Induction chemotherapy with docetaxel, cisplatin and fluorouracil followed by surgery and concurrent chemoradiotherapy improves outcome of recurrent advanced head and neck squamous cell carcinoma.

abstract：BACKGROUND/AIM:Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:F...

journal_title：Anticancer research

authors： Muto S,Takagi H,Owada Y,Inoue T,Watanabe Y,Yamaura T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND/AIM:Pelvic exenteration is a radical procedure for certain advanced or recurrent gynaecological cancers, performed with curative or palliative intent. Its validity has evolved as operative mortality and morbidity have improved. This surgery was evaluated to determine the validity of these claims. PATIENTS A...

journal_title：Anticancer research

authors： Soeda S,Furukawa S,Sato T,Ueda M,Kamo N,Endo Y,Kojima M,Nomura S,Kataoka M,Fujita S,Endo H,Takahashi T,Watanabe T,Yamada H,Fujimori K

更新日期：2019-10-01 00:00:00

abstract：:Combination therapies are used in the clinic to achieve cure, better efficacy and to circumvent resistant disease in patients. Initial assessment of the effect of such combinations, usually of two agents, is frequently performed using in vitro assays. In this review, we give a short summary of the types of analyses th...

journal_title：Anticancer research

authors： El Hassouni B,Mantini G,Li Petri G,Capula M,Boyd L,Weinstein HNW,Vallés-Marti A,Kouwenhoven MCM,Giovannetti E,Westerman BA,Peters GJ,EORTC PAMM Group.

更新日期：2019-07-01 00:00:00

abstract：AIM:The purpose of the present study was the analysis of the relationship between tumor necrosis factor-α (TNF-α) -308 G/A and cervical intraepithelial neoplasia (CIN). MATERIALS AND METHODS:A prospective case-control study was performed, enrolling 78 cases of cervical intraepithelial neoplasia and 107 controls. Every...

journal_title：Anticancer research

authors： Rotar IC,Muresan D,Radu P,Petrisor F,Apostol S,Mariana T,Butuza C,Stamatian F

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with cyclopamine on colony formation of cell...

journal_title：Anticancer research

authors： Mozet C,Stoehr M,Dimitrova K,Dietz A,Wichmann G

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:The aim of this study was to evaluate the utility of HER2/neu ECD concentration as a marker of the efficacity of clinical response to Herceptin. PATIENTS AND METHODS:Iterative measurements of HER2/neu ECD (ELISA c-erbB2/c-neu Rapid Format Elisa kit QIA10 Calbiochem) concentrations in 45 patients treated wit...

journal_title：Anticancer research

authors： Gauchez AS,Colonna M,Brand FX,Ravanel N,Pasquier D,Payan R,Mousseau M

更新日期：2009-05-01 00:00:00

abstract：:Simultaneous administration of medroxyprogesterone acetate (MPA) and tamoxifen markedly elevated the serum alanine and aspartate aminotransferase activities in 4 out of 30 patients with endometrial or ovarian carcinoma; and also slightly increased the activities of gamma-glutamyl transferase in 2 of the patients. Thes...

journal_title：Anticancer research

authors： Riippa P,Kauppila A,Sundström H,Vihko R

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Active hexose-correlated compound (AHCC) is an extract of a basidiomycete mushroom that enhances the therapeutic effects and reduces the side-effects of chemotherapy. Our previous studies demonstrated that heat-shock protein 27 (HSP27) was involved in gemcitabine-resistance of pancreatic cancer cells and it ...

journal_title：Anticancer research

authors： Tokunaga M,Baron B,Kitagawa T,Tokuda K,Kuramitsu Y

更新日期：2015-11-01 00:00:00

abstract：:Methyl-tertiary-butyl ether (MTBE) is a ubiquitous oxygen-bearing additive used to reduce engine knocking and obtain cleaner gasoline combustion. Conflicting data have been reported about a possible carcinogenic role of MTBE in humans. In this study we evaluated the effects of MTBE on cell growth and transformation in...

journal_title：Anticancer research

authors： Iavicoli I,Carelli G,Ardito R,Cittadini A,Sgambato A

更新日期：2002-07-01 00:00:00

abstract：:Studies on taurine transport in MDR (multidrug resistant) and non-MDR KB cancer cells show that both cell types contain Na(+)- and Cl(-)-dependent high-affinity and low-affinity transport systems selective for beta-amino acids and a taurine diffusion component. Good buffers, such as HEPES or MOPS, interfered with taur...

