Heterogeneity in prostate cancer: prostate specific antigen (PSA) and DNA cytophotometry.

abstract：BACKGROUND:The influence of age on the patterns and outcomes of external beam radiotherapy for clinically localized prostate cancer patients was examined. MATERIALS AND METHODS:The Japanese Patterns of Care Study surveys were used to compare the processes and outcomes of radical external beam radiotherapy in 140 elder...

journal_title：Anticancer research

authors： Ogawa K,Nakamura K,Onishi H,Koizumi M,Sasaki T,Araya M,Miyabe Y,Otani Y,Teshima T,Japanese Patterns of Care Study Working Subgroup of Prostate Cancer.

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Paclitaxel pharmacokinetics were shown to be related to toxicity and survival. PATIENTS AND METHODS:We evaluated the effects of time above paclitaxel concentrations of 0.05 micromol/l (T(>0.05) and systemic exposures (AUC) to total and unbound paclitaxel (tPAC, uPAC) on response in patients with advanced ca...

journal_title：Anticancer research

authors： Mielke S,Sparreboom A,Behringer D,Mross K

更新日期：2005-11-01 00:00:00

abstract：:The most widely-known anti-tumor drugs often induce marked immunosuppression which can give rise to one or more sepses. Anti-infection measures immediately applied can sometimes prove largely ineffective or even useless, the patient dying not as a result of the spread of the tumour but as a direct consequence of oppor...

journal_title：Anticancer research

authors： Castelli M,Baggio G,Ruberto AI,Malagoli M,Casolari C,Rossi T,Galatulas I

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Prediction of biological behavior is crucial for selection of new therapeutic modalities in GIST. Here, we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS:Fifty-five Brazilian patients with completely resected GIST were ex...

journal_title：Anticancer research

authors： Braggio E,Braggio Dde A,Small IA,Lopes LF,Valadão M,Gouveia ME,Moreira Ados S,Linhares E,Romano S,Bacchi CE,Renault IZ,Guimarães DP,Ferreira CG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Angiogenesis is involved in the development of cancer, promoting tumor growth, invasiveness and metastasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. The present case control study was carried out, to determine whether there is an association between the VEGF -2578C > A polymor...

journal_title：Anticancer research

authors： Park HM,Hong SH,Kim JW,Oh D,Hwang SG,An HJ,Kim UK,Kim NK

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that doxorubicin (DXR) showed much higher cytotoxicity against human oral squamous cell carcinoma cell lines compared to normal human mesenchymal normal oral cells (gingival fibroblast, periodontal ligament fibroblast, pulp cell), yielding high tumor-specificity. However, we u...

journal_title：Anticancer research

authors： Sakagami H,Okudaira N,Masuda Y,Amano O,Yokose S,Kanda Y,Suguro M,Natori T,Oizumi H,Oizumi T

更新日期：2017-03-01 00:00:00

abstract：:In procaryotic and also in eucaryotic cells, several systems for repairing the DNA damage have been discovered. The mechanism and genetic control of DNA excision-repair and SOS have been extensively studied. These repair processes help prevent lesions from interfering with DNA functions or from converting into permane...

journal_title：Anticancer research

authors： Tonini GP

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND/AIM:To clarify whether renal dysfunction affects the incidence of adverse events associated with oxaliplatin, the present study was designed to investigate the relationship between creatinine clearance (Ccr) and the incidence of oxaliplatin-related adverse events. PATIENTS AND METHODS:A total of 287 CRC pat...

journal_title：Anticancer research

authors： Watanabe D,Fujii H,Yamada Y,Iihara H,Ishihara T,Matsuhashi N,Takahashi T,Yoshida K,Suzuki A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:Osteosarcoma (OS) is a diagnosed primary cancer of the bone. Despite the great advances that have been made during the past decades in OS therapy, drug resistance and tumor recurrence are still major problems. It is urgent to find novel strategies to overcome drug resistance in order to prolong the survi...

journal_title：Anticancer research

authors： He C,Sun Z,Hoffman RM,Yang Z,Jiang Y,Wang L,Hao Y

更新日期：2019-04-01 00:00:00

abstract：:Fine needle aspiration (FNA) cytology, being the mainstay to diagnose thyroid nodules, does not provide definitive results in a subset of patients. The use of molecular markers testing has been described as a useful aid in differentiation of thyroid nodules that present with an indeterminate cytodiagnosis. Molecular t...

