Abstract：
BACKGROUND/AIM:In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. MATERIALS AND METHODS:Primary and secondary endpoints of this prospective observational study were local control and safety related to IG-SBRT. All lesions were treated with 24 Gy as a single fraction or 27 Gy in 3 fractions. After SBRT, Systemic therapies were administered only after the occurrence of more than three synchronous active lesions in oligometastatic patients (patients with less than 4 active synchronous lesions) or new lesions occurrence in patients with more than 3 synchronous lesions. RESULTS:From April 2011 to June 2017, 78 metastatic lesions (32 bone and 46 node) from 51 patients with prostate cancer were treated. After a median follow-up of 18.5 months (range=3-103 months), only 2 lesions (4%) relapsed inside the radiation field. All local recurrences were located on the bone. Estimated 12 and 24 months local control ratios were 98.7 and 97.4%, respectively. Except for one case, toxicity greater than G2 was not recorded. CONCLUSION:IG-SBRT is safe and can be considered as a valid therapy in patients with metastatic prostate cancer requiring a long-lasting metastases control.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Pasqualetti F,Panichi M,Sainato A,Baldaccini D,Cocuzza P,Gonnelli A,Montrone S,Molinari A,Barbiero S,Bruschi A,Notini E,Ursino S,Mazzotti V,Morganti R,Coraggio G,Cantarella M,Erba PA,Paiar Fdoi
10.21873/anticanres.12572subject
Has Abstractpub_date
2018-05-01 00:00:00pages
3119-3122issue
5eissn
0250-7005issn
1791-7530pii
38/5/3119journal_volume
38pub_type
杂志文章abstract：BACKGROUND:No investigation of amrubicin monotherapy in pre-treated advanced non-small cell lung cancer (NSCLC) patients has yet been reported. PATIENTS AND METHODS:The records were reviewed of NSCLC patients who had received amrubicin monotherapy between 2003 and 2007 with the following eligibility criteria:previousl...
journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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doi：
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doi：
更新日期：2009-12-01 00:00:00
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doi：
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