3'-Deoxy-3'-[18F]fluorothymidine positron emission tomography imaging of thymidine kinase 1 activity after 5-fluorouracil treatment in a mouse tumor model.

abstract：BACKGROUND:Chronic lymphocytic leukemia (CLL) is characterized by a clonal accumulation of neoplastic lymphocytes, indicating disruption of apoptosis. PATIENTS AND METHODS:Differential methylation hybridization analysis was performed to identify novel target genes silenced by CpG island methylation in patients with CL...

journal_title：Anticancer research

authors： Schmidt-Wolf IG,Plass C,Byrd JC,Frevel K,Pietsch T,Waha A

更新日期：2016-09-01 00:00:00

abstract：:The expression of epidermal growth factor (EGF) and its receptor (EGF-R) was examined immunohistochemically in 60 primary and 26 metastatic lesions of pancreatic carcinoma. EGF was stained mainly in the cytoplasm of tumor cells, and EGF-R was stained mainly on the surface of cells. The expression rates of EGF and EGF-...

journal_title：Anticancer research

authors： Uegaki K,Nio Y,Inoue Y,Minari Y,Sato Y,Song MM,Dong M,Tamura K

更新日期：1997-09-01 00:00:00

abstract：:CA 72-4 is a high molecular weight, pancarcinoma human tumor mucin which may play an important role in the identification (i.e., staging) and clinical management of patients with gastric carcinoma. In the present study of 242 patients with primary or recurrent gastric cancer, a higher percentage of these patients had ...

journal_title：Anticancer research

authors： Spila A,Roselli M,Cosimelli M,Ferroni P,Cavaliere F,Arcuri R,Tedesco M,Carlini S,D'Alessandro R,Perri P,Casciani CU,Greiner JW,Schlom J,Guadagni F

更新日期：1996-07-01 00:00:00

abstract：:SQM1, a membrane protein associated with methotrexate (MTX) transport was incorporated into unilamellar vesicles, forming. SQM1-Liposome. Human squamous carcinoma of the head and neck (SqCHN) cells resistant to MTX with defective MTX transport and low SQM1 expression were treated with SQM1-Liposome. SQM1 content was f...

journal_title：Anticancer research

authors： Wong YC,Bernal SD

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIM:The deacetylase sirtuin1 (SIRT1) inhibits tumor suppressor p53 and may promote tumorigenesis; however, SIRT1 effects on leukemia cells are controversial. The aim of this study was to clarify the activity of SIRT1 in leukemia cells. MATERIALS AND METHODS:The effects of SIRT1 inhibition or activation and ...

journal_title：Anticancer research

authors： Okasha SM,Itoh M,Tohda S

更新日期：2020-06-01 00:00:00

abstract：AIM:To assess the correlation between advanced non-small cell lung cancer (NSCLC) with or without pulmonary lymphangitic carcinomatosis (PLC) and fluorodeoxyglucose (FDG) uptake and its effect on survival outcomes. PATIENTS AND METHODS:We retrospectively reviewed 157 patients with NSCLC. The mean and maximum standardi...

journal_title：Anticancer research

authors： Ooi H,Chen CY,Hsiao YC,Huang WS,Hsieh BT

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND/AIM:KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expre...

journal_title：Anticancer research

authors： Lundberg IV,Wikberg ML,Ljuslinder I,Li X,Myte R,Zingmark C,Löfgren-Burström A,Edin S,Palmqvist R

更新日期：2018-02-01 00:00:00

abstract：:The present study assessed the immunohistochemical expression of ras p21 oncoprotein in 41 cases of benign and cancerous lesions of the prostate gland and correlated p21 expression with survival of patients operated for prostate cancer. Our results show that p21 is detected in both categories of patients, the expressi...

journal_title：Anticancer research

authors： Agnantis NJ,Constantinidou AE,Papaevagelou M,Apostolikas N

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIM:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) plays an important role in the adhesion, invasion, and metastasis of tumor cells. Although emerging evidence suggests that IMP3 promotes tumor progression in several malignancies, the expression of IMP3 and its prognostic implication in adenocar...

journal_title：Anticancer research

authors： Kim HG,Park MS,Sung JY,Kim YW,Kim HS,Na K

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the efficacy of anticoagulant fondaparinux postoperatively for preventing recurrence after curative resection of colorectal cancer with lymphnode metastasis. PATIENTS AND METHODS:The records of 279 patients who underwent curative resection of colorectal cancer with l...

