A possible clinical adaptation of CRM197 in combination with conventional chemotherapeutic agents for ovarian cancer.

Abstract:

AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventional chemotherapeutic agents. MATERIALS AND METHODS:CRM197, bevacizumab, and paclitaxel were intraperitoneally administered either alone or in combination with mice xenografted with ES2 human ovarian cancer cells. The tumor volumes and microvessel densities (MVD) were determined. RESULTS:Enhanced antitumor effects were observed when paclitaxel was used in combination with bevacizumab or CRM197. The antitumor effect of paclitaxel/CRM197 was significantly higher than that of paclitaxel/bevacizumab. The tumor MVD of mice treated with paclitaxel/CRM197 was significantly lower than that of mice treated with paclitaxel/bevacizumab. CONCLUSION:CRM197 in combination with paclitaxel significantly blocked tumor formation and angiogenesis. These results suggest that paclitaxel is a suitable candidate for CRM197 combination therapy.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

2461-5

issue

7

eissn

0250-7005

issn

1791-7530

pii

31/7/2461

journal_volume

31

pub_type

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