journal_title：Anticancer research

authors： Wersinger C,Rebel G,Lelong-Rebel IH

更新日期：2001-09-01 00:00:00

abstract：:Ovarian clear cell carcinoma represents a distinct histopathological subtype of epithelial ovarian cancer, with poor outcomes, especially in cases diagnosed in advanced stages of disease. However, even in these cases, it seems that the most effective treatment remains debulking surgery to no residual disease. We prese...

journal_title：Anticancer research

authors： Bacalbasa N,Balescu I,Filipescu A

更新日期：2017-10-01 00:00:00

abstract：:The effect of retinoid induced suppression of in vitro invasive ability of A549 human lung carcinoma cells on sialyltransferase activity and sialic acid content was investigated. Inhibition by retinol acetate of cell invasive potential was accompanied by a significant decrease in the enzyme activity of intact cells as...

journal_title：Anticancer research

authors： Ledinko N,Fazely F

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs), which are endogenously expressed regulatory noncoding RNAs, have an altered expression in tumor tissues. MiRNAs regulate cancer-related processes such as cell growth and tissue differentiation, and therefore, might function as oncogenes or tumor-suppressor genes. The aim of our study was ...

journal_title：Anticancer research

authors： Pesta M,Klecka J,Kulda V,Topolcan O,Hora M,Eret V,Ludvikova M,Babjuk M,Novak K,Stolz J,Holubec L

更新日期：2010-09-01 00:00:00

abstract：:African-American women with breast cancer consistently show a shortened survival when compared with Caucasians with breast cancer, however it is not clear whether this is due to socioeconomic factors or to racial differences in tumor biology. Cyclin D1 overexpression has been demonstrated in 60-80% of female breast ca...

journal_title：Anticancer research

authors： Joe AK,Arber N,Bose S,Heitjan D,Zhang Y,Weinstein IB,Hibshoosh H

更新日期：2001-09-01 00:00:00

abstract：:Mutations in the p53 gene stimulate cell division. In our study we assessed the prognostic value of mutant p53 overexpression in cervical cancer stage FIGO III detected by immunohistochemistry. In 43 tissue specimens were detected p53 overexpression in 20 cases. Mean survival time was 36.4 (SE +/- 7.66) months in the ...

journal_title：Anticancer research

authors： Gitsch G,Kainz C,Joura E,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：:The overexpression of p53, c-erbB-2 and p21ras gene products was evaluated immunohistochemically in ovarian carcinomas, borderline, and benign neoplasms. All studies were performed on cytospin preparations of cyst and/or ascitic fluid cells and mutual relations between oncoproteins were analysed. p53 and c-erbB-2 immu...

journal_title：Anticancer research

authors： Harłozińska A,Bar JK,Sobańska E,Goluda M

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:The effectiveness of mammographic screening in women aged over 50 years has been confirmed in the United States and Europe, but its effectiveness in women aged from 40 to 49 years remains controversial. The optimum age for effective screening of subjects for breast cancer by mammography in Japan was studied ...

journal_title：Anticancer research

authors： Morimoto T,Sasa M,Yamaguchi T,Kondo H,Akaiwa H,Sagara Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:SATB2 (special AT-rich sequence-binding protein 2) is a DNA-binding protein that is involved in transcriptional regulation and chromatin remodeling. SATB2 protein has been described as a promising novel marker in several human cancers. PATIENTS AND METHODS:This study compared SATB2 expression in tumor a...

journal_title：Anticancer research

authors： Sliwinska-Jewsiewicka A,Kowalczyk AE,Krazinski BE,Godlewski J,Kwiatkowski P,Kiewisz J,Grzegrzolka J,Dziegiel P,Kmiec Z

更新日期：2018-02-01 00:00:00

abstract：:Malignant cells appear to possess a special aptitude for survival. We attempted to prove this in vitro by acute nutritional and energy deprivation as a survival threat. A phosphate-buffered saline (PBS) survival test in cell culture allowed static observations. These were supplemented by classic and quantitative phase...

journal_title：Anticancer research

authors： Janeckova H,Vesely P,Chmelik R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase-2 (Cox-2) is expressed by several types of epithelial malignancies, i.e., carcinomas, and inhibition of Cox-2 may have a therapeutic role in chemoprevention and treatment of cancer. The role of Cox-2 in non-epithelial malignancies, however, is unclear. MATERIALS AND METHODS:We investigated, b...

