Expression of Nogo isoforms and Nogo-B receptor (NgBR) in non-small cell lung carcinomas.

abstract：BACKGROUND:Studies have recommended a 21-gene recurrence score (RS) to optimize adjuvant treatment for patients with early-stage breast cancer (EBC) with hormone receptor-positive (HR+) and human epidermal growth factor receptor-2 negative (HER2-) tumors. This study aimed to prospectively evaluate the impact of this RS...

journal_title：Anticancer research

authors： Zeng Y,Li Q,Qin T,Li S,Jin L,Wu J,Chen K,Deng H,Rao N,Liu Q,Su F,Jia W,Yao H

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of carcinogen-metabolizing enzyme genes have been associated with the risk of oral squamous cell carcinoma and oral leukoplakia. The overexpression of p53 protein is the most common genetic alteration in head and neck cancer. In the present study the combined or isolated presence of glu...

journal_title：Anticancer research

authors： Duarte EC,Ribeiro DC,Gomez MV,Ramos-Jorge ML,Gomez RS

更新日期：2008-03-01 00:00:00

abstract：:The effect of treatment schedule on the antitumor activity of a new platinum derivative, glycolate-0,0'-diammineplatinum (II) (254S) compared with cis- diamminedichloroplatinum (II) (CDDP) was investigated using ascites L1210 leukemia and solid Lewis lung carcinoma. The drugs were given i.p. by three treatments: as a ...

journal_title：Anticancer research

authors： Suzumura Y,Kato T,Ueda R,Ota K

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND/AIM:Tyrosine kinase inhibitors are important in the treatment of metastatic renal cell cancer (mRCC). The aim of the study was to evaluate the costs and effects of sunitinib in mRCC. PATIENTS AND METHODS:A total of 81 mRCC patients who received first-line sunitinib therapy between 2010 and 2014 were recruit...

journal_title：Anticancer research

authors： Vuorinen RL,Paunu N,Turpeenniemi-Hujanen T,Reunamo T,Jekunen A,Kataja V,Sintonen H,Purmonen T,Kellokumpu-Lehtinen PL

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:Competing mortality risks complicate treatment of elderly melanoma patients potentially leading to conservative management, including no sentinel lymph node biopsy. As systemic immunotherapy offers justification for nodal evaluation, we examined treatment trends among elderly melanoma patients. PATIENTS...

journal_title：Anticancer research

authors： Bateni SB,Johns AJ,Gingrich AA,Gholami S,Bold RJ,Canter RJ,Kirane AR

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND/AIM:In breast cancer (BC) care, radiation therapy (RT) is an efficient treatment to control localized tumor. Radiobiological research is needed to understand molecular differences that affect radiosensitivity of different tumor subtypes and the response variability. The aim of this study was to analyze gene ...

journal_title：Anticancer research

authors： Minafra L,Bravatà V,Cammarata FP,Russo G,Gilardi MC,Forte GI

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Dihydroceramide desaturase 1 (DES) is the enzyme responsible for converting dihydroceramide into ceramide in the de novo sphingolipid biosynthesis pathway. Dihydroceramide can inhibit ceramide channel formation to interfere with apoptosis. We have shown that following ceramide synthase knockdown, photodynami...

journal_title：Anticancer research

authors： Breen P,Joseph N,Thompson K,Kraveka JM,Gudz TI,Li L,Rahmaniyan M,Bielawski J,Pierce JS,VAN Buren E,Bhatti G,Separovic D

更新日期：2013-01-01 00:00:00

abstract：:The present study was performed to investigate the prognostic impact of tumor resection on survival in children and adolescents with malignant gliomas. From the HIT-GBM data base of the Gesellschaft für Paediatrische Onkologie und Haematologie (GPOH), 85 pediatric patients with malignant non-pontine gliomas were analy...

journal_title：Anticancer research

authors： Kramm CM,Wagner S,Van Gool S,Schmid H,Sträter R,Gnekow A,Rutkowski S,Wolff JE

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The pS2 protein is involved in the maintenance of the integrity of the gastrointestinal tract. In breast cancer pS2 can be demonstrated in at least half of the tumors and probably reflects the functional status of ER. Several features make it likely that pS2 is involved in growth regulation. PATIENTS AND ME...

journal_title：Anticancer research

authors： Jansen RL,Hupperets PS,Arends JW,Joosten-Achjanie SR,Volovics A,Hillen HF,Schouten HC

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Fulvestrant ('Faslodex') is a new type of oestrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. PATIENTS AND METHODS:In this open-label, Phase II trial, 30 postmenopausal Japanese women with hormone-sensitive advanced breast cancer, who had progressed on tamoxifen/t...

