Whole-transcriptome analysis reveals established and novel associations with TMPRSS2:ERG fusion in prostate cancer.

abstract：:Alterations in the p53 gene are frequently observed in a wide variety of human cancers. To elucidate the role of p53 in tumorigenesis of the dog, we analyzed nine mammary tumor cell lines, and the primary or metastatic tumors used for their establishment, for the presence of genomic p53 abnormalities. Possible genomic...

journal_title：Anticancer research

authors： Van Leeuwen IS,Hellmèn E,Cornelisse CJ,Van den Burgh B,Rutteman GR

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:The prognosis for advanced gastric cancer with paraaortic lymph node (PALN) metastasis is very poor even after a curative resection. In the present study, induction chemotherapy followed by curative surgery was performed for advanced gastric cancer with PALN metastasis. PATIENTS AND METHODS:Twenty patients ...

journal_title：Anticancer research

authors： Fujiwara Y,Omori T,Demura K,Miyata H,Sugimura K,Ohue M,Kobayashi S,Takahashi H,Doki Y,Yano M

更新日期：2015-12-01 00:00:00

abstract：:Natural antibodies directed against CEA and a related antigen, NCA, have been demonstrated in all normal and pathological sera using an EIA, although they have never been detected by RIA. These antibodies are not anti-blood group antibodies, as their titer was decreased only slightly by absorption with blood group sub...

journal_title：Anticancer research

authors： Frénoy N,Schauffler J,Cahour A,Burtin P

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Antibodies against human epidermal growth factor receptor 2 (HER2) affect metastatic breast cancer cells and cardiac myocytes. Guidelines recommend evaluation of cardiac ejection fraction (EF) every 3 months despite little supporting evidence for this need. We assessed the impact of EF screening on clinical ...

journal_title：Anticancer research

authors： Mescher C,Ding C,Defor T,Konety S,Blaes A

更新日期：2017-07-01 00:00:00

abstract：:Oxazolinodoxorubicin, a doxorubicin analog with a modified daunosamine moiety was synthesized. The properties of this compound and the parent doxorubicin were compared. The cytotoxicity in vitro studies against several human tumor cell lines (PC-3, MCF-7, SW707, HL-60, RPMI 8226, ACHN) showed higher antiproliferative ...

journal_title：Anticancer research

authors： Lukawska M,Klopotowska D,Milczarek M,Wietrzyk J,Studzian K,Szmigiero L,Porebska A,Oszczapowicz I

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIM:Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. PATIENTS AND METHODS:The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of...

journal_title：Anticancer research

authors： Sumida T,Otawa N,Kamata YU,Yamada T,Uchida K,Nakano H,Hamakawa H,Yamamoto T,Ueyama Y,Mori Y

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:In the present study, we examined the relationships between microsatellite status and Ki-67 labeling index, a proliferative marker, in colorectal cancers in order to clarify the common biological profiles of familial and sporadic cases of MSI (microsatellite inability)-positive tumors. PATIENTS AND METHODS:...

journal_title：Anticancer research

authors： Takagi S,Kumagai S,Kinouchi Y,Hiwatashi N,Nagashima F,Takahashi S,Shimosegawa T

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:During the progression from low-grade dysplastic nodule (DN) to progressed hepatocellular carcinoma (HCC), intranodular portal tracts gradually disappear, while unpaired arteries develop increasingly. Contrast-enhanced ultrasound (CEUS) is highly accurate in depicting intranodular vascularity. This study eva...

journal_title：Anticancer research

authors： Giorgio A,Calisti G,di Sarno A,Farella N,de Stefano G,Scognamiglio U,Giorgio V

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Prolonged exposure to asbestos, a potent carcinogen, has been the generally accepted factor responsible for the development of human mesotheliomas. Recent reports documenting the detection of SV40 DNA in human mesotheliomas suggest the possibility that this known tumor virus may be an additional factor invol...

journal_title：Anticancer research

authors： Arrington AS,Lednicky JA,Butel JS

更新日期：2000-03-01 00:00:00

abstract：:A brief review summarizing the relationships that exist between the DEK protein and gene regulation, oncogenesis and AIDS. ...

journal_title：Anticancer research

authors： Sitwala KV,Mor-Vaknin N,Markovitz DM

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND/AIM:Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the progn...

