Pharmacokinetics of therapeutic monoclonal antibodies used in oncology.

abstract：AIM:This retrospective observational study evaluated the role of hypo-fractionated stereotactic radiotherapy (SRT) in patients with oligo-progressive metastatic renal cell carcinoma (mRCC) treated with first-line oral tyrosine kinase inhibitors (TKI). Data on local control, delay of further progression, and safety are ...

journal_title：Anticancer research

authors： Gebbia V,Girlando A,DI Grazia A,Fazio I,Borsellino N,Piazza D,Serretta V,Pergolizzi S,Pontoriero A,Firenze A,Valerio MR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The concentration of Des-gamma-carboxy-prothrombin (DCP) or PIVKA-II has been described to be increased in patients with hepatocellular cancer, along with its elevation in vitamin K deficient states by warfarin or dicoumarol treatment. The aim of the study was to investigate its clinical value in HCC in comp...

journal_title：Anticancer research

authors： Lamerz R,Runge M,Stieber P,Meissner E

更新日期：1999-07-01 00:00:00

abstract：:A human metastatic meningiosarcoma has been established as a cell line as follows: At autopsy performed 12 hours after death, tumour nodules from the left parietal pleura were obtained under sterile conditions, minced and inoculated into culture vessels. The cells obtained were cloned, and clones with abnormal chromos...

journal_title：Anticancer research

authors： Korsgaard R,Clausen OP,Thorud E

更新日期：1984-01-01 00:00:00

abstract：AIM:To evaluate the efficacy of prophylactic radiotherapy at intervention sites in patients with malignant pleural mesothelioma (MPM). PATIENTS AND METHODS:From 05/2010 to 12/2014, 53 patients with histologically confirmed MPM were treated in order to prevent interventional site metastases. Irradiation was carried out...

journal_title：Anticancer research

authors： Janssen S,Schönhofer B,Rades D

更新日期：2015-07-01 00:00:00

abstract：:The local growth and metastatic potential of colorectal cancer is the outcome of a dynamic balance between cancer cells and the immune system, at both a local and systemic level, summarized as the "seed and soil" hypothesis. Until recently, the staging and treatment approaches for colorectal cancer appeared to be orie...

journal_title：Anticancer research

authors： Seretis F,Seretis C,Youssef H,Chapman M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS:PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes w...

journal_title：Anticancer research

authors： DA Silva Manoel-Caetano F,Silveira AF,Silva AE

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) is a multifactorial neoplasm related to tobacco smoke, alcohol consumption and molecular genetic changes such as p53 mutations. The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid cod...

journal_title：Anticancer research

authors： Drummond SN,De Marco L,Pordeus Ide A,Barbosa AA,Gomez RS

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIM:Surgical resection for esophageal cancer has remained the gold-standard therapy provided worldwide. Subcarinal lymph-nodes are classified as peri-esophageal nodes and their dissection may be performed during a 2- or 3-stage esophagectomy. The necessity and prognostic value of subcarinal lymphadenectomy i...

journal_title：Anticancer research

authors： Sdralis EK,Davakis S,Syllaios A,Lorenzi B,Kordzadeh A,Athanasiou A,Petousis S,Liakakos T,Charalabopoulos A

更新日期：2019-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a deadly malignant disease with extremely poor prognosis. Many therapeutic modalities have been proposed, but considerable uncertainty still remains about their effectiveness. Inositol hexaphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has novel anti-cancer fu...

journal_title：Anticancer research

authors： Vucenik I,Zhang ZS,Shamsuddin AM

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:It is well-known that inflammatory bowel disease (IBD) poses an increased, yet not definitely estimated, risk of colitis-associated colon cancer (CAC), which is considered a more aggressive and distinct in both genetic and molecular levels clinical entity compared to sporadic colorectal cancer (CRC). The...

journal_title：Anticancer research

authors： Antoniou E,Margonis GA,Angelou A,Zografos GC,Pikoulis E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a disinfection by-product in chlorinated drinking water, induces follicular tumors in thyroid glands in Wistar rats. The mechanisms of the MX-induced thyroid gland tumorigenesis are not known. MATERIALS AND METHODS:The expressions of p53 (primary an...