journal_title：Anticancer research

authors： Yamaoka Y,Ikeda M,Ikenaga M,Murakami H,Haraguchi N,Miyake M,Yamamoto K,Asaoka T,Nishikawa K,Miyamoto A,Miyazaki M,Hirao M,Nakamori S,Sekimoto M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIM:Vimentin3 (Vim3) was recently described as a tumour marker for the direct discrimination between benign and malignant kidney tumours. Here, we examined its expression in prostate cancer (PCa) cell lines and the regulation of its expression by endothelin receptors. MATERIALS AND METHODS:Prostate cancer c...

journal_title：Anticancer research

authors： KÖditz B,Stog A,GÖbel H,Heidegger I,Fries J,Heidenreich A,VON Brandenstein M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND/AIM:To assess prognosis of women aged 75 and older according to breast cancer (BC) diagnosis circumstances. PATIENTS AND METHODS:A retrospective cohort study was conducted in the Amiens, France, regional oncologic referral center between 2005 and 2015. Two groups were formed depending on whether the patient...

journal_title：Anticancer research

authors： Ilenko A,Sergent F,Mercuzot A,Zitoun M,Chauffert B,Foulon A,Gondry J,Chevreau J

更新日期：2017-02-01 00:00:00

abstract：:Receptors for peanut agglutinin (PNA) were isolated from Lewis lung carcinoma cells (3LL) by detergent solubilization and affinity chromatography on PNA-agarose. The isolated receptors showed heterogeneous yet distinct molecular species when they were analyzed by SDS gel electrophoresis. In vivo inoculation of the iso...

journal_title：Anticancer research

authors： Adachi M,Mizuta T,Yokota M,Shibusawa H,Yamamura M,Hamada Y,Uetsuji S,Yamamoto M,Miwa H

更新日期：1984-01-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the detection rate of bone metastases and the added value of 11C-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC). MATERIALS AND METHODS:A total of 66 untreated patients with high-risk ...

journal_title：Anticancer research

authors： Strandberg S,Karlsson CT,Ogren M,Axelsson J,Riklund K

更新日期：2016-12-01 00:00:00

abstract：:African-American women with breast cancer consistently show a shortened survival when compared with Caucasians with breast cancer, however it is not clear whether this is due to socioeconomic factors or to racial differences in tumor biology. Cyclin D1 overexpression has been demonstrated in 60-80% of female breast ca...

journal_title：Anticancer research

authors： Joe AK,Arber N,Bose S,Heitjan D,Zhang Y,Weinstein IB,Hibshoosh H

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Recent data indicate the implication of an IGF/IGFBP/protease system in the development of ectopic implants of endometrium (endometriosis) in the pelvic cavity. MATERIAL AND METHODS:We characterized mitogens and protease(s) against IGFBP-3 in the peritoneal fluid of women with or without endometriosis using...

journal_title：Anticancer research

authors： Koutsilieris M,Lavergne E,Lemay A

更新日期：1997-03-01 00:00:00

abstract：:Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly...

journal_title：Anticancer research

authors： Desoize B

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:Kallikrein-related peptidases (KLKs) comprise a serine protease family with prominent roles in tissue physiology and disease pathogenesis, including cancer. Previously, we have characterized canine Klk4-10 and -14. Herein, we continue our efforts by characterizing three novel members of the canine family...

journal_title：Anticancer research

authors： Angelopoulou K,Karagiannis GS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:There is no clear evidence in the literature regarding the regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 expression was regulated by COX2 activity was examined in vitro. MATERIALS AND METHODS:Resected lung cancer specimens were ...

journal_title：Anticancer research

authors： Shimizu K,Okita R,Saisho S,Maeda AI,Nojima Y,Nakata M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Positron emission tomography-computed tomography (PET-CT) is currently not established in the management of recurrent ovarian cancer. Here, its value in diagnosis and therapy planning was evaluated. PATIENTS AND METHODS:Seventy patients received PET-CT for suspicion of recurrent ovarian cancer. PET-CT and s...

journal_title：Anticancer research

authors： Lenhard MS,Burges A,Johnson TR,Stieber P,Kümper C,Ditsch N,Linke R,Friese K

更新日期：2008-07-01 00:00:00

abstract：:Growth inhibitory activity of YM881 (SMANCS) against 3 human cultured cell lines and one rat cultured cell line derived from glioma cells was assessed quantitatively. YM881 showed potent cytotoxicity against all glioma cell lines tested; the IC50 of this drug was 1.9-8.4 micrograms/ml. YM881 may be classified as a con...

