Intratumoral but not peritumoral lymphatic vessel density measured by D2-40 expression predicts poor outcome in gastric cancer--ROC curve analysis to find cut-off point.

abstract：BACKGROUND/AIM:SLC9A9 plays an oncogenic role in esophageal squamous carcinoma and glioblastoma. Herein, we showed an oncogenic function of SLC9A9 in colorectal cancer (CRC). MATERIALS AND METHODS:We examined SLC9A9 expression in CRC specimens by immunohistochemistry. In CRC tissues, the relationship between SLC9A9 ex...

journal_title：Anticancer research

authors： Ueda M,Iguchi T,Masuda T,Komatsu H,Nambara S,Sakimura S,Hirata H,Uchi R,Eguchi H,Ito S,Sugimachi K,Mizushima T,Doki Y,Mori M,Mimori K

更新日期：2017-05-01 00:00:00

abstract：AIM:The primary aim of the study was to assess the association between risk of recurrence and HER2 equivocal gene status through immunohistochemistry in patients with early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed clinical and pathological data of 455 consecutive patients with early breast cance...

journal_title：Anticancer research

authors： Criscitiello C,Bagnardi V,Viale G,Disalvatore D,Rotmensz N,Esposito A,Goldhirsch A,Curigliano G

更新日期：2016-07-01 00:00:00

abstract：:A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of sma...

journal_title：Anticancer research

authors： Kinoshita K,Beppu T,Miyata T,Kuramoto K,Yoshida Y,Umesaki N,Kitano Y,Nakagawa S,Okabe H,Nitta H,Imai K,Hayashi H,Yamashita YI,Komori H,Horino K,Misumi A,Baba H

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Despite having disseminated cancer, not all patients are eligible for palliative chemotherapy or targeted therapies. AIM:To study reasons for withholding palliative chemotherapy, to survey which alternatives were offered and to study survival outcomes. MATERIALS AND METHODS:Medical records of 346 patients ...

journal_title：Anticancer research

authors： Randén M,Runesdotter S,Strang P

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:This was a validation study of a regional register of oral cancer in Örebro, Sweden. The purpose was to assess the rate of errors in baseline, and treatment, and the completeness and accuracy of data on recurrences. MATERIALS AND METHODS:A total of 653 cases with squamous cell cancer in the oral cavity were...

journal_title：Anticancer research

authors： Lundin E,Bergqvist M,Ahlgren J,Reizenstein J,Lennernäs BO

更新日期：2019-01-01 00:00:00

abstract：:We assessed the prognostic value of the local tumor characteristics inflammatory stromal reaction (ISR) and vascular space invasion (VSI) together with established prognostic criteria, in cervical cancer patients. One hundred and forty-two patients with carcinoma of the cervix stage IB to IIB undergoing radical hyster...

journal_title：Anticancer research

authors： Kainz C,Gitsch G,Tempfer C,Heinzl H,Koelbl H,Breitecker G,Reinthaller A

更新日期：1994-09-01 00:00:00

abstract：:Concurrent cisplatin-based chemotherapy and radiotherapy (CCRT) plus brachytherapy is standard treatment for locally advanced cervical cancer. Platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has been proposed as an alternative approach, especially for patients with stage Ib2-IIb disease...

journal_title：Anticancer research

authors： Gadducci A,Cosio S

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine the relationship between survival and value of molecular markers in the primary tumour in a group of patients with irresectable rectal cancer, treated with preoperative chemo-radiotherapy. MATERIALS AND METHODS:Immunohistochemistry for p53, p21, bcl-2 and Ki-67 was perfor...

journal_title：Anticancer research

authors： Reerink O,Karrenbeld A,Plukker JT,Verschueren RC,Szabó BG,Sluiter WJ,Hospers GA,Mulder NH

更新日期：2004-03-01 00:00:00

abstract：AIM:The suitability of Papanicolaou staining and of hematoxylin staining for DNA single-cell cytometry was investigated in comparison to Feulgen staining. MATERIALS AND METHODS:Ten normal cervical smears and ten cervical smears containing cells of a squamous cell carcinoma in situ were analyzed. The integrated optical...

journal_title：Anticancer research

authors： Biesterfeld S,Beckers S,Del Carmen Villa Cadenas M,Schramm M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Disseminated tumor cells (DTCs) in bone marrow (BM) occur in 30-40% of primary breast cancer patients. An impaired bone microenvironment may lead to reduced bone density and osteoporosis affecting the BM as a homing site for DTCs. The bone mineral density (BMD) and its correlation to DTC in BM was evaluated....