journal_title：Anticancer research

authors： Lassus P,Ristimäki A,Huuhtanen R,Tukiainen E,Asko-Seljavaara S,Andersson LC,Miettinen M,Blomqvist C,Haglund C,Böhling T

更新日期：2005-07-01 00:00:00

abstract：:Cytogenetic and DNA flow cytometric analysis was carried out on four SV40T-transfected human buccal epithelial cells lines. One of these was immortalized and showed a nontumorigenic phenotype when tested in athymic nude mice. DNA flow cytometric ploidy values correlated well with cytogenetic ploidy values as calculate...

journal_title：Anticancer research

authors： Kulkarni Schmidt-Kastner PS,Heiden T,Tribukait B,Grafström RC

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:DMXAA (5,6-dimethylxanthenone-4-acetic acid; AS1404), a vascular disrupting agent currently in clinical trials, induces tumour endothelial cell apoptosis in vivo in mice and in cancer patients. DMXAA activates NF-kappaB in many different cell types. In this study, whether DMXAA-induced endothelial cell apopt...

journal_title：Anticancer research

authors： Woon ST,Hung SS,Wu DC,Schooltink MA,Sutherland R,Baguley BC,Chen Q,Chamley LW,Ching LM

更新日期：2007-01-01 00:00:00

abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...

journal_title：Anticancer research

authors： Kovacs CJ,Evans MJ,Daly BM

更新日期：2003-05-01 00:00:00

abstract：:Adenovirus (ADV)-mediated gene therapy with the thymidine kinase (TK) gene under control of the Rous sarcoma virus (RSV) promotor followed by the administration of acyclovir has been established in vitro for the treatment of ovarian cancer cells and has been used as the basis for intraperitoneal phase I clinical trial...

journal_title：Anticancer research

authors： Kieback DG,Delvoux B,Romano A,Ollig S,Fischer DC

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND/AIM:Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients. MATERIALS AND METHODS:Using the Surveillance, Epidemiology...

journal_title：Anticancer research

authors： Li MU,Gu S,Mao R,Ning Y,Trivedi N,Siddiqui A,Li P,Huo L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Multidrug resistance (MDR) is one of the major obstacles limiting the efficacy of cancer chemotherapy. Through screening a series of natural products, we have previously identified six naturally occurring bisbenzylisoquinoline alkaloids (BBIs) that possess potent activity to reverse P-glycoprotein (gp)-media...

journal_title：Anticancer research

authors： Zhu X,Sui M,Fan W

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:miR-96 is reported to inhibit reversion cysteine-rich Kazal motif (RECK), which is associated with tumor invasion, in solid cancer types (e.g. breast cancer, non-small cell lung cancer, esophageal cancer). The purpose of this study is to clarify whether miR-96 is similarly associated with tumor invasion in c...

journal_title：Anticancer research

authors： Iseki Y,Shibutani M,Maeda K,Nagahara H,Fukuoka T,Matsutani S,Hirakawa K,Ohira M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Prostate cancer treated with androgen ablation eventually becomes resistant. Because the androgen receptor (AR) signaling axis affects disease progression, AR coactivator molecules could provide clinical prognostic value. This study investigates the association between AR coactivator molecules and clinical o...

journal_title：Anticancer research

authors： Mori R,Wang Q,Quek ML,Tarabolous C,Cheung E,Ye W,Groshen S,Hawes D,Togo S,Shimada H,Danenberg KD,Danenberg PV,Pinski JK

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Deregulated RAS/RAF/MAPK and PI3K/AKT/mTOR signaling pathways are found in hepatocellular carcinoma (HCC). This study aimed to test the inhibitory effects of PI-103 (a small molecule inhibitor of PI3K and mTOR) and sorafenib as single agents and in combination on HCC tumorigenesis in an in vivo xenograft mod...

journal_title：Anticancer research

authors： Gedaly R,Angulo P,Chen C,Creasy KT,Spear BT,Hundley J,Daily MF,Shah M,Evers BM

更新日期：2012-07-01 00:00:00

abstract：:Intracellular accumulation of adriamycin (ADR) has been reported to be influenced by cell membrane potential. We first evaluated intracellular accumulation of ADR and 3,3'-(di-n-hexyl)-2,2'-oxacarbocyanine iodide (NK-2280), an indicator of cell membrane potential, and found a good correlation between ADR and NK-2280 i...

journal_title：Anticancer research

authors： Asaumi JI,Kawasaki S,Gao XS,Kuroda M,Hiraki Y

更新日期：1996-03-01 00:00:00