Validation of a Clinical Cancer Register at the Head and Neck Oncology Center in Örebro.

abstract：BACKGROUND:The correlation between telomerase activity and antitumor effects was investigated in cell lines of human gastric (MKN-28, MKN-45, and MKN-74) and breast (T-47D, MCF-7, ZR75-1) cancers to evaluate the possibility of utilizing this enzyme to predict tumor response to chemotherapy. MATERIALS AND METHODS:After...

journal_title：Anticancer research

authors： Terashima M,Takiyama I,Uesugi N,Sasaki N,Takagane A,Hayakawa Y,Abe K,Araya M,Nishizuka S,Shimooki O,Nakaya T,Irinoda T,Yonezawa H,Oyama K,Saito K

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) are the main immuno-biological agents used in the therapy of metastatic renal cell carcinoma (RCC). Unfortunately the promising results obtained in biological studies have not yet been confirmed in clinical studies. One reason is linked to the immunosuppr...

journal_title：Anticancer research

authors： Naglieri E,Lopez M,Lelli G,Morelli F,Amodio A,Di Tonno P,Gebbia N,Di Seri M,Chetri MC,Rizzo P,Abbate I,Casamassima A,Selvaggi FP,Colucci G

更新日期：2002-09-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) and its receptor (Flt) protein expression was immunologically studied individually and in combination with the microvascular density (MVD) determined by the factor 8-related antigen (F8RA) and their prognostic value in 118 patients with a pulmonary adenocarcinoma. The pres...

journal_title：Anticancer research

authors： Takanami I,Tanaka F,Hashizume T,Kodaira S

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:The successful use of clonal selection through fluctuation analysis of human cancer cells as a means for studying tumor progression has been previously reported. MATERIALS AND METHODS:Three clones derived from a parental population of human prostate cancer (LNCaP) cells were selected based on proliferation,...

journal_title：Anticancer research

authors： Ware JH,Zhou Z,Kopelovich L,Kennedy AR

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The pS2 protein is involved in the maintenance of the integrity of the gastrointestinal tract. In breast cancer pS2 can be demonstrated in at least half of the tumors and probably reflects the functional status of ER. Several features make it likely that pS2 is involved in growth regulation. PATIENTS AND ME...

journal_title：Anticancer research

authors： Jansen RL,Hupperets PS,Arends JW,Joosten-Achjanie SR,Volovics A,Hillen HF,Schouten HC

更新日期：1998-01-01 00:00:00

abstract：:Cervical cancer is not considered a hormone-responsive tumor in spite of the presence of estrogen receptors (ER) and progesterone receptors (PgR) in some of them. Endocrine treatments have not achieved clinical responses, however, tamoxifen has been reported to induce PgR and to inhibit cell growth of many cervical ca...

journal_title：Anticancer research

authors： Vargas Roig LM,Lotfi H,Olcese JE,Lo Castro G,Ciocca DR

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Multidrug resistance, the principal mechanism by which cancer cells develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapies. AIM:The aim of the study was to investigate the effect of K-2-11 on the reversal of multidrug resistance. MATERIALS AND METHODS:The...

journal_title：Anticancer research

authors： Cindric M,Cipak A,Serly J,Plotniece A,Jaganjac M,Mrakovcic L,Lovakovic T,Dedic A,Soldo I,Duburs G,Zarkovic N,Molnár J

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND/AIM:To assess prognosis of women aged 75 and older according to breast cancer (BC) diagnosis circumstances. PATIENTS AND METHODS:A retrospective cohort study was conducted in the Amiens, France, regional oncologic referral center between 2005 and 2015. Two groups were formed depending on whether the patient...

journal_title：Anticancer research

authors： Ilenko A,Sergent F,Mercuzot A,Zitoun M,Chauffert B,Foulon A,Gondry J,Chevreau J

更新日期：2017-02-01 00:00:00

abstract：AIM:The present study aimed to examine the survival benefit of adjuvant chemotherapy for the patients with stage IB gastric cancer according to the second English edition of the Japanese Classification of Gastric Carcinoma (2nd JCGC). PATIENTS AND METHODS:In total, 201 consecutive patients who underwent curative surge...

