The Clinical Efficacy of Enzalutamide in Metastatic Prostate Cancer: Prospective Single-center Study.

Abstract:

BACKGROUND/AIM:To evaluate the effectiveness of enzalutamide in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer, progressing after chemotherapy with docetaxel plus prednisone. PATIENTS AND METHODS:A total of 60 patients were enrolled. Reduction in serum prostate-specific antigen (PSA) was assessed as the primary endpoint, while reduction in pain, safety, progression-free survival and overall survival represented secondary endpoints. RESULTS:Enzalutamide was well tolerated, with a manageable toxicity profile and a modest objective response rate. A considerable difference in serum levels of PSA before and after treatment was observed. A significant correlation between PSA response and overall survival was also noted. The regression analysis revealed PSA level to be predictive of overall survival. CONCLUSION:Enzalutamide was shown to be an effective and well-tolerated therapeutic option in patients with metastatic castration-resistant prostate cancer progressing after docetaxel plus prednisone treatment.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Cicero G,DE Luca R,Dorangricchia P,Dieli F

doi

10.21873/anticanres.11472

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

1475-1480

issue

3

eissn

0250-7005

issn

1791-7530

pii

37/3/1475

journal_volume

37

pub_type

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