Inhibition of tetrandrine on epidermal growth factor-induced cell transformation and its signal transduction.

abstract：BACKGROUND:Y-Box-Binding (YB1) protein represents a multifunctional protein, which plays a significant role in processes of proliferation, apoptosis and control of tumour cell response to toxic agents, including chemotherapy. The present study aimed at evaluating the prognostic significance of YB1 expression in breast ...

journal_title：Anticancer research

authors： Maciejczyk A,Szelachowska J,Ekiert M,Matkowski R,Hałoń A,Lage H,Surowiak P

更新日期：2012-08-01 00:00:00

abstract：:We report a case of mucoepidermoid carcinoma of the trachea in a 23-year-old pregnant female in her 39th week. The patient had cough and wheezing in the early morning for 9 months before admission. No abnormalities were detected on a chest roentgenogram. At Caesarean section, fiberscopy revealed a polypoid lesion narr...

journal_title：Anticancer research

authors： Watanabe M,Tomita K,Burioka N,Yajima H,Nakamura H,Ohgi S,Shimizu E

更新日期：2000-05-01 00:00:00

abstract：:Pallents with breast cancer exhibit an increased risk of developing cancer from other organs, a risk that might increase due to tamoxifen treatment. This drug has been found to cause activation of oestrogen receptors, leading to oestrogenic effects on the postmenopausal endometrium. We report follow-up of 94 patients ...

journal_title：Anticancer research

authors： Willén R,Lindahl B,Andolf E,Ingvar C,Liedman R,Ranstam J

更新日期：1998-01-01 00:00:00

abstract：:We examined the antitumor effect of lipopolysaccharide extracted from Pantoea agglomerans, a Gram-negative bacterium, using intradermal administration on murine syngeneic tumors, Meth A fibrosarcoma, MH134 hepatoma and Lewis lung (LL) carcinoma. The latter two tumors are known to be relatively low in immunogenicity, h...

journal_title：Anticancer research

authors： Inagawa H,Nishizawa T,Noguchi K,Minamimura M,Takagi K,Goto S,Soma G,Mizuno D

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:Laboratory rats can develop benign or malignant tumors (TM) spontaneously or following various carcinogenic processes, e.g. irradiation. The effects of irradiation vary according to the irradiation field (RF), the dosage and the strain of rat. Radiation-induced malignant TM in rats are predominantly sarcomas....

journal_title：Anticancer research

authors： Bartel-Friedrich S,Friedrich RE,Arps H,Holzhausen HJ

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIM:Our original hypothesis was that the rectus sheath block (RSB) analgesia could enhance patient satisfaction and decrease pain following midline laparotomy. PATIENTS AND METHODS:Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and con...

journal_title：Anticancer research

authors： Kuosmanen V,Ruottinen M,Rahkola D,Saimanen I,Kaaronen V,Selander T,Purdy M,Kokki H,Kokki M,Eskelinen M

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Intratumoural hypoxia is associated with chemoresistance in glioblastoma multiforme (GBM), a highly malignant brain tumour. Adaptive response to endoplasmic reticulum stress induced by temozolomide is a major obstacle in recurrent GBM. We investigated whether hyperoxia resensitizes temozolomide-resistant GBM...

journal_title：Anticancer research

authors： Lee D,Sun S,Ho AS,Kiang KM,Zhang XQ,Xu FF,Leung GK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND/AIM:The identification of a series of oxadiazole-based compounds, as promising antiproliferative agents, has been previously reported. The aim of this study was to explore the SAR of newly-synthesized oxadiazole derivatives and identify their molecular targets. MATERIALS AND METHODS:A small library of 1,2,5...

journal_title：Anticancer research

authors： Gelain A,Mori M,Meneghetti F,Porta F,Basile L,Marverti G,Asai A,Hyeraci M,García-Argáez AN,Via LD,Guccione S,Villa S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The chronomodulated infusion of 5-FU, FA and oxaliplatin allows a significant increase in dose intensity and antitumor efficacy in patients with metastatic colorectal cancer. Here we investigated if substitution of oxaliplatin with cisplatin produced a similar antitumor activity in previously untreated patie...

journal_title：Anticancer research

authors： Natoli C,Scognamiglio MT,Martino MT,Irtelli L,De Tursi M,Cianchetti E,Mascitelli E,Tinari N,Iacobelli S

