Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry.

abstract：:Lymphocytes isolated from the peripheral blood of patients with chronic lymphocytic leukemia (CLL) and from healthy donors were studied for membrane fluidity and lipid phase separation. The degree of fluidity of the surface membrane lipids was estimated by fluorescence polarization analysis using the probe 1,6-dipheny...

journal_title：Anticancer research

authors： Deliconstantinos G,Daefler S,Krueger GR

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:The balance between cell proliferation and apoptosis plays a significant role in cancer development. The expressions of the p53 and c-myc genes, both strongly related to cell proliferation and apoptosis, were studied in sequential histological grades of oral carcinogenesis in an animal model. MATERIALS AND ...

journal_title：Anticancer research

authors： Papakosta V,Vairaktaris E,Vylliotis A,Derka S,Nkenke E,Vassiliou S,Lazaris A,Mourouzis C,Rallis G,Spyridonidou S,Anagnostopoulou S,Perrea D,Donta I,Yapijakis C,Patsouris E

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Aggrecan, the large aggregating proteoglycan, is a major component of the cartilage extracellular matrix. The C-terminal globular domain (G3) of the aggrecan molecule exhibits a pattern of alternative splicing that involves three exons. Each corresponds to a subdomain, epidermal growth factor 1(EGF1), EGF2, ...

journal_title：Anticancer research

authors： Matsui Y,Araki N,Tsuboi H,Tsumaki N,Nakata K,Kawabata H,Eyre DR,Yoshikawa H

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefiti...

journal_title：Anticancer research

authors： Kramer B,Hock C,Schultz JD,Lammert A,Kuhlin B,Birk R,Hörmann K,Aderhold C

更新日期：2017-06-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) and its receptor (Flt) protein expression was immunologically studied individually and in combination with the microvascular density (MVD) determined by the factor 8-related antigen (F8RA) and their prognostic value in 118 patients with a pulmonary adenocarcinoma. The pres...

journal_title：Anticancer research

authors： Takanami I,Tanaka F,Hashizume T,Kodaira S

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:It is of great clinical concern to preoperatively predict the need for blood transfusions during hepatectomy for hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 168 consecutive patients undergoing elective hepatectomy for HCC were retrospectively reviewed. We investigated preoperative factor...

journal_title：Anticancer research

authors： Yamamoto Y,Ikoma H,Morimura R,Konishi H,Murayama Y,Komatsu S,Shiozaki A,Kuriu Y,Kubota T,Nakanishi M,Ichikawa D,Fujiwara H,Okamoto K,Sakakura C,Ochiai T,Otsuji E

更新日期：2014-01-01 00:00:00

abstract：:Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison wi...

journal_title：Anticancer research

authors： Hagiwara A,Takahashi T,Lee R,Ueda T,Takeda M,Itoh T

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND/AIM:Cyclin D1 is a mediator of cell-cycle control that is frequently overexpressed in primary ductal breast carcinomas, but its role is controversial. A polymorphism in the CCND1 gene, G870A, results in an aberrantly spliced protein (cyclin D1b) lacking the Thr-286 phosphorylation site necessary for nuclear ...

journal_title：Anticancer research

authors： Abramson VG,Troxel AB,Feldman M,Mies C,Wang Y,Sherman L,McNally S,Diehl A,Demichele A

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND/AIM:We undertook a case-control and a case-case study to examine the possible association of p53 codon72 polymorphism with the breast cancer risk and resistance to anthracycline-based chemotherapy. PATIENTS AND METHODS:Case-control study: This study enrolled 175 patients with breast cancer treated at the Sa...

journal_title：Anticancer research

authors： Arfaoui A,Douik H,Kablouti G,Chaaben AB,Handiri N,Zid Z,Ouni N,Zouiouch F,Ayari F,Mamoughli T,Bouassida J,Abazza H,Harzallaha L,Guemira F

更新日期：2015-03-01 00:00:00

abstract：:BPA (bisphenol A or 2,2-bis(4-hydroxy-phenol)propane) and hydroquinone (HQ, 1,4-benzenediol) are present in dental resin materials, and small quantities of these substances may be eluted from the resins. Recently, attention has focused on the estrogen-like and carcinogenic adverse effects of BPA and HQ. Thus, it is im...

journal_title：Anticancer research

authors： Terasaka H,Kadoma Y,Sakagami H,Fujisawa S

更新日期：2005-05-01 00:00:00

abstract：:The development of T-lymphocytes (T cells) constitute one of the basic and most vital processes in immunology. Conventional mathematical models, being based on the systems theory, fail to sufficiently distinguish the constituents of thymocytes and are thus of limited significance. On the basis of some well thought-out...