journal_title：Anticancer research

authors： Bhatia P,Deniwar A,Friedlander P,Aslam R,Kandil E

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The tyrosine kinase inhibitors (TKI) sunitinib and imatinib were shown to induce macrocytosis in patients with renal cell cancer (RCC) and gastrointestinal stromal tumors (GIST), presumably through inhibition of the c-KIT dependent signaling pathway of erythroid progenitor cells of the bone marrow. PATIENTS...

journal_title：Anticancer research

authors： Schallier D,Trullemans F,Fontaine C,Decoster L,De Greve J

更新日期：2009-12-01 00:00:00

abstract：:Bone only metastasis in patients with estrogen receptor (ER) positive breast cancer reported to have favorable response to chemotherapy, favorable prognosis, and an "indolent" course. Therefore, we assessed the ability of MG-63 osteoblast-like human osteosarcoma cells (MG-63 cells) and MG-63 conditioned media (CM) to ...

journal_title：Anticancer research

authors： Choki I,Sourla A,Reyes-Moreno C,Koutsilieris M

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:Signaling regulation of myeloid zinc finger 1 (MZF1) has been implicated in the progression of many human malignancies; however, the mechanistic action of MZF1 in triple-negative breast cancer (TNBC) progression remains elusive. In this study, the aim was to investigate the molecular mechanisms of MZF1 a...

journal_title：Anticancer research

authors： Yue CH,Liu JY,Chi CS,Hu CW,Tan KT,Huang FM,Pan YR,Lin KI,Lee CJ

更新日期：2019-08-01 00:00:00

abstract：UNLABELLED:Adenomatous polyps are precursor lesions for colorectal carcinoma. The risk of cancer development has been associated with age and size, amount of villous component and high-grade dysplasia of adenomas. The subject-related and adenoma-related risk factors for severely dysplastic lesions were further investig...

journal_title：Anticancer research

authors： Giuliani A,Caporale A,Corona M,Ricciardulli T,Di Bari M,Demoro M,Scarpini M,Angelico F

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Bone defects due to malignant tumor often lead to repeated surgery or amputation. Thus, a major objective in orthopedic surgery is the extracorporeal devitalization of tumor-bearing bone segments following reimplantation. Extracorporeal irradiation or autoclaving are possible methods even though they may cau...

journal_title：Anticancer research

authors： Schauwecker J,Von Eisenhart-Rothe R,Burgkart R,Tuebel J,Schmitt M,Mittelmeier W,Diehl P

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Lung cancer is the second leading cause of mortality among men and women in the U.S. Among different varieties of lung cancer, the non-small cell lung cancer (NSCLC) has the highest frequency comprising about 85% of cases. We evaluated 1-methyl-4-phenylpyridinium ion (MPP(+)) for cytotoxicity against human l...

journal_title：Anticancer research

authors： Badisa RB,Mina DA,Latinwo LM,Soliman KF

更新日期：2014-10-01 00:00:00

abstract：:The present study was undertaken to evaluate the significance of grooved nuclei as an additional diagnostic criterion for primary breast carcinoma as well as their association with tumor grade in cytologic material obtained by fine needle aspiration (FNA). Cytologic slides of 105 cases of breast carcinoma (89 ductal, ...

journal_title：Anticancer research

authors： Labropoulou P,Psachoulia C,Batistatou A,Kardari M,Scopa CD

更新日期：1996-11-01 00:00:00

abstract：SPECIFIC OBJECTIVE:The Epidermal Growth Factor Receptor (EGFR) is a specific cell membrane receptor that shows homology to the product of the oncogene c-erbB2 in human breast cancer. Growth factors bound to the EGFR are able to stimulate the growth of tumor cells in an autocrine or paracrine manner. Our objective was t...

journal_title：Anticancer research

authors： Oehler MK,Rehn M,Kristen P,Sütterlin M,Caffier H

更新日期：1997-07-01 00:00:00

abstract：:The present study compared the effects of four lipophilic forms of selenium with regard to cancer chemopreventive activity, tissue selenium accumulation, and bioavailability for synthesis of a selenoprotein. These reagents included methylphenyl selenide, diphenyl selenide, triphenyl-selenonium chloride, and p-xylylbis...

journal_title：Anticancer research

authors： Ip C,Lisk DJ,Ganther HE

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Gemcitabine (dFdC) may cause radiosensitization by specific interference with homologous recombination-mediated DNA double-strand break repair. The radiosensitizing effect of dFdC might be less in normal healthy tissue and more restricted to undifferentiated tumor cells, making it a tumor-selective radiosens...

