Abstract：
BACKGROUND:Disseminated tumor cells (DTCs) in bone marrow (BM) occur in 30-40% of primary breast cancer patients. An impaired bone microenvironment may lead to reduced bone density and osteoporosis affecting the BM as a homing site for DTCs. The bone mineral density (BMD) and its correlation to DTC in BM was evaluated. MATERIALS AND METHODS:One hundred and eighty-one women (70 premenopausal, 111 postmenopausal) underwent quantitative ultrasonometry before adjuvant chemotherapy. BM aspirates were analyzed by immunocytochemistry using the ACIS system (Chromavision) based on immunostaining. RESULTS:DTCs were detected in 39% of the patients. Positive BM status correlated significantly with the nodal status. BMD was significantly reduced in the postmenopausal patients (p=0.003). Smaller tumors and higher BMD correlated significantly (p<0.014). Fifty percent of the patients with preclinical osteoporosis were BM positive, whereas 37% with normal or osteopenic BMD had DTCs. CONCLUSION:An impaired bone micro-environment as found in preclinical osteoporosis might be a homing site for DTCs.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kraemer B,Rothmund R,Banys M,Krawczyk N,Solomayer EF,Mack C,Wallwiener D,Fehm Tsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
4423-8issue
12eissn
0250-7005issn
1791-7530pii
31/12/4423journal_volume
31pub_type
杂志文章abstract：BACKGROUND:Locoregional treatments represent a good option for patients suffering from hepatocellular carcinoma (HCC) not eligible for resection or transplantation. Locoregional approaches include a wide spectrum of therapeutic methods and hepatic intra-arterial drug infusion is also considered. Fotemustine is a chemot...
journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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doi：
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更新日期：2017-08-01 00:00:00
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更新日期：2019-12-01 00:00:00
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