更新日期：2000-03-01 00:00:00

abstract：AIM:To evaluate the frequency of loss of mediator of DNA damage checkpoint protein 1 (MDC1) protein expression in endometrial cancer (EC) and to determine whether loss of MDC1 is associated with certain clinicopathological parameters. MATERIALS AND METHODS:MDC1 expression was examined in 426 samples of EC. The nuclear...

journal_title：Anticancer research

authors： Merentitis D,Nguyen BD,Samartzis EP,Noske A,Brandt S,Dedes KJ

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the role of radiation therapy alone, employing standard fractionation, in stage III-IV hypopharyngeal carcinoma. MATERIALS AND METHODS:Fourteen (38.9%) stage III and 22 (61.1%) stage IV patients with hypopharyngeal carcinoma were submitted, with curative intent, to excl...

journal_title：Anticancer research

authors： Tombolini V,Santarelli M,Raffetto N,Donato V,Valeriani M,Ferretti A,Enrici RM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this phase I study was to determine the maximum-tolerated dose (MTD) and recommended dose (RD) of combination therapy with weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and cyclophosphamide (CPA) in metastatic breast cancer (MBC) patients. PATIENTS AND METHODS:Five patie...

journal_title：Anticancer research

authors： Ota D,Akatsuka S,Nishi T,Kato T,Takeuchi M,Tsuji M,Fukuuchi A

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Zoledronic acid is a new member of the bisphosphonate (BP) class of compounds, a family of closely related synthetic molecules originally derived from the naturally occurring pyrophosphate. These compounds that are potent inhibitors of bone resorption, have been shown to reduce the growth of several cancer c...

journal_title：Anticancer research

authors： Bäckman U,Svensson A,Christofferson RH,Azarbayjani F

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:A drawback of cancer gene therapy is the failure of toxic gene introduction into a proportion of the tumor cells, resulting in re-progression of the disease. Cancer cell-specificity of the gene introduction has also been problematic. MATERIALS AND METHODS:Previously defined promoter/enhancer DNA of Q5 tumor...

journal_title：Anticancer research

authors： Kuwada E,Noguchi K,Seo N,Yamashiro H,Egawa K

更新日期：2009-04-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is highly sensitive both to radiotherapy and chemotherapy. Given its high chemo sensitivity, even two decades ago, SCLC was one of the first malignancies deemed suitable for maximising the dose and dose intensity with the support of autologous bone marrow (ABMT). On the whole, results wer...

journal_title：Anticancer research

authors： Pasini F,Durante E,De Manzoni D,Rosti G,Pelosi G

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered. MATERIALS AND METHODS:Da...

journal_title：Anticancer research

authors： Pasqualetti F,Bocci G,Mey V,Menghini V,Montrone S,Cocuzza P,Ferrazza P,Seccia V,Delishaj D,Orlandini C,Fabrini MG,Danesi R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIM:Only 0.1-0.17% of all lung cancer patients are diagnosed with stage I or II small cell lung cancer (SCLC). Radiochemotherapy remains the standard treatment for limited stage disease. This study focused on prognostic factors in early stage SCLC treated with radiochemotherapy. PATIENTS AND METHODS:Seven f...

journal_title：Anticancer research

authors： Käsmann L,Bolm L,Janssen S,Rades D

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study is to find synergistic effect using FH535 and sorafenib by targeting the RAS/RAF/MAPK and WNT/β-catenin pathways. MATERIALS AND METHODS:3H-Thymidine incorporation assays were performed to address Huh7 and liver cancer stem cell (LCSC) inhibition using FH535 and sorafenib, alone and...

journal_title：Anticancer research

authors： Galuppo R,Maynard E,Shah M,Daily MF,Chen C,Spear BT,Gedaly R

更新日期：2014-04-01 00:00:00

abstract：:The design of treatment for patients with squamous cell carcinoma of the head and neck (SCCHN) is based on prognostic factors, today essentially performance status and TNM status. It becomes increasingly important to optimise treatment and find the appropriate level of treatment and resource consumption for each patie...

journal_title：Anticancer research

authors： Wennerberg J

更新日期：1996-07-01 00:00:00

abstract：:The melastatin-like transient receptor potential M2 (TRPM2) channel is a Ca2+ permeable channel that is activated by reactive oxygen species (ROS), and its activation induces necrotic cell death. The effect of insertion of TRPM2 into A172 human glioblastoma cells (A172 cells) was investigated. The insertion of TRPM2 c...

