131I-MIBG therapy of neural crest tumours (review).

abstract：:Previous reports suggest that age, household income and travel distance from residence to treatment facility are barriers which influence access to radiotherapy. The purpose of this study was to analyse the utilisation of palliative radiotherapy in a health care system where the main goal is equal access despite place...

journal_title：Anticancer research

authors： Nieder C,Norum J,Spanne O,Bilberg I,Vagstad G,Dalhaug A

更新日期：2009-07-01 00:00:00

abstract：:A 60-year-old male patient with advanced gastric adenocarcinoma was treated by subtotal gastrectomy with dissection of the regional lymph nodes. Microscopic examination of the tumour revealed tubular adenocarcinoma which invaded the muscularis propria. There was no evidence of metastatic carcinoma in the dissected lym...

journal_title：Anticancer research

authors： Caruso RA,Parisi A,Valerio F,Napoli P,Parisi G

更新日期：2003-09-01 00:00:00

abstract：:We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematolog...

journal_title：Anticancer research

authors： Hayashi H,Kobayashi R,Suzuki A,Ishihara M,Nakamura N,Kitagawa J,Kanemura N,Kasahara S,Kitaichi K,Hara T,Tsurumi H,Moriwaki H,Itoh Y

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:DNA topoisomerase II alpha (topo II alpha) is associated with active cell proliferation of mammalian cells. Topo II alpha overexpression has been reported in a number of human malignancies and is considered to be related to their biological behaviors. MATERIALS AND METHODS:We examined the expression of topo...

journal_title：Anticancer research

authors： Ohashi Y,Sasano H,Yamaki H,Shizawa S,Kikuchi A,Shineha R,Akaishi T,Satomi S,Nagura H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIM:The matrix metalloproteinase (MMP) family of enzymes are in charge of degradation of various components of the extracellular matrix and their functional genetic polymorphisms may be associated with cancer susceptibility. The functional polymorphisms in the promoter region of MMP7 (A-181G and C-153T) have...

journal_title：Anticancer research

authors： Chou AK,Hsiao CL,Shih TC,Wang HC,Tsai CW,Chang WS,Liu LC,Way TD,Chung JG,Bau DT

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The prognostic significance of mutant p53 protein, p-glycoprotein (P-gp) and glutathione S-transferase-pi (GST-pi) in patients with unresectable non-small cell lung cancer (NSCLC) has not been established. MATERIALS AND METHODS:We performed immunohistochemical staining of p53, P-gp and GST-pi using transbro...

journal_title：Anticancer research

authors： Miyatake K,Gemba K,Ueoka H,Nishii K,Kiura K,Tabata M,Shibayama T,Takigawa N,Kawaraya M,Tanimoto M

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Estramustine is an anti-mitotic cytostatic drug that also enhances the effect of radiotherapy. The mechanism of radiosensitization is not thoroughly known. Since both radiotherapy and estramustine induce apoptosis in prostate cancer cells, we conducted an experiment to show whether radiosensitization is medi...

journal_title：Anticancer research

authors： Ståhlberg K,Kairemo K,Erkkilä K,Pentikäinen V,Sorvari P,Taari K,Dunkel L,Rannikko S

更新日期：2005-07-01 00:00:00

abstract：:Megakaryocyte polyploidization is an advantageous and regulated mechanism which leads to an increase in platelet production. In megakaryocyte cell lines, polyploidization can be obtained by using cytochalasin B, an inhibitor of the actin polymerization. The Nucleolar Organizer Regions (AgNORs) are parts of nucleolar D...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：:Malignant mesothelioma of the tunica vaginalis testis is a rare and aggressive asbestos-related malignancy that may pose difficult diagnostic problems. After 16 years of asbestos exposure, a 38-year-old petrochemical worker came to our notice with acute right testicular pain and swelling, simulating torsion of the spe...

journal_title：Anticancer research

authors： Candura SM,Canto A,Amatu A,Gerardini M,Stella G,Mensi M,Poggi G

更新日期：2008-03-01 00:00:00

abstract：:Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line...

