Carcinoma of the vulva: clinical results of exclusive and adjuvant radiotherapy.

Abstract:

BACKGROUND:The aim of this study was to evaluate the historical cohort of 61 patients with carcinoma of the vulva, treated with radiation therapy from 1986 to 1997. PATIENTS AND METHODS:Twenty-seven patients were submitted to radiation therapy alone and 34 received radiotherapy post limited surgery in early stages and post radical vulvectomy in advanced stages. The dose range varied from 59 to 63 Gy in post-operative patients and 65 Gy to 71 Gy in curative patients. RESULTS:Five-year Overall Survival (OS) and Disease-Free Survival (DFS) for patients treated with irradiation alone and for those treated with post-operative radiotherapy were 50.8% and 69.7%, respectively, without significant statistical difference. For OS multivariate analysis showed statistical difference for stage and age variables, and for stage variable in the case of DFS. CONCLUSION:In early stage vulvar cancer patients OS and DFS are good, with high control rate and low incidence of adverse effect. In loco-regionally-advanced patients, especially in those with stage IV or with > 2 positive lymph nodes, the outcomes are poor.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Tombolini V,Raffetto N,Santarelli M,Valeriani M,Necozione S,Masedu F,Enrici RM

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

3089-94

issue

4

eissn

0250-7005

issn

1791-7530

journal_volume

25

pub_type

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