Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment.

abstract：BACKGROUND/AIM:The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. PATIENTS AND METHODS:Twenty patients with small intestinal lymphoma who underw...

journal_title：Anticancer research

authors： Iida T,Nozawa H,Sonoda H,Toyama K,Kawai K,Hata K,Tanaka T,Nishikawa T,Sasaki K,Shuno Y,Kaneko M,Murono K,Emoto S,Ishii H,Kurokawa M,Ishihara S

更新日期：2020-04-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) rearrangements were first implicated as driving mutations in non-small cell lung cancer in 2007. Since then, a number of novel, small-molecule inhibitors directed against the ALK receptor have demonstrated superiority over standard chemotherapies in the treatment of ALK rearrangement-p...

journal_title：Anticancer research

authors： Millett RL,Elkon JM,Tabbara IA

更新日期：2018-09-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...

journal_title：Anticancer research

authors： Romano M,DE Francesco F,Zarantonello L,Ruffolo C,Ferraro GA,Zanus G,Giordano A,Bassi N,Cillo U

更新日期：2016-04-01 00:00:00

abstract：:Game theory can be a powerful tool for generating testable hypotheses concerning biological systems. We present a simple game that has many features analogous to a developing cellular system. The game mimics random turning on of genes in cells. Despite the randomness explicit in the mechanism, the game nonetheless res...

journal_title：Anticancer research

authors： Root-Bernstein RS,Bernstein MI

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) is considered a promising new strategy for ovarian cancer treatment. As the key component in PDT, photosensitizer metabolism and localization in cancer cells is particularly important. MATERIALS AND METHODS:The localization of the photosensitizers hematoporphyrin monomethyl ether ...

journal_title：Anticancer research

authors： Song K,Li J,Li L,Zhang P,Geng F,Dong R,Yang Q,Qu X,Kong B

更新日期：2011-10-01 00:00:00

abstract：:The influence of psychoactive and nonpsychoactive cannabinoids on macromolecular biosynthesis and cell proliferation was compared in normal and transformed human cells which differ with respect to their abilities to metabolize polycyclic hydrocarbon-containing carcinogens. delta 9-THC, delta 8-THC, 11-OH-delta 9-THC, ...

journal_title：Anticancer research

authors： Green LG,Stein JL,Stein GS

更新日期：1983-05-01 00:00:00

abstract：:A 56-year-old Caucasian smoker male patient underwent right orchiectomy and spermatic cord resection for intrascrotal transilluminating mass. Histology findings suggested diagnosis of metastasis from Renal Cell Carcinoma (RCC). After positive CT-scan for primary neoplasm, total left nephrectomy was accomplished. Patie...

journal_title：Anticancer research

authors： Lauro S,Lanzetta G,Bria E,Trasatti L,Costarelli L,Vecchione A

更新日期：1998-11-01 00:00:00

abstract：:Megakaryocyte polyploidization responds to platelet demand and results from the lack of cytoplasmic separation while the nucleus keeps dividing. In normal telophase, the plane of the actin constriction ring is determined by the tubulin spindle. In order to investigate the role of tubulin in the megakaryocyte polyploid...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:The process of tumour invasion and subsequent metastasis represents the most lethal aspect of cancer and is responsible for the majority of deaths among cancer patients. Our objective was to identify invasion-specific genes in a series of isogenic breast cancer cell lines of differing invasive potential usin...

journal_title：Anticancer research

authors： Hughes L,O'Brien SL,Gallagher WM,Mcdonnell S

更新日期：2007-05-01 00:00:00

abstract：:35 patients suffering from malignant stage III/IV glioma were enrolled into a prospectively randomized clinical trial. All patients were provided with standard oncologic treatment (neurosurgery, radiation, basic clinical care according to protocol and indication) and randomly divided into a) treatment group: receiving...

journal_title：Anticancer research

authors： Lenartz D,Stoffel B,Menzel J,Beuth J

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Neolymphangiogenesis, a process of lymphatic vessel development in neoplastic tissue, may be a key event in the transmission of cancer cells into lymph nodes. The current study examined the relationship between lymphatic vessel density (LVD) measured by podoplanin (D2-40) expression, clinicopathological para...