journal_title：Anticancer research

authors： Hakulinen P,Kosma VM,Komulainen H

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Despite more than four decades of fluoro-pyrimidine treatment in different cancers, the optimal schedule is still not known. The plasma half-life of 5-fluorouracil (5-FU) is extremely short and continuous infusion has gained popularity. In this study we explored whether repeated bolus 5-FU injections could impr...

journal_title：Anticancer research

authors： Berglund A,Carlsson G,Gustavsson B,Frödin JE,Ragnhammar P,Glimelius B

更新日期：2003-03-01 00:00:00

abstract：AIM:We report on a rare case of appendiceal primary neuroendocrine carcinoma (NEC) and discuss three cases previously described. CASE REPORT:A 58-year-old woman presented with acute abdominal pain and a low-grade fever. She was diagnosed with acute appendicitis and underwent laparoscopic appendectomy. Pathological exa...

journal_title：Anticancer research

authors： Tomioka K,Fukoe Y,Lee Y,Lee M,Wada Y,Aoki T,Murakami M

更新日期：2013-06-01 00:00:00

abstract：:Neurological complications of both fluorouracil (5-FU) and its oral prodrug, capecitabine, have been described in the literature. This study reported the case of a 70-year-old female with metastatic adenocarcinoid of the rectum who developed hyperammonemic encephalopathy, following infusional 5-FU therapy, manifesting...

journal_title：Anticancer research

authors： Advani PP,Fakih MG

更新日期：2011-01-01 00:00:00

abstract：:The influence of several oncogenes on drug resistance has recently been show by transfection studies. Therefore, we investigated the influence of transfection on adriamycin (ADR) in cell line transfected with several oncogenes accompanied with pSV2neo vector. There were differences in both the intracellular accumulati...

journal_title：Anticancer research

authors： Gaoi XS,Asaumi J,Kawasaki S,Nishikawa K,Kuroda M,Li H,Takeda Y,Hiraki Y,Ihara M,Ohnishi T

更新日期：1995-09-01 00:00:00

abstract：:Polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis of the p53 tumor suppressor gene (from exon 2 to 9) was performed on samples from 47 adult patients with primary myelodysplastic syndrome (MDS). Point mutation was found in 5 (11%) patients: exon 7 in 3, exon 4 in 1 and intron 5 ...

journal_title：Anticancer research

authors： Tang JL,Tien HF,Lin MT,Chen PJ,Chen YC

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:TNF-alpha is one of the key inflammatory cytokines and it modulates various events through several pathways. U937 myelomonocytic leukemia cells are sensitive to TNF-alpha and about 20% of these cells undergo apoptosis within 6 hours after treatment. Co-treatment of these cells with actinomycin D or cyclohexi...

journal_title：Anticancer research

authors： Nakada S,Kawano T,Saito-akita S,Iwase S,Horiguchi-Yamada J,Ohno T,Yamada H

更新日期：2001-01-01 00:00:00

abstract：AIM:To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. PATIENTS AND METHODS:This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Par...

journal_title：Anticancer research

authors： Moschos MM,Moustafa GA,Lavaris A,Damaskos C,Laios K,Karathanou E,Ladas DS,Asproudis I,Garmpis N,Kalogeropoulos C

更新日期：2018-05-01 00:00:00

abstract：:We have established a hepatocarcinoma cell line (LFCl2A) that produces voluminous tumors when injected into syngeneic Commentary rats. We have previously shown that when these cells were transfected with an episomal vector expressing the antisense IGFI cDNA the transduced cells partly lost their tumorigenic properties...

journal_title：Anticancer research

authors： Lafarge-Frayssinet C,Martin C,Van Binh PN,Achard-Ellouk S,Duc HT,Frayssinet C,Cardoso G,Desauty G,Warnet JM,Bréchot C,Sarasin A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Primary prostate carcinoma cells constitutively secrete interleukin-6 (IL-6), and high levels of IL-6 receptor are detected in prostate carcinoma tissues. These findings have implicated IL-6 in the growth and differentiation of prostate carcinomas. Herein, we examined the regulation of IL-6 receptor complex ...

