CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy.

abstract：:Bombesin (BN) is a peptide exhibiting a high affinity for the gastrin-releasing peptide (GRP) receptor, which is overexpressed by a variety of tumors, including breast or prostate cancer. The aim of the present study was the investigation of the complexes formed between a series of BN-like peptides and the nuclides (1...

journal_title：Anticancer research

authors： Gourni E,Paravatou M,Bouziotis P,Zikos C,Fani M,Xanthopoulos S,Archimandritis SC,Livaniou E,Varvarigou AD

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanPDT+HPR enhanced accumulation of C16-dihydroceramide, and that fumonisi...

journal_title：Anticancer research

authors： Boppana NB,Kraveka JM,Rahmaniyan M,Li LI,Bielawska A,Bielawski J,Pierce JS,Delor JS,Zhang K,Korbelik M,Separovic D

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND/AIM:Multidrug resistance (MDR) is often associated with overexpression of P-glycoprotein (ABCB1) in cancer cells. Apatinib is a novel Vascular endothelial growth factor receptor-TKI (VEGFR-TKI) which inhibits the function of ABCB1 in certain cancers. This study aimed to investigate the effect of apatinib on ...

journal_title：Anticancer research

authors： Zhang Q,Song Y,Cheng X,Xu Z,Matthew OA,Wang J,Sun Z,Zhang X

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS:Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180....

journal_title：Anticancer research

authors： Glei M,Fischer S,Lamberty J,Ludwig D,Lorkowski S,Schlörmann W

更新日期：2018-01-01 00:00:00

abstract：:Advanced or metastatic pancreatic cancer is an incurable disease. The main treatment is chemotherapy with cytotoxic agents. On the basis of our experience in clinical trials, the objectives have been to determine response rate, life prolongation and clinical benefit. In our trials and in those of other authors, all of...

journal_title：Anticancer research

authors： Stathopoulos GP,Androulakis N,Souglakos J,Stathopoulos J,Georgoulias V

更新日期：2008-03-01 00:00:00

abstract：:Methodological aspects of testing chemosensitivity by the 6-day subrenal capsule (SRC) assay in immunocompetent mice were investigated. Human tumor xenografts, serially transplanted in athymic nude mice, were used as source of material. All drugs were given by the intravenous route. Administration of the drugs on days...

journal_title：Anticancer research

authors： Aamdal S,Fodstad O,Pihl A

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND/AIM:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel clinical approach to the treatment of peritoneal carcinomatosis. A well-established, not anatomic ex vivo PIPAC model was used to investigate the influence of changes in internal pressure, distance of the Micropump(©) (MIP) to the distri...

journal_title：Anticancer research

authors： Khosrawipour V,Khosrawipour T,Falkenstein TA,Diaz-Carballo D,Förster E,Osma A,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-09-01 00:00:00

abstract：:Major drawbacks to present-day cancer chemotherapy are its intrinsic lack of selectivity for tumour cells, resulting in severe damage to normal rapidly dividing cells, and the widespread emergence of drug resistance. Here experimental evidence is presented demonstrating that PB-100, a beta-carboline alkaloid, selectiv...

journal_title：Anticancer research

authors： Beljanski M,Crochet S,Beljanski MS

更新日期：1993-11-01 00:00:00

abstract：:The option to treat patients presenting with HER-2 overexpressed invasive breast carcinoma with Herceptin requires quantitative determination of the HER-2 status. The aim of this study was to retrospectively evaluate the HER-2 mRNA expression levels using quantitative real-time RT-PCR (Q-RT-PCR) in tissue samples from...

journal_title：Anticancer research

authors： Bossard C,Bieche I,Le Doussal V,Lidereau R,Sabourin JC

更新日期：2005-11-01 00:00:00

abstract：:Gastric involvement is unusual in primary mediastinal large B-cell lymphoma (PMLBCL), which has not yet been adequately studied. The aim of this retrospective study was to investigate the frequency of gastric involvement in 204 consecutive patients with PMLBCL that presented at 23 hospitals in Greece. Two out of 204 p...

journal_title：Anticancer research

authors： Papageorgiou SG,Sachanas S,Pangalis GA,Tsopra O,Levidou G,Foukas P,Rondogianni P,Sotiropoulos V,Ioannidou HD,Gassiamis A,Iliakis T,Korkolopoulou P,Angelopoulou MK,Pappa V,Konstantopoulos K,Vassilakopoulos TP

