Action of interferon alpha and beta on four human melanoma cell lines in vitro.

abstract：BACKGROUND:Multidrug resistance (MDR) is one of the major obstacles limiting the efficacy of cancer chemotherapy. Through screening a series of natural products, we have previously identified six naturally occurring bisbenzylisoquinoline alkaloids (BBIs) that possess potent activity to reverse P-glycoprotein (gp)-media...

journal_title：Anticancer research

authors： Zhu X,Sui M,Fan W

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Platinum-based chemotherapy represents the standard of care for advanced non-small cell lung cancer (NSCLC) while non-platinum-based regimens are frequently administered in patients with relapse. A retrospective analysis of the sequence administration of these regimens in the first- and second-line setting w...

journal_title：Anticancer research

authors： Kotsakis A,Hatzidaki D,Vamvakas L,Vardakis N,Kalykaki A,Bozionelou V,Androulakis N,Kalbakis K,Saridaki Z,Georgoulias V,Agelaki S

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Effectiveness of a new device inserted within the common cellulose acetate cigarette filter (named hypobaric chamber tar-removing system, HCTRS) to remove tar and its carcinogenic compounds from mainstream cigarette smoke (MCS). METHODS:Eighty HCTRS prototypes were mounted inside the cellulose acetate filter o...

journal_title：Anticancer research

authors： Lazzarino G,Tavazzi B,Sinibaldi-Vallebona P,Di Pierro D,Rasi G

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) class I expression is reportedly frequently reduced in cancer. We examined heat-shock protein (HSP) expression in hepatocellular carcinoma (HCC). PATIENTS AND METHODS:HCV-related HCC was examined in 73 patients who had undergone hepatectomy, and the relationship between HSP70 a...

journal_title：Anticancer research

authors： Yoshida S,Hazama S,Tokuno K,Sakamoto K,Takashima M,Tamesa T,Torigoe T,Sato N,Oka M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The antitumor effect exerted by tumor necrosis factor (TNF) is characteristic in that it causes central necrosis of the tumor mass. Viable tumor cells surrounding the tumor mass remain, however, even after most of the mass is necrotized, and these cells gradually regrow and form tumors. To overcome this, we ...

journal_title：Anticancer research

authors： Inagawa H,Nishizawa T,Honda T,Nakamoto T,Takagi K,Soma G

更新日期：1998-09-01 00:00:00

abstract：:We report a 64-year-old woman with a 9-cm liver tumor in the left lateral section. The patient had neither hepatitis B or C virus infection, nor cirrhosis. Carbohydrate antigen 19-9 (CA 19-9) level was 1,889 U/ml. We also suspected bulky hilar lymph node metastasis, and a left lateral sectionectomy without lymph node ...

journal_title：Anticancer research

authors： Miyata T,Beppu T,Imamura YU,Hayashi H,Imai K,Chikamoto A,Yamashita YI,Fukubayashi K,Ishiko T,Baba H

更新日期：2019-04-01 00:00:00

abstract：:Overexpression of p53-protein appears to be a common event in primary breast cancer. It has been proposed that the presence of elevated levels of this protein may be an independent prognostic factor and may be important for the ability of a tumor to metastasize. This study was performed to evaluate the influence of im...

journal_title：Anticancer research

authors： Hanzal E,Gitsch G,Kohlberger P,Dadak C,Miechowiecka N,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：UNLABELLED:AIM/ BACKGROUND: To determine the feasibility and safety of intratumoral α-gal glycolipids injection for conversion of human tumors into autologous Tumor Associated Antigens (TAA) vaccine. α-Gal glycolipids bind anti-Gal--the most abundant antibody in humans. Pre-clinical studies indicated that injected α-ga...

journal_title：Anticancer research

authors： Whalen GF,Sullivan M,Piperdi B,Wasseff W,Galili U

更新日期：2012-09-01 00:00:00

abstract：:Oxazolinodoxorubicin, a doxorubicin analog with a modified daunosamine moiety was synthesized. The properties of this compound and the parent doxorubicin were compared. The cytotoxicity in vitro studies against several human tumor cell lines (PC-3, MCF-7, SW707, HL-60, RPMI 8226, ACHN) showed higher antiproliferative ...

journal_title：Anticancer research

authors： Lukawska M,Klopotowska D,Milczarek M,Wietrzyk J,Studzian K,Szmigiero L,Porebska A,Oszczapowicz I

