Isolation of tumor associated antigens from Lewis lung carcinoma by affinity chromatography on peanut agglutinin-agarose.

abstract：BACKGROUND:We hypothesize that dendritic cells (DCs) can process antigens from autologous melanoma apoptotic bodies (MABs) and induce effector T cells in melanoma patients. MATERIALS AND METHODS:Peripheral blood mononuclear cells were obtained from three stage IV melanoma patients and adherent cells were cultured in c...

journal_title：Anticancer research

authors： Chang JW,Peng M,Vaquerano JE,Zhou YM,Clinton RA,Hyun WC,Giedlin MA,Leong SP

更新日期：2000-05-01 00:00:00

abstract：AIM:We report on a rare case of appendiceal primary neuroendocrine carcinoma (NEC) and discuss three cases previously described. CASE REPORT:A 58-year-old woman presented with acute abdominal pain and a low-grade fever. She was diagnosed with acute appendicitis and underwent laparoscopic appendectomy. Pathological exa...

journal_title：Anticancer research

authors： Tomioka K,Fukoe Y,Lee Y,Lee M,Wada Y,Aoki T,Murakami M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND/AIM:The single nucleotide polymorphism -31C/G identified in the survivin gene promoter seems to be associated with over-expression of survivin, an anti-apoptotic protein. In gliomas, increased survivin expression correlated with decreased survival. The aim of the study was to investigate whether survivin gen...

journal_title：Anticancer research

authors： Kafadar D,Yaylim I,Kafadar AM,Cacina C,Ergen A,Kaynar MY,Isbir T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The heterogeneity in prostate cancer is the reason for the difficult diagnosis and prognosis of this tumor. In this study, we looked for a correlation between prostate specific antigen (PSA), tumor staging and DNA cytophotometry. MATERIALS AND METHODS:Twenty-two prostates (pT1-T4) from patients with prostat...

journal_title：Anticancer research

authors： Krause FS,Feil G,Bichler KH,Schrott KM,Akcetin ZY,Engehausen DG

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND/AIM:In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. MATERIALS AND METHODS:Primary ...

journal_title：Anticancer research

authors： Pasqualetti F,Panichi M,Sainato A,Baldaccini D,Cocuzza P,Gonnelli A,Montrone S,Molinari A,Barbiero S,Bruschi A,Notini E,Ursino S,Mazzotti V,Morganti R,Coraggio G,Cantarella M,Erba PA,Paiar F

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the historical cohort of 61 patients with carcinoma of the vulva, treated with radiation therapy from 1986 to 1997. PATIENTS AND METHODS:Twenty-seven patients were submitted to radiation therapy alone and 34 received radiotherapy post limited surgery in early stages and...

journal_title：Anticancer research

authors： Tombolini V,Raffetto N,Santarelli M,Valeriani M,Necozione S,Masedu F,Enrici RM

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The chronomodulated infusion of 5-FU, FA and oxaliplatin allows a significant increase in dose intensity and antitumor efficacy in patients with metastatic colorectal cancer. Here we investigated if substitution of oxaliplatin with cisplatin produced a similar antitumor activity in previously untreated patie...

journal_title：Anticancer research

authors： Natoli C,Scognamiglio MT,Martino MT,Irtelli L,De Tursi M,Cianchetti E,Mascitelli E,Tinari N,Iacobelli S

更新日期：2000-03-01 00:00:00

abstract：:To investigate the specific transduction of a suicide gene into human small cell lung carcinoma (SCLC) cells, we explored the promoter region of the neuron specific enolase (NSE) gene as a tumor-specific promoter. In Northern blot analysis, NSE mRNA was expressed more abundantly in the SBC3 human SCLC cell line than i...

journal_title：Anticancer research

authors： Tanaka M,Inase N,Miyake S,Yoshizawa Y

更新日期：2001-01-01 00:00:00

abstract：:Human epidemiological studies suggest an association between N-acetyltransferase (NAT) activity and the incidence of bladder and colorectal cancers. In this study, paclitaxel was selected to examine the inhibition of arylamine NAT activity, gene expression and 2-aminofluorene-DNA adduct formation in a human osteogenic...

journal_title：Anticancer research

authors： Lu KH,Wang DY,Lue KH,Hsiao YM,Chou MC,Chen YS,Chung JG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The results of chemotherapy in patients with advanced, hormone-refractory prostate cancer (HRPC) have been disappointing. Mitoxantrone has been used in the past for palliation, but it does not prolong survival. It was recently demonstrated that docetaxel is able to improve median survival as compared to mito...