更新日期：2014-11-01 00:00:00

abstract：:Adenomas of the stomach are histologically classified into tubular and villous adenomas, mixed (tubulovillous) and papillary phenotypes being also recognized. They are localized in the antrum and the body. In a previous work we reported a case of serrated adenoma of the cardia having, at the time of diagnosis, an inva...

journal_title：Anticancer research

authors： Rubio CA,Lagergren J

更新日期：2004-05-01 00:00:00

abstract：:A semiempirical molecular-orbital method (CAChe) was applied to delineate the relationship between the cytotoxicity (evaluated by 50% cytotoxic concentration, CC50) of fifteen phenoxazine derivatives and eleven physical parameters (descriptors). Most of the phenoxazine derivatives had extended and planar structure. Th...

journal_title：Anticancer research

authors： Ishihara M,Kawase M,Westman G,Samuelsson K,Motohashi N,Sakagami H

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the role of radiation therapy alone, employing standard fractionation, in stage III-IV hypopharyngeal carcinoma. MATERIALS AND METHODS:Fourteen (38.9%) stage III and 22 (61.1%) stage IV patients with hypopharyngeal carcinoma were submitted, with curative intent, to excl...

journal_title：Anticancer research

authors： Tombolini V,Santarelli M,Raffetto N,Donato V,Valeriani M,Ferretti A,Enrici RM

更新日期：2004-01-01 00:00:00

abstract：:Angiosarcoma of the breast is a malignant tumour of vascular endothelial cells. It is a rare and difficult tumour to treat. The authors report a case of cutaneous radiation-associated angiosarcoma treated with paclitaxel chemotherapy. A few days after drug administration, bleeding of skin lesions was observed and the ...

journal_title：Anticancer research

authors： Tomasello L,Gardin G,Boccardo F

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:UNC5C, one of the Netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, two reports indicated that UNC5C methylation was closely associated with loss of gene expression in colorectal cancer. ...

journal_title：Anticancer research

authors： Hibi K,Mizukami H,Shirahata A,Goto T,Sakata M,Saito M,Ishibashi K,Kigawa G,Nemoto H,Sanada Y

更新日期：2009-01-01 00:00:00

abstract：AIM:This retrospective observational study evaluated the role of hypo-fractionated stereotactic radiotherapy (SRT) in patients with oligo-progressive metastatic renal cell carcinoma (mRCC) treated with first-line oral tyrosine kinase inhibitors (TKI). Data on local control, delay of further progression, and safety are ...

journal_title：Anticancer research

authors： Gebbia V,Girlando A,DI Grazia A,Fazio I,Borsellino N,Piazza D,Serretta V,Pergolizzi S,Pontoriero A,Firenze A,Valerio MR

更新日期：2020-12-01 00:00:00

abstract：:Concentrations of soluble CD44 standard (sCD44std) and CD44 variant 6 (sCD44v6) isoforms were determined in the sera of 59 patients with distant metastasis from breast cancer receiving second line hormone- or chemotherapy, in comparison to 46 breast cancer patients without detectable recurrent disease and 21 healthy b...

journal_title：Anticancer research

authors： Kopp R,Classen S,Wolf H,Gholam P,Possinger K,Wilmanns W

更新日期：2001-07-01 00:00:00

abstract：:Fine needle aspiration (FNA) cytology, being the mainstay to diagnose thyroid nodules, does not provide definitive results in a subset of patients. The use of molecular markers testing has been described as a useful aid in differentiation of thyroid nodules that present with an indeterminate cytodiagnosis. Molecular t...

journal_title：Anticancer research

authors： Bhatia P,Deniwar A,Friedlander P,Aslam R,Kandil E

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIM:This study aimed to identify the survival benefit of intrahepatic tumour control by hepatic arterial infusion chemotherapy (HAIC) in hepatocellular carcinoma (HCC) patients with portal vein tumour thrombus (PVTT) or extrahepatic metastasis. PATIENTS AND METHODS:Between 2010 and 2017, a total of 187 cons...

journal_title：Anticancer research

authors： Sung PS,Yang K,Bae SH,Oh JS,Chun HJ,Nam HC,Jang JW,Choi JY,Yoon SK

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIM:Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with ...

journal_title：Anticancer research

authors： Jukic Z,Ferencic Z,Radulovic P,Mijic A,Fucic A

更新日期：2014-12-01 00:00:00

abstract：:B-1 F is a cell line established from estrogen-responsive murine Leydig cell tumor and maintained in vitro. We investigated the effects of steroid hormones on the growth of tumors produced by the inoculation of B-1 F cells into mice. When tumor tissues were transplanted into castrated male mice, injections of estradio...