journal_title：Anticancer research

authors： Ishii M,Oyama A,Hagiwara T,Miyazaki A,Mori Y,Kiuchi Y,Shimizu S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Circulating nucleosomes are valuable biomarkers for therapy monitoring and estimation of prognosis in cancer disease. While epigenetic and genetic modifications of DNA have been reported in blood of cancer patients, little is known about modifications of histones on circulating nucleosomes. PATIENTS AND MET...

journal_title：Anticancer research

authors： Leszinski G,Gezer U,Siegele B,Stoetzer O,Holdenrieder S

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) provide a backbone structure for the chemical synthesis of potent anticancer drugs. In contrast to 2-(N-cyclicamino)chromones, the biological activity of 3-(N-cyclicamino)chromones has not been reported. In this study, cytotoxicity of 15 3-(N-cyclicamino)chromone deriva...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Uesawa Y,Sakagami H,Tomomura M,Tomomura A,Takao K,Sugita Y

更新日期：2018-08-01 00:00:00

abstract：:We herein report a case of locally advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer that achieved a pathological complete response (pCR) with pertuzumab, trastuzumab and docetaxel therapy. A 70-year-old female presented with an elastic hard mass, 5.0 cm in diameter with broad redness and...

journal_title：Anticancer research

authors： Inoue Y,Yamashita N,Tokunaga E,Tanaka K,Ueo H,Saeki H,Oki E,Yamamoto H,Maehara Y

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Doxorubicin remains one of the few drugs with consistent single agent activity in advanced Soft Tissue Sarcomas (STS), with a demonstrated dose-response relationship. Liposomal-encapsulated Doxorubicin (LED) has been shown to be at least as active as free doxorubicin in experimental models, and phase I and I...

journal_title：Anticancer research

authors： Toma S,Tucci A,Villani G,Carteni G,Spadini N,Palumbo R

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The prognostic significance of angiogenesis, proliferation and apoptosis after interferon (IFN) was investigated in 96 patients with renal cell carcinoma (RCC). MATERIALS AND METHODS:Microvessel density in the tumor(MVD), proliferative index(PI) and apoptotic index(AI) were quantified using immunohistochemi...

journal_title：Anticancer research

authors： Yoshino S,Kato M,Okada K

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIM:Second mitochondria-derived activator of caspase (Smac) is a proapoptogenic mitochondrial protein that antagonizes inhibitors of apoptosis proteins (IAPs), resulting in induction of apoptosis. In the present study we investigated the effects of a Smac mimetic in combination with doxorubicin against osteo...

journal_title：Anticancer research

authors： Kamata E,Kawamoto T,Ueha T,Hara H,Fukase N,Minoda M,Morishita M,Takemori T,Fujiwara S,Nishida K,Kuroda R,Kurosaka M,Akisue T

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Farnesyltransferase inhibitor R115777 (Tipifamib, Zarnestra) is active in breast cancer, but its efficacy in drug combinations has not been extensively investigated. MATERIALS AND METHODS:The activity of R115777 and paclitaxel, alone and in combination, was studied in the human breast cancer cell lines, BT-...

journal_title：Anticancer research

authors： Izbicka E,Campos D,Carrizales G,Patnaik A

更新日期：2005-09-01 00:00:00

abstract：CASE REPORT:This case study reports on a patient who relapsed with thymoma (mixed type) nine years after tumor resection. After four courses of rescue chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was administered t...

journal_title：Anticancer research

authors： Li P,Du F,Gong Z,Hu B,Chi C,Chu H,Chen J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:Pelvic exenteration is a radical procedure for certain advanced or recurrent gynaecological cancers, performed with curative or palliative intent. Its validity has evolved as operative mortality and morbidity have improved. This surgery was evaluated to determine the validity of these claims. PATIENTS A...

journal_title：Anticancer research

authors： Soeda S,Furukawa S,Sato T,Ueda M,Kamo N,Endo Y,Kojima M,Nomura S,Kataoka M,Fujita S,Endo H,Takahashi T,Watanabe T,Yamada H,Fujimori K

更新日期：2019-10-01 00:00:00

abstract：:Our investigation comprises 778 cases of resection for early gastric cancer (27.4% of all stomach resections). The rate of lymph node metastasis was 1.2% in m (mucosal cancer) group, 3.3% in sm (submucosal cancer) 1 group and 22.6% in sm 2 group. In sm 2 group, lymph node extirpation of R2 is essential. The five year ...

journal_title：Anticancer research

authors： Kito T,Yamamura Y,Kobayashi S

更新日期：1988-05-01 00:00:00