journal_title：Anticancer research

authors： Hagio K,Furuya S,Nakamura J,Maruyama S,Shiraishi K,Shimizu H,Akaike H,Hosomura N,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Androgens are essential for the growth of most prostate cancers (PCa). As a result, androgen ablation is the mainstay of the treatment of PCa. Proteins of the polycomb and trithorax family are master epigenetic regulators of cell type specific gene expression including androgen receptor. MATERIALS AND M...

journal_title：Anticancer research

authors： Wang S,Tailor K,Kwabi-Addo B

更新日期：2020-05-01 00:00:00

abstract：:Calcitriol is a potent antiproliferative agent against various tumour cells in vitro. Here, the results of a study on vitamin D compounds (calcitriol's analogues PRI-1906 and PRI-2191) as potential agents in combined antitumour therapy in vitro are presented. Applying antiproliferative SRB and MTT assays, the growth i...

journal_title：Anticancer research

authors： Pelczynska M,Switalska M,Maciejewska M,Jaroszewicz I,Kutner A,Opolski A

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Genetic alterations occurring in lung cancer are the basis for defining molecular subtypes and essential for targeted therapies. Exhaled breath condensate (EBC) is a form of non-invasive sample that, amongst components, contains DNA from pulmonary tissue. Next-generation sequencing (NGS) was herein used to a...

journal_title：Anticancer research

authors： Youssef O,Knuuttila A,Piirilä P,Böhling T,Sarhadi V,Knuutila S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND/AIM:In pancreatic cancer, where the microenvironment is extremely hypoxic, analyzing signal transduction under hypoxia is thought to be significantly important. By investigating microarray analysis of pancreatic cancer cells cultured under both normoxia and hypoxia, we found that the expression of leukocyte ...

journal_title：Anticancer research

authors： Yamasaki A,Nakayama K,Imaizumi A,Kawamoto M,Fujimura A,Oyama Y,Nagai S,Yanai K,Onishi H

更新日期：2017-12-01 00:00:00

abstract：:A 56-year-old Caucasian smoker male patient underwent right orchiectomy and spermatic cord resection for intrascrotal transilluminating mass. Histology findings suggested diagnosis of metastasis from Renal Cell Carcinoma (RCC). After positive CT-scan for primary neoplasm, total left nephrectomy was accomplished. Patie...

journal_title：Anticancer research

authors： Lauro S,Lanzetta G,Bria E,Trasatti L,Costarelli L,Vecchione A

更新日期：1998-11-01 00:00:00

abstract：:The magnetic resonance (MR) findings in malignant melanoma of soft tissues, also called clear cell sarcoma of tendons and aponeuroses, have been described as a focal abnormality with a specific MR pattern of increased signal intensity (relative to normal muscle) on T1 weighted sequences and variably decreased signal i...

journal_title：Anticancer research

authors： Gandolfo N,Martinoli C,Cafiero F,Peressini A,Nicolò M,Dellachà A,Derchi LE

更新日期：2000-09-01 00:00:00

abstract：AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

journal_title：Anticancer research

authors： Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

更新日期：2011-07-01 00:00:00

abstract：:Recently we demonstrated that several flavonoids can inhibit the proliferation of certain human thyroid cancer cell lines. Among the flavonoids tested, apigenin and luteolin are the most effective inhibitors of these tumor cell lines. In the present study, we investigated the signal transduction mechanism associated w...

journal_title：Anticancer research

authors： Yin F,Giuliano AE,Van Herle AJ

更新日期：1999-09-01 00:00:00

abstract：:Human immortal cells maintain their telomeres either by telomerase or by alternative lengthening of telomeres (ALT) that is based on homologous telomeric recombination. Previous studies showed that the ALT mechanism is activated in non-ALT cells when heterochromatic features are reduced. In this study, we examined the...

journal_title：Anticancer research

authors： Jung AR,Yoo JE,Shim YH,Choi YN,Jeung HC,Chung HC,Rha SY,Oh BK

更新日期：2013-03-01 00:00:00

abstract：UNLABELLED:In non-small cell lung cancer (NSCLC), pleural effusion is a frequently observed complication, and often provides a treatment difficulties. The aim of this study is to evaluate prognostic significance of pleural effusion in patients with NSCLC. MATERIALS AND METHODS:Seven hundred and eight untreated patient...