journal_title：Anticancer research

authors： Yamamoto T,Li I,Uchida N,Nishizawa Y,Yamamoto R,Terada N,Taniguchi H,Matsumoto K,Sato B

更新日期：1992-09-01 00:00:00

abstract：:Norcantharidin (NCTD) was purified from mylabris, the dried body of the Chinese blister beetle. NCTD has been shown to exhibit anticancer activities in many human cancer cell lines, but there are no reports to show whether it induces apoptosis of human gastric cancer cells. Therefore, in the present study, we investig...

journal_title：Anticancer research

authors： Zheng LC,Yang MD,Kuo CL,Lin CH,Fan MJ,Chou YC,Lu HF,Huang WW,Peng SF,Chung JG

更新日期：2016-11-01 00:00:00

abstract：:Cisplatin is the most active anticancer agent for lung cancer. It has been reported that intracellular accumulation of cisplatin is important in determining resistance to cisplatin, which may be modulated by Na+, K(+)-ATPase activity. On the other hand, it is well-known that sorbitol, a metabolite of glucose mediated ...

journal_title：Anticancer research

authors： Bando T,Fujimura M,Kasahara K,Shibata K,Shirasaki H,Heki U,Iwasa K,Ueda A,Tomikawa S,Matsuda T

更新日期：1997-09-01 00:00:00

abstract：:The cyanoguanidine CHS 828 was recently shown to possess potent anti-tumour effects both in vitro and in vivo. The exact mechanism of action of CHS 828 is not known, but recent results have indicated that induction of programmed cell death may be one mechanism by which CHS 828 exerts its anti-tumour effects. To invest...

journal_title：Anticancer research

authors： Hansen CM,Hansen D,Holm PK,Larsson R,Binderup L

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIM:To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation. PATIENTS AND METHODS:We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institu...

journal_title：Anticancer research

authors： Okauchi S,Numata T,Nawa T,Ichimura H,Saito T,Hayashihara K,Yamada H,Satoh H,Endo T,Inage Y,Kaburagi T,Kiyoshima M,Yamada Y,Tamura T,Saito K,Inagaki M,Hizawa N,Sato Y,Shiozawa T,Sekine I,Ishikawa H,Kurihima K,S

更新日期：2020-02-01 00:00:00

abstract：:The present study compared the effects of four lipophilic forms of selenium with regard to cancer chemopreventive activity, tissue selenium accumulation, and bioavailability for synthesis of a selenoprotein. These reagents included methylphenyl selenide, diphenyl selenide, triphenyl-selenonium chloride, and p-xylylbis...

journal_title：Anticancer research

authors： Ip C,Lisk DJ,Ganther HE

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Vinflunine is a novel Vinca alkaloid currently undergoing Phase II clinical trials, which have previously demonstrated anti-vascular effects in a transplantable murine colon adenocarcinoma model. Previous studies with compounds showing similar effects in combination with standard anti-cancer agents have demo...

journal_title：Anticancer research

authors： Shnyder SD,Cooper PA,Gyselinck N,Hill BT,Double JA,Bibby MC

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to share...

journal_title：Anticancer research

authors： Mahmood S,Vu K,Tai P,Joseph K,Koul R,Dubey A,Yu E

更新日期：2015-04-01 00:00:00

abstract：:Intracellular accumulation of adriamycin (ADR) has been reported to be influenced by cell membrane potential. We first evaluated intracellular accumulation of ADR and 3,3'-(di-n-hexyl)-2,2'-oxacarbocyanine iodide (NK-2280), an indicator of cell membrane potential, and found a good correlation between ADR and NK-2280 i...

journal_title：Anticancer research

authors： Asaumi JI,Kawasaki S,Gao XS,Kuroda M,Hiraki Y

更新日期：1996-03-01 00:00:00

abstract：:Induction of apoptosis by green tea polyphenols has been observed in various tumor cell systems, but whether green tea polyphenol-induced apoptosis requires caspase 3 for execution has not been confirmed. We previously reported that green tea polyphenol-induced apoptosis involved Apaf-1 accumulation and caspase 3 acti...

journal_title：Anticancer research

authors： Hsu S,Lewis J,Singh B,Schoenlein P,Osaki T,Athar M,Porter AG,Schuster G

更新日期：2003-03-01 00:00:00