Abstract：
BACKGROUND/AIM:Patients with obstructive jaundice due to cancer of the pancreatic head often undergo preoperative endoscopic biliary drainage (EBD). The aim of the study was to evaluate the long-term impact of preoperative EBD following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma. PATIENTS AND METHODS:We studied 106 patients who underwent PD for pancreatic ductal adenocarcinoma between May 2000 and November 2013 at the Jikei University Hospital. We retrospectively examined perioperative findings as predictors of prognosis and the relationship between preoperative EBD and recurrence rate as well as overall survival. RESULTS:In univariate analysis, significant factors associated with poor disease-free survival consisted of the presence of EBD (p=0.0213), poor tumor differentiation (p=0.0023) and tumor-node-metastasis (TNM) classification IV (p=0.0027), while significant factors associated with poor overall survival consisted of the presence of EBD (p=0.0047), poor tumor differentiation (p<0.0001), TNM classification IV (p=0.0031) and microscopic or macroscopic residual tumor (p=0.0184). In multivariate analysis, poor tumor differentiation (p=0.0033) and TNM classification IV (p=0.0020) were independent factors for poor disease-free survival, while the presence of EBD (p=0.0435), poor tumor differentiation (p=0.0009), TNM classification IV (p=0.0447) and microscopic or macroscopic residual tumor (p=0.0184) were independent factors for poor overall survival. CONCLUSION:Preoperative EBD may have a negative impact on prognosis after PD for pancreatic ductal adenocarcinoma.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Furukawa K,Shiba H,Shirai Y,Horiuchi T,Iwase R,Haruki K,Fujiwara Y,Misawa T,Yanaga Ksubject
Has Abstractpub_date
2015-09-01 00:00:00pages
5079-83issue
9eissn
0250-7005issn
1791-7530pii
35/9/5079journal_volume
35pub_type
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更新日期：2010-02-01 00:00:00
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