journal_title：Anticancer research

authors： Toyokawa T,Ohira M,Sakurai K,Kubo N,Tanaka H,Muguruma K,Hirakawa K

更新日期：2015-07-01 00:00:00

abstract：:Glioblastoma multiforme (GBM), a grade IV glioma, appears to harbor therapy-resistant cancer stem cells (CSCs) that are the major cause of recurrence. All-trans retinoic acid (ATRA), a derivative of retinoid, is capable of differentiating a variety of stem cells, as well as normal neural progenitor cells, and down-reg...

journal_title：Anticancer research

authors： Karsy M,Albert L,Tobias ME,Murali R,Jhanwar-Uniyal M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND/AIM:The purpose of this study was to consider appropriate application of liquid and re-biopsy through analysis of current status in practice. PATIENTS AND METHODS:We performed a retrospective analysis of 22 patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer wh...

journal_title：Anticancer research

authors： Komiya K,Nakashima C,Nakamura T,Hirakawa H,Abe T,Ogusu S,Takahashi K,Takeda Y,Egashira Y,Kimura S,Sueoka-Aragane N

更新日期：2018-06-01 00:00:00

abstract：:Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line...

journal_title：Anticancer research

authors： Mitsuhashi N,Ishikawa H,Saito Y,Takahashi T,Sakurai H,Nozaki M,Akimoto T,Hasegawa M,Maebayashi K,Niibe H

更新日期：1997-09-01 00:00:00

abstract：:Malignant cells appear to possess a special aptitude for survival. We attempted to prove this in vitro by acute nutritional and energy deprivation as a survival threat. A phosphate-buffered saline (PBS) survival test in cell culture allowed static observations. These were supplemented by classic and quantitative phase...

journal_title：Anticancer research

authors： Janeckova H,Vesely P,Chmelik R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy. PATIENTS AND METHODS:From 1995 to 2008, 53 patients with early-st...

journal_title：Anticancer research

authors： Ohga S,Nakamura K,Shioyama Y,Sasaki T,Yoshitake T,Atsumi K,Terashima K,Asai K,Matsumoto K,Yoshikawa H,Kawano Y,Honda H

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Infiltrates of lymphocytes are found in both autoimmune thyroid disease and papillary cancer and are responsible for thyroid destruction in autoimmune disease. Their role in neoplastic transformation is not yet clear. MATERIALS AND METHODS:Phenotypic studies and the capacity to undergo apoptosis were assess...

journal_title：Anticancer research

authors： Mardente S,Lenti L,Lococo E,Consorti F,Della Rocca C,Romeo S,Misasi R,Antonaci A

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. MATERIALS AND METHODS:We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell line...

journal_title：Anticancer research

authors： Turner SD,Merz H,Yeung D,Alexander DR

更新日期：2006-09-01 00:00:00

abstract：:The identification of new prognostic parameters in Superficial Transitional Cell Carcinoma of the Bladder (STCCB) is important since conventional methods are often insufficient for prognostic purposes. We studied the proliferation activity and the DNA ploidy status of 60 pTa and pT1 Superficial Transitional Cell Carci...

journal_title：Anticancer research

authors： Pantazopoulos D,Ioakim-Liossi A,Karakitsos P,Aroni K,Kakoliris S,Kanavaros P,Kyrkou KA

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabolism, is expressed by macrophages under the control of the transcription factor Liver X Receptor (LXR), an oxysterol-activated transcriptional factor involved in cholesterol metabolism. Recent work has shown that ...

journal_title：Anticancer research

authors： El Roz A,Bard JM,Valin S,Huvelin JM,Nazih H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:One of the challenges to improving access to care is identifying disparities in health care. To determine the influence of insurance status on outcome for patients with non-small cell lung cancer (NSCLC), we analyzed data from the National Cancer Data Base (NCDB) from 1998-2011. MATERIALS AND METHODS:Data f...

journal_title：Anticancer research

authors： Shi R,Diaz R,Shi Z,Duvall E,Mills G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma, satisfactory results are still difficult to achieve. New therapeutic modalities need to be developed for the improvement of these treatments. TRAIL (TNF-related apoptosis inducing ligand) is known as a selective apoptosis indu...

journal_title：Anticancer research

authors： Takeda S,Iwai A,Nakashima M,Fujikura D,Chiba S,Li HM,Uehara J,Kawaguchi S,Kaya M,Nagoya S,Wada T,Yuan J,Rayter S,Ashworth A,Reed JC,Yamashita T,Uede T,Miyazaki T

