Comparative immunohistochemical study of ras-p21 oncoprotein in adenomatous hyperplasia and adenocarcinoma of the prostate gland.

abstract：BACKGROUND/AIM:Biosimilar agents are biologic products that have no clinically meaningful differences in terms of quality, efficacy, safety and immunogenicity compared to an already approved reference biological product, with the potential to reduce the costs of biologics. Considering the increasing numbers of oncology...

journal_title：Anticancer research

authors： Giuliani J,Bonetti A

更新日期：2019-07-01 00:00:00

abstract：:P44 Ro (Mel) is a human malignant melanoma cell line derived from a testicular metastasis in a DNA repair deficient, xeroderma pigmentosum patient. This line harbors a N-ras gene mutated in codon 61. To investigate other cellular genes possibly contributing to the expression of its transformed phenotype, four XP44 rev...

journal_title：Anticancer research

authors： Lafarge-Frayssinet C,Daya-Grosjean L,Estrade S,Frezouls G,Sarasin A,Cassingena R

更新日期：1995-07-01 00:00:00

abstract：:In screening cytotoxic agents in morphine alkaloids [TE1-10], codeinone [TE8] was cytotoxic against two human oral tumor cells lines (HSC-2 and HSG). The cytotoxic activity of codeinone (CC50=1.0-1.2 microg/mL) against HSC-2 or HSG cells was higher than that of doxorubicin (CC50=1.9-2.0 microg/mL). Human oral gingival...

journal_title：Anticancer research

authors： Kawase M,Sakagami H,Furuya K,Kikuchi H,Nishikawa H,Motohashi N,Morimoto Y,Varga A,Molnár J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Lenalidomide is an immunomodulatory drug frequently used for treatment of patients with multiple myeloma and myelodysplastic syndromes. This report presents a rare case of lenalidomide-associated hepatotoxicity and reviews the available literature. CASE REPORT:A 67-year-old male with multiple myeloma was ho...

journal_title：Anticancer research

authors： Nojkov B,Signori C,Konda A,Fontana RJ

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Endostar is a novel recombinant human endostatin expressed and purified in Escherichia coli with the N-terminal modified. It has been shown that endostar inhibited the proliferation of human umbilical vein endothelial cells (HUVECs) through the membrane surface receptor KDR/flt-1(VEGFR-2, vascular endothelia...

journal_title：Anticancer research

authors： Ling Y,Lu N,Gao Y,Chen Y,Wang S,Yang Y,Guo Q

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND AIMS:We examined the prognostic value of pre-treatment C-reactive protein (CRP) after surgical resection (SR) for hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 298 patients with HCC who underwent SR were analyzed. They were categorized into a CRP-positive group (group A: CRP >0.2 mg/dl...

journal_title：Anticancer research

authors： Nishikawa H,Arimoto A,Wakasa T,Kita R,Kimura T,Osaki Y

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND/AIM:The expression of corticotropin-releasing hormone (CRH)-related peptides involved in stress response in colorectal cancer has been reported. We examined the involvement of CRH-related peptides in cellular stress caused by anticancer drugs in colorectal cancer. MATERIALS AND METHODS:Changes in the expres...

journal_title：Anticancer research

authors： Kuwata GO,Ikeda K,Manome Y

更新日期：2020-08-01 00:00:00

abstract：:Oxazolinodoxorubicin, a doxorubicin analog with a modified daunosamine moiety was synthesized. The properties of this compound and the parent doxorubicin were compared. The cytotoxicity in vitro studies against several human tumor cell lines (PC-3, MCF-7, SW707, HL-60, RPMI 8226, ACHN) showed higher antiproliferative ...

journal_title：Anticancer research

authors： Lukawska M,Klopotowska D,Milczarek M,Wietrzyk J,Studzian K,Szmigiero L,Porebska A,Oszczapowicz I

更新日期：2012-07-01 00:00:00

abstract：:A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-...

journal_title：Anticancer research

authors： Lin WH,Song JS,Lien TW,Chang CY,Wu SH,Huang YW,Chang TY,Fang MY,Yen KJ,Chen CH,Chu CY,Hsieh HP,Chen YR,Chao YS,Hsu JT

更新日期：2012-01-01 00:00:00

abstract：:Pro- and anti-apoptotic factors and intracellular signaling pathways are targets for therapeutic development of anticancer agents. Carboxyamido-triazole (CAI) is an inhibitor of transmembrane calcium influx and intracellular calcium-requiring signal transduction pathways. The present study investigates the effects of ...