journal_title：Anticancer research

authors： Mitsuhashi N,Ishikawa H,Saito Y,Takahashi T,Sakurai H,Nozaki M,Akimoto T,Hasegawa M,Maebayashi K,Niibe H

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:In head and neck squamous cell carcinoma (HNSCC), a variety of immunomodulatory mediators contribute to strongly impaired immune functions. The secretion of C-reactive protein (CRP) by HNSCC cells and its influence on human myeloid dendritic cells (MDC) was investigated. MATERIALS AND METHODS:The CRP levels...

journal_title：Anticancer research

authors： Frenzel H,Pries R,Brocks CP,Jabs WJ,Wittkopf N,Wollenberg B

更新日期：2007-11-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the prognostic impact of central nervous system metastases (CNS) after acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in EGFR-mutant non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We defined CNS-collapse as de...

journal_title：Anticancer research

authors： Hata A,Katakami N,Yoshioka H,Takeshita J,Tanaka K,Masago K,Fujita S,Kaji R,Imai Y,Monden K,Matsumoto T,Nagata K,Otsuka K,Tachikawa R,Tomii K,Kunimasa K,Iwasaku M,Nishiyama A,Ishida T,Nishimura Y

更新日期：2015-02-01 00:00:00

abstract：:Using a cultured human colon cancer cell line (Col 2), a structurally diverse group of chemopreventive agents was evaluated for their potential to induce apoptosis. As a result, 1,4-phenylenebis(methylene)selenocyanate (p-xylylselenocyanate; p-XSC) was found to be active in this process. p-XSC, a synthetic organoselen...

journal_title：Anticancer research

authors： Lee SK,Heo YH,Steele VE,Pezzuto JM

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Since doxorubicin causes cardiotoxicity, we wished to assess relative concentrations of doxorubicin and its metabolites in cardiac tissues of patients who had been treated antemortem. We also wished to determine factors that correlate with human cardiac doxorubicin and doxorubicinol concentrations. PATIENTS AN...

journal_title：Anticancer research

authors： Stewart DJ,Grewaal D,Green RM,Mikhael N,Goel R,Montpetit VA,Redmond MD

更新日期：1993-11-01 00:00:00

abstract：:Gallic acid induced apoptotic cell death in human promyelocytic leukemia HL-60 cells. The effect of gallic acid was significantly reduced by blocking the free hydroxyl or carboxyl group with acetyl, methyl, ethyl, n-propyl or isoamyl group. This was paralleled with the decrease in the intensity of both gallate radical...

journal_title：Anticancer research

authors： Sakagami H,Satoh K,Hatano T,Yoshida T,Okuda T

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIM:Androgen-androgen receptor (AR) signal is known as a powerful driver of prostate cancer progression. We previously reported the limitation of prostate-specific antigen (PSA) at diagnosis as a prognostic biomarker of prostate cancer. Although serum total testosterone (TT) level has been reported as a prog...

journal_title：Anticancer research

authors： Izumi K,Shigehara K,Nohara T,Narimoto K,Kadono Y,Mizokami A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Disseminated tumor cells (DTCs) in bone marrow (BM) occur in 30-40% of primary breast cancer patients. An impaired bone microenvironment may lead to reduced bone density and osteoporosis affecting the BM as a homing site for DTCs. The bone mineral density (BMD) and its correlation to DTC in BM was evaluated....

journal_title：Anticancer research

authors： Kraemer B,Rothmund R,Banys M,Krawczyk N,Solomayer EF,Mack C,Wallwiener D,Fehm T

更新日期：2011-12-01 00:00:00

abstract：:This article describes previous studies on a unique protein antitumor antibiotic, neocarzinostatin. Namely, its chemical nature, mode of action at molecular and cellular levels, toxicity and pharmacology, and recent results in clinical trials obtained primarily in Japan have been reviewed briefly. ...

journal_title：Anticancer research

authors： Maeda H

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear. This study examined CD98 expression and its clinicopathological impact on GC. PATIENTS AND METHODS:Three hundred and thirty-one patien...

