Inconsistent Reporting Between Meta-analysis Protocol and Publication - A Cross-Sectional Study.

Abstract:

BACKGROUND:Inconsistent reporting in published meta-analyses compared to registered protocol are poorly understood. The aim of the study was to assess inconsistencies between registered protocols and published reports among oncology drug meta-analyses. MATERIALS AND METHODS:A cross-sectional study was performed including oncology drug meta-analyses published between January 1st and November 14th 2016 with a published protocol. Two investigators extracted data on: selection criteria, outcome(s) and statistical plan in protocol and manuscript, plus self-acknowledgement of inconsistent reporting between protocol and publication. RESULTS:Protocol registration was present in 19% (23/119) of all oncology drug meta-analyses. In meta-analyses with protocol (n=23), 70% (16/23) had issues with inconsistent reporting between protocol and published report concerning; inclusion criteria, comparator group, intervention, outcome (PICO) or statistical analysis. Self-acknowledgement of changes between protocol and publication was found in 50% (8/16). CONCLUSION:In meta-analyses with protocol, discrepancies between registered protocols and publications are frequent.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Delgado AF,Delgado AF

doi

10.21873/anticanres.11928

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

5101-5107

issue

9

eissn

0250-7005

issn

1791-7530

pii

37/9/5101

journal_volume

37

pub_type

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