journal_title：Anticancer research

authors： Kraemer B,Rothmund R,Banys M,Krawczyk N,Solomayer EF,Mack C,Wallwiener D,Fehm T

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) have a high tumorigenic ability to form patient-derived tumor xenografts (PDXs). PDXs are an attractive pre-clinical model, but gene expression and biological behavior of cancer cells in the tumor will change during establishment and passage of PDXs. MATERIALS AND METHODS:Human colo...

journal_title：Anticancer research

authors： Mukohyama J,Shimono Y,Yamashita K,Sumi Y,Mukohara T,Minami H,Kakeji Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. PATIENTS AND METHODS:A case-control study was conducted to investigate the role of these polymorph...

journal_title：Anticancer research

authors： Delort L,Chalabi N,Satih S,Rabiau N,Kwiatkowski F,Bignon YJ,Bernard-Gallon DJ

更新日期：2008-09-01 00:00:00

abstract：AIM:To determine the maximally tolerated dose (MTD), recommended phase II dose (RPTD) and toxicity profile of gemcitabine plus irinotecan combination. PATIENTS AND METHODS:Thirty-nine evaluable patients with advanced solid tumors were treated with gemcitabine (Gem) and irinotecan (Iri) on days 1, 8 and 15 of a 28-day ...

journal_title：Anticancer research

authors： Dugan E,Truax R,Meadows KL,Blobe GC,Morse MA,Fernando NH,Gockerman JP,Petros WP,Hurwitz HI

更新日期：2009-12-01 00:00:00

abstract：:Adrenocortical Carcinoma (ACC) is rare with an annual incidence of 0.5-2 cases per million worldwide. Some ACC tumors over express N-cadherin, which correlates with metastatic potential. ADH-1 (Exherin™) is a competitive inhibitor of N-cadherin, resulting in rapid onset of tumor vascular angiolysis and apoptosis in pr...

journal_title：Anticancer research

authors： Yarom N,Stewart D,Avruch L,Malik R,Wells J,Jonker DJ

更新日期：2011-11-01 00:00:00

abstract：:The cell proliferation activity of sixteen childhood primitive neuroectodermal tumors (PNETs) was observed immunocytochemically, to determine the cell kinetics and cell proliferation activity of these relatively undifferentiated, malignant brain tumors. Two mouse anti-human monoclonal antibodies (MoABs) were employed ...

journal_title：Anticancer research

authors： Bodey B,Bodey B Jr,Gröger AM,Siegel SE,Kaiser HE

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIM:Bevacizumab (BV) has been used for the treatment of recurrent glioblastoma. However, it also induces epithelial-mesenchymal transition (EMT) in glioblastoma cells, which compromises its efficacy. BATF2 (basic leucine zipper ATF-like transcription factor 2), a multi-target transcriptional repressor, has b...

journal_title：Anticancer research

authors： Huang W,Zhang C,Cui M,Niu J,Ding W

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:3,4',7-O-trimethylquercetin (34'7TMQ), a derivative of quercetin, inhibited ovarian cancer cell migration and invasion without affecting proliferation. In this study, the apoptotic effect of 34'7TMQ on three cancer cell lines (CRL-1978, CRL-11731, SK-OV-3) was evaluated. MATERIALS AND METHODS:Expression...

journal_title：Anticancer research

authors： Ashraf AHMZ,Afroze SH,Yamauchi K,Zawieja DC,Keuhl TJ,Erlandson LW,Uddin MN

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:During the complex process of melanoma cell detachment from the primary tumor and subsequent metastasis, different cell surface proteins are involved in tumor cell interactions with extracellular matrix (ECM) components and surrounding cells. Melanoma cells are able to vary their expression patterns of adhes...

journal_title：Anticancer research

authors： Laube F

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the diagnostic value of FDG PET in the follow-up for breast cancer in disease-free patients and patients suspected of having recurrent or metastatic disease. As a single imaging tool, PET can be compared with the conventional diagnostic means used for different examin...

journal_title：Anticancer research

authors： Siggelkow W,Zimny M,Faridi A,Petzold K,Buell U,Rath W

更新日期：2003-03-01 00:00:00

abstract：:We have previously shown that transfection of NIH 3T3 cells with the T24 H-ras oncogene converts the cells to a tumorigenic and metastatic phenotype, in proportion to levels of ras expression. We hypothesize that ras-induced increases in malignancy occur via altered expression of various genes. We have identified OPN ...