journal_title：Anticancer research

authors： Kuratsu J,Takaki S,Kochi M,Mihara Y,Ushio Y

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND/AIM:Since androgens affect urothelial bladder cancer (UBC), we examined whether 5α-reductases (5-AR) have genomic alterations in UBC and whether 5α-reductase inhibitors (5-ARI) affect UBC. MATERIALS AND METHODS:The cBioPortal was used to analyze genomic alternations of 5-ARs in UBC cancer genomic datasets. ...

journal_title：Anticancer research

authors： Chen CC,Huang CP,Tsai YT,Hseih TF,Shyr CR

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors previously exposed to platinum compounds and paclitaxel has not yet been defined. The present phase II study evaluated the activity and toxicity of a paclitaxel-ifosfamide-cisplatin combination in the afore...

journal_title：Anticancer research

authors： Polyzos A,Kosmas C,Tsavaris N,Toufexi H,Lagadas A,Gogas H,Giannakopoulos K,Kouraklis G,Griniatsos J,Felekouras E,Tsigris C,Nikiteas N,Papadopoulos O,Giannopoulos A

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND/AIM:Fluorescence-guided surgery (FGS) of cancer is an emerging technology. We have previously shown the importance of resecting both the tumor and the tumor microenvironment (TME) for curative FGS. We also previously developed a syngeneic model using the mouse lymphoma cell line EL-4, expressing red fluoresc...

journal_title：Anticancer research

authors： Hasegawa K,Suetsugu A,Nakamura M,Matsumoto T,Kunisada T,Shimizu M,Saji S,Moriwaki H,Bouvet M,Hoffman RM

更新日期：2016-09-01 00:00:00

abstract：:Surgery remains the mainstay of treatment for breast cancer, including complete or partial mastectomy and lumpectomy. Breast reconstruction has gained popularity mainly due to its tremendous impact on the psychological status of the patients. Autologous fat grafting is a well-established method used in cosmetic surger...

journal_title：Anticancer research

authors： Spartalis E,Tsilimigras DI,Charalampoudis P,Karachaliou GS,Moris D,Athanasiou A,Spartalis M,Bolkas V,Dimitroulis D,Nikiteas N

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:We examined the anti-tumor effect of 5-S-GAD, a novel potent inhibitor of protein tyrosine kinases, isolated from the flesh fly in order to investigate the potential use of this compound as an anti-tumor agent. METHODS:In vitro growth inhibition was evaluated using the alamarBlue assay kit. In vivo anti-tumor ...

journal_title：Anticancer research

authors： Akiyama N,Hijikata M,Kobayashi A,Yamori T,Tsuruo T,Natori S

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) directed against epidermal growth factor receptor (EGFR) are important in the treatment of non-small cell lung cancer (NSCLC), especially those harboring EGFR mutations. But little is known regarding the clinical value of serum tumor marker levels measured prior to treatment...

journal_title：Anticancer research

authors： Takeuchi A,Oguri T,Sone K,Ito K,Kitamura Y,Inoue Y,Asano T,Fukuda S,Kanemitsu Y,Takakuwa O,Ohkubo H,Takemura M,Maeno K,Ito Y,Niimi A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Solar ultraviolet-B (UVB) and vitamin D have been found inversely correlated with cancer incidence, mortality, and survival rates in many studies. MATERIALS AND METHODS:In this work, two sets of cancer data were used: age-adjusted cancer incidence and mortality rates in 2002 for 21 Western developed countri...

journal_title：Anticancer research

authors： Grant WB

更新日期：2006-07-01 00:00:00

abstract：UNLABELLED:The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer. MATERIALS AND METHODS:The immunohistological e...

journal_title：Anticancer research

authors： Havelund BM,Sørensen FB,Lindebjerg J,Spindler KL,Jakobsen A

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor (PD-ECCF) and has a function of angiogenesis in vitro and in several types of human carcinoma tissues. We have reported that expression of dThdPase was an independent prognostic factor in 116 gastric carcinomas...

journal_title：Anticancer research

authors： Konno S,Takebayashi Y,Higashimoto M,Katsube T,Kanzaki A,Kawahara M,Takenoshita S,Aiba M,Ogawa K

更新日期：2003-11-01 00:00:00