patient was assessed as CR, three as PR, two as NC and four as PD. One out of two patients with estrogen rec...

journal_title：Anticancer research

authors： Wada T,Nishiyama K,Maeda M,Hara S,Tanaka N,Yasutomi M,Kurita T

更新日期：1995-07-01 00:00:00

abstract：:The metabolic transformations of labeled pyridoxine by hepatoma cells were studied. Buffalo rats were fed ad libitum a commercially prepared pyridoxine sufficient diet for 20 days at which time they were inoculated intramuscularly with hepatoma 7777 cells in both hind leg muscles. After tumor development, 50 microCi [...

journal_title：Anticancer research

authors： Tryfiates GP

更新日期：1983-01-01 00:00:00

abstract：:Exposure of human promyelocytic leukemic HL-60 cells to millimolar concentration of sodium ascorbate induced apoptotic cell death. The extent of apoptosis induction was a positive function of temperature at the time of exposure. The incorporation of [1-14C] ascorbic acid into the cytosolic fraction of HL-60 cells was ...

journal_title：Anticancer research

authors： Amano Y,Sakagami H,Tanaka T,Yamanaka Y,Nishimoto Y,Yamaguchi M,Takeda M

更新日期：1998-07-01 00:00:00