journal_title：Anticancer research

authors： Watanabe T,Sano M,Ohno S,Inaji H,Nishimura R,Shin E,Nomura Y,Morris C

更新日期：2004-03-01 00:00:00

abstract：:E-selectin which is expressed on endothelial cells plays an important role in the adhesion of cancer cells to the vascular endothelium, being the ligand for a carbohydrate antigen expressed on cancer cells. In this study, the clinical usefulness of this protein was examined. E-selectin was expressed on the endothelial...

journal_title：Anticancer research

authors： Matsuura N,Narita T,Mitsuoka C,Kimura N,Kannagi R,Imai T,Funahashi H,Takagi H

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND/AIM:Cold atmospheric plasma (CAP) attenuates tumor cell proliferation and induces apoptosis in various cell lines. While exerting marginal effects on non-neoplastic cells this unfolds promising applications in cancer therapy. The aim of the study was to analyse the effects of different CAP sources and applic...

journal_title：Anticancer research

authors： Gümbel D,Suchy B,Wien L,Gelbrich N,Napp M,Kramer A,Ekkernkamp A,Daeschlein G,Stope MB

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The doxorubicin-docetaxel combination is active in breast cancer; the aim of the present study was to evaluate the complete response rate and safety profile of the doxorubicin and docetaxel regimen as first-line chemotherapy in metastatic breast cancer patients. PATIENTS AND METHODS:Forty-three patients ent...

journal_title：Anticancer research

authors： Mattioli R,Lippe P,Massacesi C,Cappelletti C,Nacciarriti D,Bisonni R,Graziano F,Menichetti ET,Imperatori L,Testa E,Laici G,Balletra A,Silva RR

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Breast cancer is associated with inflammatory processes based on an up-regulation of cyclooxygenase-2 (COX-2) expression. The antiproliferative effects of calcitriol (1,25(OH)(2)D(3)) mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy. First data suggest a ...

journal_title：Anticancer research

authors： Thill M,Fischer D,Hoellen F,Kelling K,Dittmer C,Landt S,Salehin D,Diedrich K,Friedrich M,Becker S

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether high-dose-rate (HDR) intracavitary brachytherapy (IBT) dose ratios can predict treatment outcomes in patients with stage IIB cervical cancer. PATIENTS AND METHODS:Ninety-three patients treated with weekly cisplatin-based concurrent chemoradiotherapy and HDR IBT were analyzed. Pote...

journal_title：Anticancer research

authors： Cho O,Noh OK,Oh YT,Chang SJ,Chun M

更新日期：2017-01-01 00:00:00

abstract：:Pseudomyxoma peritonei (PMP) is a clinical condition characterized by diffuse intraabdominal spread of mucinous tumor implants that form on peritoneal surfaces. To complement the efficacy of cytoreductive surgery, an effective cytotoxic drug is required as an intraperitoneal agent for microscopic cytoreduction locoreg...

journal_title：Anticancer research

authors： Chua TC,Akther J,Yao P,Morris DL

更新日期：2009-10-01 00:00:00

abstract：AIM:Hepatic resection for hepatic ovarian cancer metastases remains controversial. The purpose of this study was to evaluate the clinical outcome of CT-guided high dose rate brachytherapy (CT-HDRBT) for minimally invasive cytoreduction of isolated metachronous ovarian cancer metastases to the liver. PATIENTS AND METHO...

journal_title：Anticancer research

authors： Collettini F,Poellinger A,Schnapauff D,Denecke T,Wust P,Braicu IE,Sehouli J,Hamm B,Gebauer B

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:To investigate the optimal duration of oral HCFU administration for minimization of side effects induced by long-term administration. PATIENTS AND METHODS:In total, 155 patients allocated to two groups of different duration of the therapy were reviewed: twice or three times per day doses of oral HCFU (8 mg/Kg ...

journal_title：Anticancer research

authors： Ito K,Kato T,Koike A,Miura K,Yamaguchi A,Sakou T,Takagi H

更新日期：2000-11-01 00:00:00

abstract：:Due to their estrogen-mimicking ability, pesticides are considered as prime etiological suspects of increasing tumor incidence, although a direct link is still undefined. The present study aimed to identify the effect of xenoestrogens (lindane, propoxur and endosulfan) at 20 mg/l each on tumorigenesis, by evaluating e...

journal_title：Anticancer research

authors： Bharathi SP,Raj HM,Jain S,Banerjee BD,Ahmed T,Arora VK

更新日期：2013-01-01 00:00:00

abstract：:This study investigates the treatment management and survival of inoperable advanced non-small cell lung cancer (NSCLC) patients. The objective was to treat all patients with induction chemotherapy and then to stratify them for surgery, radiotherapy, second-line chemotherapy or supportive treatment. Of the 359 patient...