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIM:The utility of nanoparticle albumin-bound paclitaxel (nab-PTX) monotherapy in patients with relapsed small-cell lung cancer (SCLC) has not been fully evaluated. We aimed to investigate the efficacy and safety of nab-PTX monotherapy in relapsed SCLC patients, including heavily treated patients. PATIENTS ...

journal_title：Anticancer research

authors： Nakao M,Fujita K,Suzuki Y,Arakawa S,Sakai Y,Sato H,Muramatsu H

更新日期：2020-03-01 00:00:00

abstract：:Gn-RH agonists or surgical castration are considered standard treatment for patients affected by metastatic prostate cancer. Despite greater cost, chemical castration is often considered the treatment of choice as it is psychologically better tolerated. We report our experience of one patient undergoing treatment with...

journal_title：Anticancer research

authors： Rocco B,Ferrari M,Scardino E,Matei DV,Verweij F,Varela R,De Cobelli O

更新日期：2005-01-01 00:00:00

abstract：:The requirements on sunscreens have essentially changed, since some years ago it was demonstrated that approximately 50% of free radicals, that are formed in the skin by solar radiation, originate from the visible and infrared regions of the solar spectrum. In addition, a critical radical concentration threshold could...

journal_title：Anticancer research

authors： Zastrow L,Lademann J

更新日期：2016-03-01 00:00:00

abstract：AIM:To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). PATIENTS AND METHODS:We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as first-line chemotherapy whenever ...

journal_title：Anticancer research

authors： Fukuchi M,Ishibashi K,Tajima Y,Okada N,Yokoyama M,Chika N,Hatano S,Matsuzawa T,Kumamoto K,Kumagai Y,Baba H,Mochiki E,Ishida H

更新日期：2013-10-01 00:00:00

abstract：:Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment. Inhibition of ACAT results in suppression of pr...

journal_title：Anticancer research

authors： Zabielska J,Sledzinski T,Stelmanska E

更新日期：2019-07-01 00:00:00

abstract：:The antioxidative activity and antimutagenic effects of the water-soluble beta-(1-3)-D-glucan derivatives from biotechnologically important species, in particular carboxymethyl-glucan (CM-G) and sulfoethyl-glucan (SE-G) both from the baker's yeast Saccharomyces cerevisiae, and carboxymethyl-chitin-glucan (CM-CG) from ...

journal_title：Anticancer research

authors： Krizková L,Duracková Z,Sandula J,Slamenová D,Sasinková V,Sivonová M,Krajcovic J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND/AIM:Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatm...

journal_title：Anticancer research

authors： Sumida T,Ishikawa A,Kamata YU,Nakano H,Yamada T,Mori Y

更新日期：2016-06-01 00:00:00

abstract：AIM:This retrospective observational study evaluated the role of hypo-fractionated stereotactic radiotherapy (SRT) in patients with oligo-progressive metastatic renal cell carcinoma (mRCC) treated with first-line oral tyrosine kinase inhibitors (TKI). Data on local control, delay of further progression, and safety are ...

journal_title：Anticancer research

authors： Gebbia V,Girlando A,DI Grazia A,Fazio I,Borsellino N,Piazza D,Serretta V,Pergolizzi S,Pontoriero A,Firenze A,Valerio MR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in carcinogenesis and carcinoma progression. In this study we investigated the expression of HB-EGF in human colonic non-neoplastic and neoplastic tissues. MATERIALS AND METHODS:We performe...

journal_title：Anticancer research

authors： Ito Y,Higashiyama S,Takeda T,Okada M,Matsuura N

更新日期：2001-03-01 00:00:00

abstract：:Development of multidrug-resistance (MDR) remains a major cause of failure in the treatment of cancer with chemotherapeutic agents. In our efforts to explore alternative treatment regimens for multidrug-resistant tumors we have examined the sensitivity of MDR tumor cell lines to lymphokine activated killer (LAK) cells...

journal_title：Anticancer research

authors： Gautam SC,Chikkala NF,Lewis I,Grabowski DR,Finke JH,Ganapathi R

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy. PATIENTS AND METHODS:From 1995 to 2008, 53 patients with early-st...