journal_title：Anticancer research

authors： Boehmer A,Anastasiadis AG,Feyerabend S,Nagele U,Kuczyk M,Schilling D,Corvin S,Merseburger AS,Stenzl A

更新日期：2005-11-01 00:00:00

abstract：:Angiogenesis is essential for tumour growth. Mostly hypervasculariced renal cell carcinoma (RCC) usually express angiogenic factors, e.g. basic fibroblast factor (bFGF), vascular endothelial growth factor, and angiogenin (ag). This study was designed to evaluate the improvement of serological angiogenesis-factors, the...

journal_title：Anticancer research

authors： Wechsel HW,Bichler KH,Feil G,Loeser W,Lahme S,Petri E

更新日期：1999-03-01 00:00:00

abstract：:A significant number of human tumors from diverse histological origins contain c-K-ras oncogenes which have been activated by somatic point mutations resulting in single amino acids substitutions in the encoded p21 ras protein. In addition to these qualitative changes, other genetic alterations leading to increased ex...

journal_title：Anticancer research

authors： Kahn S,Yamamoto F,Almoguera C,Winter E,Forrester K,Jordano J,Perucho M

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) is a multifactorial neoplasm related to tobacco smoke, alcohol consumption and molecular genetic changes such as p53 mutations. The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid cod...

journal_title：Anticancer research

authors： Drummond SN,De Marco L,Pordeus Ide A,Barbosa AA,Gomez RS

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Macrophage colony stimulating factor (M-CSF) binds to colony-stimulating factor-1 receptor (CSF-1R) and thereby stimulates the proliferation, differentiation and behaviour of monocytes, macrophages and their bone marrow progenitors. Previous studies have suggested that high expression of these markers is cor...

journal_title：Anticancer research

authors： Richardsen E,Sørbye SW,Crowe JP,Yang JL,Busund LT

更新日期：2009-10-01 00:00:00

abstract：AIM:To analyze retrospectively the results of postoperative radiotherapy for localized prostate cancer and to investigate the clinical significance of nadir prostate-specific antigen (PSA) value within 12 months (nPSA12) as an early estimate of clinical outcome after radiotherapy. PATIENTS AND METHODS:Seventy-six pati...

journal_title：Anticancer research

authors： Ogawa K,Nakamura K,Sasaki T,Onishi H,Koizumi M,Araya M,Mukumoto N,Mitsumori M,Teshima T,Japanese Patterns of Care Study Working Subgroup of Prostate Cancer.

更新日期：2009-11-01 00:00:00

abstract：:Elevated levels of hypoxia inducible factor-1 (HIF1) are linked to tumor metastasis, angiogenesis, poor patient prognosis and response to chemotherapy. HIF1α is a master regulator of the hypoxic response, including in cancer cells, through transcriptional activation of several target genes. Previously, we identified c...

journal_title：Anticancer research

authors： Masoud GN,Wang J,Chen J,Miller D,Li W

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:To investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities and p53 status in sensitivity to high-LET heavy-ion beam and in sensitizing effect of etoposide or cisplatin in combination with heavy-ion beam. MATERIALS AND METHODS:NMT-1 (wild-type p53 cell) is a pa...

journal_title：Anticancer research

authors： Takahashi T,Fukawa T,Hirayama R,Yoshida Y,Musha A,Furusawa Y,Ando K,Nakano T

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND/AIM:High expression of the Bcl-2-interacting cell death suppressor (BIS), an anti-apoptotic protein, in various human cancers is linked to a poor outcome. The purpose of this study was to clarify whether BIS is associated with the migration and invasive characteristics of A549 cells. MATERIALS AND METHODS:B...

journal_title：Anticancer research

authors： Lee J,Yun HH,Kim S,Ji SH,Kuh HJ,Lee JH

更新日期：2018-09-01 00:00:00

abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...

journal_title：Anticancer research

authors： Kovacs CJ,Evans MJ,Daly BM

更新日期：2003-05-01 00:00:00

abstract：:We assessed the prognostic value of the local tumor characteristics inflammatory stromal reaction (ISR) and vascular space invasion (VSI) together with established prognostic criteria, in cervical cancer patients. One hundred and forty-two patients with carcinoma of the cervix stage IB to IIB undergoing radical hyster...

journal_title：Anticancer research

authors： Kainz C,Gitsch G,Tempfer C,Heinzl H,Koelbl H,Breitecker G,Reinthaller A

更新日期：1994-09-01 00:00:00

abstract：:A semiempirical molecular-orbital method (CAChe) was applied to delineate the relationship between the cytotoxicity (evaluated by 50% cytotoxic concentration, CC50) of fifteen phenoxazine derivatives and eleven physical parameters (descriptors). Most of the phenoxazine derivatives had extended and planar structure. Th...

