Abstract:
BACKGROUND:Platinum-based chemotherapy represents the standard of care for advanced non-small cell lung cancer (NSCLC) while non-platinum-based regimens are frequently administered in patients with relapse. A retrospective analysis of the sequence administration of these regimens in the first- and second-line setting was performed. PATIENTS AND METHODS:The records of patients enrolled in the Hellenic Oncology Research Groups's randomized advanced NSCLC trials from February 1997 to September 2006 were retrospectively reviewed. The efficacy of non-platinum-based chemotherapy administered as first- or second-line treatment (n=94, cohort A) was compared to that of non-platinum-based first-line followed by platinum-based second-line chemotherapy (n=267, cohort B), and the reverse sequence (n=123, cohort C). RESULTS:The objective response rate (ORR) to first-line chemotherapy was higher in cohort C compared to cohort A (45.5% vs. 25.5%, respectively, p=0.002) and cohort B (45.5% vs. 21.3%, p=0.0001). The ORR to second-line therapy was 17%, 13.1% (p=0.349) and 7.3% (p=0.027) in cohorts A, B and C, respectively. Time to progression and the overall survival were comparable among the three cohorts in both first- and second line therapy. CONCLUSION:Platinum-based first-line chemotherapy improved response rate compared to non-platinum-based regimens; however, the overall survival was comparable, irrespective of the sequence administration of these regimens is the first- and second-line setting.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kotsakis A,Hatzidaki D,Vamvakas L,Vardakis N,Kalykaki A,Bozionelou V,Androulakis N,Kalbakis K,Saridaki Z,Georgoulias V,Agelaki Ssubject
Has Abstractpub_date
2010-10-01 00:00:00pages
4335-42issue
10eissn
0250-7005issn
1791-7530pii
30/10/4335journal_volume
30pub_type
杂志文章abstract::The objective of the present study was to investigate the effect of dietary phytosterols on the growth and metastasis of the human breast cancer MDA-MB-231 cell line xenografted in SCID mice. Two groups of animals were fed AIN-93G diet supplemented with 0.2% cholic acid and 2% sterol (cholesterol or phytosterol mixtur...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Recent developments in detection of micrometastasis have revealed a considerable incidence of systemic disease in patients who would previously have been diagnosed as having solid tumours only. The purpose of this study was to investigate the prevalence and clinical significance of circulating carcinoma cell...
journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.11130
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND/AIM:Androgen-androgen receptor (AR) signal is known as a powerful driver of prostate cancer progression. We previously reported the limitation of prostate-specific antigen (PSA) at diagnosis as a prognostic biomarker of prostate cancer. Although serum total testosterone (TT) level has been reported as a prog...
journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.11908
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journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
doi:
更新日期:2010-02-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2015-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:
更新日期:2015-10-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Anticancer research
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更新日期:2012-01-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2013-12-01 00:00:00
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更新日期:2015-03-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2015-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2001-11-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:1995-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:Anticancer research
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更新日期:2000-09-01 00:00:00
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journal_title:Anticancer research
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