journal_title：Anticancer research

authors： Ohga S,Nakamura K,Shioyama Y,Sasaki T,Yoshitake T,Atsumi K,Terashima K,Asai K,Matsumoto K,Yoshikawa H,Kawano Y,Honda H

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIM:Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients. MATERIALS AND METHODS:Using the Surveillance, Epidemiology...

journal_title：Anticancer research

authors： Li MU,Gu S,Mao R,Ning Y,Trivedi N,Siddiqui A,Li P,Huo L

更新日期：2019-02-01 00:00:00

abstract：:The relationship between apoptosis and chemosensitivity remains complex. We tested the chemosensitivity of 45 patients with advanced breast cancer (BC) ex vivo against anthracyclines (A: doxorubicin, epirubicin), taxanes (T: paclitaxel, docetaxel), cisplatin (DDP) and CMF and any correlation with the expression of p53...

journal_title：Anticancer research

authors： Rein DT,Schöndorf T,Breidenbach M,Janát MM,Weikelt A,Göhring UJ,Becker M,Mallmann P,Kurbacher CM

更新日期：2000-11-01 00:00:00

abstract：:The time course and characteristics of the tumor marker CASA (Cancer Associated Serum Antigen) during the menstrual cycle were analysed. We investigated whether hormonal influences in women and the score of this tumor marker ought to be considered in diagnosis. It could be demonstrated that CASA is not influenced by p...

journal_title：Anticancer research

authors： Meisel M,Römer T,Straube W

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Primary serous-papillary peritoneal carcinoma is able to spread to the retroperitoneal lymph nodes, but there is no evidence of the pattern of lymphatic metastasis. Because of the fact that this tumor entity is indistinguishable histologically from primary serous-papillary ovarian carcinoma, its taxonomic po...

journal_title：Anticancer research

authors： Steinhagen PR,Sehouli J

更新日期：2011-04-01 00:00:00

abstract：:Advanced or metastatic pancreatic cancer is an incurable disease. The main treatment is chemotherapy with cytotoxic agents. On the basis of our experience in clinical trials, the objectives have been to determine response rate, life prolongation and clinical benefit. In our trials and in those of other authors, all of...

journal_title：Anticancer research

authors： Stathopoulos GP,Androulakis N,Souglakos J,Stathopoulos J,Georgoulias V

更新日期：2008-03-01 00:00:00

abstract：:This study is a sequel in our continuing efforts to improve the colony forming efficiency of the Human Tumor Colony Assay. We have previously reported that the use of culture media supplemented with rat red blood cells and a low oxygen environment resulted in notable improvements in the clonal growth of three differen...

journal_title：Anticancer research

authors： Katoh A,Charoensiri S,Tchirkow G

更新日期：1987-05-01 00:00:00

abstract：UNLABELLED:Synthetic cannabinoid WIN55,212-2 (WIN) has shown a promise as an anticancer agent but causes psychoactive side-effects. In the present study, nano-micelles of styrene maleic acid (SMA)-conjugated WIN were synthesized to reduce side-effects and increase drug efficacy. SMA-WIN micelles were characterised and ...

journal_title：Anticancer research

authors： Xian S,Parayath NN,Nehoff H,Giles NM,Greish K

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the diagnostic value of FDG PET in the follow-up for breast cancer in disease-free patients and patients suspected of having recurrent or metastatic disease. As a single imaging tool, PET can be compared with the conventional diagnostic means used for different examin...

journal_title：Anticancer research

authors： Siggelkow W,Zimny M,Faridi A,Petzold K,Buell U,Rath W

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Various localized side effects which accompany head and neck irradiation [IR] have been widely reported. However, systemic side effects/have been only sparsely reported in the short-term period post-IR in an animal model. The potential modulatory role of zinc-desferrioxamine [Zn-DFO] on IR effects was examin...

journal_title：Anticancer research

authors： Nagler RM,Barak V,Nagler A

更新日期：2000-05-01 00:00:00

abstract：:The expression of the HMG-CoA-reductase and LDL-receptor genes was examined in primary human embryonic tumours and in normal human first trimester foetal tissues. All embryonic and extra-embryonic tissues examined contained RNA that hybridized with the HMG-CoA-reductase and LDL-receptor cDNA-probes. However, the trans...

journal_title：Anticancer research

authors： Engström W,Schofield PN

更新日期：1987-05-01 00:00:00