journal_title：Anticancer research

authors： Naito T,Satoh H,Ishikawa H,Yamashita YT,Kamma H,Takahashi H,Ohtsuka M,Hasegawa S

更新日期：1997-11-01 00:00:00

abstract：UNLABELLED:The role of the insulin like growth factor (IGF) system in various human malignancies has been well established. The aim of this study was to determine the levels of mRNA expression of insulin-like growth factor-binding protein (IGFBP)-1, -3 and -7 genes in benign and malignant breast tissue and explore thei...

journal_title：Anticancer research

authors： Subramanian A,Sharma AK,Banerjee D,Jiang WG,Mokbel K

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:It has been demonstrated that 2-Methoxyestradiol (2-ME), one of the estrogen metabolites, induces apoptosis in many different tumor cell lines. In the present study, the effects of 2-ME on human cervical cancer HeLaS3 cells and on normal cervical epithelial cells were evaluated. MATERIALS AND METHODS:Acridi...

journal_title：Anticancer research

authors： Li L,Bu S,Bäckström T,Landström M,Ulmsten U,Fu X

更新日期：2004-03-01 00:00:00

abstract：:The incidence of breast cancer is increasing rapidly in Taiwan but is still low compared with western countries. The impact of body size factors in western countries inspired us to have a case-control study. A matched case-control study was done on 122 pairs of incident cases of female breast cancer and community cont...

journal_title：Anticancer research

authors： Chie WC,Chen CF,Lee WC,Chen CJ

更新日期：1996-09-01 00:00:00

abstract：:The relationship between antioxidant-enzyme defence responses and cellular growth suppression in human MCF-7 (breast) and SW480 (colon) cancer cells, exposed to CLA in culture was studied. MCF-7 and SW480 cells (1 x 10(6)/flask) were cultured in appropriate medium for 4, 8 and 12 days with varying levels of CLA (0-30 ...

journal_title：Anticancer research

authors： O'Shea M,Stanton C,Devery R

更新日期：1999-05-01 00:00:00

abstract：:The effect of conagenin (CNG) on intestinal toxicity induction by 5-fluorouracil (5-Fu) was investigated. In mice given sublethal doses of 5-Fu (50mg/kg, i.v.) for 5 consecutive days, a decrease in body weight and diarrhea accompanied with hemorrhaging of the duodenum, atrophy of cecum and reduced small intestine leng...

journal_title：Anticancer research

authors： Kawatsu M,Yamashita T,Ishizuka M,Takeuchi T

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Principal caregivers (PCs) of cancer patients experience high levels of stress that may significantly impact their quality of life (QoL). PCs' QoL during early phases of the disease (when patients were still on chemotherapy) were assessed. PATIENTS AND METHODS:The PCs of all patients meeting the inclusion c...

journal_title：Anticancer research

authors： Pellegrino R,Formica V,Portarena I,Mariotti S,Grenga I,Del Monte G,Roselli M

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND/AIM:Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells in...

journal_title：Anticancer research

authors： Juzeniene A,Bernoulli J,Suominen M,Halleen J,Larsen RH

更新日期：2018-04-01 00:00:00

abstract：:Smokeless tobacco consumption is causally associated with oral cavity cancers; however, extensive cytogenetic studies have not been done. In the present study, individuals consuming dry snuff or tobacco with lime have been studied for frequency of micronucleated cells (MNC) in exfoliated buccal mucosa and chromosome a...

journal_title：Anticancer research

authors： Trivedi AH,Dave BJ,Adhvaryu SG

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND/AIM:The main objective of the present study was to evaluate the significance of apoptosis in the Fletcher's risk classification for gastrointestinal stromal tumors (GISTs). MATERIALS AND METHODS:Apoptotic cells were identified by immunostaining for single-stranded DNA (ssDNA). We assigned each GIST to one o...

journal_title：Anticancer research

authors： Mochizuki K,Kondo T,Oishi N,Tahara I,Inoue T,Kasai K,Nakazawa T,Katoh R

更新日期：2018-05-01 00:00:00