journal_title：Anticancer research

authors： Ishihara M,Kawase M,Westman G,Samuelsson K,Motohashi N,Sakagami H

更新日期：2007-11-01 00:00:00

abstract：:Approximately 85% of patients with advanced ovarian cancer will experience recurrence of the disease. In 311 patients CA125 serum levels were determined at follow up investigation in our department. A sensitivity of 92% and specificity of 89% were calculated. Reflecting the further course of disease, specificity could...

journal_title：Anticancer research

authors： Meier W,Baumgartner L,Stieber P,Hasholzner U,Fateh-Moghadam A

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIM:Several epidemiological studies have reported the chemopreventive potential of biochanin A, in cancer development and progression. We investigated the anticancer potential of combination of biochanin A and temozolomide against U-87 MG and T98 G [glioblastoma multiforme (GBM)] cells. MATERIALS AND METHOD...

journal_title：Anticancer research

authors： Desai V,Jain A,Shaghaghi H,Summer R,Lai JCK,Bhushan A

更新日期：2019-01-01 00:00:00

abstract：:Adrenomedullin (AM) is a hypotensive polypeptide that has been shown to stimulate cyclic AMP and intracellular free Ca2+ agents that are known to induce expression of proto-oncogenes, in various cell types. Transforming growth factor-beta 1 (TGF-beta1) is a multifunctional polypeptide that regulates proliferation, dif...

journal_title：Anticancer research

authors： Kane S,Prentice MA,Mariano JM,Cuttitta F,Jakowlew SB

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Women with recurrent ovarian cancer have a poor prognosis and short survival. However, some women are long-term survivors and it is unclear whether they share specific common characteristics. CASE REPORT:We present the case of a 63-year-old woman with histologically-proven recurrent ovarian cancer and a sur...

journal_title：Anticancer research

authors： Hilal Z,Schultheis B,Hartmann F,Dogan A,Cetin C,Krentel H,Schiermeier S,Tempfer CB

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:The aim of this study was to examine the interobserver variance in delineating the contour of unresectable pancreatic cancer for chemoradiotherapy. PATIENTS AND METHODS:CT images of two cases of unresectable pancreatic tumors (head and body cancer) were sent to eight radiation therapy facilities in a CD-ROM...

journal_title：Anticancer research

authors： Yamazaki H,Nishiyama K,Tanaka E,Koiwai K,Shikama N,Ito Y,Arahira S,Tamamoto T,Shibata T,Tamaki Y,Kodaira T,Oguchi M

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The cytosine deaminase/5-fluorocytosine (CD/5-FC), strategy for cancer gene therapy shows considerable promise in experimental models but, because CD is a cytosolic enzyme, intracellular production of 5-fluorouracil (5-FU) causes the demise of the transduced cells before cytotoxic concentrations of' 5-FU can...

journal_title：Anticancer research

authors： Rehemtulla A,Hamstra DA,Kievit E,Davis MA,Ng EY,Dornfeld K,Lawrence TS

更新日期：2004-05-01 00:00:00

abstract：:Small cell lung cancer (SCLC) cells express cholinergic nicotinic receptors on their membranes, and the stimulatory effect on cell growth of nicotine has been described in cell cultures. We investigated three SCLC cell lines, all showing high levels of fluorescence intensity when labeled with FITC alpha-bungarotoxin i...

journal_title：Anticancer research

authors： Pratesi G,Cervi S,Balsari A,Bondiolotti G,Vicentini LM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIM:Recent progress with BRAF and immune checkpoint inhibitors has dramatically changed the treatment landscape of metastatic melanoma (MM). The limited duration of responses to new agents, however, justifies the, still important, role of chemotherapy in the management of MM. This study prospectively explore...

journal_title：Anticancer research

authors： Linardou H,Pentheroudakis G,Varthalitis I,Gogas H,Pectasides D,Makatsoris T,Fountzilas G,Bafaloukos D,Hellenic Cooperative Oncology Group.

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:As a majority of ovarian cancer patients will ultimately develop recurrent disease, there is an urgent need for alternative or additional approaches in the treatment of this cancer. MATERIALS AND METHODS:The antitumour effect of i.p. administered cisplatin, liposomal muramyltripeptide phosphatidylethanulami...

journal_title：Anticancer research

authors： Klimp AH,De Vries EG,Scherphof GL,Daemen T

更新日期：2000-07-01 00:00:00