High energy shock waves (HESW) for sonodynamic therapy: effects on HT-29 human colon cancer cells.

Abstract:

BACKGROUND:Whether high energy shock waves (HESW), generated by a piezoelectric generator, were able to activate a sonosensitizer, 5-aminolevulinic acid (ALA) and induce inhibition of cell growth in HT-29 human colorectal cancer cells was investigated. MATERIALS AND METHODS:Cell survival and cell death pathways were investigated by cell growth curves, flow cytometry analysis and ELISA nucleosome evaluation. HT-29 cells were exposed to ALA and different HESW treatments: E1 (energy flux density = 0.22 mJ/mm2; 500 and 1000 shots) and E2 (energy flux density = 0.88 mJ/mm2; 500 and 1000 shots). RESULTS:A significant reduction of HT-29 cell growth with respect to untreated cells was observed only after treatment with ALA and HESW E2, 500 shots. In particular, HESWE2, 500 shots, was able to induce an arrest of HT-29 cells exposed to ALA in the G0/G1-phase of the cell cycle. CONCLUSION:HESW is proposed for the sonodynamic treatment of cancer cells.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Canaparo R,Serpe L,Catalano MG,Bosco O,Zara GP,Berta L,Frairia R

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

3337-42

issue

5A

eissn

0250-7005

issn

1791-7530

journal_volume

26

pub_type

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