journal_title：Anticancer research

authors： Perabo FG,Wirger A,Kamp S,Lindner H,Schmidt DH,Müller SC,Kohn EC

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to evaluate the impact of laparoscopic gastrectomy (LG) for gastric cancer on long-term survival in patients with postoperative infectious complications (PIC). PATIENTS AND METHODS:A total of 608 patients who underwent gastrectomy were classified into two groups based on the su...

journal_title：Anticancer research

authors： Nagata H,Tsujimoto H,Kouzu K,Itazaki Y,Ishibashi Y,Tsuchiya S,Sugihara T,Ito N,Harada M,Nomura S,Kishi Y,Ueno H

更新日期：2020-12-01 00:00:00

abstract：:The insufficient interobserver reproducibility limits the practical use of histomorphological tumor grading in daily routine pathology. In this study, the reasons for the quite low rates of agreement between different observers have been investigated by the application of a factor analytical technique, i.e. principal ...

journal_title：Anticancer research

authors： Sun DQ,Feng CH,Böcking A,Biesterfeld S

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance. Regulatory T-cells (Tregs) influence CSCs through several mechanisms. In different solid tumours, the presence of both cell populations correlated with poor survival. In vulvar cancer, little is know...

journal_title：Anticancer research

authors： Napoletano C,Bellati F,Ruscito I,Pernice M,Zizzari IG,Caponnetto S,Tomao F,Frigerio L,Liberati M,Rughetti A,Caserta D,Panici PB,Nuti M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:For eradicating portal venous tumor extension and intrahepatic metastasis in hepatocellular carcinoma (HCC), anatomical resection is, in theory, preferable. PATIENTS AND METHODS:We carried-out a retrospective cohort study in 110 patients who underwent curative hepatic resection (anatomical resection; n=20, ...

journal_title：Anticancer research

authors： Yamashita Y,Imai D,Bekki Y,Takeishi K,Tsujita E,Ikegami T,Yoshizumi T,Ikeda T,Shirabe K,Ishida T,Maehara Y

更新日期：2014-08-01 00:00:00

abstract：:Details of 197 colorectal carcinomas from 180 patients were retrieved from our files, with the aim of analyzing the clinical histories and pathological parameters of all patients up to 40 years, and to support these data with the results of the DNA content analysis of tumoral cells by static cytometry. The incidence o...

journal_title：Anticancer research

authors： Caruso ML,Rizzi E

更新日期：1998-05-01 00:00:00

abstract：:Keratinocytes originating from adult human hair follicles, the most convenient biopsy tissue, can be serially cultured using a combination of two techniques. Primary cultures are established using plucked scalp hair follicles and the bovine eye lens capsule as a growth substrate. Subsequently, cells from these culture...

journal_title：Anticancer research

authors： Weterings PJ,Roelofs HM,Jansen BA,Vermorken AJ

更新日期：1983-05-01 00:00:00

abstract：:Important strategies against cancer are based on the understanding of the mechanisms of tumor progression. To elucidate alterations regarding tumor progression, we have performed proteomic differential display analysis for the expression of intracellular proteins in the regressive murine fibrosarcoma cell clone QR-32 ...

journal_title：Anticancer research

authors： Takenawa T,Kuramitsu Y,Wang Y,Okada F,Tokuda K,Kitagawa T,Ueyama Y,Nakamura K

更新日期：2013-01-01 00:00:00

abstract：:Eight patients with metastatic hypernephroma were treated with constant infusion recombinant Interleukin-2 (rIL-2), changes in renal and hepatic function and protein levels were monitored during 2 cycles of treatment. The rIL-2 infusion caused a reversible fall in ures and a non-reversible rise in creatinine. Liver fu...

journal_title：Anticancer research

authors： Ubhi SS,Horsburgh T,Veitch PS,Bell PR

更新日期：1991-11-01 00:00:00

abstract：:Elevated levels of hypoxia inducible factor-1 (HIF1) are linked to tumor metastasis, angiogenesis, poor patient prognosis and response to chemotherapy. HIF1α is a master regulator of the hypoxic response, including in cancer cells, through transcriptional activation of several target genes. Previously, we identified c...

journal_title：Anticancer research

authors： Masoud GN,Wang J,Chen J,Miller D,Li W

更新日期：2015-07-01 00:00:00

abstract：:This review presents the clinical pharmacokinetics of the marketed therapeutic monoclonal antibodies used in oncology. Aspects regarding absorption, tissue distribution, elimination as well as factors influencing pharmacokinetics, pharmacodynamics and kinetic interactions are also discussed. ...

journal_title：Anticancer research

authors： Levêque D,Wisniewski S,Jehl F

更新日期：2005-05-01 00:00:00

abstract：:Development of multidrug-resistance (MDR) remains a major cause of failure in the treatment of cancer with chemotherapeutic agents. In our efforts to explore alternative treatment regimens for multidrug-resistant tumors we have examined the sensitivity of MDR tumor cell lines to lymphokine activated killer (LAK) cells...