journal_title：Anticancer research

authors： Donizy P,Rudno-Rudzinska J,Halon A,Dziegala M,Kabarowski J,Frejlich E,Dziegiel P,Kielan W,Matkowski R

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND/AIM:Despite an expected prognostic disadvantage for upper tract versus lower tract metastatic urothelial carcinomas (UTUC/LTUC), only few studies have been conducted to elucidate potential differences in chemotherapy treatment. PATIENTS AND METHODS:A post-hoc subgroup analysis of a non-interventional study ...

journal_title：Anticancer research

authors： Heers H,DE Geeter P,Goebell PJ,Matz U,DE Schultz W,Edlich B,Retz M,Hegele A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Using three commercially available, unmodified PSA assays, 917 sera of 355 patients after radical prostatectomy underwent native and lyophilisation-concentrated PSA-detection to evaluate the benefit of serum concentration as a tool to increase sensitivity for earlier detection of recurrent prostate cancer af...

journal_title：Anticancer research

authors： Haese A,Huland E,Graefen M,Huland H

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Whether high energy shock waves (HESW), generated by a piezoelectric generator, were able to activate a sonosensitizer, 5-aminolevulinic acid (ALA) and induce inhibition of cell growth in HT-29 human colorectal cancer cells was investigated. MATERIALS AND METHODS:Cell survival and cell death pathways were i...

journal_title：Anticancer research

authors： Canaparo R,Serpe L,Catalano MG,Bosco O,Zara GP,Berta L,Frairia R

更新日期：2006-09-01 00:00:00

abstract：:D-penicillamine (PSH) is a copper chelator that generates hydrogen peroxide and inhibits neovascularization. As hydrogen peroxide is toxic to some tumor cells and to blood vessels, we reasoned that PSH plus copper would inhibit tumors in vivo and in vitro. To test this hypothesis, we first incubated murine J558L plasm...

journal_title：Anticancer research

authors： Samoszuk M,Nguyen V

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND/AIM:Gemcitabine is a drug commonly used to treat pancreatic cancer but chemoresistance to it is a common clinical issue. KML001 (sodium meta-arsenite) has demonstrated certain antitumor activity. The objective of the study was to evaluate the influence of KML001 on the anticancer activity of gemcitabine agai...

journal_title：Anticancer research

authors： Yang MH,Lee KT,Yang S,Lee JK,Lee KH,Rhee JC

更新日期：2015-01-01 00:00:00

abstract：:The most widely-known anti-tumor drugs often induce marked immunosuppression which can give rise to one or more sepses. Anti-infection measures immediately applied can sometimes prove largely ineffective or even useless, the patient dying not as a result of the spread of the tumour but as a direct consequence of oppor...

journal_title：Anticancer research

authors： Castelli M,Baggio G,Ruberto AI,Malagoli M,Casolari C,Rossi T,Galatulas I

更新日期：1997-11-01 00:00:00

abstract：:The androgen-signaling pathway plays a critical role in prostate cancer development and progression. We have recently demonstrated that the Wilms' tumor suppressor gene product, WT1, binds to multiple sites in the androgen receptor (AR) promoter and transcriptionally represses the AR gene promoter in vitro. We asked w...

journal_title：Anticancer research

authors： Zaia A,Fraizer GC,Piantanelli L,Saunders GF

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:We have identified a novel cancer/testis antigen, TRAG-3, (Taxol Resistance Associated Gene-3) that was initially discovered in search for new genes involved in drug resistance by differential display. Early study of TRAG-3 revealed minimal to absent expression in various normal tissues and over-expression i...

journal_title：Anticancer research

authors： Feller AJ,Duan Z,Penson R,Toh HC,Seiden MV

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Tumour stage and the appropriate course of treatment in patients with breast cancer are primarily characterized by the state of metastasis in the axillary lymph nodes. In recent years, substantial research has focused on the prediction of lymph node status based on various pathological and molecular markers ...

journal_title：Anticancer research

authors： Mojarad S,Venturini B,Fulgenzi P,Papaleo R,Brisigotti M,Monti F,Canuti D,Ravaioli A,Woo L,Dlay S,Sherbet GV

