Abstract：
BACKGROUND:Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy. PATIENTS AND METHODS:From 1995 to 2008, 53 patients with early-stage POAML were reviewed. Tumors were categorized as either superficial or mass-forming type. In principle, superficial lesions (n=11) were treated with 24 Gy, while the mass-forming lesions (n=42) were irradiated with 30 Gy. The median follow-up period was 3.9 years. RESULTS:All four cases of relapse had mass-forming lesions. The 5-year overall and progression-free survival rates were 100% and 91.5%, respectively. Although 30 patients experienced grade 2 or 3 late adverse events, no patients had radiation-related retinopathy. CONCLUSION:Early-stage POAML can be well-controlled with radiotherapy. However, the risk of distant relapse should be noted, in particular, for mass-forming tumors.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Ohga S,Nakamura K,Shioyama Y,Sasaki T,Yoshitake T,Atsumi K,Terashima K,Asai K,Matsumoto K,Yoshikawa H,Kawano Y,Honda Hsubject
Has Abstractpub_date
2013-12-01 00:00:00pages
5575-8issue
12eissn
0250-7005issn
1791-7530pii
33/12/5575journal_volume
33pub_type
杂志文章abstract：BACKGROUND/AIM:Osteosarcoma (OS) is a diagnosed primary cancer of the bone. Despite the great advances that have been made during the past decades in OS therapy, drug resistance and tumor recurrence are still major problems. It is urgent to find novel strategies to overcome drug resistance in order to prolong the survi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13277
更新日期：2019-04-01 00:00:00
abstract：:Inv(3)(q21q26)/t(3;3)(q21;q26) is a feature of a distinctive entity of acute myeloid leukemia (AML) associated with normal or elevated platelet count, atypical megakaryocytes and multilineage dysplasia in the bone marrow, as well as minimal to no response to chemotherapy and poor clinical outcome. The presence of an i...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast tumors and these breast tumors are usually aggressive and highly metastatic. Unfortunately, treatment options for TNBCs are limited; we have identified a novel molecule, 2'-3'-dehydrosalannol (DHS) and in this study we investigated the an...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:The aim of our study was to investigate whether apoptin and e4orf4 pro-apoptotic genes, transferred by means of electroporation, were suitable for gene therapy of tumours. The two genes were chosen for our study because the proteins they encode induce apoptosis in transformed cells only. The apoptin gene was synthesis...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Canine lymphoma has lately drawn focus as a model of human non-Hodgkin's lymphoma due to its spontaneous occurrence and similar biological behavior. Cells with stem cell-like characteristics are believed to play a key role in therapeutic failure. Thus, an initial characterization and the possibility of speci...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Laparoscopic surgery in patients with endometrial cancer has been more widely used in the last 5-10 years, and numerous reports concerning recurrence rate and the surgical technique, laparoscopic vs. open, have been published. However, no data are available concerning the surgical technique of an open or clo...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：:MDL 103,323, an enclomiphene analog, was tested for binding to the estrogen receptor, inhibition of human tumor xenografts and prevention of carcinogen-induced mammary tumors. MDL 103,323 had 5-6 fold greater affinity for the human estrogen receptor than did either tamoxifen or enclomiphene. Consistent with enhanced b...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND/AIM:We have previously reported that alternate-day S-1 had comparable effects and milder adverse events than the respective consecutive-day regimen in head and neck cancer (HNC) patients. The aim of this study was to investigate the anticancer effects of both regimens and underlying mechanisms in vitro. MAT...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13810
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Delayed elimination of methotrexate associated with serious side-effects has been attributed to the co-administration of benzimidazole proton pump inhibitors. PATIENTS AND METHODS:We have retrospectively analyzed the causes of delayed methotrexate elimination in patients who had received the rescue agent gl...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:The prognostic impact of neutrophil to lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) was examined using patients with a follow-up period more than 5 years. PATIENTS AND METHODS:Two hundred and eighty four consecutive resected NSCLC patients were reviewed retrospectively. In this study, patien...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：:To elucidate the rates of appearance of hepatocellular carcinoma (HCC) and the prognosis of alcoholic liver cirrhosis upon infection with hepatitis virus, we retrospectively studied 190 consecutive patients. The patients were divided into three groups based on whether they were exposed either to hepatitis B virus (HBV...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Increasing evidence suggests that COX-2 promotes carcinogenesis but it is controversial as to whether COX-2 expression is a prognostic factor for rectal carcinoma. MATERIALS AND METHODS:Data of 62 consecutive patients with rectal carcinoma in UICC-stages I-III, which were curatively resected between 1995 an...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:HIC-1 (hypermethylated in cancer-1) is a candidate tumor suppressor gene, identified in a region of frequent loss of heterozygosity on chromosome 17p13.3, which is telomeric from TP53 and often deleted in surgically resected lung cancers. To determine the significance of HIC-1 in lung cancer, we assessed its...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Reduction of nitroblue tetrazolium by blood monocytes was significantly increased following post-operative radiation therapy for breast cancer. Attachment and ingestion of yeast particles by monocytes was not affected. Exposure of purified monocytes in vitro to 13 Gy did not significantly affect NBT reduction of yeas...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：AIM:To investigate whether the negative quality of life result of a large randomized exercise intervention study (BREX) was due to considerable spontaneous recovery after adjuvant treatments. PATIENTS AND METHODS:The change in QoL was studied in the control patients of the BREX study (Group 1) and a group of similar f...
