Abstract：
BACKGROUND/AIM:The toxicity of the proteasome inhibitor MG132 was tested alone and combined either with the topoisomerase I inhibitor topotecan or the topoisomerase II inhibitor etoposide against a panel of 18 cell lines representing six pediatric tumor types. MATERIALS AND METHODS:MG132, topotecan, etoposide and their combination were evaluated. Cell viability was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Combination indices for simultaneous treatment schedules were determined by the method of Chou and Talalay. RESULTS:Concentrations inducing growth inhibition of 50% (GI50s) ranged between 0.140-1.30 μmol/l (median=0.55 μmol/I) for MG132. GI50s of 0.004-3.48 μmol/l (median=30 nmol/I) were calculated for topotecan and 0.117-45.0 μmol/l (median=2.74 μmol/l) for etoposide. Additive/synergistic effects were observed in eight cell lines (including all Ewing sarcoma cell lines) for the combination of MG132 with etoposide, but only in three cell lines for its combination with topotecan. CONCLUSION:The combination of proteasome and topoisomerase II inhibitor deserves further evaluation, especially for Ewing sarcoma.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Destanovic E,Boos J,Lanvers-Kaminsky Cdoi
10.21873/anticanres.12684subject
Has Abstractpub_date
2018-07-01 00:00:00pages
3977-3984issue
7eissn
0250-7005issn
1791-7530pii
38/7/3977journal_volume
38pub_type
杂志文章abstract：BACKGROUND:The possibilities and limitations of computer tomography (CT) examination for detecting primary gastric cancer tumors have been poorly understood. The aim of the present study was to evaluate the pre-operative assessment of gastric cancer tumors using 32-multidetector row-CT. PATIENTS AND METHODS:A prospect...
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doi：
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