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：:The effects of the 18 carbon chain length series of fatty acids on the viability of a 3T6 derived mouse fibroblast cell line were tested. An overall concentration dependent cytotoxic effect was demonstrated with the saturated fatty acid, and cis- and trans- mono- and dienoic fatty acids; however, within a narrow range...

journal_title：Anticancer research

authors： Girao LA,Cantrill RC,Ruck AC,Davidson BC

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Different phenomena can result in enlargement of mental foramen and mandibular canal. At the foreground of diagnosis is the assessment of the biological properties of the tissue which causes such detailed lesions of the skeleton. CASE REPORT:This report describes a palpable mass at the site of the mental fo...

journal_title：Anticancer research

authors： Friedrich RE,Matschke J,Wilczak W

更新日期：2019-08-01 00:00:00

abstract：AIM:To assess the correlation between advanced non-small cell lung cancer (NSCLC) with or without pulmonary lymphangitic carcinomatosis (PLC) and fluorodeoxyglucose (FDG) uptake and its effect on survival outcomes. PATIENTS AND METHODS:We retrospectively reviewed 157 patients with NSCLC. The mean and maximum standardi...

journal_title：Anticancer research

authors： Ooi H,Chen CY,Hsiao YC,Huang WS,Hsieh BT

更新日期：2016-08-01 00:00:00

abstract：:A large variety of models of both artificial and spontaneous metastases have been developed in experimental animals. These models have enabled the characterization of metastatic cancer cells and have helped in understanding the metastatic process. Studies of experimental metastases of human tumors have so far been rat...

journal_title：Anticancer research

authors： Doré JF,Bailly M,Bertrand S

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:No investigation of amrubicin monotherapy in pre-treated advanced non-small cell lung cancer (NSCLC) patients has yet been reported. PATIENTS AND METHODS:The records were reviewed of NSCLC patients who had received amrubicin monotherapy between 2003 and 2007 with the following eligibility criteria:previousl...

journal_title：Anticancer research

authors： Igawa S,Takahashi T,Nakamura Y,Tsuya A,Ono A,Shukuya T,Murakami H,Endo M,Yamamoto N

更新日期：2008-11-01 00:00:00

abstract：:Whether serum testosterone (T) can become an adjunct test able to validate the PSA-weighted risk of prostate cancer (PR.CA) in the "grey" diagnostic area (PSA =3.0 to <10.0 ng/ml) was investigated. Seven hundred and eighteen men participated in a prostate screening program using the cutoff PSA value of > or =3.0 ng/ml...

journal_title：Anticancer research

authors： Karamanolakis D,Lambou T,Bogdanos J,Milathianakis C,Sourla A,Lembessis P,Halapas A,Pissimissis N,Dessypris N,Petridou ET,Koutsilieris M

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND/AIM:In pancreatic cancer, where the microenvironment is extremely hypoxic, analyzing signal transduction under hypoxia is thought to be significantly important. By investigating microarray analysis of pancreatic cancer cells cultured under both normoxia and hypoxia, we found that the expression of leukocyte ...

journal_title：Anticancer research

authors： Yamasaki A,Nakayama K,Imaizumi A,Kawamoto M,Fujimura A,Oyama Y,Nagai S,Yanai K,Onishi H

更新日期：2017-12-01 00:00:00

abstract：:A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-...

journal_title：Anticancer research

authors： Lin WH,Song JS,Lien TW,Chang CY,Wu SH,Huang YW,Chang TY,Fang MY,Yen KJ,Chen CH,Chu CY,Hsieh HP,Chen YR,Chao YS,Hsu JT

更新日期：2012-01-01 00:00:00

abstract：:The aim of our study was to establish a simple method for routine analysis of c-erbB-2 gene expression in tumour samples. We constructed a plasmid for the in vitro synthesis of competitor RNA to be used as an internal exogenous control during the RT-PCR detection of c-erbB-2 expression. The competitor RNA harbors a 19...

journal_title：Anticancer research

authors： Schneeberger C,Eder S,Speiser P,Zeillinger R

更新日期：1996-03-01 00:00:00