journal_title：Anticancer research

authors： Kal HB,El Sharouni SY,Barten-van Rijbroek AD

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The chronomodulated infusion of 5-FU, FA and oxaliplatin allows a significant increase in dose intensity and antitumor efficacy in patients with metastatic colorectal cancer. Here we investigated if substitution of oxaliplatin with cisplatin produced a similar antitumor activity in previously untreated patie...

journal_title：Anticancer research

authors： Natoli C,Scognamiglio MT,Martino MT,Irtelli L,De Tursi M,Cianchetti E,Mascitelli E,Tinari N,Iacobelli S

更新日期：2000-03-01 00:00:00

abstract：AIM:Neoadjuvant epirubicin/docetaxel (ET) combination chemotherapy was administered to breast cancer patients in order to investigate their clinical and pathological response. Moreover, the breast-conserving surgery (BCS) rate, disease-free (DFS) and overall survival (OS), safety profile and the correlation of biologic...

journal_title：Anticancer research

authors： Nishimura R,Rai Y,Matsuo F,Anan K,Hara S,Imamura S,Itoyanagi N,Kato M,Okido M,Kudaka M,Ishikawa E,Kamada Y,Watanabe R,Shirouzu M,Mitsuyama S,Takamatsu Y,Tamura K

更新日期：2012-08-01 00:00:00

abstract：:A new cell line, designated CC2/CUHK2, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. The cell line grew well without interruption for over 12 months and over 90 passages. The doubling time of CC2/CUHK2 was 72 hours at passage 57. When seeded at a density of 1.5 x 10(3) cells p...

journal_title：Anticancer research

authors： Ho TH,Chew EC,Tam JS,Hou HJ,Yam HF,Chew-Cheng SB,Wong FW

更新日期：1993-07-01 00:00:00

abstract：:The effects of silybinin, an antioxidant, on the pharmacokinetics of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single dose of tamoxifen was administered intravenously (2 mg/kg) and orally (10 mg/kg) without or with silybinin (0.5, 2.5 and 10 mg/kg) to rats. Silybinin significantly ...

journal_title：Anticancer research

authors： Kim CS,Choi SJ,Park CY,Li C,Choi JS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIM:Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia ...

journal_title：Anticancer research

authors： Hirahara N,Edamatsu T,Fujieda A,Fujioka M,Wada T,Tajima Y

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of docetaxel plus S-1 combination chemotherapy as a first-line treatment in patients with advanced or recurrent gastric cancer was verified retrospectively. PATIENTS AND METHODS:Eighteen patients with advanced or recurrent gastric cancer were enrolled. The regimen used was intravenou...

journal_title：Anticancer research

authors： Tsutani Y,Ohara M,Suzuki T,Minami K,Miyahara E,Kameda A,Noso Y

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND/AIM:Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatm...

journal_title：Anticancer research

authors： Sumida T,Ishikawa A,Kamata YU,Nakano H,Yamada T,Mori Y

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND/AIM:Occult cancers' reported rates vary from 2-12% and serous tubal intraepithelial carcinomas (STICs) have been identified in 3-12% of the prophylactically removed tubes of women carrying a BRCA mutation. The aim of this study was to evaluate the incidence of tubal minor epithelial atypia (STIL), STIC, and ...

journal_title：Anticancer research

authors： Ricciardi E,Tomao F,Aletti G,Bazzurini L,Bocciolone L,Boveri S,Landoni F,Lapresa MT,Maruccio M,Parma G,Peccatori F,Petrella MC,Zanagnolo V,Colombo N,Maggioni A

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIM:Patients with obstructive jaundice due to cancer of the pancreatic head often undergo preoperative endoscopic biliary drainage (EBD). The aim of the study was to evaluate the long-term impact of preoperative EBD following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma. PATIENTS AND ME...

journal_title：Anticancer research

authors： Furukawa K,Shiba H,Shirai Y,Horiuchi T,Iwase R,Haruki K,Fujiwara Y,Misawa T,Yanaga K

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Screening gastroscopic examinations were performed in a cohort of individuals at high risk for developing gastric carcinoma (GC). PATIENTS AND METHODS:Five gastric biopsies were obtained following the Houston schema. Five histological parameters of gastritis were investigated: acute gastritis, chronic gastr...

journal_title：Anticancer research

authors： Saieva C,Rubio CA,Nesi G,Zini E,Filomena A

更新日期：2012-05-01 00:00:00