journal_title：Anticancer research

authors： Mori S,Murakami-Mori K,Bonavida B

更新日期：1998-11-01 00:00:00

abstract：:Inv(3)(q21q26)/t(3;3)(q21;q26) is a feature of a distinctive entity of acute myeloid leukemia (AML) associated with normal or elevated platelet count, atypical megakaryocytes and multilineage dysplasia in the bone marrow, as well as minimal to no response to chemotherapy and poor clinical outcome. The presence of an i...

journal_title：Anticancer research

authors： De Braekeleer E,Douet-Guilbert N,Le Bris MJ,Ianotto JC,Berthou C,Gueganic N,Bovo C,Basinko A,Morel F,De Braekeleer M

更新日期：2013-02-01 00:00:00

abstract：:The androgen-signaling pathway plays a critical role in prostate cancer development and progression. We have recently demonstrated that the Wilms' tumor suppressor gene product, WT1, binds to multiple sites in the androgen receptor (AR) promoter and transcriptionally represses the AR gene promoter in vitro. We asked w...

journal_title：Anticancer research

authors： Zaia A,Fraizer GC,Piantanelli L,Saunders GF

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation of Cdc2, are required for the G2 arrest induced by DNA damage. METHODS:We treated 184B5 cell line and its E6 transformed ...

journal_title：Anticancer research

authors： Luo Y,Rockow-Magnone SK,Joseph MK,Bradner J,Butler CC,Tahir SK,Han EK,Ng SC,Severin JM,Gubbins EJ,Reilly RM,Rueter A,Simmer RL,Holzman TF,Giranda VL

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIM:Several epidemiological studies have reported the chemopreventive potential of biochanin A, in cancer development and progression. We investigated the anticancer potential of combination of biochanin A and temozolomide against U-87 MG and T98 G [glioblastoma multiforme (GBM)] cells. MATERIALS AND METHOD...

journal_title：Anticancer research

authors： Desai V,Jain A,Shaghaghi H,Summer R,Lai JCK,Bhushan A

更新日期：2019-01-01 00:00:00

abstract：:The effects of silybinin, an antioxidant, on the pharmacokinetics of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single dose of tamoxifen was administered intravenously (2 mg/kg) and orally (10 mg/kg) without or with silybinin (0.5, 2.5 and 10 mg/kg) to rats. Silybinin significantly ...

journal_title：Anticancer research

authors： Kim CS,Choi SJ,Park CY,Li C,Choi JS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Pulmonary complications (PCs) after esophagectomy for patients with esophageal cancer have been correlated with prolonged hospital stays and in-hospital mortality. Previous studies have shown that minimally-invasive esophagectomy (MIE) is associated with a lower rate of PCs compared to conventional open surg...

journal_title：Anticancer research

authors： Kubo N,Ohira M,Yamashita Y,Sakurai K,Toyokawa T,Tanaka H,Muguruma K,Shibutani M,Yamazoe S,Kimura K,Nagahara H,Amano R,Ohtani H,Yashiro M,Maeda K,Hirakawa K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly SV40 or more likely cytomegalovirus (CMV). One report indicate...

journal_title：Anticancer research

authors： Lehrer S,Labombardi V,Green S,Pessin-Minsley MS,Germano IM,Rosenzweig KE

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study was to investigate the relationship between Technetium-99m (Tc-99m) tetrofosmin accumulation in tumors which may represent the expression of multidrug resistance (MDR)--mediated P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) as well as response to chemotherapy in patients ...

journal_title：Anticancer research

authors： Kao CH,Ho YJ,Shen YY,Lee JK

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study, we showed that amentoflavone promotes sorafenib-induced apoptosis in hepatocellular carcinoma (HCC) cells in vitro. However, whether amentoflavone augments anticancer efficacy of sorafenib in HCC in vivo is unknown. The aim of the present study was to verify the anticancer effect of ...

journal_title：Anticancer research

authors： Tsai JJ,Hsu FT,Pan PJ,Chen CW,Kuo YC

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to share...

journal_title：Anticancer research

authors： Mahmood S,Vu K,Tai P,Joseph K,Koul R,Dubey A,Yu E

更新日期：2015-04-01 00:00:00