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Effect of serum selenium levels on radiotherapy-related toxicity in patients undergoing radiotherapy for head and neck cancer.

Abstract：

AIM:To investigate whether there is a difference in selenium levels before and after radiotherapy (RT) and to study the effects of serum selenium levels on RT-related toxicity in patients undergoing RT for head and neck cancer. PATIENTS AND METHODS:A population of 47 consecutive patients was enrolled in the study. RT was given by conventional fractionation. RT-related acute toxicity was evaluated once a week. Blood samples were obtained before and after RT to evaluate selenium levels. RESULTS:There was no significant difference between the levels of selenium before and after RT (58.09 ± 1.36 μg/l and 56.34 ± 1.11 μg/l, p-value=0.747, respectively). Grade III-IV mucositis, dysphagia, radiodermatitis, and nausea were seen in 6 (12.7%), 32 (68.2%), 24 (51.1%), and 3 (6.4%) patients, respectively. It was found that there was no statistically significant difference in the levels of selenium before and after RT, and no observed differences in regard to RT-related toxicities. CONCLUSION:The serum selenium levels do not affect RT-related toxicities.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Eroglu C,Unal D,Cetin A,Orhan O,Sivgin S,Oztürk A

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

3587-90

issue

8

eissn

0250-7005

issn

1791-7530

pii

32/8/3587

journal_volume

32

pub_type

杂志文章

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