Single-stranded DNA (ssDNA) Labeling Index Is Related to Risk Grade in Patients with Gastrointestinal Stromal Tumors.

abstract：:We examined the optimal timing for the enhancement of antitumor effects of CDDP analogues, cis- diammine-1,1- cyclobutane dicarboxylate platinum (II); CBDCA combined with hyperthermia against the CD-1 mice bearing Ehrlich ascites tumor (EAT) cells in vivo. The prolonged tumor doubling time was observed when two modali...

journal_title：Anticancer research

authors： Mizuuchi H,Yoshiga K,Sakurai K,Tsumura M,Takada K

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIM:Anthracyclines, such as doxorubicin, though widely used in anticancer therapy, they are associated with cardiotoxic side-effects. The aim of this trial was to investigate long-term follow-up cardiotoxicity findings in patients treated with doxorubicin and concomitant metoprolol or enalapril 10 years earl...

journal_title：Anticancer research

authors： Georgakopoulos P,Kyriakidis M,Perpinia A,Karavidas A,Zimeras S,Mamalis N,Kouvela M,Charpidou A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The cytosine deaminase/5-fluorocytosine (CD/5-FC), strategy for cancer gene therapy shows considerable promise in experimental models but, because CD is a cytosolic enzyme, intracellular production of 5-fluorouracil (5-FU) causes the demise of the transduced cells before cytotoxic concentrations of' 5-FU can...

journal_title：Anticancer research

authors： Rehemtulla A,Hamstra DA,Kievit E,Davis MA,Ng EY,Dornfeld K,Lawrence TS

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:We investigated the influence of age on short-term complications in women undergoing intraoperative radiotherapy (IORT) for early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed data of 188 women who underwent IORT during breast-conserving surgery (BCS). The study group consisted of 54 patie...

journal_title：Anticancer research

authors： Tuschy B,Berlit S,Romero S,Sperk E,Wenz F,Kehl S,Sütterlin M

更新日期：2013-09-01 00:00:00

abstract：UNLABELLED:Synthetic cannabinoid WIN55,212-2 (WIN) has shown a promise as an anticancer agent but causes psychoactive side-effects. In the present study, nano-micelles of styrene maleic acid (SMA)-conjugated WIN were synthesized to reduce side-effects and increase drug efficacy. SMA-WIN micelles were characterised and ...

journal_title：Anticancer research

authors： Xian S,Parayath NN,Nehoff H,Giles NM,Greish K

更新日期：2015-09-01 00:00:00

abstract：:Eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D(3)], an analog of calcitriol (1α,25-dihydroxyvitamin D(3)), possesses a hydroxypropoxy substituent at the 2β-position of calcitriol. Eldecalcitol has potent biological effects on bone disease such as osteoporosis. The marketing of eldecalcitol has very recen...

journal_title：Anticancer research

authors： Kubodera N,Hatakeyama S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The influence of age on the patterns and outcomes of external beam radiotherapy for clinically localized prostate cancer patients was examined. MATERIALS AND METHODS:The Japanese Patterns of Care Study surveys were used to compare the processes and outcomes of radical external beam radiotherapy in 140 elder...

journal_title：Anticancer research

authors： Ogawa K,Nakamura K,Onishi H,Koizumi M,Sasaki T,Araya M,Miyabe Y,Otani Y,Teshima T,Japanese Patterns of Care Study Working Subgroup of Prostate Cancer.

更新日期：2006-03-01 00:00:00

abstract：:Human vaginal malignant melanoma represents rare gynecological malignancies of poor prognosis. We have established a melanoma tumor line in nude mice, designated Mela-1, and have examined the histological and biological characteristics of this tumor. The Mela-1 tumor has preserved the histological, histochemical and b...

journal_title：Anticancer research

authors： Sawada M,Terada N,Nishizawa Y,Ito S,Wakamatsu K,Takemura K,Yamamoto T,Ozaki M,Sakamoto H,Tanizawa O

更新日期：1994-07-01 00:00:00

abstract：:The role of intensive pre- and postoperative chemotherapy in unresectable nonmetastatic neuroblastoma is still controversial. A preoperative regimen that included deferoxamine, cyclophosphamide, etoposide, carboplatin and thiotepa (D-CECaT) was evaluated in 10 children over one year of age at diagnosis, and this was f...

journal_title：Anticancer research

authors： Donfrancesco A,Deb G,Dominici C,De Sio L,Inserra A,Boglino C,Takahashi M,Uchino J,Helson L

更新日期：1995-09-01 00:00:00

abstract：:The influence of bovine serum albumin on estradiol-17 beta growth and responsiveness of human mammary cancer MCF-7 cells was studied and compared to that of dextran-coated charcoal-treated fetal calf serum and other bovine serum proteins. To reveal the protein factor role, a culture defined medium was used. It was com...

