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Decreased Expression of SATB2 Associates with Tumor Growth and Predicts Worse Outcome in Patients with Clear Cell Renal Cell Carcinoma.

Abstract：

BACKGROUND/AIM:SATB2 (special AT-rich sequence-binding protein 2) is a DNA-binding protein that is involved in transcriptional regulation and chromatin remodeling. SATB2 protein has been described as a promising novel marker in several human cancers. PATIENTS AND METHODS:This study compared SATB2 expression in tumor and matched unchanged renal tissues collected from 57 patients with clear cell renal cell carcinoma (ccRCC). SATB2 mRNA levels were determined by quantitative polymerase chain reaction, while SATB2 protein expression was estimated by immunohistochemistry. Moreover, the associations between SATB2 expression in ccRCC samples and clinicopathological and survival data of the patients were investigated. RESULTS:The mRNA level of SATB2 was lower in tumor tissues than in samples of corresponding unchanged kidney. Although the average immunoreactivity of SATB2 protein did not differ significantly between cancer cells and epithelial cells of proximal convoluted tubules, the decreased SATB2 expression in tumor specimens inversely correlated with the size of primary tumor and predicted worse patients' outcome. CONCLUSION:The results of the presented study suggest the tumor-suppressing function of SATB2 and that the expression level of this protein can be considered a potential prognostic factor in ccRCC.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Sliwinska-Jewsiewicka A,Kowalczyk AE,Krazinski BE,Godlewski J,Kwiatkowski P,Kiewisz J,Grzegrzolka J,Dziegiel P,Kmiec Z

doi

10.21873/anticanres.12292

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

839-846

issue

2

eissn

0250-7005

issn

1791-7530

pii

38/2/839

journal_volume

38

pub_type

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