更新日期：2007-03-01 00:00:00

abstract：:To investigate the specific transduction of a suicide gene into human small cell lung carcinoma (SCLC) cells, we explored the promoter region of the neuron specific enolase (NSE) gene as a tumor-specific promoter. In Northern blot analysis, NSE mRNA was expressed more abundantly in the SBC3 human SCLC cell line than i...

journal_title：Anticancer research

authors： Tanaka M,Inase N,Miyake S,Yoshizawa Y

更新日期：2001-01-01 00:00:00

abstract：:The tumor progression concept was first defined by Foulds at the end of the nineteen fifties. His work about the evolution of mammary tumors led to the conclusion that a tumor is initiated as soon as a cell interacts with an oncogenic agent and that the tumor progresses by acquiring in a permanent and irreversible way...

journal_title：Anticancer research

authors： Lemieux L

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy (CCRT) is used to treat advanced head and neck cancer. The accuracy of evaluating lymph nodes metastases following CCRT is important for subsequent therapy. PATIENTS AND METHODS:Patients were divided into two groups, the complete response (CR) and the non-CR groups, as determine...

journal_title：Anticancer research

authors： Nishimura G,Matsuda H,Taguchi T,Takahashi M,Komatsu M,Sano D,Sakuma N,Arai Y,Takahashi H

更新日期：2012-02-01 00:00:00

abstract：:Information on chromosomal structural rearrangements in leukemia and solid tumors was retracted from a computerized databank and the literature. A binomial test procedure was used to determine the statistical significance of the observed numbers of breaks. Some 131 human cancer-specific chromosomal structural rearrang...

journal_title：Anticancer research

authors： De Braekeleer M

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:This retrospective study aimed to determine the efficacy and toxicity of a combined chemotherapeutic regimen of gemcitabine and cisplatin (GC) for the treatment of metastatic urothelial carcinomas (UCs) in patients 80 years of age and over. PATIENTS AND METHODS:Twelve patients who were at least 80 years old...

journal_title：Anticancer research

authors： Tanji N,Fukumoto T,Miura N,Yanagihara Y,Azuma K,Sasaki T,Nishida T,Kikugawa T,Shimamoto K,Aoki K,Yokoyama M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIM:Shortcomings of current methods of prostate cancer detection call for improved biomarkers. The transmembrane protease, serine 2:ets-related gene (TMPRSS2:ERG) gene fusion leads to the overexpression of ERG, an E-twenty six (ETS) family transcription factor, and is the most prevalent genetic lesion in pro...

journal_title：Anticancer research

authors： Chow A,Amemiya Y,Sugar L,Nam R,Seth A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND/AIM:Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. MATERIALS AND METHODS:Specimens were obtained from 62 patients wit...

journal_title：Anticancer research

authors： Midorikawa R,Hisaka T,Sakai H,Nomura Y,Goto Y,Sato T,Kawahara R,Ishikawa H,Fujita F,Yasunaga M,Tanigawa M,Naito Y,Akiba J,Yano H,Tanaka H,Akagi Y,Okuda K

更新日期：2019-08-01 00:00:00

abstract：:We have established a hepatocarcinoma cell line (LFCl2A) that produces voluminous tumors when injected into syngeneic Commentary rats. We have previously shown that when these cells were transfected with an episomal vector expressing the antisense IGFI cDNA the transduced cells partly lost their tumorigenic properties...

journal_title：Anticancer research

authors： Lafarge-Frayssinet C,Martin C,Van Binh PN,Achard-Ellouk S,Duc HT,Frayssinet C,Cardoso G,Desauty G,Warnet JM,Bréchot C,Sarasin A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:No investigation of amrubicin monotherapy in pre-treated advanced non-small cell lung cancer (NSCLC) patients has yet been reported. PATIENTS AND METHODS:The records were reviewed of NSCLC patients who had received amrubicin monotherapy between 2003 and 2007 with the following eligibility criteria:previousl...

journal_title：Anticancer research

authors： Igawa S,Takahashi T,Nakamura Y,Tsuya A,Ono A,Shukuya T,Murakami H,Endo M,Yamamoto N

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) is a risk factor for tonsillar squamous cell carcinoma (TSCC) and the presence of HPV is correlated to a better clinical outcome. To find additional biomarkers that, together with HPV, predict clinical outcome, the aim of the present study was to evaluate epidermal growth factor re...

journal_title：Anticancer research

authors： Romanitan M,Näsman A,Munck-Wikland E,Dalianis T,Ramqvist T

更新日期：2013-04-01 00:00:00