journal_title：Anticancer research

authors： Germain P,Harbrioux G

更新日期：1993-09-01 00:00:00

abstract：:Concomitant neoplasm and abdominal aortic aneurysm (AAA) is not a rare clinical association and can pose problems if antiblastic treatment is required. The literature shows lack of consensus owing to the fact that AAA can modify the liquid load and the hemodynamic setting so that chemotherapy toxicity profile becomes ...

journal_title：Anticancer research

authors： Lauro S,Lanzetta G,Bria E,Trasatti L,Gelibter A,Vecchione A

更新日期：1999-03-01 00:00:00

abstract：:Experiments were designed to compare the efficacy of recombinant IL-2 immunotherapy and IL-2 gene therapy of i.p. growing murine plasmacytoma X63-Ag8.653. The kinetics of peritoneal exudate mononuclear cells were monitored during the progression and gene therapy of the plasmacytoma, using cytofluorometric analysis and...

journal_title：Anticancer research

authors： Bubeník J,Zeuthen J,Bubeníková D,Símová J,Jandlová T

更新日期：1993-09-01 00:00:00

abstract：:The adenomatous polyposis coli (APC) gene was investigated in Swedish patients with familial adenomatous polyposis (FAP). A combination of analyses including single stranded conformation polymorphism (SSCP), heteroduplex (HD), protein truncation test (PTT) and direct sequencing was used to enable optimal mutation dete...

journal_title：Anticancer research

authors： Nordling M,Engwall Y,Wahlström J,Wiklund L,Eriksson MA,Gustavsson B,Fasth S,Larsson PA,Martinsson T

更新日期：1997-11-01 00:00:00

abstract：:Metastatic pancreatic malignant melanoma is considered to be a highly aggressive neoplasm, and only few metastasectomies for lesions originating from the skin or the ocular region have been reported. We report a case of resection of pancreatic metastasis of malignant melanoma originating from the nasal cavity. An isol...

journal_title：Anticancer research

authors： Sugimoto M,Gotohda N,Kato Y,Takahashi S,Kinoshita T,Shibasaki H,Kojima M,Ochiai A,Zenda S,Akimoto T,Konishi M

更新日期：2013-02-01 00:00:00

abstract：:We studied a combined utilization of serum tumour markers and proton nuclear magnetic resonance 1H NMR spectroscopy of plasma in the detection of pancreatic cancer. Serum concentrations of carcinoembryonic antigen (CEA), carboanhydrate antigens CA 50 and CA 242, and 1H NMR spectra of plasma were determined in a series...

journal_title：Anticancer research

authors： Pasanen PA,Kauppinen R,Eskelinen M,Partanen K,Pikkarainen P,Alhava E

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy with gemcitabine improves median survival for patients with unresectable pancreatic cancer. Recently, hyperfractionated accelerated radiotherapy (HART) has been used to treat these patients; however, the safety and efficacy are not well defined. PATIENTS AND METHODS:The standard...

journal_title：Anticancer research

authors： Maemura K,Shinchi H,Noma H,Mataki Y,Kurahara H,Maeda S,Hiraki Y,Nakajo M,Natsugoe S,Takao S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors previously exposed to platinum compounds and paclitaxel has not yet been defined. The present phase II study evaluated the activity and toxicity of a paclitaxel-ifosfamide-cisplatin combination in the afore...

journal_title：Anticancer research

authors： Polyzos A,Kosmas C,Tsavaris N,Toufexi H,Lagadas A,Gogas H,Giannakopoulos K,Kouraklis G,Griniatsos J,Felekouras E,Tsigris C,Nikiteas N,Papadopoulos O,Giannopoulos A

更新日期：2007-05-01 00:00:00

abstract：:Various lignified materials, including pine cone extract and a commercial lignin, stimulated the morphological change (spreading) of mouse peritoneal macrophages, and their functional maturation as judged by increase in NBT-reducing activity. When these materials were treated with NaClO2 to decompose the phenolic stru...

journal_title：Anticancer research

authors： Kikuchi K,Sakagami H,Fujinaga S,Kawazoe Y,Oh-Hara T,Ichikawa S,Kurakata Y,Takeda M,Sato T

更新日期：1991-03-01 00:00:00

abstract：:Recurrent breast cancer (BC) tends to show an aggressive behavior and the number of cases of long-term survival is limited. Two rare cases of recurrent breast cancer were treated with a multidisciplinary approach. The outcome of the two cases indicated an excellent survival period of more than 13 years after recurrenc...

journal_title：Anticancer research

authors： Uramoto H,Hanagiri T

更新日期：2011-01-01 00:00:00

abstract：:The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. In addition, the triterpenoid fraction (800 microgram...