journal_title：Anticancer research

authors： Wang G,Krueger GR,Buja LM

更新日期：2004-05-01 00:00:00

abstract：:Immunohistochemical analysis of the p53 tumor suppressor gene was performed in 69 human pancreatic ductal adenocarcinomas, using a highly specific anti-p53 antibody. Nuclear immunoreactivity was found in 40 tumors, yielding an overall frequency of 58%. Immunoblotting confirmed that nuclear immunoreactivity was associa...

journal_title：Anticancer research

authors： Yokoyama M,Yamanaka Y,Friess H,Buchler M,Korc M

更新日期：1994-11-01 00:00:00

abstract：:The usefulness of lymphocyte subset change as an indicator for predicting survival time and the effectiveness of combined treatment with an immunopotentiator, lentinan, and carboplatin (CBDCA) were investigated. Of 13 patients with advanced unresectable cancer entered in this study, 9 were administered 2 mg/body lenti...

journal_title：Anticancer research

authors： Matsuoka H,Yano K,Seo Y,Saito T,Tomoda H,Tsurumoto S

更新日期：1995-09-01 00:00:00

abstract：UNLABELLED:Lesions containing somatostatin receptors (SSR) in rats and in man can be visualized in vivo using radiolabeled octreotide (OCT) analogs. SSR scintigraphy was initially performed with [123I-Tyr3]OCT and later with [111In-DTRA0]OCT. With the latter the residence time of radioactivity (111In) in SSR-positive t...

journal_title：Anticancer research

authors： Breeman WA,de Jong M,Bernard B,Hofland LJ,Srinivasan A,van der Pluijm M,Bakker WH,Visser TJ,Krenning EP

更新日期：1998-01-01 00:00:00

abstract：AIM:To determine the effectiveness of postoperative concurrent daily low-dose cisplatin-based chemoradiation (CCRT) in patients with high-risk cervical cancer. PATIENTS AND METHODS:Patients with stage IB, IIA, or IIB cervical cancer who were initially treated with radical hysterectomy and pelvic lymphadenectomy, and w...

journal_title：Anticancer research

authors： Mitsuhashi A,Uno T,Usui H,Tate S,Hirashiki K,Kato K,Kiyohara H,Kato S,Ito H,Shozu M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Oxaliplatin (L-OHP), active in a wide range of human and animal tumours, also CDDP-resistant, possesses unique molecular characteristics of action. However, the mechanisms by which the damage induced by L-OHP triggers a death signal are not yet fully defined. MATERIALS AND METHODS:After L-OHP treatment of t...

journal_title：Anticancer research

authors： Marchetti P,Galla DA,Russo FP,Ricevuto E,Flati V,Porzio G,Ficorella C,Cifone MG

更新日期：2004-01-01 00:00:00

abstract：:The retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46) is a nuclear protein of 46 kDa and contains four repeats that end with Trp-Asp (WD) residues. In this study, we reveal that the RbAp46 protein level upon SUMO-1 expression was increased. The increasing level of RbAp46 protein by SUMO-1 was not regulated...

journal_title：Anticancer research

authors： Giri R,Yeh HH,Wu CH,Liu HS

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND/AIM:Recent progress with BRAF and immune checkpoint inhibitors has dramatically changed the treatment landscape of metastatic melanoma (MM). The limited duration of responses to new agents, however, justifies the, still important, role of chemotherapy in the management of MM. This study prospectively explore...

journal_title：Anticancer research

authors： Linardou H,Pentheroudakis G,Varthalitis I,Gogas H,Pectasides D,Makatsoris T,Fountzilas G,Bafaloukos D,Hellenic Cooperative Oncology Group.