journal_title：Anticancer research

authors： Satoh T,Kaira K,Takahashi K,Takahashi N,Kanai Y,Asao T,Horiguchi J,Oyama T

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:In 1979, Montgomery and Asberg introduced an inventory for screening of depression. To our knowledge, the associations between the MADRS and the risk of breast cancer (BC) are rarely considered together in a prospective study. PATIENTS AND METHODS:In an extension of the Kuopio Breast Cancer Study, 115 women...

journal_title：Anticancer research

authors： Eskelinen M,Ollonen P

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The concepts of vasculogenic mimicry and mosaic vessels have been proposed as novel modes of tumour neovascularisation. However, the presence and significance of these types of neovascularisation remain unclear. MATERIALS AND METHODS:ECV304 human bladder carcinoma cells were used to determine how tumour cel...

journal_title：Anticancer research

authors： Fujimoto A,Onodera H,Mori A,Nagayama S,Yonenaga Y,Tachibana T

更新日期：2006-01-01 00:00:00

abstract：:We have previously shown that transfection of NIH 3T3 cells with the T24 H-ras oncogene converts the cells to a tumorigenic and metastatic phenotype, in proportion to levels of ras expression. We hypothesize that ras-induced increases in malignancy occur via altered expression of various genes. We have identified OPN ...

journal_title：Anticancer research

authors： Chambers AF,Behrend EI,Wilson SM,Denhardt DT

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Various prognostic factors have been investigated in order to predict the minority of male germ cell tumor (GCT) patients who will develop resistant disease. However, no prognostic system has been proven accurate. MATERIALS AND METHODS:Paraffin-embedded tissue specimens, obtained from primary lesions during...

journal_title：Anticancer research

authors： Pectasides D,Papaxoinis G,Nikolaou M,Valavanis C,Aravantinos G,Fountzilas G,Tamvakis N,Pectasides E,Lekka I,Arapantoni-Dadioti P,Zizi A,Ghiconti I,Economopoulos T

更新日期：2009-02-01 00:00:00

abstract：:Cisplatin toxicity could be decreased by adjusting its dosage to each patient. For this purpose, a limited sampling method was established and validated based on a Bayesian approach taken using the values of assays during a 5-day continuous infusion of cisplatin. Using this method, a dosing model to achieve a target p...

journal_title：Anticancer research

authors： Desoize B,Dumont P,Manot L,Urien S,Dufour R,Berthiot G

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND/AIM:ANRIL is a long noncoding RNA located on INK4 locus, which encodes p15 and p16 that cause G1 phase arrest in the cell cycle. ANRIL positively regulates proliferation of several kinds of cancer cells such as lung and gastric cancers. This study, examined the effect of ANRIL in head and neck squamous cell ...

journal_title：Anticancer research

authors： Matsunaga N,Wakasaki T,Yasumatsu R,Kotake Y

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The optimal palliative chemotherapy in endometrial cancer is unknown. CASE REPORT:A patient was diagnosed to have primary endometrioid endometrial cancer metastatic to the pelvic, paraaortic and right inguinal lymph nodes (FIGO IVb). After radical surgery, she received 6 adjuvant cycles of cisplatin and epi...

journal_title：Anticancer research

authors： Idris T,Winter R,Lang U,Petru E

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND/AIM:Osteosarcoma originates from mesenchymal stem cells with impaired bone differentiation. In the present study we investigated the effect of ascorbic acid (AsA) on osteogenic differentiation and apoptosis of the MG-63 osteosarcoma cell line. MATERIALS AND METHODS:We evaluated the expression of runt-relate...

journal_title：Anticancer research

authors： Valenti MT,Zanatta M,Donatelli L,Viviano G,Cavallini C,Scupoli MT,Dalle Carbonare L

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) wit...

journal_title：Anticancer research

authors： Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial. PATIENTS AND METHODS:We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with ...

journal_title：Anticancer research

authors： Yang WC,Chen CH,Tang JY,Wu CF,Liu YC,Sun Y,Lin SF

更新日期：2014-07-01 00:00:00