journal_title：Anticancer research

authors： Gautam SC,Chikkala NF,Lewis I,Grabowski DR,Finke JH,Ganapathi R

更新日期：1992-05-01 00:00:00

abstract：:The growth inhibitory effect of trimetrexate (TMQ) is maintained in MCF-7 breast cancer but is decreased in Hs 824.T human bone marrow cells by a priming- and non-toxic 5-fluorouracil (5-FU) dose. Incubation of MCF-7 breast cells with 10 microM TMQ alone or in combination with 10 M 5-FU (TMQ 2 h prior to 5-FU [TMQ/5-F...

journal_title：Anticancer research

authors： Bowen D,Johnson DH,Southerland WM,Hughes DE,Hawkins M Jr

更新日期：1999-09-01 00:00:00

abstract：:The emergence of molecular and cytogenetic correlates has opened exciting avenues to a better understanding of acute lymphocytic leukemia (ALL) and in turn has sharpened the clinician's ability for classification and treatment. While the pathophysiology and etiology of ALL remains vague, the clinical significance of t...

journal_title：Anticancer research

authors： Botti AC,Verma RS

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND/AIM:Despite an expected prognostic disadvantage for upper tract versus lower tract metastatic urothelial carcinomas (UTUC/LTUC), only few studies have been conducted to elucidate potential differences in chemotherapy treatment. PATIENTS AND METHODS:A post-hoc subgroup analysis of a non-interventional study ...

journal_title：Anticancer research

authors： Heers H,DE Geeter P,Goebell PJ,Matz U,DE Schultz W,Edlich B,Retz M,Hegele A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Whether high energy shock waves (HESW), generated by a piezoelectric generator, were able to activate a sonosensitizer, 5-aminolevulinic acid (ALA) and induce inhibition of cell growth in HT-29 human colorectal cancer cells was investigated. MATERIALS AND METHODS:Cell survival and cell death pathways were i...

journal_title：Anticancer research

authors： Canaparo R,Serpe L,Catalano MG,Bosco O,Zara GP,Berta L,Frairia R

更新日期：2006-09-01 00:00:00

abstract：:This review aims to provide insight into treatment of malignant pleural mesothelioma (MPM) considering effects on survival, quality of life (QoL) and costs, in order to determine the value of pemetrexed in MPM treatment. Cisplatin in combination with pemetrexed or raltitrexed increased survival in MPM, whereas vinorel...

journal_title：Anticancer research

authors： Boons CC,VAN Tulder MW,Burgers JA,Beckeringh JJ,Wagner C,Hugtenburg JG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Gold(I) and platinum(II) d(10) and d(8) electronic complexes such as (Au(PPh(2)CH(2)CH(2)PPh(2))(2))Cl and cisplatin, ((H(3)N)(2)PtCl(2)), possess strong antineoplastic activities. Almost no information is available regarding the anticancer activity of isoelectronic silver(I) d(10) complexes. This study exam...

journal_title：Anticancer research

authors： Fourie E,Erasmus E,Swarts JC,Tuchscherer A,Jakob A,Lang H,Joone GK,Van Rensburg CE

更新日期：2012-02-01 00:00:00

abstract：AIM:To evaluate the role of radiotherapy alone or combined with chemotherapy in the treatment of recurrent vulvar cancer, emphasising the prognostic factors and outcomes. MATERIALS AND METHODS:Twenty women with loco-regional recurrence of vulvar carcinoma were retrospectively reviewed. Eleven patients were managed wit...

journal_title：Anticancer research

authors： Raffetto N,Tombolini V,Santarelli M,Valeriani M,Galla DA,Enrici RM

更新日期：2003-05-01 00:00:00

abstract：:We report a case of renal cell carcinoma with solitary metachronous metastasis to contralateral adrenal gland occurring 9 months after radical nephrectomy. The patient was treated with a contralateral adrenalectomy and is alive for 87 months. The literature was reviewed and 5-year survival of solitary metachronous met...

journal_title：Anticancer research

authors： Yamasaki Y,Koga S,Nishikido M,Noguchi M,Kanetake H,Saito Y

更新日期：1999-11-01 00:00:00

abstract：:Ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (Cys-186 in mammalian Ras p21 proteins) in order to extend their biological activity. Previous studies have indicate an intermediate in the mevalonate pathway, most likely farnesyl pyrophosphate, is the donor of this isopreny...

journal_title：Anticancer research

authors： Chen X,Hasuma T,Yano Y,Yoshimata T,Morishima Y,Wang Y,Otani S

更新日期：1997-07-01 00:00:00