journal_title：Anticancer research

authors： Chambers AF,Behrend EI,Wilson SM,Denhardt DT

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Docetaxel is a very active drug against breast cancer, but at the standard dose causes severe myelosuppression. In order to reduce the toxicity while maintaining the activity, weekly docetaxel administration was tested. PATIENTS AND METHODS:We enrolled 30 patients with metastatic breast cancer, who had been...

journal_title：Anticancer research

authors： Maisano R,Mare M,Zavettieri M,Caristi N,Mesiti M,Scisca C,La Torre F

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND/AIM:MicroRNAs (miRNAs) are closely associated with a number of cellular processes, including cell development, differentiation, proliferation, carcinogenesis, and apoptosis. The aim of the present study was to elucidate the molecular mechanisms underlying the tumor suppressor activity of miRNA-203 (miR-203) ...

journal_title：Anticancer research

authors： Kim JS,Choi DW,Kim CS,Yu SK,Kim HJ,Go DS,Lee SA,Moon SM,Kim SG,Chun HS,Kim J,Kim JK,Kim DK

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) have provided backbone structure for the chemical synthesis of potent anticancer drugs. In this study, the cytotoxicity of fifteen 2-(N-cyclicamino)chromone derivatives was investigated and subjected to quantitative structure-activity relationship (QSAR) analysis. MATE...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Sakagami H,Tomomura M,Tomomura A,Uesawa Y,Takao K,Sugita Y

更新日期：2018-07-01 00:00:00

abstract：:Development of multidrug-resistance (MDR) remains a major cause of failure in the treatment of cancer with chemotherapeutic agents. In our efforts to explore alternative treatment regimens for multidrug-resistant tumors we have examined the sensitivity of MDR tumor cell lines to lymphokine activated killer (LAK) cells...

journal_title：Anticancer research

authors： Gautam SC,Chikkala NF,Lewis I,Grabowski DR,Finke JH,Ganapathi R

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Osteoscopy is a minimally-invasive endoscopic technique for inspecting lesions inside bone marrow cavities. We describe the feasibility of osteoscopic surgery of giant cell tumor of bone (GCTB) in order to preserve the proximal fibula, and thereby achieve immediate recovery and avoid complications. PATIENTS...

journal_title：Anticancer research

authors： Futani H,Kumanishi S,Minakawa GO,Yoshiya S

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Endostar is a novel recombinant human endostatin expressed and purified in Escherichia coli with the N-terminal modified. It has been shown that endostar inhibited the proliferation of human umbilical vein endothelial cells (HUVECs) through the membrane surface receptor KDR/flt-1(VEGFR-2, vascular endothelia...

journal_title：Anticancer research

authors： Ling Y,Lu N,Gao Y,Chen Y,Wang S,Yang Y,Guo Q

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The mouse epidermal JB6 cell system is a model for studying tumor promotion. We used the JB6 Cl 41 cell line to examine the mechanism of the anti-tumor-promoting effect of tetrandrine, an alkaloid isolated from Stephania tetrandra S Moore. MATERIALS AND METHODS:The anti-tumor-promoting effect of tetrandrine...

journal_title：Anticancer research

authors： Nomura M,Yamazaki R,Takaya M,Kikuchi M,Takahashi-Nishioka T,Akiyama K,Akiyama N,Moritani S,Kobayashi S

更新日期：2007-09-01 00:00:00

abstract：:CD62L is the human homologue of the murine lymphocyte homing receptor, mel-14. We investigated CD62L + cells in the spleen from patients with gastric cancer. Flow cytometric analysis revealed that CD62L + cells were decreased in the peripheral blood, but inversely increased in the spleen in parallel with disease progr...

journal_title：Anticancer research

authors： Noma K,Yamaguchi Y,Okita R,Matsuura K,Toge T

更新日期：2005-01-01 00:00:00

abstract：AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

journal_title：Anticancer research

authors： Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND/AIM:In breast cancer (BC) care, radiation therapy (RT) is an efficient treatment to control localized tumor. Radiobiological research is needed to understand molecular differences that affect radiosensitivity of different tumor subtypes and the response variability. The aim of this study was to analyze gene ...

journal_title：Anticancer research

authors： Minafra L,Bravatà V,Cammarata FP,Russo G,Gilardi MC,Forte GI

更新日期：2018-05-01 00:00:00