journal_title：Anticancer research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:In order to decrease surgery-related morbidity, we evaluated the reliability of the evaluation of lymph node metastasis in patients with uterine corpus cancer by positron-emission tomography (PET) with 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) before surgical staging. MATERIALS AND METHODS:Patients with newly...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:Many retrospective trials have demonstrated a survival benefit for elective lymph node dissection (ELND) in the treatment of clinical stage I malignant melanoma, but two randomized trials have found none. The relevant medical literature was reviewed with special attention devoted to the tumor burden of nodal disease. ...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:Transient hypocalcaemia is a frequent complication after total knee arthroplasty (TKA). In this study, we investigated the factors associated with the development of hypocalcaemia after TKA in order to explore its clinical significance and treatment. PATIENTS AND METHODS:A retrospective analysis of the chan...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Amitriptyline, a tricyclic antidepressant, was able to reverse the multidrug resistance efflux pump of human colon cancer subline SW 620 and multidrug resistant (mdr) mouse lymphoma cells by decreasing rhodamine 123 efflux. The inhibitory effect of amitriptyline on the efflux pump was dose dependent. An investigation ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The relationship between the composition of breast cyst fluid (BCF), the menstrual status and in addition some endocrine events in the history of patients (n = 131) with gross cystic breast disease was investigated. The dehydroepiandrosterone (DHA) levels in type II (K+/Na+ < 1) cysts of the follicular group were sign...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:The production of DNA interstrand crosslinks (ISC) by BCNU and other bifunctional alkylators and the effects of these drugs on the repair of radiation-induced DNA-single strand breaks (SSB) were studied in two human glioblastoma used to assess both DNA-ISCs and DNA-SSBs. BCNU-treated UWR2 and UWR3 cells showed a signi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:Macrophages in varying states of activation differ in their ability to perform antibody-dependent cellular cytotoxicity (ADCC). To define further the activation requirements for macrophages to perform cytolytic functions, we stimulated peptone-elicited peritoneal macrophages, which exhibit only a low level of ADCC, wi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND/AIM:To investigate the outcomes of laparoscopic surgery in colorectal cancer patients with dialysis. PATIENTS AND METHODS:Fourteen dialysis (dialysis group) and 567 non-dialysis (non-dialysis group) patients who underwent laparoscopic and open surgery for colorectal cancer between April 2008 and December 20...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14176
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Multidrug resistance, the principal mechanism by which cancer cells develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapies. AIM:The aim of the study was to investigate the effect of K-2-11 on the reversal of multidrug resistance. MATERIALS AND METHODS:The...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：:The 5-year survival of colorectal cancer patients with distant metastases is below 30%, despite the development and use of a variety of chemotherapeutic regimens. Therefore, new therapeutic strategies are warranted. Whereas radioimmunotherapy (RIT) has shown disappointing results in bulky disease, it may be a promisin...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：AIM:To investigate whether there is a difference in selenium levels before and after radiotherapy (RT) and to study the effects of serum selenium levels on RT-related toxicity in patients undergoing RT for head and neck cancer. PATIENTS AND METHODS:A population of 47 consecutive patients was enrolled in the study. RT ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：:The proteasome inhibitor, bortezomib, is known to be effective in the therapy of various neoplasms. The objective of this study was the analysis of the ex vivo activity of bortezomib in paediatric acute lymphoblastic leukaemia (ALL), in comparison to paediatric acute myeloid leukaemia (AML). A total of 159 patients en...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:Human immortal cells maintain their telomeres either by telomerase or by alternative lengthening of telomeres (ALT) that is based on homologous telomeric recombination. Previous studies showed that the ALT mechanism is activated in non-ALT cells when heterochromatic features are reduced. In this study, we examined the...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND/AIM:Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that allows accurate irradiation with reduced damage to surrounding tissues. Here, we analyzed borderline-resectable pancreatic cancer (BRPC) with arterial abutment (BR-A) patients with IMRT as neoadjuvant therapy and performed c...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12172
更新日期：2017-12-01 00:00:00
