Gene mutations in esophageal mucosa of chagas disease patients.

Abstract:

BACKGROUND:Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS:PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes were performed. RESULTS:SSCP analysis showed a mobility shift in 2/20 patients with grade IV megaesophagus (CDKN2A exon 1 and FHIT exon 7) and in 1/10 patients without megaesophagus (TP53 exons 5 and 8). However, DNA sequencing indicated a silent mutation in exon 7 of the FHIT gene (GCT --> GCC) in codon 88 in only one case of megaesophagus. CONCLUSION:Gene mutations are rare events in the exons investigated in esophageal mucosa of Chagas disease patients and further investigations are important to clarify the possible involvement of this silent mutation in exon 7 (FHIT gene) in the advanced grades of megaesophagus and esophageal carcinogenesis.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

DA Silva Manoel-Caetano F,Silveira AF,Silva AE

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1243-7

issue

4

eissn

0250-7005

issn

1791-7530

pii

29/4/1243

journal_volume

29

pub_type

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