Abstract：
:Studies on taurine transport in MDR (multidrug resistant) and non-MDR KB cancer cells show that both cell types contain Na(+)- and Cl(-)-dependent high-affinity and low-affinity transport systems selective for beta-amino acids and a taurine diffusion component. Good buffers, such as HEPES or MOPS, interfered with taurine uptake. The basal taurine Vmax measured in isoosmotic medium represented 1/5 of taurine captured by uptake in KB non-MDR, but was negligible in KB MDR cells. High-and low- affinity uptake systems were reduced by medium hyperosmolarity in both cell types. Although properties of low-and high-affinity transport systems were similar in both cell types, Vmax (but not Km) were reduced in MDR compared to non-MDR cells. Taurine uptake was unaffected by chemotherapeutic agents (doxorubicin, vinblastine) or MDR revertants (verapamil). Taurine did not affect cell proliferation of MDR or non-MDR cells nor did it alter the inhibitory effect of doxorubicin or vinblastine cell proliferation.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Wersinger C,Rebel G,Lelong-Rebel IHsubject
Has Abstractpub_date
2001-09-01 00:00:00pages
3397-406issue
5eissn
0250-7005issn
1791-7530journal_volume
21pub_type
杂志文章abstract：:Major drawbacks to present-day cancer chemotherapy are its intrinsic lack of selectivity for tumour cells, resulting in severe damage to normal rapidly dividing cells, and the widespread emergence of drug resistance. Here experimental evidence is presented demonstrating that PB-100, a beta-carboline alkaloid, selectiv...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2011-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1997-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
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journal_title：Anticancer research
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更新日期：2005-11-01 00:00:00
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journal_title：Anticancer research
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
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journal_title：Anticancer research
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更新日期：2015-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
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更新日期：2013-12-01 00:00:00
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更新日期：1990-01-01 00:00:00
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journal_title：Anticancer research
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更新日期：2013-03-01 00:00:00
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更新日期：2009-07-01 00:00:00
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