journal_title：Anticancer research

authors： Stathopoulos GP,Dafni UG,Malamos NA,Rigatos S,Kouvatseas G,Moschopoulos N

更新日期：1999-07-01 00:00:00

abstract：:Gross cystic disease (GCD) represents an advanced form of fibrocystic disease of the breast. Bearers of macrocysts have been reported to be at risk of developing breast cancer. Natural killer (NK) cells are a lymphocyte subset deeply involved in immunosurveillance against neoplasia. We investigated whether breast cyst...

journal_title：Anticancer research

authors： Ardizzoja M,Masera RG,Tacconis P,Sartori ML,Arisio R,Massobrio M,Angeli A

更新日期：1994-03-01 00:00:00

abstract：:African-American women with breast cancer consistently show a shortened survival when compared with Caucasians with breast cancer, however it is not clear whether this is due to socioeconomic factors or to racial differences in tumor biology. Cyclin D1 overexpression has been demonstrated in 60-80% of female breast ca...

journal_title：Anticancer research

authors： Joe AK,Arber N,Bose S,Heitjan D,Zhang Y,Weinstein IB,Hibshoosh H

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Although significant accumulation of prostaglandin E(2) (PGE(2)) in the human prostate cancer tissues has been reported, there is lack of substantial evidence regarding the key role of PGE(2)-induced E-prostanoid-4 receptor (EP4) on Snail, a master regulator of epithelial mesenchymal transition (EMT). In thi...

journal_title：Anticancer research

authors： Kim HN,Narayanan NK,Lasano S,Narayanan B

更新日期：2011-12-01 00:00:00

abstract：:In previous studies performed by our group, we observed that 2-deoxyglucose blocked the acidification of the medium used for culture of colon cancer cells caused by incubation with biguanides and it had an additive inhibitory effect on growth. In the present work, we found that 3-bromopyruvate can also prevent the low...

journal_title：Anticancer research

authors： Lea MA,Qureshi MS,Buxhoeveden M,Gengel N,Kleinschmit J,Desbordes C

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND/AIM:Matrix metalloproteinase 20 (MMP20) is a member of the family of matrix metalloproteinases. Under normal conditions the expression of MMP20 is restricted to ameloblasts and odontoblasts. In order to identify a possible expression of MMP20 under pathological conditions, we investigated three major human t...

journal_title：Anticancer research

authors： Kraus D,Reckenbeil J,Perner S,Winter J,Probstmeier R

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND/AIM:To evaluate the effectiveness of enzalutamide in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer, progressing after chemotherapy with docetaxel plus prednisone. PATIENTS AND METHODS:A total of 60 patients were enrolled. Reduction in serum prostate-specific antige...

journal_title：Anticancer research

authors： Cicero G,DE Luca R,Dorangricchia P,Dieli F

更新日期：2017-03-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) rearrangements were first implicated as driving mutations in non-small cell lung cancer in 2007. Since then, a number of novel, small-molecule inhibitors directed against the ALK receptor have demonstrated superiority over standard chemotherapies in the treatment of ALK rearrangement-p...

journal_title：Anticancer research

authors： Millett RL,Elkon JM,Tabbara IA

更新日期：2018-09-01 00:00:00

abstract：:The antitumor effects of "half-mustard type" phenothiazines were studied on 57 different tumor cell lines, including leukemias, non-small lung cancer, colon, central nervous system, ovarian, renal, breast, and prostate cancer, as well as melanoma cell cultures. Alkyl-urea derivatives of phenothiazines displayed in vit...

journal_title：Anticancer research

authors： Wuonola MA,Palfreyman MG,Motohashi N,Kawase M,Gabay S,Nacsa J,Molnár J

更新日期：1997-09-01 00:00:00

abstract：:The results of palliative chemotherapy in 162 patients suffering from exocrine pancreatic cancer are presented. They are mainly discussed with respect to the possibility of improving survival of exocrine pancreatic cancer patients by an efficacy-orientated sequential polychemotherapy (EOSP). In about 40% of the patien...

journal_title：Anticancer research

authors： Klapdor R,Bahlo M,Babinski A,Broemel T,Müller C,Seutter R

更新日期：2003-03-01 00:00:00

abstract：:We assessed the effect of granulocyte apheresis in patients exhibiting increased granulocyte-to-lymphocyte ratio in order to overcome granulocytosis occurring in the terminal stages of malignancies. 17 patients with post-operative recurrent metastatic tumors including 6 gastric, 3 colonic, 2 rectal, 1 esophageal and 5...

journal_title：Anticancer research

authors： Tabuchi T,Ubukata H,Sato S,Nakata I,Goto Y,Watanabe Y,Hashimoto T,Mizuta T,Adachi M,Soma T

更新日期：1995-05-01 00:00:00