更新日期：2015-02-01 00:00:00

abstract：:Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the drug efficacy under two-dimensional (2D) culture conditions usually differs from that of three-dimensional (3D) culture conditions. In the present study, an in vitro tumor tissue model was constructed by s...

journal_title：Anticancer research

authors： Iwase Y,Nakayama M,Yamato M,Okano T

更新日期：2015-12-01 00:00:00

abstract：:12-O-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter of the phorbol ester type and protein kinase C (PKC) activator, consists of two characteristic structural elements: the phorbol body and the retinoyl ester chain. Therefore, possible binding of the incomplete tumor promoter RPA to the human transport ...

journal_title：Anticancer research

authors： Schlatterer K,Gminski R,Schlatterer J,Hecker E,Chandra P,Schlatterer B,Krauter G,Chandra A

更新日期：2005-09-01 00:00:00

abstract：AIM:To investigate the prognostic significance of cancer antigen 15-3 (CA15-3) in primary breast cancer (BC). PATIENTS AND METHODS:This prospective study included 368 women: 62 patients with benign breast disease (BBD), 159 patients with invasive BC and 88 healthy blood donors (control). The median follow-up was 76 mo...

journal_title：Anticancer research

authors： Nisman B,Maimon O,Allweis T,Kadouri L,Maly B,Hamburger T,Peretz T

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIM:Soluble mesothelin-related peptide (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we compared the diagnostic performances of SMRP in matched pleural effusion (PE-SMRP) and serum (S-SMRP). MATERIALS AND METHODS:Diagnosis on pleural biopsies was performed for all patien...

journal_title：Anticancer research

authors： Ferro P,Canessa PA,Battolla E,Dessanti P,Franceschini MC,Chiaffi L,Morabito A,Fontana V,Pezzi R,Fedeli F,Pistillo MP,Roncella S

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND/AIM:Activation of the c-JUN N-terminal kinase (JNK) signaling pathway has been associated with poor survival of ovarian cancer patients, but the role(s) and significance of JNK signaling in ovarian cancer cells remain poorly understood. In the present study, we aimed to investigate the role of JNK specifical...

journal_title：Anticancer research

authors： Seino M,Okada M,Shibuya K,Seino S,Suzuki S,Ohta T,Kurachi H,Kitanaka C

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIM:Phenothiazines constitute a versatile family of compounds in terms of biological activity, which have also gained a considerable attention in cancer research. MATERIALS AND METHODS:Three phenothiazines (promethazine, chlorpromazine and thioridazine) have been tested in combination with 11 active selenoc...

journal_title：Anticancer research

authors： GajdÁcs M,NovÉ M,Csonka Á,Varga B,SanmartÍn C,DomÍnguez-Álvarez E,Spengler G

更新日期：2020-09-01 00:00:00

abstract：:Details of 197 colorectal carcinomas from 180 patients were retrieved from our files, with the aim of analyzing the clinical histories and pathological parameters of all patients up to 40 years, and to support these data with the results of the DNA content analysis of tumoral cells by static cytometry. The incidence o...

journal_title：Anticancer research

authors： Caruso ML,Rizzi E

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that disproportionately affects women with darker skin. Epidemiological studies indicate that higher vitamin D levels prevent incidence of TNBC and translate to higher survival rates in those that have TNBC. MATERIALS AND METHODS:Th...

journal_title：Anticancer research

authors： Richards SE,Weierstahl KA,Kelts JL

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Microparticles are known to be increased in various malignancies. In this prospective study, microparticle levels were evaluated in patients with benign and malignant ovarian lesions. PATIENTS AND METHODS:Microparticles from platelets/megakaryocytes, activated platelets and endothelial cells, tissue factor ...

journal_title：Anticancer research

authors： Rank A,Liebhardt S,Zwirner J,Burges A,Nieuwland R,Toth B

更新日期：2012-05-01 00:00:00

abstract：:The bcl-2 proto-oncogene suppresses apoptosis in a variety of cell types and is essential for normal renal development. PAX8 is a member of the paired box class of transcription factors and is developmentally regulated. bcl-2 and PAX8 are both expressed in the kidney during development and throughout life, demonstrati...

journal_title：Anticancer research

authors： Hewitt SM,Hamada S,Monarres A,Kottical LV,Saunders GF,McDonnell TJ

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:It is unclear whether radiomic phenotypes of brain metastases (BM) are related to radiation therapy prognosis. This study assessed whether a convolutional neural network (CNN)-based radiomics model which learned computer tomography (CT) image features with minimal preprocessing, could predict early response ...

journal_title：Anticancer research

authors： Cha YJ,Jang WI,Kim MS,Yoo HJ,Paik EK,Jeong HK,Youn SM

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:The toxicity of the proteasome inhibitor MG132 was tested alone and combined either with the topoisomerase I inhibitor topotecan or the topoisomerase II inhibitor etoposide against a panel of 18 cell lines representing six pediatric tumor types. MATERIALS AND METHODS:MG132, topotecan, etoposide and thei...

journal_title：Anticancer research

authors： Destanovic E,Boos J,Lanvers-Kaminsky C

更新日期：2018-07-01 00:00:00