journal_title：Anticancer research

authors： Kimura Y,Taniguchi M,Baba K

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines. CASE REPORT:We administered the patient clonazepam. After taking clonazepam, the patient...

journal_title：Anticancer research

authors： Koga M,Nakadozono M,Nukariya K,Nogi H,Kobayashi T,Nakayama K

更新日期：2008-07-01 00:00:00

abstract：:We have previously shown that L-glutamic acid gamma-monohydroxamate (GAH) exhibits an antitumor activity, both in vitro and in vivo. In this report we explore the selective cytotoxicity of GAH in vitro by comparing the survival of tumor and normal cells. GAH exerts an irreversible delayed effect with tumoral cells and...

journal_title：Anticancer research

authors： Thomasset N,Chabanas A,Tournaire R,Malley S,Navarro C,Lawrence JJ,Doré JF,Vila J

更新日期：1993-09-01 00:00:00

abstract：:In order to estimate the environmental risk of the use of Alachlor, experiments on laboratory animals were conducted. Alachlor and 2,6 diethylaniline content in blood serum was quantified. Three groups of male ACI/T rats and C3H/FEJ mice were treated with three different doses of Alachlor. Six hours after the intraper...

journal_title：Anticancer research

authors： Galati R,Federico A,Cortese G,Zito R

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the progression-free survival (PFS) and toxicity associated with adjuvant administration of carboplatin and pemetrexed for completely resected patients with stage IB, II and IIIA non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-five eligible NSCLC patient...

journal_title：Anticancer research

authors： Karapanagiotou EM,Boura PG,Papamichalis G,Konstantinou M,Sepsas E,Chamalakis G,Simsiris P,Gkiozos I,Syrigos KN

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:We previously showed the usefulness of a fused protein of human pancreatic ribonuclease1 (hRNase1) with human epidermal growth factor (hEGF) for molecular targeting of EGF receptor (EGFR)-overexpressing cells. In this study, the mechanisms underlying the inhibition of cell growth by RNase-EGF fused proteins ...

journal_title：Anticancer research

authors： Hoshimoto S,Ueda M,Jinno H,Kitajima M,Futami J,Seno M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The rearrangement of actin cytoskeleton is being increasingly considered a marker of cancer cell activity, but the fine structure and remodeling of microfilaments within tumor tissue still remains unclear. MATERIALS AND METHODS:We used the recently introduced silicon-rhodamine (SiR)-actin dye to visualize e...

journal_title：Anticancer research

authors： Klementieva NV,Snopova LB,Prodanets NN,Furman OE,Dudenkova VV,Zagaynova EV,Lukyanov KA,Mishin AS

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Inconsistent reporting in published meta-analyses compared to registered protocol are poorly understood. The aim of the study was to assess inconsistencies between registered protocols and published reports among oncology drug meta-analyses. MATERIALS AND METHODS:A cross-sectional study was performed includ...

journal_title：Anticancer research

authors： Delgado AF,Delgado AF

更新日期：2017-09-01 00:00:00

abstract：:Rats were inoculated subcutaneously into both flanks with a transplantable adenocarcinoma of the colon. They were treated intravenously with either 5-FUrd (5-fluorouridine) or 5-FdUrd (5-fluoro-2'-deoxyuridine) with or without addition of dipyridamole 20 and 30 min later, respectively, for 3 consecutive days. Dipyrida...

journal_title：Anticancer research

authors： el Hag IA,Roos G,Jönsson PE,Stenram U

更新日期：1990-01-01 00:00:00

abstract：:Eighteen patients with Zollinger-Ellison syndrome were studied with 111In-pentetreotide SPECT in order to localize gastrinoma, the tumour responsible for this pathology. NMR imaging was also carried out. Eight patients were operated. 111In-pentetreotide was reinjected 4 hours before operation and the radioactivity of ...

journal_title：Anticancer research

authors： Scopinaro F,Schillaci O,Delle Fave G,Danieli R,Materia A,Tavolaro R,Angeletti S,Marignani M,Massa R,Gualdi G,Polettini E,Picardi V,Basso N

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND/AIM:Despite numerous studies, the etiology of chronic lymphocytic leukemia (CLL) remains unknown. A hypothesis of autoantigen stimulation in leukemic clone selection might explain 'stereotypy' of B-cell receptors. In healthy cells, cofilin-1 (CFL1) has multiple functions. Its role was described in several ma...

journal_title：Anticancer research

authors： Karp M,Karczmarczyk A,Bojarska-Junak A,Purkot J,Chojnacki M,ZajĄc M,Korpysz M,Tomczak W,Hus M,Morawska M,Giannopoulos K

更新日期：2020-11-01 00:00:00