Abstract:
BACKGROUND:Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS:PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes were performed. RESULTS:SSCP analysis showed a mobility shift in 2/20 patients with grade IV megaesophagus (CDKN2A exon 1 and FHIT exon 7) and in 1/10 patients without megaesophagus (TP53 exons 5 and 8). However, DNA sequencing indicated a silent mutation in exon 7 of the FHIT gene (GCT --> GCC) in codon 88 in only one case of megaesophagus. CONCLUSION:Gene mutations are rare events in the exons investigated in esophageal mucosa of Chagas disease patients and further investigations are important to clarify the possible involvement of this silent mutation in exon 7 (FHIT gene) in the advanced grades of megaesophagus and esophageal carcinogenesis.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
DA Silva Manoel-Caetano F,Silveira AF,Silva AEsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
1243-7issue
4eissn
0250-7005issn
1791-7530pii
29/4/1243journal_volume
29pub_type
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
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journal_title:Anticancer research
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doi:
更新日期:2001-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
doi:
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journal_title:Anticancer research
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doi:
更新日期:2011-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2016-08-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
更新日期:2003-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Anticancer research
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doi:
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pub_type: 杂志文章,评审
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